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Literature Review: Aktivitas Batang dan Daun Sambiloto (Andrographis Paniculata Nees) terhadap Target Molekular Terapi Diabetes
Get PDFAndrographis paniculata Nees, so-called sambiloto is a plant that is effective as an alternative therapy for diabetes mellitus (DM). Sambiloto is a multi-compound plant that contains diterpenoids, flavonoids and polyphenols. This study aims to explain the activity of chemical compounds contained in the stems and leaves of sambiloto against five molecular targets for DM therapy, namely Dipeptidyl Peptidase 4 (DPP4), Protein Tyrosine Phosphatase (PTP1B), α-glucosidase, Glucose Transporter (GLUT) and glucokinase.
This study uses a systematic review method by making PRISMA checklists and flow diagrams, determining inclusion-exclusion criteria, search engines and keywords to get relevant data. The data is obtained from the primary research results presented in the data extraction table, and then is analyzed comprehensively.
The results of the study are: the diterpenoids and flavonoids can provide activity against molecular targets, such as 19-triphenyl isoandrographolide which can inhibit DPP4, α-glucosidase and activate glucokinase; andrographolactone can inhibit PTP1B; deoxyandrographolide increase translocation and acceleration of GLUT4; 15-p-methoxybenziliden 14-deoxy-11,12-didehydroandrographolide inhibits α-glukosidase; and flavonoid groups such as apigenin compounds can inhibit DPP4, PTP1B, and activate glucokinase.
Andrographis paniculata Nees, disebut juga sambiloto adalah tanaman yang berkhasiat sebagai terapi alternatif diabetes melitus (DM). Sambiloto merupakan tanaman multi-compounds yang memiliki kandungan senyawa antara lain: diterpenoid, flavonoid dan polifenol. Studi ini bertujuan menjelaskan aktivitas senyawa kimia yang terkandung di dalam batang dan daun sambiloto terhadap lima target molekular terapi DM, yaitu Dipeptidyl Peptidase 4 (DPP4), Protein Tyrosine Phosphatase (PTP1B), α-glukosidase, Glucose Transporter (GLUT) dan glukokinase.
Studi ini menggunakan metode systematic review, yakni dengan membuat PRISMA checklist dan diagram flow, menetapkan kriteria inklusi-eksklusi, search engine serta kata kunci untuk mendapatkan data yang relevan. Data yang diperoleh berupa hasil penelitian primer yang disajikan dalam tabel ekstraksi data, selanjutnya ditelaah secara komprehensif.
Hasil studi menunjukkan bahwa golongan senyawa diterpenoid dan flavonoid yang terkandung dalam batang dan daun sambiloto dapat memberikan aktivitas terhadap target molekular, seperti senyawa 19-trifenil isoandrografolid dapat menghambat DPP4, α-glukosidase dan mengaktivasi glukokinase; senyawa andrografolakton dapat menghambat PTP1B; senyawa deoksiandrografolid meningkatkan translokasi dan akselerasi GLUT4; senyawa 15-p-metoksibenziliden 14-deoksi-11,12-didehidroandrografolid menghambat α-glukosidase; dan Golongan flavonoid seperti senyawa apigenin mampu menghambat DPP4, PTP1B, serta mengaktivasi glukokinase
PERAN MEDIASI KEPUASAN KONSUMEN DAN MODERASI ORIENTASI INOVASI PADA HUBUNGAN ANTARA INOVASI PERSEPSIAN DAN KESETIAAN MEREK DI RS DR. MOEWARDI SURAKARTA, JAWA TENGAH
Get PDFThis study aims to examine the effect of perceived innovation, consumer satisfaction on brand loyalty and the influence of innovation orientation on the relationship between perceived innovation and brand loyalty. When consumers are satisfied with a product, they will buy more. Continuous innovation makes consumers satisfied because producers always update their products or services.The data obtained through questionaires are distributed to Dr. Moewardi Surakarta Hospital’s service user and employee. Sampling technique that used is purposive sampling with a population of service users (general outpatients / non BPJS) 77 respondents and 77 hospital employees. Hypothesis testing using by mediation and moderation regression analysis. The results of this study indicate that perceived innovation has a significant effect on brand loyalty, customer satisfaction has a significant effect on brand satisfaction at Dr. Moewardi Surakarta Hospital.
Keywords : perceived innovation, customer satisfaction, innovation orientation, brand loyalty.This study aims to examine the effect of perceived innovation, consumer satisfaction on brand loyalty and the influence of innovation orientation on the relationship between perceived innovation and brand loyalty. When consumers are satisfied with a product, they will buy more. Continuous innovation makes consumers satisfied because producers always update their products or services.The data obtained through questionaires are distributed to Dr. Moewardi Surakarta Hospital’s service user and employee. Sampling technique that used is purposive sampling with a population of service users (general outpatients / non BPJS) 77 respondents and 77 hospital employees. Hypothesis testing using by mediation and moderation regression analysis. The results of this study indicate that perceived innovation has a significant effect on brand loyalty, customer satisfaction has a significant effect on brand satisfaction at Dr. Moewardi Surakarta Hospital.
Keywords : perceived innovation, customer satisfaction, innovation orientation, brand loyalty
PENGARUH LINGKUNGAN KERJA, PEMBELAJARAN ORGANISASIONAL, DAN PERILAKU ADAPTIF TERHADAP PRODUKTIVITAS KERJA TENAGA KESEHATAN
Get PDFThis study aims to examine the effect of the work environment, organizational learning, and adaptive behavior on the work productivity of health workers. Work productivity is important for the hospital in producing an output or work result in accordance with the specified quality. Data obtained through a questionnaire distributed to health workers. The research sample used was 200 This study used purposive sampling. In Surakarta. Hypothesis testing uses multiple linear regression. The first and third hypotheses are supported and the second hypothesis is not supported.
Keywords: Work Environment, Organizational Learning, Adaptive Behavior, and Work ProductivityThis study aims to examine the effect of the work environment, organizational learning, and adaptive behavior on the work productivity of health workers. Work productivity is important for the hospital in producing an output or work result in accordance with the specified quality. Data obtained through a questionnaire distributed to health workers. The research sample used was 200 This study used purposive sampling. In Surakarta. Hypothesis testing uses multiple linear regression. The first and third hypotheses are supported and the second hypothesis is not supported.
Keywords: Work Environment, Organizational Learning, Adaptive Behavior, and Work Productivit
Analisis Rekayasa Nilai Lampu Hias dalam Usaha Pengembangan Produk
Get PDFCurrently, the sales of decorative lighting products are very low because the design of decorative lights are less attractive to consumers. Therefore, the company must develop the product to produce quality products that are updated and attractive to consumers. This research aims to develop the decorative light products using value engineering. Value engineering was used to increase benefits withoutt increasing costs, reducing costs without reducing benefits, or a combination of both. This research was conducted to find out the level of efficiency that can be achieved from several recommended alternatives. Research results showed that the value of the initial design (Product A) was 3,48 x 10-7; product B was 3,16 x 10-7; and product C was 8,83 x 10-7. The use of raw materials has also changed from its initial design which was using a mixture of copper and brass with a thickness of 0,8 mm to an alternative design by using a mixture of copper and brass with a thickness of 0,5 mm. In addition, the study showed that product C are more preferable for consumers.
Keywords: decorative lighting, product development, pairwise comparison, value engineeringSaat ini penjualan produk lampu hias sangat menurun dikarenakan desain lampu hias yang dihasilkan kurang diminati konsumen. Untuk itu perusahaan harus melakukan pengembangan produk agar menghasilkan produk yang bermutu dan tidak ketinggalan zaman serta mampu menarik perhatian konsumen. Penelitian ini bertujuan melakukan pengembangan produk lampu hias dengan menggunakan rekayasa nilai. Rekayasa nilai digunakan untuk meningkatkan manfaat tanpa menambah biaya, mengurangi biaya dengan tidak mengurangi manfaat, atau kombinasi dari keduanya. Penelitian ini dilakukan untuk mengetahui seberapa besar efisiensi yang bisa dicapai dari beberapa alternatif yang direkomendasikan. Hasil penelitian menunjukkan bahwa nilai desain awal (Produk A) adalah 3,48 x 10-7; nilai produk B ialah 3,16 x 10-7; dan nilai produk C sebesar 8,83 x 10-7. Penggunaan bahan baku juga mengalami perubahan dari produk desain awal yang menggunakan bahan baku campuran tembaga dan kuningan dengan ketebalan 0,8 mm dengan produk desain alternatif yang menggunakan bahan baku campuran tembaga dan kuningan dengan ketebalan 0,5 mm. Hasil akhir desain produk yang paling diminati konsumen adalah produk C.
Kata kunci: lampu hias, pengembangan produk, perbandingan berpasangan, rekayasa nila
PERAN SERTIFIKASI GURU, NILAI KERJA DAN IKLIM SEKOLAH PADA KESEJAHTERAAN PROFESIONAL GURU (TEACHER'S PROFESSIONAL WELL BEING) PADA GURU SEKOLAH DASAR
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Improving the quality of education is carried out by increasing teacher professional well being. This study aims to determine the effect of teacher certification, work values and school climate on teacher professional well being. The sampling technique used was accidental sample. The number of samples in this study were 61 teachers who had and had not received certification. The data analysis technique used multiple regression and t test. The results showed that there was an influence between work value and school climate on teacher professional well being, while perceptions of teacher certification did not have a significant effect. The contribution of the three variables is 69.2% and 30.80% is influenced by other factors. Each - each variable gave an effective contribution of 48.15% while the work value contributed 19.37%. Teacher professional well being, viewed from certified and uncertified teachers, does not show any difference. Teacher professional well being, viewed from the tenure of teachers who have worked for 20 years and less than 20 years, also does not show any difference.
Key words: Teacher Certification, Work Value, School Climate, and teacher professional well being
Abstrak
Peningkatan mutu pendidikan dilakukan dengan meningkatkan teacher professional well being. Penelitian ini bertujuan untuk mengetahui pengaruh sertifikasi guru, nilai kerja dan iklim sekolah terhadap teacher professional well being. Teknik sampling yang digunakan adalah accidental sample. Jumlah sample yang dalam penelitian ini adalah 61 guru yang sudah dan belum mendapatkan sertifikasi. Teknik analisis data menggunakan regresi berganda dan uji t. Hasil penelitian menunjukkan bahwa ada pengaruh antara work value dan iklim sekolah terhadap teacher professional well being sedangkan persepsi terhadap sertifikasi guru tidak berpengaruh secara significant. Sumbangan ketiga variabel sebesar 69,2% dan 30,80 % dipengaruhi oleh faktor lainnya. Masing - masing variabel memberikan sumbangan efektif sebesar sebesar 48,15 % sedangkan work value memberikan sumbangan sebesar 19,37 %. Teacher professional well being ditinjau dari guru yang telah tersertifikasi dan belum tersertifikasi tidak menunjukkan adanya perbedaan. Teacher professional well being ditinjau dari masa kerja guru yang telah bekerja selama 20 tahun dan kurang dari 20 tahun juga tidak menunjukkan adanya perbedaan.
Key word: Sertifikasi Guru, Nilai Kerja, Iklim Sekolah, dan teacher professional well being
 
Effect of Ethanol Extract from Clove Flower (Syzygium aromaticum) on the Growth of Trichophyton rubrum in vitro
Get PDFIndonesia is one of the countries with a tropical climate that has high temperature and humidity, a good atmosphere for fungal growth so that fungi can be found somewhere. Fungus Trichophyton rubrum is a fungal disease that attacks the nails, skin, hair. One of the preventions of this disease is by giving traditional medicines, namely clove flowers (Syzygium aromaticum) which contain chemical compounds saponins, tannins, flavonoids. Serves as an antioxidant that can prevent dermatosis. The purpose of this study was to determine the inhibition power of clove flowers (Syzygium aromaticum) on the growth of Trichophyton rubrum fungi. This research was carried out an experimental method with the Kirby Bauer method. Concentration dilution of clove ethanol extract (Syzygium aromaticum) from concentration 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 100%. The results of this study showed that the clove ethanol extract (Syzygium aromaticum) inhibit the growth of Trychophyton rubrum fungus from the concentration of 10% inhibition zone 14 mm, 20% inhibition zone 26 mm, 30% inhibition zone 36 mm, 40% inhibition zone 41 mm, 50% 45 mm inhibition zone, 60% 46 mm inhibition zone, 70% 48 mm inhibition zone, 80% 49 mm inhibition zone, 90% 51.0 mm inhibition zone, 100% inhibition zone of 56 mm.Indonesia is one of the countries with a tropical climate that has high temperature and humidity, a good atmosphere for fungal growth so that fungi can be found somewhere. Fungus Trichophyton rubrum is a fungal disease that attacks the nails, skin, hair. One of the preventions of this disease is by giving traditional medicines, namely clove flowers (Syzygium aromaticum) which contain chemical compounds saponins, tannins, flavonoids. Serves as an antioxidant that can prevent dermatosis. The purpose of this study was to determine the inhibition power of clove flowers (Syzygium aromaticum) on the growth of Trichophyton rubrum fungi. This research was carried out an experimental method with the Kirby Bauer method. Concentration dilution of clove ethanol extract (Syzygium aromaticum) from concentration 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 100%. The results of this study showed that the clove ethanol extract (Syzygium aromaticum) inhibit the growth of Trychophyton rubrum fungus from the concentration of 10% inhibition zone 14 mm, 20% inhibition zone 26 mm, 30% inhibition zone 36 mm, 40% inhibition zone 41 mm, 50% 45 mm inhibition zone, 60% 46 mm inhibition zone, 70% 48 mm inhibition zone, 80% 49 mm inhibition zone, 90% 51.0 mm inhibition zone, 100% inhibition zone of 56 mm
Perancangan Ulang Tata Letak Fasilitas Menggunakan Metode Systematic Layout Planning Pada PT Pilar Kekar Plasindo
Get PDFGood equipment and product design are meaningless if there is no good layout planning. Problems that are owned by PT. Pilar Kekar Plasindo occurs in the production of small polyethylene. This is because small polyethylene production has large material total transfer distance. Small polyethylene problems, namely the distance between stations, cross-movement, backtracking, and the broken machine that is still placed in the production section. This makes the material handling costs and distances become large. So this research aims to produce a layout design of production facilities that can minimize the distance and cost of material movement. The method used is Systematic Layout Planning (SLP). Three alternative designs were compared, and the second proposed facility layout was chosen because it was able to reduce the total cost of material transfer by 68.3% and reduce the distance of material transfer by 59.6% from the initial facility layout.Peralatan dan desain produk yang baik tidak akan berarti jika tidak terdapat perencanaan tata letak fasilitas yang baik. Masalah yang dimiliki oleh PT. Pilar Kekar Plasindo terjadi pada bagian produksi polyethylene kecil. Masalah tersebut disebabkan oleh produksi polyethylene kecil yang memiliki jarak transfer total material yang besar. Masalah-masalah yang terjadi pada produksi polyethylene kecil yaitu jarak antar stasiun, cross-movement, backtracking, dan mesin-mesin rusak yang masih ditempatkan di bagian produksi. Kondisi tersebut membuat biaya penanganan material dan jarak menjadi besar. Penelitian ini bertujuan untuk menghasilkan desain tata letak fasilitas produksi yang dapat meminimalkan jarak dan biaya perpindahan material. Metode yang digunakan adalah Systematic Layout Planning (SLP). Pada penelitian ini tiga desain alternatif dibandingkan dan usulan tata letak fasilitas kedua terpilih karena mampu mengurangi total biaya transfer material sebesar 68,2% dan mengurangi jarak transfer material sebesar 59,6% dari tata letak fasilitas awal
Uji Efek Penghambatan Enzim Xantin Oxidase Kombinasi Ekstrak Daun Kumis Kucing (Orthosiphon aristatus L.) dan Daun Sidaguri (Sida rhombifolia L.)
No full textHyperuricemia is a high level of uric acid in the blood and can cause gout. One of the drugs used to treat hyperuricemia is allopurinol with a mechanism of inhibiting the activity of xanthine oxidase (XO). The use of these drugs can cause various side effects if used for a long period of time. Sidaguri and kumis kucing plants are known to contain flavonoids and are proven to treat gout with each plant can reduce uric acid levels in the blood and increase its excretion in urine. This study was carried out to test the combination of sidaguri and kumis kucing extracts with certain ratios in inhibiting the activity of the xanthine oxidase enzyme.
In this study, a combination of extracts was made using maceration method. The inhibition of xanthine oxidase activity by ethanol extract in vitro was determined by decreasing the production of uric acid monitored with a spectrophotometer at (λ) 292nm with xanthine as a substrate. Then determined the best IC50. As a comparison allopurinol is used.
Based on the results of in vitro tests, the best comparison of the combination of kumis kucing extract and sidaguri extract can inhibit the activity of XO enzymes with the best IC50 in a row is the combination of kumis kucing and sidaguri extracts 1:1 (20.99ppm), 1:2 (39.64ppm), and 1:0.5 (52.28ppm).Hiperurisemia merupakan tingginya kadar asam urat dalam darah dan dapat menimbulkan penyakit gout. Salah satu obat yang digunakan untuk mengatasi hiperurisemia adalah allopurinol dengan mekanisme menghambat aktivitas xanthine oxidase (XO). Selain itu digunakan probenesid yang meningkatkan pengeluaran asam urat melalui urine. Penggunaan obat tersebut menimbulkan berbagai efek samping jika digunakan dalam jangka waktu yang lama. Tumbuhan sidaguri dan kumis kucing diketahui mengandung flavonoid dan terbukti mengobati asam urat dengan masing-masing tanaman dapat menurunkan kadar asam urat dalam darah dan meningkatkan eksresinya dalam urine. Studi ini dilakukan untuk menguji kombinasi ekstrak kumis kucing dan sidaguri dengan rasio tertentu dalam menghambat aktivitas enzim xanthine oxidase.
Pada studi ini, kombinasi ekstrak dibuat dengan menggunakan metode maserasi. Penghambatan aktivitas xanthine oxidase oleh ekstrak etanol secara in vitro ditentukan melalui penurunan produksi asam urat yang di monitor dengan spektrofotometer pada (λ) 292nm dengan xanthine sebagai substrat. Kemudian ditentukan IC50 terbaik. Sebagai pembanding digunakan allopurinol.
Berdasarkan hasil uji in vitro, perbandingan terbaik kombinasi ekstrak kumis kucing dan ekstrak sidaguri dapat menghambat aktivitas enzim XO dengan IC50 terbaik berturut-turut adalah kombinasi ekstrak kumis kucing dan sidaguri 1:1 (20,99ppm), 1:2 (39,64ppm), dan 1:0,5 (52,28ppm)
Evaluasi Office Ergonomic di PT. NDM dengan Metode Rapid Office Strain Assessment (ROSA)
Get PDFThe sickness of office workers are generally caused by wrong posture, repetitive movements, and fixed position for long periods of time. An office worker hazard assessment will cover equipment used such as mouse, keyboard, monitor, desk, and chair. Each of these equipment has prerequisite ergonomic condition, so that users can use it comfortably. The method used in this study is Rapid Office Strain Assessment (ROSA). ROSA is an office ergonomic assessment method designed to measure the risks associated with computer use and to determine the level of change action based on reports of worker discomfort. Based on the analysis of the cause identification, it is known that the work station of the administration and purchasing departemen of PT. NDM has inadequate facilities and it is not adapted to the worker’s posture. Inadequate facilities especially in chairs, tables, and keyboard setting. The conclusion of the study is that management must believe that human resources are an important asset of the organization. Looking at the results of the assessment using ROSA method which requires that repairs to the works station must be carried out immediately to reduce ergonomic risks and other health complaints by workers who using computer.
Keywords: Ergonomic, ROSA method, Strain AssessmentKeluhan sakit para pekerja kantoran umumnya disebabkan oleh postur tubuh yang salah, gerakan berulang, dan posisi yang tetap dalam jangka waktu yang lama. Pengkajian penyebab keluhan pekerja kantoran meliputi peralatan yang digunakan seperti mouse, keyboard, monitor, meja, dan kursi. Masing-masing dari peralatan tersebut memiliki prasyarat kondisi ergonomis, sehingga pengguna dapat menggunakannya dengan nyaman. Metode yang digunakan dalam penelitian ini adalah Rapid Office Strain Assessment (ROSA). ROSA merupakan salah satu metode peniliaan office ergonomic yang dirancang untuk mengukur risiko terkait dengan penggunaan komputer serta untuk menetapkan tingkat tindakan perubahan berdasarkan laporan dari ketidaknyamanan pekerja. Berdasarkan hasil analisis identifikasi penyebab diketahui bahwa work station departemen administrasi dan purchasing PT. NDM memiliki fasilitas yang belum memadai dan tidak sesuai dengan postur tubuh pekerja. Fasilitas yang belum memadai terutama pada bagian kursi, meja, dan pengaturan keyboard. Kesimpulan dari penelitian adalah manajemen harus meyakini bahwa sumber daya manusia merupakan asset penting dari organisasi. Hasil penilaian dengan metode ROSA disimpulkan bahwa perbaikan pada work station harus dilaksanakan segera untuk mengurangi risiko ergonomis dan keluhan kesehatan lain oleh pekerja.
Kata kunci: Ergonomi, Metode ROSA, Strain Assessmen
ANALISIS DETERMINAN RETURN SAHAM INDUSTRI MANUFAKTUR TERDAFTAR DI BURSA EFEK INDONESIA TAHUN 2017 - 2020
Get PDFThis research aims to examining factors that affect stock returns. The dependent variable used in this study is stock returns. Independent variables used in this study is Economic Value Added (EVA), Operating cash flow, Earnings, Operating Leverage, dan Market Value Added (MVA). The population in this research is manufacturing companies listed in Indonesia Stock Exchange 2017-2020. The sample in this study is 21 companies selected by using purposive sampling method. This study used multiple linear regression analysis as an analytical tool. The results showed that H1 Economic Value Added ( EVA ) had no significant effect on stock returns. H2 Operating Cash Flow is a significant effect on stock returns. H3 Earnings significant effect on stock returns. H4 Operating Leverage no significant effect on stock returns. H5 Market Value Added ( MVA ) had no significant effect on stock returns