Internal Medicine and Medical Investigation Journal (IMMINV)
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Features of Three- and Four-Part Proximal Humeral Fractures and Outcome of Internal Fixation Using the Philos® Locking Plate
Full text linkBackground: Proximal humeral fractures are among common types of fractures and remain a challenging issue for surgical management. This study aimed to assess the clinical outcomes and complication rates of three- vs. four-part proximal humeral fractures, treated with internal fixation using the Philos® plate.Material and Methods: In this cohort study, a total of 30 consecutive patients with three-part or four-part proximal humeral fractures based on the Neer classification were included. Surgical treatment was performed with open reduction and internal fixation using the Philos® plate. The constant score was evaluated 6 months later in follow-up. The P<0.05 was considered significant.Results: Four-part fractures were mainly caused by trauma from above, while insults of opposite direction were responsible for more than half of 3 part fractures (P=0.01). Open fractures were only observed in patients with a four-part fracture (P=0.018). No significant differences were noticed regarding gender, cause, and side of the fracture.The presence of other fractures, fracture of the implant, reduction loss, avascular necrosis (AVN) of humerus head, rotator cuff injury, and revision surgery were significantly higher in patients with four-part fractures.The mean constant score was 81.40±11.61 and 65.09±16.09 for three-part and four-part fractures, respectively (P=0.006).Conclusion: Open reduction and internal fixation with Philos® plate yield acceptable results in both types of fractures, however, the prognosis of this intervention is poorer four-part fractures
Nephrogenic Diabetes Insipidus Due to Urinary Tract Obstruction: A Systematic Review
Full text linkBackground: Nephrogenic diabetes insipidus (NDI) due to obstructive uropathy is not widely known by physicians and hence not well represented in the literature. To better understand its presentation, clinical course, and available treatments, we conducted a systematic review of case reports on NDI due to urinary tract obstruction.Methods: This observational study was a systematic review of 19 human cases found in the literature. It was done retrospectively to focus on whether NDI can occur due to obstruction of the urinary tract and, if so, what the mechanism (pathophysiology) is.Results: We found that the most common symptom of NDI due to urinary tract obstruction was polyuria. The most common cause of NDI due to urinary tract obstruction was cancer. The most common site for obstruction was the ureter. And the most common test used to confirm the diagnosis was failure to concentrate urine after the administration of desmopressin. Surgical intervention was the most common treatment to relieve obstruction.Conclusion: We found that urinary tract obstruction can cause NDI. With early diagnosis and timely relief of the obstruction, NDI can be reversible
The Relationship Between Perception of Disease and Quality of Life in Patients with Acne Vulgaris from 2013 to 2014
Full text linkBackground: Acne vulgaris is a common skin disease that can affect people in any ages. The development of acne have adverse effects on life quality. Psychological disorders increased in these patients and their psycho social activities have been affected. Since few studies have been done regarding illness perception in people with acne in Iran, this study aimed to investigate the association of perception of acne disease and quality of life in central of IranMethods: we analyzed 200 patients Acne Vulgaris referred to Khatam-Al Anbia in 2013-14 by questionnaire of perception of disease (Brief IPQ) and quality of life (DLQL. the data was analyzed using t-test and Chi-square by SPSS-16Results: Mean age of patients was 24.3 years and 158 people (79%) were women and 42 people (21 %) were men. Mean quality life score in women was 8.79±5.3 and in men was 8.69±5.18. Most patients had moderate acne and duration of their disease was between 1 to 5 years. 136 people were 18 to 25 years old and 64 persons were higher than 25 years. The mean perception scores in men and women were 51.83 and 53.26 respectively In this study, there was a relation between sex (P=0.03), Acne severity and duration with quality of life score.Conclusion: Women and patients with severe acne and longer duration of symptoms had higher quality life score that had more disorder in life.. There was relation between perception and sex and duration of symptoms
Chemical Decellularization Methods and Its Effects on Extracellular Matrix
Full text linkBackground: Extracellular matrix (ECM) produced by tissue decellularization processes as a biological scaffold due to its unique properties compared to other scaffolds for migration and implantation of stem cells have been used successfully in the field of tissue engineering and regenerative medicine in the last years. The objective of this manuscript was to provide an overview of the chemical decellularization methods, evaluation of decellularized ECM and the potential effect of the chemical decellularization agents on the biochemical composition.Methods: We searched in Google Scholar, PubMed, Scopus, and Science Direct. The literature search was done by using the following keywords: “ECM, biologic scaffold, decellularization, chemical methods, tissue engineering.” We selected articles have been published from 2000 to 2016, and 15 full texts and 97 abstracts were reviewed.Results:Employing an optimization method to minimize damage to the ECM ultrastructure as for a result of the lack of reduction in mechanical properties and also the preservation of essential proteins such as laminin, fibronectin, Glycosaminoglycans (GAGs), growth factor is required. Various methods include chemical, physical and enzymatic technics were studied. However, on each of these methods can have undesirable effects on ECM.Conclusion: It is suggested that instead of the Sodium dodecyl sulfate (SDS) which have high strength degradation, we can use zwitterionic separately or in combination with SDS. Tributyl phosphate (TBP) due to its unique properties can be used in decellularization process
Rare Coexistence of Myasthenia Gravis and Lambert-Eaton Myasthenic Syndrome with Adenocarcinoma of the Bladder: A Case Report
Full text linkAbstract Introduction: The coexistence of myasthenia gravis and Lambert-Eaton myasthenic syndrome (LEMS) is very rare.Case report: Herein we report an 82 year old man a known case of adenocarcinoma of bladder who came with ptosis in left eye, diplopia, and dysphagia, weakness of both lower extremities and autonomic dysfunction. According to history, physical examination and para clinical work ups coexisting of myasthenia gravis and LEMS was diagnosed.Discussion: our patient is the first patient with Overlap myasthenic syndrome on the base of adenocarcinoma of bladder. The purpose of this case report is to emphasize on this fact that a patient with LEMS should be evaluate carefully for detecting underlying malignancies. Although in the most cases the origin is lung, extra pulmonary origin such as urinary system should be evaluate carefully too
Study of Diseases Associated ESR above 100 among the Patients who Visited Shahid Sadoughi Hospital in the Second half of 2013
Full text linkIntroduction: ESR (Erythrocyte Sedimentation Rate) is the sedimentation rate of red blood cells per unit of time that is expressed in millimeters. ESR test is simple and inexpensive and fast and can be somewhat diagnostic manual to confirm the diagnosis, rule out the diagnosis, follow-up course of the disease and so on, so it is of interest to practitioners.Methods: Descriptive and cross-sectional study on 124 patients in all wards of Shahid Sadooghi hospital in the second 6 months of 1393, that had raised ESR of 100 at least one time. All information including gender, age, diagnosis of the presence or absence of fever and indigenous of them cases in the archive hospital patients were taken.Results: 56% female and 44% were male. 16% of patients in the age range 0-19 years, 56% aged 20-64 years and 28% were aged over 64 years. 41% of patients were admitted with fever. 59% were native and 41 % were non-native. Infectious causes (45.9%), malignancy (14.5%), collagen vascular disease (16.9%), internal disease and hematology (16.9%) and other causes (5.6%) were formed cases. Diabetic foot (7%), pneumonia (7%), RA (6%), ESRD (5.6%), metastatic lung cancer (4%), TB (3%) formed the majority of cases.In feverish cases pneumonia (11.5%), diabetic foot (7.6%), tuberculosis (5.7%), pyelonephritis (5.7%) and RA (5.7%) were the most frequent form. Infectious causes of fever (65.3%), collagen vascular (13.4%), malignancies (5.7%) and other causes (15.6%).conclusion: In patients with extremely high sediment in terms of gender segregation is almost the same of hospital commiunity
Assessment of knowledge, attitude and practice of clinical students’ of Yazd University of Medical Sciences toward Isolation Precaution
No full textBackground: To determine the level of knowledge, attitude and practice among clinical students’ of Yazd University of Medical Sciences toward Isolation Precaution -1394.Methods and material: A descriptive –analytical cross-sectional study was developed and distributed to 300 clinical students who studied in Yazd University of Medical Sciences. The self-administered questionnaire was composed of demographic data and three parts, knowledge, attitude, and practice, toward Isolation precaution (standard, droplet, airborne and contact precautions). Results: The survey was completed by 325 (response rate: 92/3%) of potential respondents. Mean scores of knowledge, attitude, and practice towards standard, droplets, airborne and contact isolation precautions were poor. In addition, a linear correlation was found between three items of the survey including knowledge-attitude, knowledge-practice and attitude- practice in all subgroups of isolation precautions.Conclusion: clinical students’ of Yazd University of Medical Sciences seemed to have low levels of knowledge, attitude and practice towards infection control. There are numerous educational deficits in our clinical students’ of Yazd University of Medical Sciences in relation to infection control that must urgently be addresse
Prevalence and demographic characteristics of non-alcoholic fatty liver disease in corpses at Kerman Forensic Medicine Center, 2011
Full text linkIntroduction: Fatty liver is a multi-factorial gastrointestinal disorder that can lead to different disease and finally death. It is mostly silent without any obvious symptoms. This study is designed to determine the prevalence fatty liver after cadaver autopsy in 102 cadaver and its correlation with associated risk factors.Method: Liver autopsy was done on 102 cadaver refereeing to the legal medicine ward of Kerman on 2013. Clinical information and pathologic findings were recorded in statistical checklist. Finally data were analyzed with fisher’s exact test and mann-whitney U statistical test in SPSS environment ver.20Results: Mean of age was 43.25 ± 4.25 Pathologic findings showed 18(17.64) fatty liver. None of risk factors showed a significant relation with the prevalence of fatty liver (P>0.05),Conclusion: According to the finding and based on similar scientific evidences fatty liver in this study has higher prevalence rate in compared with other studies and more detailed study with larger sample sizes is recommended for more accurate findings.