Fine Chemical Technologies (E-Journal) / Тонкие химические технологии
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ФИЗИКО-ХИМИЧЕСКИЕ СВОЙСТВА БИОРАЗЛАГАЕМОГО СВЕРХРАЗВЕТВЛЕННОГО ПОЛИЭФИРПОЛИОЛА НА ОСНОВЕ 2,2-БИС(МЕТИЛОЛ)ПРОПИОНОВОЙ КИСЛОТЫ
Get PDFSynthetic surfactants have a wide application in various areas from medicine to agriculture, with biodegradable surfactants holding the greatest promise. Promising compounds for the synthesis of such surfactants are polyethylene oxide and polymers are the poly(α-hydroxyacid)s: polylactide (i.e. PLA), polyglycolide (i.e. PGA), poly-ε-caprolactone (PCL), polyhydroxybutyrate (PHB) and their copolymers. Because the biodegradation of polymeric surfactants yields natural metabolites, their medical and biotechnological applications are most attractive. A number of studies shows advantages of branched polymer surfactants compared linear surfactants, however, systematic studies of the correlation between the branched structures of amphiphilic copolymers and their surface activities are absent. Hyperbranched polyester polyol based on 2,2-bis(methylol)propionic acid are widely used as modifiers of polymeric materials (for example, in the manufacture of paintwork materials), additives for polymers to improve extrusion and also as nanocontainers for targeted drug delivery. In the present study the colloidal chemical properties of the polyether polyol 2,2-bis (methylol) propionic acid of the fourth pseudo generation (trade name Boltorn H40) were studied and it was shown that they reduce the interfacial tension at the hydrocarbon solution of surfactant/water to low
СИСТЕМНЫЙ ПОДХОД К ИНФОРМАЦИОННОЙ ПОДДЕРЖКЕ ФАРМАЦЕВТИЧЕСКОЙ РАЗРАБОТКИ ГОТОВЫХ ЛЕКАРСТВЕННЫХ СРЕДСТВ
Get PDFThe article considers the application of the system approach for constructing informational support for the life cycle of the production of medicinal products. The principal difficulties of creating a single informational system of the entire life cycle are considered in this article. A brief analysis of the information and computer support of individual links in the life cycle is given. Particular attention is paid to the use of a systematic approach to the creation of information support for the pharmaceutical development of medicines. The principle of QbD - “Quality planned for development” - was taken as a basis. For the implementation the QbD principle on the basis of the system approach, it is proposed to use the Shewhart-Deming iteration cycle to create an information support for a sustainable search for the optimal version (the program) of the conducted studies. The possibility of combining the PDCA cycle and the methodology of the system approach is shown. On its basis, system-theoretic multiple models of nformation support for pharmaceutical development in the graphic-analytical nomination were constructed. The method of applying the criterial approach for the formation of global and local criteria for managing research and the construction of system management models in the Melentiev’s brackets nomination are presented. The information modeling of the stage of pharmaceutical development has been carried out. Functional models have been constructed in the IDEF0 nomination
МАГНИТНЫЕ И ТЕРМИЧЕСКИЕ СВОЙСТВА НАНОМАТЕРИАЛОВ НА ОСНОВЕ ВЫСОКОРАЗВЕТВЛЕННЫХ ФЕРРОЦЕНСОДЕРЖАЩИХ ПОЛИМЕРОВ
Get PDFNew magnetic nanomaterials with magnetization up to 32 Gs·cm3/g were synthesized from highly branched ferrocene-containing polymers by thermal structural transformations in a field of 2.5 kOe. The structure and properties of the prepared polymers were studied by IR spectroscopy, transmission electron microscopy (TEM) and thermogravimetric analyses. According to IR spectroscopy the content of 1,3,5-substituted benzene rings in the ferrocene-containing polymer increases at 500°C. X-ray diffraction study showed that iron in such a sample is present exclusively in the form of Fe3O4 magnetite. As the heating temperature increased to 600°C, the composition of the samples became more complex: along with magnetite they contain cementite Fe3C and wustite FeO.97O. The magnetization of the ferrocene-containing polymer depends on the synthesis and heat treatment temperature. For a sample synthesized at 140°C the formation of a magnetically ordered phase begins at 500°C, and at 800°C the magnetization reaches a maximum value of 32 Gs·cm3/g. The average size of magnetic particles according to TEM analysis was 8-26 nm. The principal possibility of controlling the size and composition of the nanoparticles, as well as their magnetization depending on the conditions of production and the temperature of polymer structuring is shown. The obtained results provide a good basis for the directed synthesis of magnetic ferrocene-containing polymers with preset characteristics
ВЛИЯНИЕ ТЕХНОЛОГИЧЕСКИХ ПАРАМЕТРОВ ЛАЗЕРНОЙ НАПЛАВКИ НА СВОЙСТВА КОМПОЗИТОВ NiCrBSiС-WC
Get PDFIt was investigated the influence of technological parameters of laser cladding on the thickness of the carbide composite coatings with similar composition and properties of matrix and different types of reinforcing inclusions (spherical tungsten carbides (WC) and recycled carbides). Special attention is paid to physical-mechanical and service properties of the composites such as hardness and resistance to abrasive wear. It is established that the thickness of the carbide composite coatings increases with increasing laser power and flow rate of the carrier gas, and with decreasing speed of the laser and the step of cladding. The study showed that at the addition of 50 wt.% WC matrix has smaller hardness values 540-560 HV, which allows to obtain the structure of the carbide composite coatings without cracks. At the same time, at addition of 80 wt.% WC matrix has higher hardness 670 HV, which does not provide the structure without cracks. Resistance of composites NiCrBSiC-WC to cracking, as well as their wear resistance, increases with increasing content of tungsten carbide. The wear resistance of the coatings received from powder Technicord 655-SL, with a reinforcement by recycled carbide, comparable to that for coatings from spherical tungsten carbide Tekmat WC-125. Coatings NiCrBSiCWC, obtained by laser cladding, are used to increase the service life of the equipment telemetering systems, in particular, it is possible to prevent of abrasion and provide of increasing the service life of the contact pads of the equipment for measurement while drilling
ПОЛУЧЕНИЕ ДИСПЕРСНЫХ ПОРОШКОВ НИКЕЛЯ ПРИ ЭЛЕКТРОХИМИЧЕСКОЙ ПЕРЕРАБОТКЕ РЕНИЙСОДЕРЖАЩЕГО ЖАРОПРОЧНОГО СПЛАВА
Get PDFThe article is devoted to the substantiation of the proposed technological scheme of electrochemical processing of rhenium-containing heat-resistant alloy ZhS32-VI of composition (mass %): Re - 4.0; Co - 9.3; W - 8.6; Y - 0.005; Lа - 0.005; Al - 6.0; Cr - 5.0; Tа - 4.0; Nb - 1.6; Mо - 1.1; С - 0.16; B - 0.15; Cе - 0.025, Ni - 60.05 to obtain nickel-containing cathode deposits. The results of studying the composition, surface morphology and granulometric analysis of cathodic precipitates obtained during the electrochemical processing of the spent heat-resistant alloy ZhS32-VI with the use of acid electrolytes are presented. Anodic dissolution of ZhS32-VI was performed in the galvanostatic mode. The effect of the electrolyte composition on the process parameters (current yield, distribution of alloy components between the electrolysis products, particle size distribution of the cathode product), electrochemical processing of this alloy were established. It is shown that depending on the nature of the electrolyte, cathode deposits of different chemical and phase composition can be obtained. They differ in the size and morphology of the surface. It has been established that the value of the cathode precipitate grains obtained in acid electrolytes is almost the same: 99% of the cathode precipitate grains are in the range from 0.04 to 0.60 μm. The main difference is a slight increase in the amount of fine fraction when sulphosalicylic acid is added to the electrolyte. All the cathodic deposits obtained have a dendritic structure, the development of which depends on the nature of the electrolyte, the precipitates obtained with the use of a nitrate electrolyte having the most developed structure and the smallest particle size
ХЛОРОПРЕНОВЫЙ КАУЧУК: ПРИМЕНЕНИЕ И ПОЛУЧЕНИЕ
Get PDFPolychloroprene is widely used as a special-purpose rubber in such industries as automotive, construction, textile industry. Chloroprene rubber takes a significant share in the market of elastomers due to its properties. In recent years, a gradual increase in demand for chloroprene rubbers is expected. This trend is most clearly seen in regions with a developed automotive industry. World leaders in the production of chloroprene rubbers and latex demonstrate their interest in increasing production capacity. In Russia, chloroprene rubber is not produced, the demand is completely met by import. In this paper, the main industrial methods for the production of chloroprene monomer, based on various feedstocks: acetylene and butadiene-1,3, exist in the world practice. Advantages and disadvantages of each of the above methods for producing chloroprene monomer are given. Technical solutions for the improvement of the chloroprene-monomer preparation technology for the steps of chlorination of butadiene-1,3 and dehydrochlorination of 3,4-dichlorobutene-1 in a column apparatus are proposed. An improved process for the preparation of chloroprene rubber from butadiene-1,3 is described. The development of a modern technology for the production of chloroprene rubber based on domestic raw materials will make it possible to obtain a high-quality target product, which will lead to the exclusion of its imports
ВЫБОР ЗАЩИТНЫХ ГРУПП ПРИ ОПТИМИЗАЦИИ СИНТЕЗА МОНОМЕРОВ γ-ПНК НА ОСНОВЕ L-ГЛУТАМИНОВОЙ КИСЛОТЫ
Get PDFThis work is devoted to optimization of the synthesis of γ-S-carboxyethyl monomers of PNA based on L-Glu. PNA are promising compounds that hybridize with DNA or RNA, and due to their properties they are used in molecular biology, personalized medicine, and can also be used to create nanomaterials. To increase the yield of the desired monomers, it has been proposed to replace the benzyl protecting group with the carboxy function of the side radical by cyclohexyl one. Two synthetic schemes were proposed. In the first of them, γ-benzyl-N-Boc-glutamic acid, which was reduced to β-amino alcohol, was the starting compound. The hydroxyl group was protected by a dimethyl-tert-butylsilyl group. The benzyl ester in the side radical was cleaved by reduction on a palladium catalyst using ammonium formate. However, the subsequent acylation of cyclohexyl alcohol failed. In the second of the proposed schemes, a known sequence of reactions was used, which led to the formation of a cyclic derivative of Cbz-protected glutamic acid. Then, the resulting compound was acylated with cyclohexyl alcohol to give the desired ester. The subsequent transformation of the protective groups of the ester resulted in the diprotected L-glutamic acid in three stages. Subsequent reduction gave the desired protected β-amino alcohol containing a cyclohexyl protecting group in the side radical. This compound was further used in the Mitsunobu reaction to obtain a completely protected core of the PNA monomer. Subsequent thiolysis reaction resulted in the formation of the target secondary amine, the stability of which substantially exceeded the stability of its analog with benzyl protection, obtained and investigated before. The structure of the new compounds obtained is confirmed by 1H-NMR spectroscopy
НИКОЛАЙ ПРОКОФЬЕВИЧ ФЕДОРЕНКО: ТОЧНЫЙ РАСЧЕТ И ПРЕДВИДЕНИЕ
Get PDFThe article is devoted to the 100th anniversary of the birth of Nikolay Prokofyevich Fedorenko, a graduate of M.V. Lomonosov MITHT, a participant of the Great Patriotic War, the head of MITHT department for chemical industry economy (1951-1962), since 1953 to 1958 - the deputy director of MITHT for studies. N.P. Fedorenko is Doctor of Economics, professor, academician of the Academy of Sciences of the USSR, member of the presidium of the Academy of Sciences of the USSR, academician-secretary of the Economy department of the Academy of Sciences of the USSR, one of the main founders and the first director of the Central Economics and Mathematics Institute of the Academy of Sciences of the USSR (1963-1985). N.P. Fedorenko was the most talented organizer of the economic science. He made a large contribution to the chemicalization of the national economy, to the application of modern mathematical methods and computing hardware for economic research, to the planning, management and studying of the theoretical and methodological bases of optimum performance of economy.Статья посвящена 100-летию со дня рождения Николая Прокофьевича Федоренко, выпускника МИТХТ им. М.В. Ломоносова, участника Великой Отечественной войны, заведующего кафедрой экономики химической промышленности МИТХТ (1951-1962 гг.), с 1953 г. по 1958 г. - заместителя директора МИТХТ по учебной работе. Н.П. Федоренко - доктор экономических наук, профессор, академик АН СССР, член президиума АН СССР, академик-секретарь Отделения экономики АН СССР, один из главных основателей и первый директор ЦЭМИ АН СССР (1963-1985), талантливейший организатор экономической науки, внесший крупный вклад в разработку проблем химизации народного хозяйства, в применение современных математических методов и вычислительной техники для экономических исследований, в планирование, управление, изучение теоретических и методологических основ оптимального функционирования экономики
ИНФОРМАЦИОННАЯ ПОДДЕРЖКА РАСЧЕТОВ ПАРАМЕТРОВ ТЕРМОЭЛЕКТРИЧЕСКИХ ОХЛАДИТЕЛЕЙ
Get PDFThis article describes the development of information systems for modeling a number of polynomial functions based on experimental data, on the basis of which the parameters of thermoelectric coolers are calculated. The input data is entered manually or by uploading files with input data. The calculation is carried out in several stages, including different types of calculations. Some of them are done in parallel and independently of each other. At the first stage, the functions of the measured quantities are calculated by the method of least squares. On their basis the iterative calculation of the main parameters, and also the calculation of a number of additional parameters of the branches are carried out. For convenience in analyzing results, the IS visualizes them in a tabular form and in the form of graphs, giving them in priority of importance for the operator. The results can be exported by copying or automatically in an Excel file.Описывается разработка информационной системы для моделирования по экспериментальным данным ряда полиноминальных функций, на основе которых рассчитываются параметры термоэлектрических охладителей. Ввод исходных данных производится вручную или посредством автоматического импорта файлов с входными данными. Расчет производится в несколько этапов, включающих в себя несколько видов расчетов, в том числе проводимых параллельно и независимо друг от друга. На первом этапе рассчитываются функции измеряемых величин методом наименьших квадратов. На их основе происходит итерационный расчет основных параметров, а также расчет ряда дополнительных параметров ветвей. Для удобства анализа получаемые результаты расчетов информационная система визуализирует их в табличном виде и в виде графиков, предоставляя их в приоритете важности для оператора. Полученные результаты могут быть экспортированы копированием или автоматически в файл Excel
МЕТОД ПРЕПАРАТИВНОГО СИНТЕЗА 8-ОКСО-2’-ДЕЗОКСИГУАНОЗИНА ДЛЯ ЛАБОРАТОРНОГО ПРИМЕНЕНИЯ
Get PDFA preparative method for the synthesis of 8-oxo-2'-deoxyguanosine (8-oxo-dG) giving a high yield up to 80% and suitable for laboratory use is suggested. The urgency of the development of this method is associated with the need to obtain large quantities of 8-oxo-dG for the study of biological and pharmaceutical activity. Evidence of this need was obtained in the last decades, when the mechanisms of the interface of DNA repair with intracellular signaling through 8-oxo-dG were discovered and its anti-inflammatory and protective effects were revealed. The suggested method is based on the scheme used to prepare 8-oxo-dG-containing oligonucleotides, but has a number of important modifications. The use of N,N-dimethylformamide as a solvent makes it possible to increase the yield of the nucleophilic substitution reaction and avoid expensive and complicated further purification of silver acetate. Control of the reaction kinetics allows achieving the maximum yield and purity of the product. Alkaline hydrolysis, in contrast to ammonolysis, provides complete and rapid removal of acyl groups, and reversed-phase chromatography on silanized silica gel is an effective and inexpensive method of purification. Such a purification scheme minimizes contamination of the product with residual organic solvents, which is important for biological experiments. From the economic point of view, it is advantageous because of the absence of expensive solvents and the possibility of reusing the carrier. The method makes it possible to obtain pure 8-oxo-dG in preparative amounts and exceeds both its prototype and other existing techniques in the final output. Some intermediate compounds and significant methodological features of the reaction are described