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Activité antiradicalaire et cytotoxique de l’extrait acétate d’éthyle des feuilles de Mezoneuron benthamianum, Fabaceae, sur les lignées cellulaires PC3 et MCF-7
Get PDFCes dernières années, l’intérêt pour l’utilisation des plantes dans la prévention et le traitement du cancer s’est accru, en raison de leur richesse en constituants phytochimiques variés et de leurs effets secondaires limités. La présente étude s’est penchée sur une espèce de plante médicinale de la flore ivoirienne, afin d’évaluer son potentiel cytotoxique sur deux lignées cellulaires cancéreuses. La cytotoxicité a été évaluée selon la méthode MTS (tétrazolium [3-(4,5-diméthylthiazol-2-yl) -5-(3-carboxyméthoxyphényl) -2-(4-sulfophényl) -2H-tétrazolium sur les lignées cancéreuses de prostate PC3 et mammaire MCF-7 en utilisant la doxorubicine comme contrôle positif de mort cellulaire. L’activité antiradicalaire a été évaluée par les tests de DPPH et l’ABTS, avec pour standards respectifs l’acide ascorbique et l’acide gallique. La meilleure activité cytotoxique a été observée sur la lignée PC3 (CI50 = 17,79 ± 0,09 µg/mL). Cependant l’activité antiradicalaire de cet extrait (CI50 = 13,97 ± 0,9 µg/mL pour le test de DPPH et 66,77 ± 0,9 μg/mL pour le test de l’ABTS) est moins intéressante que les contrôles (CI50 de 7,09 ± 0,3 µg/ mL pour l’acide ascorbique et une CI50 de 21,47 ± 0,4 μg/mL pour l’acide gallique). En effet, Mezoneuron benthamianum a montré une bonne efficacité contre les cellules PC3, une lignée issue d’un cancer de la prostate. Cette plante pourrait être à l’origine de découverte de nouvelles molécules anticancéreuses pouvant être utilisées dans la thérapie du cancer de la prostate.
In recent years, there has been growing interest in using plants for the prevention and treatment of cancer, due to their rich variety of phytochemical constituents and limited side effects. This study focused on a medicinal plant species from the Ivorian flora to evaluate its cytotoxic potential on two cancer cell lines. Cytotoxicity was assessed using the MTS assay (tetrazolium [3-(4,5-dimethylthiazol-2-yl) -5-(3-carboxymethoxyphenyl) -2-(4-sulfophenyl) -2H-tetrazolium]) on the prostate cancer cell line PC3 and the breast cancer cell line MCF-7, with doxorubicin used as the positive control for cell death. Antioxidant activity was evaluated using DPPH and ABTS assays, with ascorbic acid and gallic acid as respective standards. The best cytotoxic activity was observed on the PC3 cell line (IC50 = 17.79 ± 0.09 µg/mL). However, the antioxidant activity of this extract (IC50 = 13.97 ± 0.9 µg/mL in the DPPH assay and 66.77 ± 0.9 µg/mL in the ABTS assay) is less notable than that of the controls (IC50 of 7.09 ± 0.3 µg/mL for ascorbic acid and 21.47 ± 0.4 µg/mL for gallic acid). Nevertheless, Mezoneuron benthamianum demonstrated strong efficacy against PC3 cells, a cell line derived from prostate cancer. This plant could potentially lead to the discovery of new anticancer molecules that may be used in prostate cancer therapy
The Influence of Parent-Adolescent Conflict on Adolescent Academic Retention in the South Dayi District in the Volta Region, Ghana
Get PDFParent-adolescent conflict is a global problem that confronts most families. It remains a key concern due to its consequences on emotional, social, and psychological well-being, as well as its long-term implications for the family and the adolescents' overall development. The purpose of this study was to explore the influence of parent-adolescent conflict on adolescents’ academic performance. The study adopted a qualitative approach and case study design. Thirty-two (32) participants were purposively selected from two Senior High Schools in the South Dayi District, and the data were thematically analyzed. Findings showed that poverty, neglect of parental obligations, broken homes, and single parenting were the leading causes of conflict between parents and adolescents. It was also revealed that parent-adolescent conflict resulted in school drop-out, lack of concentration in school, and early relationship with the opposite sex, among others. It was concluded that the adolescent stage is delicate; therefore, effective interventions and strategies must be initiated by the government in collaboration with district authorities and Non-Governmental Organizations (NGOs), to enable educators, parents, and school counsellors to help adolescents who may be experiencing academic difficulties as a result of conflict at home. It was recommended that schools should develop comprehensive counselling services, including frequent counselling sessions, to help students facing adolescent-parent conflict focus on their academic work and manage their time properly
Teachers' Attitudes towards Using Cooperative Learning through Technology for Developing Writing Skills in a Military Context
Get PDFTeachers of English for Specific Purposes (ESP) consider writing one of the most challenging productive skills for military students to master. Writing is a vital skill for their future careers, as they must pass the high-stakes STANAG 6001 (Standardisation Agreement 6001) test for promotion. Teachers play a crucial role in teaching ESP by addressing students’ current needs and designing goal-oriented assignments to develop their writing skills and improve performance. Therefore, the purpose of the study was to explore ESP teachers’ attitudes toward using cooperative learning through technology to enhance writing skills and to assess their readiness to implement this instructional strategy, since successful implementation largely depends on teachers’ attitudes. The study used a quantitative approach. Data were collected through a questionnaire and analyzed with descriptive statistics. Participants included 58 teachers from various military educational institutions in NATO member, partner, and candidate countries such as Georgia, Ukraine, Latvia, and the UK. SPSS 27 was used for data analysis. The results show that most ESP teachers have positive attitudes toward using cooperative learning via technology to develop writing skills, as it can foster cooperation among English language learners. Although teachers note that students lack the necessary skills for effective cooperative group work and that the method places too much responsibility on students, these findings suggest that this complex approach has the potential to help military students improve their writing performance
L'impact de l'information digitale sur le public marocain ayant un niveau d’études égal ou supérieur à BAC+5: cas de la guerre à Gaza
Get PDFLes contenus des plateformes numériques émergentes constituent un axe important de la recherche en Sciences de l’Information et de la Communication (SIC). A travers cet article, nous nous interrogeons sur la réception de ce type de contenus dans le contexte de la guerre de Gaza 2023-2025 qui a opposé le mouvement palestinien Hamas à Israël. Nous avons mené une enquête auprès d’un échantillon constitué de 101 Marocains ayant un niveau d’études égal ou supérieur à BAC+5. Nous avons tenté d’analyser leur perception de l'information numérique et d’explorer leurs tendances et préférences dans la réception des nouveaux processus médiatiques. Cette étude s’intéresse à l’impact des informations numériques présentées sous des formats hybrides sur la compréhension de l’actualité et sur les positions des internautes sur la question palestinienne, ainsi qu’aux effets psychologiques des informations liées au dossier en question. Par ailleurs, il est nécessaire d’élargir l’échantillon pour atteindre une meilleure représentativité et pouvoir généraliser les résultats.
Content on emerging digital platforms is an important area of research in Information and Communication Sciences (ICS). In this article, we examine how this type of content was received during the 2023-2025 Gaza war between the Palestinian movement Hamas and Israel. We surveyed 101 Moroccans holding a master’s degree or higher. We aimed to analyze their engagement with digital information and to explore the trends and preferences in their reception of new media processes. To this end, we carried out an exploratory survey involving 101 participants, based on a structured questionnaire. The survey sought to shed light on several aspects, including the impact of digital information presented in hybrid formats on news comprehension and on users' positions regarding the Palestinian cause, as well as the psychological effects of such information. While the findings are insightful, it is important to note that this study could be expanded to cover a more representative sample of the target population. This would enable us to generalize the results and provide a more comprehensive understanding of the subject matter. 
Signes de dépression chez les étudiants redoublants de l’Institut Supérieur Pédagogique de la Gombe à Kinshasa : Enquête qualitative
Get PDFCette étude avait pour finalité d’examiner de manière systématique les manifestations dépressives chez des étudiants confrontés à l’échec universitaire. Pour répondre à cet objectif, une démarche qualitative s’appuyant sur la méthode clinique a été mobilisée, permettant d’appréhender la singularité de chaque participant. L’échantillon, constitué selon une procédure non probabiliste de type occasionnel, comprenait cinq étudiants ayant tous redoublé leur première année de licence. La collecte des données s’est effectuée à l’aide de deux outils complémentaires : la technique du récit de vie, qui a permis d’explorer la dimension subjective et biographique des expériences étudiantes, et l’Échelle de Dépression de Beck – Version Adolescent, utilisée comme instrument psychométrique pour objectiver la présence et l’intensité des symptômes dépressifs. Le traitement des données a reposé sur la méthode de l’étude de cas, favorisant une analyse clinique approfondie des trajectoires individuelles. Les résultats convergents issus des analyses narratives et des scores psychométriques indiquent que l’ensemble des participants présentent des manifestations de souffrance psychique s’exprimant sous forme de signes dépressifs. Cette symptomatologie apparaît intimement liée à l’expérience de l’échec académique, lequel constitue un événement potentiellement déstabilisant pour l’estime de soi, la motivation et le sentiment de compétence. Au regard de ces observations, l’étude souligne l’importance de mettre en place, au sein des établissements universitaires, des dispositifs institutionnels de santé mentale et de soutien psychosocial. De tels services permettraient d’accompagner les étudiants en difficulté, de prévenir l’intensification des symptômes dépressifs et de promouvoir un environnement académique favorisant le bien-être et la réussite.
The purpose of this study was to systematically examine depressive symptoms in students facing academic failure. To achieve this objective, a qualitative approach based on clinical methodology was used, allowing for an understanding of each participant's unique situation. The sample, which was selected using a non-probabilistic, opportunistic procedure, included five students who had all repeated their first year of undergraduate studies. Data was collected using two complementary tools: the life story technique, which explored the subjective and biographical dimensions of the students' experiences, and the Beck Depression Inventory – Adolescent Version, used as a psychometric instrument to objectively assess the presence and intensity of depressive symptoms. Data processing was based on the case study method, which allowed for an in-depth clinical analysis of individual trajectories. The convergent results from narrative analyses and psychometric scores indicate that all participants show signs of psychological distress in the form of depressive symptoms. These symptoms appear to be closely linked to the experience of academic failure, which can be potentially destabilizing for self-esteem, motivation, and feelings of competence. In light of these observations, the study highlights the importance of establishing institutional mental health and psychosocial support systems within universities. Such services would make it possible to support students in difficulty, prevent the intensification of depressive symptoms, and promote an academic environment conducive to well-being and success
The Impact of Marketing Communications on Consumer Behavior in The Saudi Arabian Telecom Industry
Get PDFMarketing plays a central role in helping organizations retain existing customers and attract new ones in an increasingly competitive and rapidly evolving environment. Advances in communication technologies have expanded the ability of firms to reach and engage consumers through a mix of traditional and digital channels. This study investigates how Saudi telecom operators leverage these channels to influence consumer behavior, shape perceptions, and stimulate purchasing decisions. A qualitative case study methodology was adopted, incorporating four in-depth, semi-structured interviews with marketing communication and product management specialists from major local telecom operators. These interviews provided rich, practitioner-level insights into strategic communication practices. The primary data were complemented by secondary sources, including industry reports and prior academic literature, and analyzed using thematic analysis to identify recurring patterns and to compare them with established theories of marketing communication and consumer behavior. The results show a strong and purposeful relationship between marketing communication channels and consumer behavioral responses. Telecom operators in Saudi Arabia are increasingly dependent on digital platforms - particularly social media - for targeted engagement, real-time interaction, and influencing consumer motivations at the consideration stage. Meanwhile, traditional channels such as television and outdoor advertising continue to dominate large-scale brand-building campaigns due to their broad reach and credibility. The findings further reveal that communication style, message framing, and cross-channel integration play an essential role in shaping consumer attitudes, perceptions, and intentions. Consumers’ motivations are driven primarily by utilitarian factors such as pricing, network coverage, and data speed; however, emotional and hedonic elements are strategically incorporated to reinforce brand identity and enhance customer affinity. Overall, the study underscores the critical importance of marketing communication in shaping consumer behavior within the Saudi telecom industry and highlights the deliberate strategic alignment between communication activities and desired behavioral outcomes
Effect of the Energy Transition on Food Security: The Role of the Female Agricultural Workforce in WAEMU Countries
Get PDFThis study analyses the role of women in the relationship between the energy transition and food security in the 8 WAEMU countries (1996-2022). The use of an ARDL model shows that the energy transition significantly and symmetrically improves food security in the short term, but has a negative and asymmetric effect in the long term. The interaction between the energy transition and the female agricultural workforce has a positive effect in the long term, but is neutral in the short term. We recommend maximising short-term benefits and actively involving women in agriculture to improve long-term food security
Comparación de los recursos naturales turísticos de cuatro comunidades del municipio de Escárcega, Campeche
Get PDFEscárcega, municipio del estado mexicano de Campeche, conformada por nueve comunidades y dos juntas municipales; situada en el sur-sureste del Estado, rica en gastronomía, social y recursos naturales: flora y fauna. Aunque rica tambien han sido sobre explotados sus recursos y otros más desaprovechados. Es fundamental conservar los mismos a través de practicas sustentables. Por tanto para realizar acciones es indispensable realizar diagnósticos en las comunidades más importantes y que tengan influencia en el proyecto del tren Maya con la finalidad de agrupar dichas actividades y construir alianzas entre los sectores que existen en Escárcega. Por lo anterior para la realización de este proyecto la muestra se definió de manera aleatoria analizando variables de superficie, número de habitantes, recursos naturales que poseen, cercanía de la ruta del Tren Maya, entre otros; además de las características de los recursos naturales que pueden ser aprovechados para el turismo rural. También se diseñó y se aplicó cuestionarios de manera fisica para obtener la información que se agrupa en recusrsos naturales, sociales y áreas de oportunidad dirigidos a los representantes (Comisarios y Agentes municipales), vecinos y líderes naturales de cada comunidad. En los resultados obtenidos muestra la similitud tanto en recursos potencialmente favorables para el desarrollo del turismo rural tambien en las áreas de oportunidad como: Organización, comunicación organizacional y capacitación en temas de turismo (diseño de rutas, mercadotecnia dirigida al turismo).
Escárcega, municipality of the Mexican state of Campeche, is made up of nine communities and two municipal boards; Located in the south-southeast of the State, rich in gastronomy, social and natural resources: flora and fauna. Although rich, its resources have also been overexploited and others more wasted. It is essential to conserve them through sustainable practices. Therefore, to carry out actions, it is essential to carry out diagnoses in the most important communities that have an influence on the Maya train project in order to group these activities and build alliances between the sectors that exist in Escárcega. Therefore, to carry out this project, the sample was defined randomly by analyzing surface variables, number of inhabitants, natural resources they have, and proximity to the Mayan Train route, among others; in addition to the characteristics of natural resources that can be used for rural tourism. Questionnaires were also designed and applied physically to obtain information that is grouped into natural and social resources and areas of opportunity aimed at representatives (Commissioners and Municipal Agents), neighbors, and natural leaders of each community. The results obtained show the similarity in potentially favorable resources for the development of rural tourism and also in the areas of opportunity such as Organization, organizational communication, and training on tourism issues (route design, marketing aimed at tourism)
Cardiovascular Risk Assessment Among Workers in the West Attica Landfill
Get PDFIntroduction: Landfill workers are frequently exposed to a multitude of deleterious factors that can adversely affect their health. These include environmental contaminants such as dioxins, furans, biogas, and heavy metals, as well as occupational hazards like noise, vibration, and extreme temperatures. Aims and Scope: This pilot study, conducted at the Integrated Solid Waste Management Facility of Fili (OEDA Filis), aimed to measure environmental risk parameters and assess their effects on the cardiovascular health of workers. Method: Data collection involved questionnaires to record personal history, work stress and job positions, clinical examinations, and blood lipid tests. Cardiovascular risk (Heart Score) was evaluated based on standards set by the Hellenic Heart Association, which incorporated the Heart Score using Greek data. Results: The majority of employees at OEDA Filis were married men from lower socioeconomic backgrounds, with 77% reporting no chronic health issues and self-assessing their health status as good. Most subjects had body mass indices categorized as either normal or overweight. Environmental assessments identified elevated concentrations of PM10 and phenanthrene in the workplace, though levels of benzo(a)pyrene and naphthalene were within safety thresholds. About 21% of the workforce was identified as being at considerable risk for cardiovascular disease. No statistically significant relation was found between the Heart Score and job positions (p = 0.3), indicating that occupational role alone does not predict cardiovascular risk. However, elevated Heart Scores were more frequently observed among positions with greater exposure to environmental and occupational hazards. Conversely, office workers, who had reduced exposure to exhaust, noise, and air pollutants, exhibited lower Heart Scores. Univariate analysis showed a significant association between occupational stress and Heart Score (p = 0.037); workers under high stress had significantly lower levels of high-density lipoprotein (HDL) (p = 0.006). Additionally, a significant association existed between the use of personal protective equipment (PPE) and lower Heart Score risk index values (p = 0.012), highlighting the protective impact of PPE in mitigating cardiovascular risk among exposed workers. Conclusion: This study enhances understanding of the associations between cardiovascular risk and exposure to environmental and occupational hazards at landfill sites. It underscores the critical need to establish a specialized observatory for continuous monitoring of occupational health and safety at these locations. Such an observatory should include regular health assessments for workers and systematic monitoring of environmental pollutants. Furthermore, the study advocates for initiatives aimed at improving the cardiovascular health of landfill workers, underscoring their necessity in this high-risk occupational environment
Evaluation in vitro de l’activité antiproliférative de la teinture extraite du bois de cœur de Pterocarpus soyauxii Taub (Fabaceae) utilisée par les populations autochtones en République du Congo
Get PDFLes enquêtes ethnobotaniques réalisées auprès des populations autochtones du département de la Lékoumou ont montré une utilisation prépondérante en médecine traditionnelle de Pterocarpus soyauxii. Le but de ce travail est d’évaluer les propriétés antiprolifératives de l’extrait aqueux du bois de cœur de Pterocarpus soyauxii. L’activité antiproliférative de l’extrait a été évaluée in vitro sur deux lignées cellulaires cancéreuses, la lignées cellulaires CRL11147 (cellules de mélanome) et MCF-7 (cellules tumorales mammaires) en utilisant le test de MTT. Les extraits aqueux du bois de cœur de Pterocarpus soyauxii à différentes concentrations ont montré une activité antiproliférative contre les cellules cancéreuses avec des valeurs d’inhibition supérieures à 50% à des concentrations supérieures à 55 µg/ml. Par Contre, les extraits dont les concentrations sont comprises entre 55 µg/ml et 30 µg/ml n’induisent aucune inhibition de la prolifération sur les deux lignées cellulaires. Notre étude a permis d’identifier le Pterocarpus soyauxii comme plantes médicinales aux propriétés antiprolifératives.
Ethnobotanical surveys of the indigenous populations of the Lékoumou department have shown that Pterocarpus soyauxii is widely used in traditional medicine. The aim of this study was to evaluate the antiproliferative properties of the aqueous extract of Pterocarpus soyauxii heartwood. The antiproliferative activity of the extract was assessed in vitro on two cancer cell lines, CRL11147 (melanoma cells) and MCF-7 (breast tumour cells) using the MTT assay. Aqueous extracts of Pterocarpus soyauxii heartwood at different concentrations showed antiproliferative activity against cancer cells, with inhibition values of over 50% at concentrations above 55 µg/ml. In contrast, extracts with concentrations between 55 µg/ml and 30 µg/ml did not induce any inhibition of proliferation in the two cell lines. Our study identified Pterocarpus soyauxii as a medicinal plant with antiproliferative properties