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High-Efficiency Absorber for Damping Transverse Wake Fields Physical Review Special Topics -Accelerators and Beams (PRST-AB) High-Efficiency Absorber for Damping Transverse Wake Fields
No full textAbstract Transverse wake fields generated by intense beams may propagate long distances in the vacuum chamber and dissipate power in different shielded elements such as bellows, vacuum valves or vacuum pumps. Induced heating in these elements may be high enough to deteriorate vacuum conditions. We have developed a broadband water-cooled bellowsabsorber to capture and damp these harmful transverse fields without impacting the longitudinal beam impedance. Experimental results at the PEP-II SLAC B-factory demonstrate high efficiency of this device. This absorber may be useful in other machines like synchrotron light sources or International Linear Collider
Redalyc.An intraoperative transesophageal echocardiography-guided maneuver to assist the removal of an intraventricular thrombus
No full textEnteric Pathogens and Coinfections in Foals with and without Diarrhea
No full textDiarrhea is a major clinical problem affecting foals up to 3 months of age. The aim of this study was to identify enteric microorganisms involved in monoinfections and coinfections and the associated virulence factors in healthy and diarrheic foals. Diarrheic (D) ( = 56) and nondiarrheic (ND) foals ( = 60) up to three months of age were studied. Fecal samples were analyzed for identification of infectious agents (microbiological culturing, molecular techniques, and microscopic analyses). Escherichia coli fimH (30% versus 25%), Salmonella spp. (25% versus 7%), Strongyloides westeri (25% versus 25%), Clostridium perfringens type A (21% versus 10%), E. coli ag43 (20% versus 35%), Strongylus (11% versus 18%), and vapA-positive Rhodococcus equi (5% versus 2%) were the most frequent enteric pathogens detected in D and ND foals, respectively. The frequency of toxin A-positive C. perfringens was significantly increased in the D ( = 0.033) compared with the ND animals. R. equi strains harboring virulent plasmids were also identified (VapA 85-kb type I and VapA 87-kb type I) in D and ND foals. Coinfections were observed in 46% of the D and 33% of the ND foals. Our results demonstrate the great diversity of enteric pathogens, virulence factors, and coinfections involved in enteric infections of foals
Cardiovascular Risk Factors and Visiting Nurse Intervention -Evaluation of a Croatian Survey and Intervention Model: the CroHort Study
No full textA B S T R A C T The aim of this study is to identify factors that influence the success of the implementation of the primary and secondary prevention programs i
Biomass burning in Siberia and Kazakhstan as an important source for haze over the Alaskan Arctic in April 2008, Geophys
Get PDFThe Study on the Organization Approach of Agricultural Model Component Library Based on Topic Map
Get PDFComparison between superdarn flow vectors and equivalent ionospheric currents from ground magnetometer arrays
Get PDF[1] Equivalent ionospheric currents obtained with the spherical elementary current systems (SECS) method and derived from nearly 100 ground magnetometers spread over North America and Greenland are compared with ionospheric flow vectors measured by the SuperDARN radars during both the summer and winter seasons. This comparison is done over a range of spatial separations, magnetic latitudes, magnetic local times, and auroral electrojet activity to investigate under what conditions the vectors are anti-parallel to one another. Our results show that in general the equivalent ionospheric currents are anti-parallel to the flows and the best results are achieved within the auroral oval during active geomagnetic conditions in the dawn, dusk and noon sectors in the northern hemisphere summer. These results indicate the best anti-parallel alignment occurs when the currents and flows are large and well defined. Factors that may influence the alignment include ionospheric conductivity gradients and quiet time backgrounds. Our results can be used to approximate the macroscopic ($1000 km) ionospheric convection patterns. The SECS maps represent a value-added product from the raw magnetometer database and can be used for contextual interpretation; they can help with our understanding of magnetosphere-ionosphere coupling mechanisms using ground arrays and the magnetospheric spacecraft data, and they can be used as input for other techniques
Sensitivity analysis of optimal operation of irrigation supply systems with water quality considerations
Get PDFAbstract. A model for optimal operation of water supply/irrigation systems of various water quality sources, with treatment plants, multiple water quality conservative factors, and dilution junctions is presented. The objective function includes water cost at the sources, water conveyance costs which account for the hydraulics of the network indirectly, water treatment cost, and yield reduction costs of irrigated crops due to irrigation with poor quality water. The model can be used for systems with supply by canals as well as pipes, which serve both drinking water demands of urban/rural consumers and field irrigation requirements. The general nonlinear optimization problem has been simplified by decomposing it to a problem with linear constraints and nonlinear objective function. This problem is solved using the projected gradient method. The method is demonstrated for a regional water supply system in southern Israel that contains 39 pipes, 37 nodes, 11 sources, 10 agricultural consumers, and 4 domestic consumers. The optimal operation solution is described by discharge and salinity values for all pipes of the network. Sensitivity of the optimal solution to changes in the parameters is examined. The solution was found to be sensitive to the upper limit on drinking water quality, with total cost being reduced by 5% as the upper limit increases from 260 to 600 mg Cl l −1 . The effect of income from unit crop yield is more pronounced. An increase of income by a factor of 20 results in an increase of the total cost by a factor of 3, thus encouraging more use of fresh water as long as the marginal cost of water supply is smaller than the marginal decrease in yield loss. The effect of conveyance cost becomes more pronounced as its cost increases. An increase by a factor of 100 results in an increase of the total cost by about 14%. The network studied has a long pipe that connects two distinct parts of the network and permits the supply of fresh water from one part to the other. Increasing the maximum permitted discharge in this pipe from 0 to 200 m 3 h −1 reduces the total cost by 11%. Increasing the maximum discharge at one of the sources from 90 to 300 m 3 h −1 reduces the total cost by about 8%
Pharmaceutical Candidate Optimization
Get PDFABSTRACT The studies reported here were conducted to investigate the transport characteristics of apixaban (1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo [3,4-c]pyridine-3-carboxamide) and to understand the impact of transporters on apixaban distribution and disposition. In human permeability glycoprotein (P-gp)-and breast cancer resistance protein (BCRP)-cDNA-transfected cell monolayers as well as Caco-2 cell monolayers, the apparent efflux ratio of basolateral-to-apical (Pc B-A ) versus apical-to-basolateral permeability (Pc A-B ) of apixaban was >10. The P-gp-and BCRP-facilitated transport of apixaban was concentration-and time-dependent and did not show saturation over a wide range of concentrations (1-100 mM). The efflux transport of apixaban was also demonstrated by the lower mucosal-to-serosal permeability than that of the serosal-tomucosal direction in isolated rat jejunum segments. Apixaban did not inhibit digoxin transport in Caco-2 cells. Ketoconazole decreased the P-gp-mediated apixaban efflux in Caco-2 and the P-gp-cDNA-transfected cell monolayers, but did not affect the apixaban efflux to a meaningful extent in the BCRP-cDNA-transfected cell monolayers. Coincubation of a P-gp inhibitor (ketoconazole or cyclosporin A) and a BCRP inhibitor (Ko134) provided more complete inhibition of apixaban efflux in Caco-2 cells than separate inhibition by individual inhibitors. Naproxen inhibited apixaban efflux in Caco-2 cells but showed only a minimal effect on apixaban transport in the BCRP-transfected cells. Naproxen was the first nonsteroidal antiinflammatory drug that was demonstrated as a weak P-gp inhibitor. These results demonstrate that apixaban is a substrate for efflux transporters P-gp and BCRP, which can help explain its low brain penetration, and low fetal exposures and high milk excretion in rats
Therapeutic capsule endoscopy: Opportunities and challenges
Get PDFABSTRACT The increasing demand for non-invasive (or less-invasive) monitoring and treatment of medical conditions has attracted both physicians and engineers to work together and investigate new methodologies. Wireless capsule endoscopy is a successful example of such techniques which has become an accepted routine for diagnostic inspection of the gastrointestinal tract. This method offers a non-invasive alternative to traditional endoscopy and provides the opportunity for exploring distal areas of the small intestine which are otherwise not accessible. Despite these advantages, wireless capsule endoscopy is still limited in functionality compared to traditional endoscopy. Wireless capsule endoscopes with advanced functionalities, such as biopsy or drug delivery, are highly desirable. In this article, the current status of wireless capsule endoscopy is reviewed together with some of its possible therapeutic applications as well as the existing challenges