2875 research outputs found
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Dynamics of SLC25A51 Reveal Preference for Oxidized NAD+ and Substrate Led Transport
No full textSLC25A51 is a member of the mitochondrial carrier family (MCF) but lacks key residues that have been attributed contribute to the mechanism of other nucleotide MCF transporters. Thus, how SLC25A51 transports NAD+ across the inner mitochondrial membrane remains unclear. To elucidate its mechanism, we used Molecular Dynamic simulations to reconstitute used Molecular Dynamic simulations to study reconstituted SLC25A51 homology models into lipid bilayers and generated hypotheses to test. We observed spontaneous binding of cardiolipin phospholipids to three distinct sites on the exterior of SLC25A51’s central pore and found that mutation of these sites impaired cardiolipin binding and transporter activity. We also observed that stable formation of the required matrix gate was controlled by a single salt bridge. Using simulation data and in-cell activitybiochemical assays we We identified binding sites in SLC25A51 for NAD+ and showed that its binding and specificity selectivity for NAD+ was guided by an electrostatic interaction between NAD+ the charged nicotinamide ring in the ligand and a negatively charged patch in the pore. In turn, interaction of NAD+ with interior residue E132 guided the ligand to dynamically engage and weaken the salt bridge gate, representing a ligand-induced initiation of transport
Data for Automated Face-To-Face Conversation Detection on a Commodity Smartwatch with Acoustic Sensing
No full textA dataset for conversation modelin
Instrucción que da la Junta de Salud Pública de esta ciudad [de Guatemala], para la curación de la tos epidémica de los niños, 1814 junio 16
No full textInstrucción impresa de salud pública sobre el tratamiento de la tos epidémica en niños. La publicación describe las tres etapas de la enfermedad (inicio, aumento y disminución) y recomienda ciertos tratamientos para cada etapa, incluyendo restricciones dietéticas, remedios inductores de vómito, purgas leves, sangrías y el uso de varios medicamentos y remedios de apoyo (agua de canela, infusión de hierbas y sedantes). En conclusión, la Junta de Salud Pública insta a los padres a seguir estas instrucciones para el bienestar de sus hijos. También les asegura que los casos de viruela que se han visto en la capital pueden ser tratados fácilmente mediante métodos sencillos, mencionando además la disponibilidad de la vacunación. —— Printed public health instruction on the treatment of epidemic cough in children. The publication describes the three stages of the disease (onset, increase, and decrease) and recommends certain treatments for each stage, including dietary restrictions, vomiting-inducing remedies, gentle purges, bloodletting, and the use of various medications and supportive remedies (cinnamon water, infusion of herbs, and sedatives). In conclusion, the Public Health Board urges parents to follow these instructions for the well-being of their children. It also assures them that the cases of smallpox that have been seen at the capital can be easily treated through simple methods, while also mentioning the availability of vaccination. 2 f. (4 p.
Micro-economic study on willingness to adopt SSI technologies
No full textMicro-economic study of the effects of tax breaks, loans, and risk reduction on the
willingness of small and marginal farmers to adopt different types of SSI technologies
Cognitive Bias Modification for Depression
No full textChapter titled, "Cognitive Bias Modification for Depression" written by Christopher G. Beevers, Mary E. McNamara, Mackenzie Zisser, and Rachel L. Weisenburger for a forthcoming book, APA Handbook of Depression, edited by Jeremy Pettit and Thomas Olino
Monitoring Wetland Evolution in Galveston Bay through UAS mapping
No full textThis dataset includes aerial imagery collected using a UAS platform equipped with a PPK module at four select wetland sites in Galveston Bay, TX during seven field surveys from September 2021 to July 2023. GNSS data associated with the collected UAS imagery (i.e., PPK data for the UAS and on-site ground control points for validation), are also included in this data repository
Replication Data for: Quantifying and Localizing Underground Pipeline Emissions Using A Continuous Monitoring System and Modeling Approach: DINA
No full textReplication Data for: Quantifying and Localizing Underground Pipeline Emissions Using A Continuous Monitoring System and Modeling Approach: DIN
Decreto al Obispo de Guadalajara que se establezcan cuatro custodias franciscanas en las provincias internas, 1780 junio 14
No full textDecreto real dirigido al Obispo de Guadalajara Antonio Alcalde y Barriga, OP, proponiendo la creación de cuatro custodias de religiosos franciscanos observantes en las provincias internas de Nueva España. Estas custodias se establecerían para mejorar la gestión espiritual y temporal de las misiones y pueblos en esa área, debido a los problemas causados por la división actual de responsabilidades entre obispos y religiosos. Cada custodia tendría su propio líder y vicarios para supervisar de cerca a los misioneros. Se planea establecer casas de hospicio en las sedes de cada provincia para albergar y capacitar a los religiosos. Esto se hace con la esperanza de promover la difusión del cristianismo entre los indígenas y mejorar la vida de los fieles en esas regiones. Las custodias no serían fundaciones formales y su existencia dependería de la voluntad real. También se destaca la importancia de evitar que los religiosos en las misiones perciban derechos parroquiales, lo que ha causado conflictos. La propuesta fue inicialmente presentada por Fray Antonio de los Reyes de la Orden de San Francisco Observantes y presidente de las misiones de la Sonora en la Pimería Alta. —— Royal decree addressed to the Bishop of Guadalajara Antonio Alcalde y Barriga, OP, proposing the creation of four custodies of observant Franciscans in the internal provinces of New Spain. These custodies would be established to improve the spiritual and temporal management of missions and towns in that area to address the problems the current division of responsibilities between bishops and friars has caused between the two groups. Each custody would have its own leader and vicars to closely supervise the missionaries. He proposes to establish convents in the headquarters of each province to house and train the friars. This is done with the hope of promoting the spread of Christianity among the Indigenous people and improving the lives of the faithful in those regions. The custodies would not be formal foundations, and their existence would depend on the will of the sovereign. He also emphasizes the importance of preventing the friars in the missions from receiving parochial rights, which has caused conflicts. Friar Antonio de los Reyes of the Order of Observant Franciscans and president of the missions of Sonora in the Pimería Alta initially presented the proposal. 9 f. (18 p.