The Egyptian Cardiothoracic Surgeon (ECTS - E-Journal)
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Effects of long-term treatment with the neuroleptics haloperidol, clozapine and olanzapine on immunoexpression of NMDA receptor subunits NR1, NR2A and NR2B in the rat hippocampus.
No full textBACKGROUND: Antagonists of the N-methyl-d-aspartate receptor (NMDA-R) are associated with symptoms of schizophrenia, leading to the hypothesis that NMDA-R hypofunction leads to the pathogenesis of disease. We evaluated the long-term effect of neuroleptic administration on the NMDA subunits via immunohistochemical analysis. METHODS: Rats received olanzapine, clozapine and haloperidol before evaluation of the expression of the NR1, NR2A and NR2B subunit proteins in the hippocampal areas of the brain, via a densytometric analysis of immunoexpression in the rat hippocampus. RESULTS: All of the neuroleptics examined caused a decrease in the expression of the NR1 subunit, and thus, one can assume that both olanzapine, clozapine and haloperidol decreased the number of NMDA receptors in the CA1 and CA2 areas of the brain. CONCLUSIONS: A decrease in hippocampal glutamatergic signalling after long-term neuroleptic administration may cautiously explain the incomplete effectiveness of these drugs in the therapy of schizophrenia-related cognitive disturbances
Drive System Dynamics Compensator for a Mechanical System Emulator
No full textA system compensator is designed to cancel the mechanical characteristics of a power electronics-controlled induction motor drive with a coupled electrical generator system. The emulation scheme using the compensator enables accurate emulation of high speed and high power mechanical system dynamics. The compensator is developed based on the system transient response of the test rig, considering the full operating range of the test system. The design process of the compensator is described and it is validated in both the time and frequency domains. Finally, the effectiveness of the compensator is demonstrated by simulation and experimental emulation of aero gas engine dynamics
An extended framework of cages formed of pre synthesised and functionalised heterometallic cages
No full textFree functional muscle transfer for restoration of upper limb function in preschool children
No full textDistributed internal strain measurement during composite manufacturing using optical fibre sensors
No full textAfter manufacturing a composite laminate, it is expected to store residual stresses that might affect the mechanical response of the plate. An optical fibre sensor was embedded in an epoxy carbon fibre panel, measuring the development of residual strain by monitoring in-situ and in real-time the manufacturing process, from the resin infusion to the curing cycle, and the changes experienced within. An optical sensor interrogator detects and measures changes in strain and temperature along the optical fibre length with high precision and accuracy, making it possible to obtain a full strain/temperature profile. Data acquired from the embedded sensor led to track and characterize the strain profile at every stage of the manufacturing process. This work showed that the infusion stage is highly related to the residual strain after the curing process. Moreover, the residual strain is 40% higher near the edge compared to the mean value measured in the laminate
Characterising Phase Q and the Q-Process with Iodine and Xenon
No full textIodine-xenon systematics constrain the incorporation mechanism and loss during processing of Q-Xe and Xe-P3, and indicate their relationship to one another
Crystal structure of catena-poly[hemi[1,3-bis(2,6-diisopropylphenyl)imidazolium] [[μ3-acetato-κ3 O:O:O'-tri-μ2-acetato-κ6 O:O'-dicopper(II)(Cu-Cu)]-μ-chlorido] dichloromethane sesquisolvate]
No full textThe title copper(II) complex, {(C27H37N2)[Cu4(CH3COO)8Cl]·3CH2Cl2}n, is a one-dimensional coordination polymer. The asym. unit is composed of a copper(II) tetraacetate paddle-wheel complex, a Cl- anion situated on a twofold rotation axis, half a 1,3-bis(2,6-diisopropylphenyl)imidazolium cation (the whole mol. being generated by twofold rotation symmetry) and one and a half of a dichloromethane solvent mol. (one being located about a twofold rotation axis). The central metal-org. framework comprises of a tetranuclear copper(II) acetate 'paddle-wheel' complex which arises from the dimerization of the copper(II) tetraacetate core comprising of three μ2-bidentate acetate and one μ3-tridentate acetate ligands per binuclear paddle-wheel complex. Both CuII atoms of the binuclear component adopt a distorted square-pyramidal coordination geometry (τ = 0.04), with a Cu···Cu sepn. of 2.6016 (2) Å. The apical coordination site of one CuII atom is occupied by an O atom of a neighboring acetate bridge [Cu-O = 2.200 (2) Å], while that of the second CuII atom is occupied by a bridging chloride ligand [Cu···Cl = 2.4364 (4) Å]. The chloride bridge is slightly bent with respect to the Cu···Cu internuclear axis [Cu-Cl-Cu = 167.06 (6)°] and the tetranuclear units are located about a twofold rotation axis, forming the one-dimensional polymer that propagates along [101]. Charge neutrality is maintained by the inclusion of the 1,3-bis(2,6-diisopropylphenyl)imidazolium cation within the crystal lattice. In the crystal, the cation and dichloromethane solvent mols. are linked to the coordination polymer by various C-H···O and C-H···Cl hydrogen bonds. There are no other significant intermol. interactions present
