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Single-cell genotyping and transcriptomic proling in focal cortical dysplasia
Full text linkFocal cortical dysplasia type II (FCDII) is a cortical malformation causing refractory epilepsy. FCDII arises from developmental somatic mutations in mTOR pathway genes, leading to focal cortical dyslamination and abnormal cytomegalic cells. Which cell types carry pathogenic mutations and how they affect cell-type-specific transcriptional programs remains unknown. To address this question, here we combined single-nucleus genotyping and transcriptomics in morphologically-identified cells using surgical cortical samples from genetically-characterized FCDII patients. Mutations were predominantly detected in glutamatergic neurons and astrocytes and only a small fraction of mutated cells exhibited cytomegalic features, revealing incomplete penetrance of FCDII-causing mutations. Moreover, we identified cell-type-specific transcriptional dysregulations in both mutated and non-mutated FCDII cells, including synapse and neurodevelopment-related pathways, that may account for epilepsy, and dysregulation of mitochondrial metabolism pathways in cytomegalic cells. Together, these findings reveal cell-autonomous and non-cell-autonomous mechanisms at play in FCDII, towards the development of precision therapies for this disorder
Fashioning Creative Expertise with Generative AI: Graphical Interfaces for Design Space Exploration Better Support Ideation Than Text Prompts
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Kann die Schweiz die 4-Tage-Woche? Dieses Pilotprojekt will es herausfinden
No full textZum ersten Mal soll das 4-Tage-Modell in wissenschaftlicher Begleitung grossflächig getestet werden. Warum die Schweiz diesbezüglich eine Knacknuss sein könnte – und wieso trotzdem viele an einen Erfolg glauben
Biographically Burdened Fathers and Their Daughters: Integrity-Violating Experiences of Ambivalence in the Context of Compulsory Welfare Measures
No full textUnd, wie lange arbeiten Sie noch?
Full text linkHeute ist in der Schweiz jede fünfte Person zwischen 65 und 74 Jahren erwerbstätig. Bei der Entscheidung weiterzuarbeiten, spielen viele Faktoren eine Rolle: etwa die Gesundheit und finanzielle Situation, aber auch Familie und Freund*innen. Interviews zeigen, dass frühere Lebens- und Karriereentscheidungen sowie der eigene Handlungsspielraum bei der Arbeit einen Einfluss ausüben
Partizipation im Kindesschutz; Wahrnehmung des Kindesschutzverfahrens mit Fokus auf Gerechtigkeit
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University continuing education as a recontextualisation of work-related learning needs
No full textThe Swiss university continuing education (UCE) system is embedded in a dynamic
and competitive continuing education market. Supply and demand are increasingly
focussed on the needs of working students, which relate to their immediate
professional requirements and challenges. Potential work-related learning needs are
thereby relevant for planning and developing UCE programmes. This study analyses
factors of work-related learning needs from the students’ perspective as possible
criteria in the selection of UCE programme or training. As result of an exploratoryempirical
analysis, which re-contextualized work as a specific context in which learning
needs emerge, a taxonomy based on three factors of work-related skills and metacompetences
was identified
Constructing Collaborative Spaces: An Ethnography of Entrepreneurial Place-Making
No full textEntrepreneurship increasingly takes place in new collaborative spaces, such as incubators, science parks, or coworking spaces. Despite the broad consensus on the various benefits that collaborative spaces can have for entrepreneurs, we are only just beginning to understand how entrepreneurs are implicated in the construction of these supportive contexts. In response, we draw on the phenomenological literature on place to create a conceptual vocabulary attentive to how collaborative space and entrepreneurial processes are related. Based on an ethnography of a coworking space in Paris, we identify three types of place-making entrepreneurs engage in to nurture their entrepreneurial journey: (a) projective identity formation, where entrepreneurs use place as a symbolic signifier to give form to their nascent venture and entrepreneurial identity; (b) rudimentary inscriptions, in which entrepreneurs define the purpose of the collaborative space in a deliberately vague manner so as not to limit the range of activities that the place can accommodate, (c) spatial appropriation, in which entrepreneurs re-create, manipulate, and personalize the material arrangement of place according to their specific needs. Our contribution is to show how entrepreneurs – through place-making – construct collaborative spaces both at the level of representation, affect, and materiality, and how this in turn can be generative for entrepreneurship