The Egyptian Cardiothoracic Surgeon (ECTS - E-Journal)
Not a member yet
46902 research outputs found
Sort by
Mood disorders in systemic lupus erythematosus: Results from an international, inception cohort study.
No full textOBJECTIVE: To determine the frequency, clinical and autoantibody associations and outcome of mood disorders in a multi-ethnic/racial, prospective, inception cohort of SLE patients. METHODS: Patients were assessed annually for mood disorders (4 types as per DSM-IV) and 18 other neuropsychiatric (NP) events. Global disease activity (SLEDAI-2K), SLICC/ACR damage index (SDI) and SF-36 subscale, mental (MCS) and physical (PCS) component summary scores were collected. Time to event, linear and ordinal regressions and multi-state models were used as appropriate. RESULTS: Of 1,827 SLE patients, 88.9% were female, 48.9% Caucasian, mean±SD age 35.1±13.3 years, disease duration 5.6±4.8 months and follow-up 4.73±3.45 years. Over the study 863 (47.2%) patients had 1,627 NP events. Mood disorders occurred in 232/1827 (12.7%) patients and 98/256 (38.3%) events were attributed to SLE. The estimated cumulative incidence of any mood disorder after 10 years was 17.7% (95%CI=[15.1%,20.2%]). There was a greater risk of mood disorder in patients with concurrent NP events (p≤0.01) and lower risk with Asian race/ethnicity (p=0.01) and immunosuppressive drugs (p=0.003). Mood disorders were associated with lower mental health subscale and MCS scores but not with SLEDAI-2K, SDI scores or lupus autoantibodies. Antidepressants were used in 168/232 (72.4%) patients with depression.126/256 (49.2%) mood disorders resolved in 117/232 (50.4%) patients. CONCLUSION: Mood disorders, the second most frequent NP event in SLE patients, have a negative impact on HRQoL and improve over time. The lack of association with global SLE disease activity, cumulative organ damage and lupus autoantibodies emphasize their multifactorial etiology and a role for non-lupus specific therapies. This article is protected by copyright. All rights reserved
Arginine dipeptides affect insulin aggregation in a pH- and ionic strength-dependent manner
No full textPair Programming Teams and High-Quality Knowledge Sharing: A Comparative Study of Coopetitive Reward Structures
No full textThere has been a growing research interest in understanding knowledge sharing in agile development. Yet, empirical research that sheds light on its underlying practices, such as pair programming, is evolving. This study uses insights from coopetition and software literature to focus inquiry on the relation between coopetitive rewards and high-quality knowledge sharing in pair programming teams. Theoretical hypotheses are developed and validated, suggesting that: coopetitive rewards influence high-quality knowledge sharing in both directly and over time through their impact on the level of knowledge sharing satisfaction, and, the impact of coopetitive rewards on high-quality knowledge sharing is dependent upon task complexity and the history of working under similar reward structure. This study generates new understanding related to the use of rewards in pair programming teams, and offers a rigorous and replicable seven-step experimental process for simulating coopetitive structures and investigating their role in pair programming and in similar collaborative contexts
Story, song, and ceremony: shaping dispositions in Japanese elementary schools during Taisho and early Showa
No full textJapanese elementary schools of the Taisho and early Showa periods sought to shape children into ‘good Japanese’ through an imaginary communicated in a range of media and activities, intended to form children's dispositions through a combination of discipline and attraction. Ceremonies for the reading of the Imperial Rescript on Education, held on four major annual holidays, disciplined children into awe of the Emperor. In contrast, stories of exemplary heroes were communicated in forms aimed at inspiring children and moving their emotions, from textbook stories and songs, to plays at gakugeikai (school revues). Such heroes ranged from medieval imperial loyalists such as Kusunoki Masashige and his family, to figures from the Russo-Japanese War such as Nogi Maresuke and Hirose Takeo. Education movements of the Taisho period, pedagogically progressive in their focus on whole-person education, encouraging drama, singing, and other artistic activities, could serve nationalist purposes by making such heroes' stories more emotionally involving
Exchange coupling in hybrid anisotropy magnetic multilayers quantified by vector magnetometry
No full text
