Rubatosis Publications (E-Journals)
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Herbal remedies on post acne hyperpigmentation
No full textOne of the most prevalent skin problems is acne. Nearly all teenagers are affected, and up to 41% of adults may still have the condition. Regardless of skin tone, pigmentary consequences are significant cosmetic concerns for all patients, and they may cause the patient greater problems than the primary skin disorder did. Darker skinned people appear to have a higher likelihood of pigmentary disorders, which should be taken into account while examining these patients. Even mild to moderate acne might result in post-acne hyperpigmentation. Acne with hyperpigmentation manifests as dark patches or blotches on the skin. There are many cosmetic products available in the market that reduces hyperpigmentation, but it is best to look for herbal remedies that reduce dark spots. The aim of this study is to determine the importance of herbs for the treatment of post acne hyperpigmentation
Molecular docking study of ferulic acid
No full textThe main purpose of this study is the molecular docking of Ferulic acid with various enzymes such as 2PRG, 6COX, 1HD2, 2HCK, 2IOK, 2Y6W, 2YXJ, 4IEH, 5FDO, 3MWD, 3QNT. A molecular docking study was carried out by AutoDock 4. The results of the molecular docking study revealed that ferulic acid binds to the different enzymes. The results show the high affinity of ferulic acid with 2PRG, 6COX, 1HD2, 2HCK, 2IOK, 2Y6W, 2YXJ, 4IEH, 5FDO, 3MWD, 3QNT. The binding energy of the ferulic acid was compared with the known Anti-diabetic, anti-inflammatory, anticancer, antioxidant, Anti-apoptotic and Antihyperlipidemic standard drugs that inhibits 2PRG, 6COX, 1HD2, 2HCK, 2IOK, 2Y6W, 2YXJ, 4IEH, 5FDO, 3MWD, 3QNT enzyme. This study has tremendous scope in the pharmaceutical industry and biology for designing novel formulations for inhibiting different enzymes responsible for various diseases
Harnessing Medicinal Plant Phytochemicals: Unveiling Pharmacological Potential and Novel Drug Delivery Strategies
No full textThe significant progress in the field of anticancer research has spurred a growing interest in bioactive compounds with potential pharmacological properties. One well-established challenge in utilizing these natural bioactives is their inherent low solubility, leading to limited bioavailability and difficulties in formulating effective drug delivery strategies to specific target sites. In response to this challenge, this review provides a comprehensive overview of the latest advancements in the development of innovative drug delivery systems. Our analysis focuses on published data related to key plant secondary metabolites known for their potent anticancer potential, specifically the flavone, isoflavone, and stilbene groups, which have been successfully formulated using novel drug delivery systems. While the precise mechanisms of action for these selected natural compounds remain a subject of ongoing investigation, their anticancer effects are undeniable. Consequently, current research efforts are primarily dedicated to identifying these bioactive compounds' most effective delivery systems. Recent studies aim to elucidate the exact mechanisms of action and therapeutic benefits of these compounds and address the crucial issue of designing suitable natural compound delivery systems capable of efficiently transporting therapeutic doses to the intended target sites. This multifaceted approach underscores the ongoing commitment to advancing the field of anticancer research and improving the delivery of bioactive compounds with promising anticancer potential
Design, Development and Invitro Evaluation of Bilayer Tablets of Loratidine (IR) and Phenylephrine (SR)
No full textThe present study was carried out to develop the Bilayer tablets of Phenylephrine as sustained release and Loratidine as immediate release component. Phenylephrine is a selective α1-adrenergic receptor agonist of the Phenylephrine class used primarily as a decongestant, as an agent to dilate the pupil, and to increase blood pressure. Loratadine is a second-generation peripheral histamine H1-receptor blocker used to treat allergies. In the present study the bilayer tablets of Phenylephrine (SR) and Loratidine (IR) was formulated and evaluated, percentage friability for all the formulations was below 1% indicating that the friability was within the range of standard specification. All the formulations showed post-compression parameters i.e. friability and drug content were within acceptable official IP limits. Various sustained release formulations were formulated with super disintegrant, polymer alone; and microcrystalline cellulose was used as diluents. The tablets were evaluated for Pharmacopeial and non-Pharmacopeial (industry specified) tests. Based on the results, F-8, F-4 were identified as better formulation amongst all formulations
Exploring the Drug delivery systems of Natural products on inflammation-mediated Disorders: a short Note
No full textAdvancements in diagnostic tools and clinical procedures have unveiled much about the causes and workings of these conditions. In vitro and in vivo experimental models have paved the way for numerous biomedical breakthroughs, notably in discovering potential drugs to tackle metabolic disorders. Natural compounds have garnered attention as promising candidates due to their antioxidant and anti-inflammatory properties, offering hope for managing conditions like diabetes, obesity, heart diseases, and cancer. Efforts are ongoing to enhance the effectiveness and availability of these compounds through specialized drug delivery methods. Our focus delves into the recent strides made in understanding how inflammatory responses kickstart metabolic disorders, especially in diabetes, obesity, heart diseases, and cancer. We explore the potential of natural products in combating these conditions and provide a roster of biological targets for efficient screening in drug development. Furthermore, we discuss insights gained from both preclinical and clinical studies, aiming to pinpoint optimal approaches for using phytochemical drug delivery systems in treating metabolic disorders. This comprehensive review aims to shed light on the latest developments and potential avenues in addressing the complexities of metabolic disorders through innovative drug strategies
Illuminating the Molecular Operations through Study of Protein Interactions
Get PDFMolecular mechanism research is a fascinating area involving multidisciplinary scientists. This study offers insight into the characterization of protein interactions, which is an important subject of this research. The discussion covers case studies on the principles associated with neurotransmitter release and associated factors. The concentration on methods like Nuclear magnetic resonance (NMR) spectroscopy and X-ray crystallography, as well as other biophysical methods, are also included. These studies have revealed a complex cascading process leading to neurotransmitter release: (i) a tight complex of the soluble SNAP receptor (SNARE) proteins brings the plasma membranes and synaptic vesicle together, essential activity for membrane fusion; (ii) auto-inhibitory closed conformation is adopted by SNARE syntaxin-1 (iii) Munc18-1 plays a vital role by interacting with closed syntaxin-1 and with the SNARE complex; (iv) opening of syntaxin-1 is mediated by Munc13s; (v) through distinct interactions with the SNARE complex, complexions play dual roles; (vi), synaptotagmin-1 interacts simultaneously with the membranes and the SNAREs and acts as Ca21 sensor; and (vii) neurotransmitter release is modulated by a Munc13 homo-dimer to Munc13-RIM hetero-dimer switch. This review highlights the complex molecular mechanisms and explains how these mechanisms are significantly influenced by strong and weak protein interactions
Role of artificial intelligence in drug development
Get PDFIn the last decade, artificial intelligence (AI) has revolutionised the field of drug research. Staff abilities (55 percent), data structure (52 percent), and resources were all factors in AI deployment (49 percent ). Nearly 60% of respondents said they expected to hire more people in the next two years to assist AI usage or adoption in drug development. AI in areas like as drug research and development, drug repurposing, boosting pharmaceutical productivity, and clinical trials, among others, minimises human effort and allows for the achievement of objectives in a short amount of time. On the one hand, AI techniques used in drug development bring the drug development process and the use of various models closer to medicinal chemists, while on the other hand, AI methods used in drug development bring the drug development process and the use of various models closer to mathematicians
Cancer and neurodegenerative disorders: Pathogenic convergence through microRNA regulation
No full textDespite the fact that cancer and neurodegenerative disorders are two separate diseases with unique pathology, it can be construed from emerging pieces of evidence that these two types of diseases share common mechanisms of genetic and molecular abnormalities. Recent studies and current understanding show that individual microRNAs (miRNAs) may be involved in the pathology of these two apparently diverse diseases, indicating that there is a common mechanism that leads to the theory of dysregulation in gene expression at the post-transcriptional level. Several miRNA-based therapeutic approaches have shown efficacy in the modulation of activities of miRNAs, indicating their potential to treat a number of pathological conditions. On the same lines, the role of miRNAs in the converging pathways of leading both diseases suggests good prospects for developing common therapeutic strategies for both diseases. Not only for therapeutic approaches, but the miRNAs also dysregulated in both diseases might be promisingly viewed as uniquely informative diagnostic markers. In this paper, we review recent studies on the miRNAs involved in both cancer and neurodegenerative diseases
Elucidating Genomic Instability and its Outcomes as Cancer Origin
Get PDFIncreased propensity of alterations in the genome during the life cycle of cells is called as genomic instability. It is a major cause of oncogenesis. There are four major mechanisms that control the genome instability while the normal cells divide. These mechanisms are DNA replication of high precision and accuracy in S-phase, mitosis involving precise chromosome separation, correct repair of infrequently occurring DNA damage, and cell cycle development in synchronized manner. This briefly throws light on processes at molecular level that play significant role in preventing oncogenesis through genomic instability
Formulation and evaluation of herbal face cream with green tea extract
No full textFace cream is a semi-solid preparation for improving skin colour. The purposes of the present research work was to formulate and evaluate herbal face cream with green tea extract, turmeric, aloe vera gel as a skin toner. Herbal creams offer several advantages over synthetic creams. The majority of existing creams which has prepared from drugs of synthetic origin and gives extras fairness to face, but it has several side effects such as itching or several allergic reactions. Herbal creams do not have any of these side effects, without side effects it gives the nourishment to skin. Method carried out to prepare herbal cream was vanishing cream formulation. Firstly, oil phase was prepared, Secondly aqueous phase was prepared. Then aqueous phase was added into the oil phase at 700 c with continuous stirring. Now, once the transfer was completed it was allowed to come at room temperature all the while being stirred. Perfume was added at last just before the finished product was transferred to suitable container. The above prepared herbal cream was evaluated with parameters such as pH, homogeneity by visual and by touch, appearance (colour), rub out (spread ability, wetness), washability, consistency and emolliency. The study suggests that the composition of extract and the base of the cream F1 are more stable and safe