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Analisis Perencanaan dan Pengendalian Obat Kategori A dengan Metode ABC-VEN dan EOQ di IFRS RSIS Mojokerto
Get PDFThe high residualvalue of drug inventory at IFRS RSIS Mojokerto indicates that drug management has not been managed optimally. The priority scale of supervision and control at planning stage needs to be carried out using the ABC-VEN method analyzing and calculating the EOQ value in order to achieve the most economical ordering value to avoid overstock. The purpose of this study was to determine drug classificationusing the ABC-VEN method, planning control using with EQQ and measuringthe efficiency value at IFRS RSIS Mojokerto.
The design of this research is descriptive quantitative. Retrieval of retrospective data from the January-October 2020 financial statement at IFRS RSIS Mojokerto. The data were analyzed by ABC-VEN to get categoryA drugs. Drug inventory control was calculated by calculating the value of EOQ,ROP, efficiency value by calculating ITOR.
The results of drug classification using the ABC-VEN method obtained categoryA drugs absorbing 68.05% of the total investment value. Control of planning category A drug needs resulted in the value of the remaining inventory dropping from 48.4% to 36% of the total inventory value, ITOR increased from 2.0 to 4.1 times per month. The conclusion of the ABC-VEN, EOQ and ROP analysis can be used to determine the priority scale of procurement and control to avoid over-stocking of drug supplies in the hospital.Nilai sisa persediaan obat yang tinggi di IFRS RSIS Mojokerto mengindikasikan manajemen pengelolaan obat belum dikelola secara optimal. Skala prioritas pengawasan dan pengendalian pada tahap perencanaan kebutuhan perlu dilakukan dengan menggunakan analisis metode ABC-VEN dan menghitung nilai EOQ agar dicapai nilai pemesanan paling ekonomis untuk menghindari overstock. Tujuan penelitian ini untuk mengetahui klasifikasi obat dengan metode ABC-VEN, pengendalian perencanaan dengan EQQ dan mengukur nilai efisiensinya di IFRS RSIS Mojokerto.
Rancangan penelitian ini adalah deskriptif kuantitatif. Pengambilan data retrospektif dari laporan keuangan bulan Januari-Oktober 2020 di IFRS RSIS Mojokerto. Data dilakukan analisis ABC-VEN untuk mendapatkan obat kategori A. Pengendalian persediaan obat dengan perhitungan nilai EOQ, ROP, nilai efisiensi dengan perhitungan ITOR.
Hasil klasifikasi dengan metode ABC-VEN diperoleh skala prioritas yaitu obat kategori A yang yang menyerap anggaran 68.5% dari total nilai investasi. Pengendalian perencanaan obat kategori A mengakibatkan nilai sisa persediaan turun dari angka 48,4% menjadi 36 % dari total nilai persediaan, ITOR mengalami kenaikan dari 2,0 menjadi 4,1 kali per bulan. Kesimpulan analisis ABC-VEN, EOQ dan ROP dapat digunakan untuk menentukan skala prioritas pengadaan dan pengendalian untuk menghindari over stock persediaan obat di rumah sakit
Interaksi Farmakokinetika Kombinasi Captopril Dengan Rebusan Daun Sirsak (Annona Muricata L.) Pada Tikus Putih Jantan (Rattus Norvegicus) Galur Wistar
Get PDFHypertension is a disease that cannot be cured, but can only be controlled, therefore hypertensive patients must get the treatment for the rest of their life. Currently, the treatment pattern of the community has started to return to using natural ingredients as a therapeutic alternative. The community considers the use of herbal medicines is safe, but actually when the herbal medicines is taken together with synthetic medicines, there are interaction potential that should be monitored. The purpose of this study was to analyze the Pharmacokinetic Interaction of Captopril Combination with Soursop Leaf Decoction.
This study was an advanced experimental study with a random block design. The group of test animals was divided into three groups, namely the captopril group, the combination group of captopril and soursop leaf decoction at the same time, and the combination group of captopril and soursop leaf decoction with an consumption interval of 2 hours.
The results of the descriptive analysis showed that there were differences in the pharmacokinetic profile of each group. Combination with captopril with soursop leaf decoction is able to increase captopril levels in blood plasma and increase the elimination rate of captopril. However, the statistical analysis showed there is no significant difference.Hipertensi merupakan penyakit yang tidak dapat disembuhkan, tetapi hanya bisa dikontrol, sehingga pasien yang menderita hipertensi harus mengkonsumsi obat seumur hidup. Saat ini pola pengobatan masyarakat sudah mulai kembali menggunakan bahan alam sebagai pilihan terapi. Masyarakat menilai penggunaan obat herbal aman untuk dikonsumsi, tetapi sebenarnya obat herbal jika dikonsumsi dengan obat konvensional masih memiliki potensi terjadinya interaksi. Tujuan penelitian ini adalah menganalisis Interaksi Farmakokinetika Kombinasi Captopril dengan Rebusan Daun Sirsak.
Penelitian ini merupakan penelitian eksperimental tingkat lanjut dengan desain blok random. Kelompok hewan uji dibagi menjadi tiga kelompok, yaitu kelompok captopril, kelompok kombinasi captopril dan rebusan daun sirsak secara bersamaan, dan kelompok kombinasi captopril dan rebusan daun sirsak yang diberikan dengan jeda waktu 2 jam.
Hasil analisis deskriptif menunjukkan terdapat perbedaan profil farmakokinetika pada setiap kelompok. Kombinasi dengan kaptopril dengan rebusan daun sirsak dapat meningkatkan kadar kaptopril di dalam plasma darah dan meningkatkan laju eliminasi dari captopril. Hasil analisis statistik dengan SPPS tidak menunjukkan perbedaan yang signifikan
Formulasi dan Uji Antibakteri Masker Peel-Off Ekstrak Daun Gulma Siam (Chromolaena odorata L.) Terhadap Propionibacterium Acnes
Get PDFLeaves of gulma siam (Choromolaena odorata L.) contain tannins, phenols, flavonoids, saponins, and steroids which are effective for killing acne-causing bacteria. Applied as anti-acne, the extract of gulma siam is formulated as a preparation of a peel-off gel mask. This research produces formulas of peel-off masks made from the extract of gulma siam leaves and perpetrates an antibacterial test on the peel-off masks against propionibacterium acnes.
Four formulas of peel-off masks were made using different concentrations of the extract of gulma siam leaves. The concentrations were 3.25% (FI), 7.5% (FII), 15% (FIII), and 20% (FIV). The preparations of the peel-off masks were physically evaluated for organoleptic, spreadability, homogeneity, pH, viscosity, and dry time. A well diffusion method was implemented to test antibacterial potencies against propionibacterium acnes. The potency measurement was based on the resistance around wells in the form of a clear zone.
Predicated on the evaluation results of the physical properties of gulma siam leave extracts during storage, organoleptically, the extracts were homogenous, had a pH of 4.5-6.5, and had a dry time of 15-21 minutes. Concerning spreadability, FIII and FIV lived up to the criteria. Meanwhile, for viscosity, all formulas of peel-off masks were unstable during storage. FI and FII presented weak and medium antibacterial activities, respectively. Moreover, FII and FIV showed strong ones. The ANOVA analysis showcased differences in antibacterial activities among the four formulas (p < 0.05). In conclusion, the extract of gulma siam leaves in the form of a peel-off mask preparation was a potential actibacterial ingredient for dealing with propionibacterium acnes.Daun Gulma Siam (Choromolaena odorata L.) memiliki senyawa tanin, fenol, falvonoid, saponin dan steroid dapat membunuh bakteri penyebab jerawat. Penggunaan sebagai antijerawat maka ekstrak daun gulma siam diformulasikan sebagai sediaan masker gel peel-off. Maka tujuan dari penelitian ini untuk menghasilkan formula masker peel-off yang berasal dari ekstrak daun gulma siam dan dilakukan pengujian antibakteri masker peel-off terhadap Propionibcterium acnes.
Dibuat formula masker peel-off menggunakan konsentrasi ekstrak dari daun gulma siam sebesar 3,25% (FI), 7,5% (FII), 15% (FIII), 20% (FIV). Sedian masker peel-off selanjutnya dievaluasi secara fisik meliputi organoleptik, daya sebar, homogenitas, pH, viskositas dan waktu kering. Kemudian metode sumuran dilakukan untuk menguji potensi antibakteri Propionibacterium acnes, pengukuran potensi berdasarkan hambatan disekitar sumuran dalam bentuk zona bening.
Evaluasi sifat fisik dari Masker peel-off ekstrak daun gulma siam selama penyimpanan yaitu secara organoleptis, bersifat homogen, memiliki rentang pH 4,5-6,5, dan memiliki waktu kering 15-21 menit. Untuk uji daya sebar hanya FIII & FIV yang memenuhi kriteria, sedangkan viskositas semua formula masker peel-off tidak stabil selama penyimpanan. Uji aktivitas antibakteri pada FI termasuk kategori lemah, FII kategori sedang, sedangkan pada FIII dan FIV tergolong kategori kuat. Analisis ANOVA memperlihatkan adanya perbedaan aktivitas antibakteri dari keempat formula sebesar (p<0,05). Sehingga diperoleh kesimpulan bahwa ekstrak daun gulma siam dalam bentuk sediaan masker peel-off memiliki potensi sebagai antibakteri pada bekteri Propionibacterium acnes
The Integrasi OEE dan Six Big Losses Untuk Meningkatkan Nilai Efektivitas Mesin Steamer (Pendekatan FMEA di UMKM Marrone Brownies)
No full textThe problem that often occurs in production target are not achieved is breakdown engine. Machines are the core of production. As is the case UMKM Marrone is a home industry for making brownies that uses machines as foundation of its production. One of the machines used is steamer ks-601. Steamer machine is a machine used to steam a brownies. The damage that occurs to the steamer engine is due to lack of maintenance, causing the steamer engine performance to not be optimal. The methods used to reduce engine damage are Overall Equipment Effectiveness, six big losses, and Failure Mode and Effect Analysis. OEE aims to improve the performance of a device. Six big losses are six losses caused by the use of ineffective equipment. FMEA is a factor that affects failure with the aim of obtaining factors that require further treatment. The results of the application of OEE found that the average calculation of the OEE of the steamer was 82.19%, still below the JIPM standard, which was 85. Then based on the six big losses, the breakdown losses were 6.08%, set up & adjustment losses were 5.21%, idling minor & stoppage losses were 21.42%, reduced speed losses were 1.48%, process defect losses were 5.04%, and reduced yield 0%. Analysis using the FMEA method shows that the highest RPN is at the turn of the fire adjust switch 175. Then the proposed improvement is carried out using the automatic maintenance method with the CILT stage.Permasalahan yang sering terjadi dalam target produksi yang tidak tercapai adalah kerusakan mesin. Mesin merupakan inti dari produksi. Seperti halnya, UMKM Marrone merupakan home industri pembuatan brownies yang menggunakan mesin sebagai tumpuan produksinya. Salah satu mesin yang digunakan mesin steamer KS-601. Mesin steamer merupakan mesin yang digunakan untuk mengukus brownies. Kerusakan yang terjadi pada mesin steamer dikarenakan kurangnya perawatan, sehingga menyebabkan kinerja mesin steamer belum maksimal. Metode yang digunakan dalam mengurangi kerusakan mesin yaitu Overall Equipment Effectiveness, six biglosses, dan Failure Mode and Effect Analysis. OEE bertujuan untuk meningkatkan performasi dari suatu alat. Six big losses adalah enam kerugian yang diakibatkan oleh penggunaan peralatan yang tidak efektif. FMEA adalah faktor yang mempengaruhi kegagalan dengan tujuan didapatkan faktor yang memerlukan penanganan lebih lanjut. Hasil penerapan OEE didapati perhitungan rata-rata OEE mesin steamer adalah 82,19% masih dibawah standar JIPM yaitu ≥85. Kemudian berdasarkan six big losses didapati nilai breakdown losses 6,08%, set up & adjustment losses 5,21% , idling minor &stoppage losses 21,42%, reduced speed losses 1,48%, process defect losses 5,04% , dan reduced yield 0%. Analisis mengunakan metode FMEA menunjukkan bahwa RPN tertinggi pada pergantian part fire adjust switch 175. Kemudian usulan perbaikan dilakukan dengan metode autonomus maintenance dengan tahapan CILT
Potensi Antihiperpigmentasi Daun Michelia Alba: Studi In Silico
Get PDFMichelia alba empirically provides a youthful effect associated with the formation of melanin or skin pigment by tyrosinase enzyme. However, the excessive formation of melanin results in hyperpigmentation and various dermatological disorders such as freckles, melasma, and age spots. Synthetic antihyperpigmentations, which suppress melanin production, have been widely used, but have shown adverse side effects. This study aims to examine the potential of M. alba as a natural antihyperpigmentation agent.
The in-silico research was conducted on the compounds contained in M. alba leaves through molecular docking against tyrosinase enzyme (PDB ID: 1BUG) followed by analysis of physicochemical properties and absorption, distribution, metabolism, excretion, and toxicity profiles (ADMET).
The molecular docking results of cis-linalool oxide, trans-linalool oxide, linalool, β-elemene, α-humulene, and nerolidol in M. alba leaves against 1BUG indicated that nerolidol, α-humulene, and β-elemene showed lower docking scores than kojic acid and hydroquinone as controls. Nerolidol, α-humulene, and β-elemene interacted with 1BUG via hydrogen bonding, Van der Walls, and alkyl/π-alkyl and π-π stacking interactions. All compounds did not violate Lipinski and Veber rules based on the analysis of physicochemical properties. All compounds also had good absorption, distribution, metabolism, excretion, and toxicity profiles based on the parameters in each of these evaluations in the ADMET analysis.Michelia alba secara empiris memberikan efek awet muda yang berhubungan dengan pembentukan melanin atau pigmen warna kulit oleh enzim tirosinase. Namun, hiperpigmentasi atau penggelapan kulit dan kelainan pigmen kulit lainnya seperti melasma dan bintik hitam dapat terjadi akibat pembentukan melanin yang berlebihan. Antihiperpigmentasi sintetik yang mampu menekan produksi melanin telah banyak digunakan, tetapi menunjukkan efek samping yang merugikan. Penelitian ini bertujuan mengkaji potensi M. alba sebagai agen antihiperpigmentasi alami.
Penelitian dilakukan secara in silico pada senyawa-senyawa yang terkandung dalam daun M. alba melalui molecular docking terhadap enzim tirosinase (identitas PDB: 1BUG) yang dilanjutkan dengan analisis sifat fisikokimia dan profil penyerapan, distribusi, metabolisme, ekskresi, dan toksisitas (ADMET).
Hasil simulasi molecular docking senyawa cis-linalool oksida, trans-linalool oksida, linalool, β-elemena, α-humulena, dan nerolidol dalam daun M. alba terhadap 1BUG menunjukkan bahwa nerolidol, α-humulena, dan β-elemena memiliki skor penambatan yang lebih baik dari kontrol asam kojat dan hidrokuinon. Nerolidol, α-humulena, dan β-elemena berinteraksi dengan 1BUG melalui ikatan hidrogen, interaksi Van der Walls, dan interaksi alkil/π-alkil dan π- π stacking. Seluruh senyawa tidak melanggar aturan Lipinski dan Veber berdasarkan analisis sifat fisikokimia. Seluruh senyawa juga memiliki profil penyerapan, distribusi, metabolisme, ekskresi, dan toksisitas yang baik berdasarkan parameter dalam masing-masing evaluasi tersebut dalam analisis ADMET
Pengembangan Kuesioner Pengetahuan Masyarakat tentang Penyakit Ginjal Kronik
Get PDFTo reduce the prevalence of chronic kidney disease, a pillar of health paradigms through community empowerment has been introduced. Society with profound knowledge of such disease has proved to be able to raise awareness of kidney disease early detection. Meanwhile, limited data on public knowledge of chronic kidney disease make the education programs in health promotion seem ineffective. This study therefore aims to develop a questionnaire with high validity and reliability to assess public knowledge of this disease.
The development included five stages of conceptualisation, instrument construction, a trial with Study 1 of 240 medical and non-medical students and Study 2 of 300 participants from Sleman Regency in Yogyakarta, a test of the revision, and an analysis using the Cronbach’s alpha reliability test. A validity test compared this questionnaire with another reliable questionnaire.
Both studies yielded a knowledge scale with two variables comprising kidney disease knowledge (risk factors, causes, symptoms, management) and kidney disease prevention knowledge with Cronbach’s alpha of 0.623 and 0.703 (Study 1) and 0.361 and 0.545 (Study 2). This has proved that the preliminary psychometric evidence (factor structure, reliability, convergent validity) satisfied the requirements for an instrument used to measure public knowledge of chronic kidney disease.Salah satu upaya yang dilakukan untuk menekan prevalensi penyakit ginjal kronik yakni melalui pilar paradigma sehat dengan pemberdayaan masyarakat. Masyarakat berpengetahuan baik tentang penyakit tersebut terbukti dapat meningkatkan kewaspadaan deteksi dini penyakit ginjal. Sementara itu, data pengetahuan masyarakat Indonesia tentang penyakit ginjal kronik masih terbatas sehingga program edukasi dalam promosi kesehatan terkesan masih kurang efektif. Oleh karena itu, penelitian ini bertujuan untuk menyediakan kuesioner valid dan reliable yang dapat digunakan untuk mengukur tingkat pengetahuan masyarakat mengenai penyakit ginjal kronik.
Pengembangan kuesioner dilakukan dalam 5 tahap yakni konseptualisasi, konstruksi alat ukur, uji coba melalui studi 1 pada 240 mahasiswa medis dan non-medis serta studi 2 yang melibatkan 300 masyarakat di Kabupaten Sleman, Yogyakarta. Tahap selanjutnya adalah tes revisi dan tahap analisis melalui uji reliabilitas alpha cronbach. Sementara itu, uji validitas dilakukan dengan membandingkan kuesioner dengan kuesioner terpercaya lainnya.
Kedua studi menunjukkan skala pengetahuan masing- masing tersusun atas 2 variabel meliputi pengetahuan tentang gagal ginjal (faktor risiko, penyebab, gejala, penanganan) dan pencegahan gagal ginjal dengan nilai alpha cronbach masing-masing 0, 623 dan 0,703 serta 0,361 dan 0, 545, berturutan. Hasil tersebut menunjukkan bukti awal properti psikometrik (struktur faktor, reliabilitas, dan validitas konvergen) yang memadai sebagai instrumen untuk mengukur tingkat pengetahuan tentang penyakit ginjal kronik
The Effect of Variations of Red Bricks, Sand, Sawdust, and Green Tea (Camellia sinensis) Media on the Fat Content of Salted Egg Yolks
Get PDFSalting is done to extend the shelf life of duck eggs. A variety of media can be used for salting eggs, including a mixture of salt, sand, red brick, sawdust, and brewed tea. Salted eggs are popular among the general public, but they contain a lot of fat, which, if consumed in excess, can cause blood vessel blockage (atherosclerosis). Green tea is a plant that has many benefits, one of which is that it can help people lose weight. Duck eggs were ripened for 12 days in a variety of salting media with different ingredients for this study. Red bricks, sand, sawdust, salt, and brewed green tea are among the materials used. This study aimed to determine the fat content of salted egg yolks using the Soxhlet extraction method, as well as the color, aroma (smell), and taste of salted eggs. The data in this study were analyzed using One-Way ANOVA and the results revealed that variations in salting media had a significant effect on fat content in salted egg yolks. The results showed the changes in fat content in salted egg yolks without treatment with a fat content of 36.28 percent, and with treatment with media A (sand, red bricks, and sawdust); media B (sand, red bricks, and sawdust); media 1 (media A added with green tea); and media 2 (media B added with green tea), with the fat contents of 35.22%; 32.86%, and 30.49%. Mixed media of green tea affects the fat content of salted egg yolks, from 36.50% to 32.86% and 30.49%.Salting is done to extend the shelf life of duck eggs. A variety of media can be used for salting eggs, including a mixture of salt, sand, red brick, sawdust, and brewed tea. Salted eggs are popular among the general public, but they contain a lot of fat, which, if consumed in excess, can cause blood vessel blockage (atherosclerosis). Green tea is a plant that has many benefits, one of which is that it can help people lose weight. Duck eggs were ripened for 12 days in a variety of salting media with different ingredients for this study. Red bricks, sand, sawdust, salt, and brewed green tea are among the materials used. This study aimed to determine the fat content of salted egg yolks using the Soxhlet extraction method, as well as the color, aroma (smell), and taste of salted eggs. The data in this study were analyzed using One-Way ANOVA and the results revealed that variations in salting media had a significant effect on fat content in salted egg yolks. The results showed the changes in fat content in salted egg yolks without treatment with a fat content of 36.28 percent, and with treatment with media A (sand, red bricks, and sawdust); media B (sand, red bricks, and sawdust); media 1 (media A added with green tea); and media 2 (media B added with green tea), with the fat contents of 35.22%; 32.86%, and 30.49%. Mixed media of green tea affects the fat content of salted egg yolks, from 36.50% to 32.86% and 30.49%
Modifikasi Perilaku Menurunkan Konsumsi Daging Merah
Get PDFPenelitian ini bertujuan untuk menguji pengaruh variabel perilaku mengurangi konsumsi daging merah. Perilaku mengurangi konsumsi daging merah disebabkan oleh niat mengurangi konsumsi dahing merah. Niat mengurangi konsumsi daging merah dipengaruhi oleh sikap terhadap konsumsi daging merah, pengalaman masa lalu, kesadaran terhadap akibat mengonsumsi daging merah, dan keyakinan prokelingkunganan. Data diperoleh melalui kuesioner yang telah dibagikan kepada masyarakat. Teknik penyampelan yang digunakan yaitu Purposive Sampling sebanyak 200 responden. Uji hipotesis menggunakan analisis permodelan persamaan structural (Structural Equation Modelling – SEM) dan analisis regresi logistik. Hasil penelitian mendapatkan hasil perilaku mengurangi konsumsi daging tidak berpengaruh pada niat mengurangi konsumsi daging merah, niat menurunkan konsumsi daging merah tidak berpengaruh pada sikap terhadap konsumsi daging merah, niat terhadap konsumsi daging merah tidak berpengaruh positing pada pengalaman masa lalu, dan kesadaran terhadap akibat mengonsumsi daging merah berpengaruh positih pada keyakinan prokelingkungana
Analisis Efektivitas Penerapan Operation Breakdown (OB) di PT. Dan Liris melalui Evaluasi Cycle Time dengan Metode Continuous Improvement
Get PDFPT. Dan Liris has a problem with the production system. Operation Breakdown (OB) is an example of a problem that occurs and has an impact on achieving production targets, delivery accuracy, and product prices. Based on the observations, there was a time mismatch at OB in the production process. The Continuous Improvement method was used as a research method in solving this problem. The data collected by observations, interviews, and literature studies. This research was conducted with the repeated production orders at least three times. Based on the collected data, the actual cycle time were obtained, which were compared with the OB. The data obtained become the basis for determining the solution. The root causes obtained were grouped into five main factors, namely man, machine, method, material, and environment. Of the five factors, two factors that could be used to solve the problem are the man factor and the method. The proposed improvements were the creation of a priority form, a checklist form for the use of machines and attachments, an output form, and the addition of a leadership training agenda. After testing and evaluating the implementation of the improvements, it was found that the forms submitted needed to be revised so that a digital form template was obtained as the final solution that could be used.
Keywords: 5M, cycle time, continuous improvement, leadership, operation breakdownPT. Dan Liris memiliki permasalahan pada sistem produksinya. Operation Breakdown (OB) adalah salah satu contoh permasalahan yang terjadi dan berdampak pada pencapaian target produksi, ketepatan shipment, juga harga jual produk. Berdasarkan observasi yang telah dilakukan, terjadi ketidaksesuaian waktu pada OB pada proses produksi. Metode Continuous Improvement digunakan sebagai metode penelitian dalam pemecahan masalah ini. Penelitian ini mengambil data dengan cara observasi lapangan, wawancara, dan studi literatur. Penelitian ini dilakukan dengan batasan orderan produksi berulang minimal tiga kali. Berdasarkan data terkumpul diperoleh cycle time aktual yang kemudian dibandingkan dengan OB. Data yang diperoleh menjadi dasar dalam penentuan solusi. Akar permasalahan yang diperoleh dikelompokkan menjadi lima faktor utama, yaitu man, machine, method, material, dan environment. Dari kelima faktor tersebut, dua faktor yang dapat dilakukan pemecahan masalah yaitu faktor man dan method. Usulan perbaikan yang diajukan ialah pembuatan form prioritas, form checklist penggunaan mesin dan attachment, form output, dan penambahan agenda training leadership. Setelah dilakukan uji coba dan evaluasi implementasi perbaikan diketahui bahwa form-form yang diajukan perlu dilakukan revisi sehingga didapatkan sebuah template form digital sebagai solusi yang akhir yang dapat digunakan.
Kata kunci: 5M, cycle time, continuous improvement, leadership, operation breakdow
A Hepatoprotective Effect of Extract Ethanol Gynura procumbens on Liver Injury Induced by Toxic Dose of Paracetamol
No full textGynura procumbens is a plant that contains flavonoid compounds as antioxidants and has a hepatoprotective effect. A hepatoprotector is a compound that can protect the liver from liver damage. One way to determine liver function is to measure the enzyme activity of Serum Glutamic Oxaloacetic Transaminase (SGOT) and Serum Glutamic Pyruvic Transaminase (SGPT). This study aimed to determine the hepatoprotective effect of the extract ethanol of Gynura procumbens on the liver induced by paracetamol toxic dose. This study used 20 white male rats divided into five groups: positive control group, negative control (NaCMC 1%), and paracetamol dose of 2.400mg/kg bw). EDSNY 100 mg/kg bw, 200 mg/kg bw, 300 mg/kg bw + 2.400 mg/kg paracetamolThe rat blood samples were taken through the lateral vein, and then the SGOT and SGPT were measured before, after 4 days, and on the 6th day after paracetamol induction. The results showed that the ethanol extract of Gynura procumbens significantly reduced the levels of SGPT in mice at a dose of 300 mg/kg bw. However, the ethanol extract of Gynura procumbens leaves could not reduce SGOT levels in rats. From the histopathological results, it was evident that both low, medium, and high doses had not been able to significantly improve liver damage induced by toxic doses of paracetamol. However, the ethanol extract of Gynura procumbens leaves appeared to reduce the number of areas of necrosis and degeneration of hepatocytes compared to the negative control group. Based on the study's results, the ethanol extract of Gynura procumbens leaves at a dose of 300 mg/kg bw was able to protect against an increase in SGPT. Still, it hadn't shown that it was the best way to protect the liver from damage caused by too much paracetamol.Gynura procumbens is a plant that contains flavonoid compounds as antioxidants and has a hepatoprotective effect. A hepatoprotector is a compound that can protect the liver from liver damage. One way to determine liver function is to measure the enzyme activity of Serum Glutamic Oxaloacetic Transaminase (SGOT) and Serum Glutamic Pyruvic Transaminase (SGPT). This study aimed to determine the hepatoprotective effect of the extract ethanol of Gynura procumbens on the liver induced by paracetamol toxic dose. This study used 20 white male rats divided into five groups: positive control group, negative control (NaCMC 1%), and paracetamol dose of 2.400mg/kg bw). EDSNY 100 mg/kg bw, 200 mg/kg bw, 300 mg/kg bw + 2.400 mg/kg paracetamolThe rat blood samples were taken through the lateral vein, and then the SGOT and SGPT were measured before, after 4 days, and on the 6th day after paracetamol induction. The results showed that the ethanol extract of Gynura procumbens significantly reduced the levels of SGPT in mice at a dose of 300 mg/kg bw. However, the ethanol extract of Gynura procumbens leaves could not reduce SGOT levels in rats. From the histopathological results, it was evident that both low, medium, and high doses had not been able to significantly improve liver damage induced by toxic doses of paracetamol. However, the ethanol extract of Gynura procumbens leaves appeared to reduce the number of areas of necrosis and degeneration of hepatocytes compared to the negative control group. Based on the study's results, the ethanol extract of Gynura procumbens leaves at a dose of 300 mg/kg bw was able to protect against an increase in SGPT. Still, it hadn't shown that it was the best way to protect the liver from damage caused by too much paracetamol