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Thrombophilia, Pulmonary Embolism (PE) and Deep Venous Thrombosis (DVT) in pregnant women: a brief communication
Get PDFVenous thromboembolism (VTE), deep vein thrombosis and pulmonary embolism, are among the main causes of morbidity and mortality in pregnancy with an estimated incidence of 1 per thousand women years. Despite identification of maternal and pregnancy-specific risk factors for development of pregnancy-associated venous thromboembolism, limited data are available to inform on optimal approaches for prevention. The relatively low overall prevalence of pregnancyassociated venous thromboembolism has prompted debate about the validity of recommendations, which are mainly based on expert opinion, and have resulted in an increased use of pharmacological thromboprophylaxis in pregnancy and postpartum
Hope And Pediatric Cancer
Get PDFPediatric cancer is rare when compared to the incidence of cases in adults. In Brazil it is the second largest cause of death by disease in children and adolescents. Cancer is a life-altering disease that brings with it fear, disbelief, anger, uncertainty, devastation, at the time it is diagnosed. In childhood cancer, diagnosis extends to the whole family. The diagnosis brings psychological and social changes in family dynamics and needs emotional support, discussion of possible therapies and possible death. Hope comes, bringing with it a meaning in illness, contributing positively to a better adaptation and adherence to treatment and consequently the quality and the prospect of life. Hope has been shown as a positive factor when facing this new reality. However there are few studies dealing with this issue
Posterior Mediastinal Chondrosarcoma- A rare entity
Get PDFIntroduction:Chondrosarcoma is a well defined tumor of soft tissue with calcification. Extraskeletal myxoid chondrosarcoma is an unusual sarcoma of soft tissue adding only 3% to all soft tissue tumors. Majority of mediastinal foci originates from variety of tissues, the reason being their diverse embryological and anatomical approximations. Chondrosarcomas are more common in males with 2:1 male to female ratio. The exact pathology of these tumors is unclear; however recent data ensures that these tumors have multidirectional delineation. Classical histopathological features of chondrosarcoma include S-100 positivity, EMA positivity. These features of Immunohistochemical favor extra skeletal myxoid chondrosarcoma.Case Report:Recent data signifies that the tumor is known for its rare occurrence, here we have reported a unique case of 40 years old male visited Abbasi Shaheed Hospital for pre employment checkup without any symptoms. All the tests were negative except Chest X-ray PA view which revealed dense mass on lower lobe of lung. For further evaluation, CT scan of chest with contrast was ordered and eventually the mass was resected surgically. On the basis of macro and microscopic findings, histopathological tests and immunohistochemical stains, the mass was found to be chondrosarcoma with myxoid origin. This tumor has to be distinguishing among the list of different diseases like hamartoma, hydatid cyst, and neuroendocrine tumors for the differential diagnosis of the case.Conclusion: Our paper reports an extraskeletal mesenchymal chondrosarcoma originating in the posterior mediastinum with a rare presentation.Â
A Patient Perception as a Nursing Care in Emergency Sector
Get PDFThe work process by nurses in the emergency sector is comprised of two complementary dimensions, managing and caring. Therefore,the aim of this study was Know the perception of patients to the support of the nursing assistance in Emergency sector. This is a field research, exploratory, descriptive qualitative approach. The survey was conducted in Dr. Luiz Milton Arêa Leão Hospital - Satélite, located in the city of Teresina - PI, Brazil, which caters exclusively by the Unified Health System, and reference in its coverage area.We interviewed thirteen (13) patients who remained in observation in the emergency sector in that hospital. For this study was used as a criterion for inclusion of service users who entered the emergency sector in the periodMarch-April 2014 and who remained in the sector at the time of the interview.  A pilot test was conducted with the instrument to validate and suitability for the target audience, which is excluded from the sample. Ethical aspects were respected, as provided for in Resolution 466/2012 of the National Health Council, Brazil (2013). In this sense, we observed through the reports of the participants carrying out a qualified nursing care, where it identified a good conduct of professionals to provide the necessary assistance. A nursing care and systematic termination  during the stay of patients in hospital was evidenced. It is perceived  that there is a satisfaction from patients and the care of thenursing team, which is performed through actions inherent to these professionals, such as goodwill, the act of providing a welcoming atmosphere, with technical scientific background, and ability in dealing with conflict situations and ethical
Motor Learning and Virtual Reality in Down Syndrome; a Literature Review
Get PDF Down syndrome (DS) is caused by trisomy of human chromosome 21 (Hsa21) and results in a large number of phenotypes including learning difficulties, cardiac defects and distinguishing facial features. The purpose of this study was to analyse research findings about “motor learning†and “virtual reality†in patients with DS. Relevant studies were identified by searching PubMed, Web of Science and BVS. Using key words, we searched for articles that included Down syndrome, virtual reality, and motor learning. Only studies on humans were eligible. The search  identified seven relevant papers. Most studies showed that individuals with Down syndrome are able to learn new tasks, and that improvements can be enhanced via the use of virtual reality. We conclude that individuals with Down syndrome respond positively and effectively, with improvements in sensory motor control, when stimulated with tasks that are complementary to conventional therapy, including therapy involving virtual reality
Craniofacial Fibrous Dysplasia Addressed Through the Intraoral and Nasal Access
Get PDFBackground: The Craniofacial Fibrous Dysplasia is a benign disease, pseudoneoplasic, rare and asymptomatic of slow growth promoting replacement of bone tissue by an amorphous connective tissue, promoting bone deformation that can invade and cause compression of important structures such as the skull base and facial orbital bone. This study aims to present a clinical case of a Craniofacial Fibrous Dysplasia, emphasizing an alternative of an aesthetic surgical access by an intraoral approach. Case Report: We report the clinical case of patient IMS, 21 years of age with craniofacial fibrous dysplasia presenting deformity of the left facial middle third in orbital, nasal and maxilla region who was submitted to surgery for facial recontouring. The surgical access was intraoral associated with access for rhinoplasty. A lesion scrape was realized for facial recontouring and nasal osteotomy for correction of deviation caused by the injury. Conclusions: It was concluded that the surgical technique associated with the intraoral access with nasal extension is an important tool in addressing these lesions, allowing a large surgical field and satisfactory aesthetic and functional results without facial scars
Does Pancreas Cyst Size Correlate with the Risk for Malignancy?
Get PDFContext: Some studies have suggested that small pancreas cysts can be observed. Large cysts or those with increasing size may require intervention. Mucin-producing or malignant cysts have been suspected by increased cyst flid viscosity, elevated flid CEA level, imaging features, and cytopathology.Objective: The purpose of this analysis is to determine the actual correlation of pancreas cyst size and the presence of malignant or premalignant features.Design: Retrospective study of all consecutive pancreatic cysts that were referred for analysis by endoscopic ultrasound (EUS) over an 18 month period at a single center academic tertiary referral institution.Patients or Participants: A total of 65 cysts in 65 patients were examined (36 men, 29 women, mean age of 56.8 and 59.3 years, respectively).Main outcome measures: The diagnostic predictability of pancreas cyst size alone to identify mucin producing or malignant cysts and all nonmucinous cysts based on cytopathology.Results: The mean 2D size of malignant or mucinous cysts was 9.88cm2. The mean 2D size of all nonmucinous cysts was 16.4cm2 but was not statistically signifiant (p=0.15). Pseudocysts tended to be larger and had a mean size of 22.5cm2 and was statistically different in size from the malignant or mucinous cysts (p=0.044) as well as mean size of serous cysts (7.51cm2, p=0.023). The difference in size between mucinous and serous cysts also was not statistically signifiant (p= 0.62).Conclusions: Pseudocysts have a larger mean size than malignant or mucinous cysts as well as serous cysts. However, the parameter of cysts size alone does not aid in differentiating mucinous and nonmucinous cysts. Cyst flid analysis is essential to determine the type of cyst and optimal management
Retraction notice on "Chocolate with high Cocoa content as a weight-loss accelerator"
No full textThis article accidentally appeared online for some days in the same url where this notice can now be found. A public disclaimer has been published in the publisher's website explaining how it all happened. Indeed that manuscript was finally rejected and never published as such.We are absolutely committed with serious publishing. We adhere the Principles of Transparency and Best Practice in Scholarly Publishing, the joint statement of DOAJ, COPE, OASPA and WAME and WAME's Publication Ethics Policies for Medical Journals.This is our code of conduct http://www.publishopenaccess.com/journals/info-for-editors/code-of-conduct/We are sorry for the inconvenience. We are taking measures to prevent this kind of mistakes from happening again
The impact of triptan and doxycycline on neuroinflammatory biomarkers in acute migraine: study protocol of a randomized controlled trial
Get PDFBackgroundIncreased inflammatory cytokines and matrix metalloproteinases (MMPs) have been recently implicated in migraine. Inflammation may be a key player in the pathophysiology of migraine by altering blood-brain barrier (BBB) function. As an inflammation induced MMP, MMP-9 is involved in both BBB disruption and neuropathic pain, and is largely derived by neutrophil degranulation during neutrophil-BBB interaction. The tetracycline group of antibiotics may suppress MMP production and neutrophil degranulation.Methods/DesignWe hypothesize that migraine is a primary neuroinflammatory disorder. We will address this theory by measuring serum biomarkers in healthy controls and after one of three abortive therapy strategies for acute migraine attacks and inter-ictally. We intend to investigate known neuroinflammatory biomarkers with a focus on BBB breakdown during acute migraine attacks and assess marker responses to conventional treatment (triptans), novel MMP targeted therapy (doxycycline), or a combination of triptan and doxycycline. We will measure the effects of the interventions on neuroinflammatory markers for acute migraine attacks, clinical outcomes (headache relief and recurrence) for acute migraine attacks, inter-ictal neuroinflammatory load per serum biomarkers in migraineurs versus healthy controls, and neuroinflammatory markers correlation with headache duration and peak headache intensity during acute migraine attacks.Discussion                                 To our knowledge, this trial will be the first systematic study on the use of a MMP inhibitor in episodic migraine. Our pilot project data will supplement future projects investigating novel therapeutic strategies such as MMP inhibitors in both migraine acute treatment and prevention.Trial RegistrationClinicalTrials.gov NCT01653522, registered 07/23/2012
Acute abdomen in a patient with haemophilia A: A case study
Get PDFBackground: Haemophilia A is a hereditary haemorrhagic disorder that can cause bleeding in the intestinal loops and, on rare occasions, simulate an acute surgical abdomen. Careful assessment of coagulation must be performed in these patients, followed by an attempt to correct the dysfunctions. Often, the administration of the deficient factor is sufficient to resolve the problem, avoiding unnecessary surgeries. Case report: We present a male patient, 15-years-old, of indigenous descent, who was a diagnosed with haemophilia A. The young man was admitted with abdominal pain in the right iliac fossa; ultrasonography suggested acute appendicitis. He underwent an exploratory laparotomy that revealed a normal appendix and the presence of a caecal wall haematoma, without other abnormalities. Conclusion: This case describes an unusual instance of decompensation of a patient with haemophilia A that simulated an acute surgical abdomen. The case suggests the need for further evaluation of carriers of coagulopathies, whether acquired or congenital, when they suffer abdominal pain. Otherwise, clinically treatable dysfunctions are prone to surgical treatment, with a potential for increased morbidity and mortality.Â