Internal Medicine and Medical Investigation Journal (IMMINV)
Not a member yet
148 research outputs found
Sort by
Antibacterial Activities of 5-Nitro-2-uryl and 5-Nitro-2-Imidazolyl Derivatives of 1,3,4-Thiadiazole
Full text linkIntroduction: Nitrofurans and nitroimidazoles are broad-spectrum antimicrobial agents, which affect the microbial DNA. The aim of the present study was to evaluate the new derivatives of these two groups of antimicrobials against certain Gram-positive and Gram-negative bacterial strains. Materials and Methods: Seven new derivatives of nitrofurans and nitroimidazoles were synthesized, and 6.4 mg of each derivative was dissolved in dimethyl sulfoxide. Then, 8 serial dilutions (0.5, 1, 2, 4, 8, 16, 32, and 64 μg/ml) of each derivative was prepared using Muller-Hinton broth, and the minimum inhibitory concentration for each derivative was measured and compared to ciprofloxacin (standard). Results: All the derivatives had no antibacterial effects against Gram-negative bacteria (minimum inhibitory concentration > 64 μg/ml); only 2-(5-nitro-2-furyl)-5-(n-pentylsulfunyl)-1,3,4-thiadiazole exhibited mild antibacterial effects against Klebsiella pneumonia (minimum inhibitory concentration of 16-32 μg/ml). The antibacterial effects of the derivatives against Gram-positive bacteria also showed variations from complete inhibition of the growth of Staphylococcus epidermidis and Bacillus subtilis (minimum inhibitory concentration < 0.5 μg/ml) by 2-(5-nitro-2-furyl)-5-(n-buthylthio)-1,3,4-thiadiazole to no inhibition of S. epidermidis and streptococcus pyogenes. Conclusion: These compounds have weak antibacterial effects; only two derivatives showed antibacterial effects similar to that of the positive control
Prevalence of Restless Legs Syndrome in Patients with Chronic Renal Failure undergoing Hemodialysis
No full textIntroduction: Sleep disorders like restless legs syndrome (RLS) are common in hemodialysis (HD) patients and associated with reduced quality of life. In this study, we evaluated the frequency of RLS in HD patients for diagnosis and control of the signs of RLS to increase the quality of life of them. Materials/Methods: The Society who had been studied was 118 Chronic Renal Failure (CRF) patients who were under dialysis treatment in dialysis units of the west of Mazandaran. Register of information was done by a questionnaire that completed with interview and laboratory measurements. The data recorded and analyzed by the Chi-Square test. Results: In this study, 118 HD patients were evaluated. 16.1% of patients affected by RLS. Most patients (65.61%) were more than 60 years old. There was no correlation between sex and age with RLS. There was no correlation between laboratory findings including hemoglobin, Calcium, Ferritin, and creatinine with suffering by RLS. There was a correlation between blood urea nitrogen (BUN) and suffering from RLS. There was no correlation between body mass index(BMI), family history, the cause of CRF, the period of CRF diagnosis, the period of dependency on dialysis, weekly frequency of dialysis, ferritin, and Erythropoietin (EPO) intake, drug history of patients and suffering by RLS. Conclusion: According to this study, we found that RLS is a common problem in HD patients and there is no correlation between affected by RLS and laboratory findings except BUN
Computed tomographic evaluation of angle and distance between superior mesenteric artery (SMA) and abdominal aorta in : Normal values in Iranian population according to different body mass index value
No full textAbstractThe primary purpose of present study is to “prove” that the angle and distance between the superior mesenteric artery (SMA) and aorta are significantly correlated with the body mass index (BMI). This in turn indicates the strong etiological role of this factor for the causation of SMA syndrome. The superior mesenteric artery syndrome is characterized by the compression of the third segment of the duodenum by the mesentery at superior mesenteric artery level and a resulting duodenal (±gastric) dilatation. The disease is closely related with the depletion of the fat pad between the vessels narrowing the angle and reducing the distance between the vessels. A prospective study of 300 patients (163 males and 137 females) in the age range of 40-70 years (mean age 51 years) who had undergone multislice detector CT scan in Alzahra Hospital for various other complaints in the year 1395. CT scans had been performed with routine protocol comprising of plain phase followed by arterial and venous phases to measure the angle between the aorta and superior mesenteric artery,BMI was also calculated. Mean values for distance and angle were obtained with P value of 5% and 95 % confidence intervals. Pearson coefficients and T test were also calculated and results were tabulated. A strong positive correlation was observed between BMI and the angle between the aorta and SMA. With increment in BMI, the angle also increases leading to a smaller chance of developing superior mesenteric artery syndrome
A Title: A Patient with Severe Bradycardia Five Years After Copperhead Snake Bite
No full textIntroduction: Copperhead (Agkistrodon contortrix) snakes are responsible for approximately 40% of all pit viper envenomations in the US.
Case Presentation: A 14-year-old girl was bitten by a copperhead snake bite. Electrocardiogram taken approximately one hour after envenomation showed sinus rhythm with no acute ST or T wave changes. She was not administered anti-venom but was monitored, treated with antibiotics and discharged without any significant complications after 2 days time. Approximately 5 years after the incident, she began having issues of refractory constipation. Subsequently, she suffered from numerous episodes of recumbent and ambulatory syncope outside of any acute gastrointestinal distress and occurring without warning. A dual-chamber pacemaker (Medtronic™), programmed for “rate-drop” response, was inserted in the patient.
Conclusion: Delayed sequelae from a copperhead snakebite appears to be possible given our patient’s presentation. However, the mechanism of delayed autonomic dysfunction and/or possible direct cardiac effect remains unclear
Pleuritis in 25 year old Female with Systemic Lupus Erythromatosus: Case Report
No full textSystemic lupus erythematosus (SLE) is a complex and multi-faceted disease that affects various organs of the human body and is predominantly seen in young group and females. The patient was a 25-year-old woman, According to the history taking from the patient, she suffered from progressive weakness and narcosis so that she was unable to walk and perform daily work at the time of the visit. In our examination, the young woman was lean and pale, with Icterus, body mass index of 22 and normal thyroid tests. Vital signs on admission were as follows: BP:10/7, PR:92, RR:20, T:38.5. In the heart examination, the heart sounds were normal and there was no heart murmur and additional sounds. In echocardiography for the patient, EF was 60%. Chest X-ray revealed pleural effusion for the patient. CT scans did not confirm the involvement of lung parenchyma and bilateral mild pleural effusion and pericardial effusion for the patient. The pleural fluid was evacuated under ultrasound.. Autoimmune examination results determined the diagnosis of SLE for the patien
Pain: More than Meets the Eye, an Atypical Case of Ocular Squamous Cell Carcinoma
No full textIntroduction Eye pain is common and initially managed by primary care physicians. In the rare refractory case or atypical appearance, consultation with ophthalmology is needed. Case presentationA 35-year-old Hispanic male patient with a history of pterygium presented with complaints of worsening left eye pain for months .Over the past two weeks, the patient had also noticed more redness and soreness that occurred all day. He noticed darkening in the medial vision of his left eye, persistence of left eye pain and visual changes. An excisional biopsy of the lesion was performed. The final biopsy reports revealed an ocular surface squamous cell carcinoma in situ arising from pterygium.DiscussionTopical application and injections of immunotherapy such as mitomycin C and 5-fluorouracil have been shown to be effective. Recurrence is high and follow-up examination by ophthalmology is essential.
Assessment of Central Venous Catheterization Using Electrocardiographic versus Landmark Techniques in Pediatrics Undergoing Open Heart Surgery; Which Technique is Superior?
Full text linkIntroduction: Central venous catheterization has been usually performed during major surgeries in order of central venous pressure assessment and fluid therapy. Variety of techniques has been performed for central venous catheterization previously but the information in this regard about pediatrics is limited. In the current study, the comparison of electrocardiographic technique with landmark one for central venous catheterization performance has been done. Methods: This is a cross-sectional study conducted on 75 patients underwent central venous catheterization for elective cardiovascular thoracic surgery. In the first step, the location of catheterization was estimated based on body surface landmarks. Then catheterization was done using electrocardiography. Then by cardio-surgeon aid, during open cardiac surgery, the catheter tip location was found (gold standard). Finally, chest X-ray was taken and catheter place based on radiological markers was recorded.Results: In the current study, 75 children with age under 18 years and gender distribution of 42.7% females and 57.3% males were assessed. Mean of central venous catheter depth in gold standard method was 7.5±1.35 centimeters. Significant association between central venous catheter placement in gold standard technique and both landmark and electrocardiographic was seen (P-value<0.001; r=0.94 and P-value<0.001; r=0.77). Logistic regression showed a significant association between weight and placement of catheter tip in landmark technique (P-value=0.038) as following formula (Depth of central venous catheter= 5.33+0.07*weight).Conclusion: Our study showed that the use of ECG for CVC considering carina-to-tip as reference was superior to the landmark. In addition, catheter tip correct position was affected by weight but not height based on landmark technique
A Comparative Study of the Detection of cAMP response element binding protein (CREB) in the Peripheral Blood of Alzheimer's Patients and the Healthy subjects as a Biomarker for the diagnosis of Alzheimer
Full text linkIntroduction: Alzheimer's disease is a neurodegenerative disease, which usually helps some biomarkers, such as amyloid proteins, to diagnose the disease. Therefore, the purpose of this study was to compare the expression of a protein binding protein to the adjuvant responder to circular adenosine monophosphate (CREB) in peripheral blood of patients to Alzheimer's and healthy elderly people as a biomarker for diagnosing Alzheimer. Materials and Methods: In this case-control study, 32 patients with Alzheimer's disease and 32 normal blood samples were taken. Using real time PCR, CREB expression was evaluated. Results: The mean CREB level in the case group was 0.89 ± 0.30 and in the control group was 1.01 ± 0.03. The mean of BDNF level in the case group was significantly higher than the control group (P <0.001). There was no significant relationship between the level of CREB with age, sex, MMSE score and Cornell scale for depression in dementia (P> 0.05). Conclusion: Reducing CREB levels in people with Alzheimer's disease can be a factor in diagnosis in comparison to healthy people
Rise of Blood Borne Infections in Pakistan. Is It a Call for Action?
Full text linkThese types of articles do not need abstracts
Post-treatment Guillain-Barre Syndrome in a Patient with Brucellosis; A Case Report
Full text linkIntroduction: Guillain-Barre Syndrome is an uncommon complication during acute brucellosis. Case presentation: In this study, we present a case of Guillain-Barre Syndrome in a 22-year old male patient with complaints of weakness in his lower limbs. He had a history of acute Brucella infection for four months and received antimicrobial medication. Conclusion: the patients can be affected by GBS after antimicrobial treatment