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Analisa Penerapan Konsep Kaizen 5S Terhadap Efektivitas Kerja Menggunakan Uji Regresi Linier Berganda
Get PDFStandardization of 5S (Seiri, Seiton, Seiso, Seiketsu and Shitsuke) and waste elimination (Muda) are the 3 main pillars of gemba Kaizen in improvement with a common sense and low cost approach. Dirty and unkempt machines, dirty work environment are some of the problems faced by PT. XYZ. All of this causes a waste of both cost and time. Poor workplace management can also lead to waste. Discipline and morale of the workers are also one of the problems that exist in PT. XYZ. Lack of awareness and discipline of employees can be seen in the ongoing production activities. This study uses a case study method which is part of an interactive qualitative research method that applies the 5S concept in solving problems and uses a linear regression test which aims to determine the significant effect of the simultaneous and dominant 5S Kaizen concept on the work effectiveness of PT. XYZ. The results showed that the concept of Kaizen 5S simultaneously had a significant effect on work effectiveness. While the variables that have the most dominant influence on work effectiveness.Standarisasi 5S (Seiri, Seiton, Seiso, Seiketsu dan Shitsuke) dan penghapusan pemborosan (Muda) adalah 3 pilar utama dari gemba Kaizen dalam perbaikan dengan pendekatan akal sehat dan berbiaya rendah. Mesin-mesin yang kotor dan tidak terawat, lingkungan kerja yang kotor merupakan sebagian permasalahan yang dihadapi oleh PT. XYZ. Semuanya itu menyebabkan pemborosan baik dari segi biaya maupun waktu. Pengelolaan tempat kerja yang tidak baik, juga dapat menyebabkan pemborosan. Kedisiplinan dan moral para pekerja juga menjadi salah satu masalah yang ada di PT. XYZ. Kurangnya kesadaran serta kedisiplinan karyawan dapat dilihat pada kegiatan produksi yang berlangsung. Penelitian ini menggunakan metode studi kasus yang merupakan bagian dari metode penelitian kualitatif interaktif yang menerapkan konsep 5S dalam menyelesaikan masalah dan dievaluasi menggunakan uji regresi linear yang bertujuan untuk mengetahui secara signifikan pengaruh konsep Kaizen 5S secara simultan dan dominan terhadap efektifitas kerja PT. XYZ. Hasil penelitian menunjukan bahwa konsep Kaizen 5S secara simultan mempunyai pengaruh yang signifikan terhadap efektifitas kerja. Sedangkan variabel yang mempunyai pengaruh paling dominan terhadap efektifitas kerja di PT. XYZ adalah variabel Seiketsu
Pengaruh Penerapan Sistem Informasi Akuntansi, Budaya Organisasi, Motivasi Kerja, dan Disiplin Kerja terhadap Kinerja Karyawan
Get PDFThis study aims to partially determine the variables of the application of accounting information systems, organizational culture, work motivation, and work discipline on employee performance at BPPKAD Cilacap Regency and to determine the variables that have a dominant influence on employee performance. This research is a descriptive study and the data used in this study are primary, namely by distributing questionnaires directly to 79 employees at BPPKAD Cilacap Regency. The sampling technique in this study used a purposive sampling technique and obtained 59 samples. Data analysis used descriptive statistical tests, data quality tests, and multiple linear regression analysis. The hypothesis was tested using a t-test with SPSS for windows version 26.0. The results of this study indicate that the application of accounting information systems, organizational culture, work motivation, and work discipline positively affect employee performance. It is concluded that the research results on employee performance imply that it can improve the performance of its employees, because by having high performance, in carrying out their duties and responsibilities employees can create loyalty and work spirit so that goals can be achieved optimally and result in increased BPPKAD services in Cilacap Regency to the public.
This study aims to partially determine the variables of the application of accounting information systems, organizational culture, work motivation, and work discipline on employee performance at BPPKAD Cilacap Regency and to determine the variables that have a dominant influence on employee performance. This research is a descriptive study and the data used in this study are primary, namely by distributing questionnaires directly to 79 employees at BPPKAD Cilacap Regency. The sampling technique in this study used a purposive sampling technique and obtained 59 samples. Data analysis used descriptive statistical tests, data quality tests, and multiple linear regression analysis. The hypothesis was tested using a t-test with SPSS for windows version 26.0. The results of this study indicate that the application of accounting information systems, organizational culture, work motivation, and work discipline positively affect employee performance. It is concluded that the research results on employee performance imply that it can improve the performance of its employees, because by having high performance, in carrying out their duties and responsibilities employees can create loyalty and work spirit so that goals can be achieved optimally and result in increased BPPKAD services in Cilacap Regency to the public
Pengaruh Edukasi Kepada Perilaku Masyarakat Dalam Swamedikasi Batuk Anak di Desa “X”, Kecamatan Purwantoro, Wonogiri
Get PDFIn the recent trend, self-medication has been carried out widely, including in Central Java Province, Indonesia. Several driving factors have been previously studied, suggesting that education might play a role in developing the behavior of a self-medicating community. In particular, this study aimed to determine the effect of community education on the behavior of self-medication for children's cough in Village “X”, Purwantoro District, Wonogiri. Preliminaly study was conducted with a pretest-posttest one-group approach. A cluster sampling technique of 256 respondents was performed by distributing questionnaires to the public community before and after being given education. The data were analyzed descriptively with univariate and bivariate tests based on Wilcoxon tests. As a result, the behavior of respondents has significantly improved after being given education with consecutive pretest and post-test. As the post-test result, the community's knowledge, attitudes, and behavior were in a high category in performing self-medication for the children's cough, notably compared to the pretest one with the sufficient category. The Wilcoxon test analysis was obtained at 0.000 (p <0.05), concluding that the providing adequate education positively affects the community's behavior in performing self-medication for children's cough.Akhir-akhir ini pengobatan sendiri sudah banyak dilakukan, termasuk di Provinsi Jawa Tengah, Indonesia. Beberapa faktor yang dipelajari sebelumnya, menunjukkan bahwa edukasi berperan dalam mengembangkan perilaku masyarakat dalam melakukan swamedikasi. Penelitian ini bertujuan untuk mengetahui pengaruh edukasi kepada perilaku masyarakat dalam swamedikasi batuk anak di Desa “X” Kecamatan Purwantoro, Wonogiri. Penelitian dilakukan dengan pendekatan one-group pretest-posttest dengan pengambilan sampel menggunakan teknik cluster sampling dan didapat sampel sebanyak 256 responden. Penelitian dilakukan dengan menyebarkan kuesioner kepada masyarakat umum sebelum dan sesudah diberikan edukasi. Data dianalisis secara deskriptif dengan uji univariat dan bivariat berdasarkan uji Wilcoxon. Hasilnya, perilaku responden meningkat secara signifikan setelah diberikan edukasi. Berdasarkan hasil post-test, pengetahuan, sikap, dan perilaku masyarakat dalam pengobatan sendiri batuk anak berada pada kategori tinggi, apalagi dibandingkan dengan pretest dengan kategori cukup. Analisis uji Wilcoxon diperoleh nilai 0,000 (p<0,05), menyimpulkan bahwa pemberian edukasi yang memadai berpengaruh positif terhadap perilaku masyarakat dalam swamedikasi batuk anak
Elimination of the Ultraviolet Spectrophotometric-Based Limitation on the Quantification of Metformin HCl in Acid-Stage Medium for a Comparative Dissolution Testing
Get PDFHerein, this work aimed to develop an ultraviolet spectrophotometric assay for metformin HCl in comparative dissolution testing along with the acid stage medium due to low molar absorptivity. Metformin HCl was incorporated into the immediate tablet formulation to mimic the analytical matrix system. The dissolution validation procedure was carried out by linearity, accuracy, precision, the limit of quantification, filter compatibility, and aliquot stability that fulfil the USP method for validation of dissolution procedure, particularly assay of the analyte.The results revealed that metformin HCl had difficulty quantifying in acid pH due to the absence UV-band peak. The addition of pH-shifting agents promoted better performance for metformin quantification. Therefore, the method was successfully developed along with R2, predicted R2, accuracy, and precision of 0.9999, 0,9998, 100.57%, and 1.27%, respectively. In addition, it had the minimum placebo interference (0.47%) and was stable for long-term storage under determined conditions
Studi Mekanisme Molekuler Antibakteri dari Daun Telang (Clitoria ternatea L.)
No full textThe bacterium is one of the infectious pathogens that cause infectious diseases. A problem currently developing in the treatment of infectious diseases is antimicrobial resistance. Antimicrobial resistance is the inability of an antibiotic to cure infectious diseases so that new antimicrobial compounds are needed that can kill infectious pathogens (by bacteria, fungi, viruses, and multi-cellular parasites). The butterfly pea plant (Clitoria ternatea L.) has been identified as a potential antibacterial plant. This literature study aims to determine the antibacterial activity and identify molecular mechanisms based on the chemical content of telang leaves that have not been done before.
This literature study uses the systematic literature review (SLR) method to determine the activity and antibacterial mechanisms based on the bioactive compounds contained by using PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyzes) as the review protocol. Data search strategy using search engines: science direct, google scholar, and Pubmed. The keyword search uses a combination of words in the problem statement and uses the Boolean "OR" and "AND".
The finding shows that the relevant literature obtained 22 articles that met the criteria consisting of articles on chemical compounds, antibacterial activities and mechanisms. The SLR results showed that telang leaf has potential as an antibacterial and has a molecular mechanism, namely, interfering with the permeability of cell membranes, inhibiting nucleic acid and protein synthesis and inhibiting the formation of biofilms. Chemical compounds that have the potential as antibacterial agents are kaempferol, quercetin, cyclotide, b-sitosterol alkaloids and tannins.Bakteri merupakan salah satu patogen yang menyebabkan terjadinya penyakit infeksi. Masalah yang saat ini berkembang dalam pengobatan penyakit infeksi adalah resistensi antimikroba. Resistensi antimikroba merupakan ketidakmampuan suatu antibiotik untuk menyembukan penyakit infeksi, sehingga dibutuhkan senyawa antimikroba baru yang mampu membunuh patogen penginfeksi (bakteri, jamur, virus dan parasit multi seluler). Tanaman telang (Clitoria ternatea L.) telah diidentifikasi sebagai tanaman yang berpotensi sebagai antibakteri. Tujuan studi literatur ini untuk mengetahui aktivitas antibakteri dan mengidentifikasi mekanisme molekuler berdasarkan kandungan kimia dari daun telang yang belum dilakukan sebelumnya.
Penelitian menggunkan metode systematic literature review (SLR) untuk mengetahui aktivitas dan mekanisme antibakteri berdasarkan senyawa bioaktif yang terkandung dengan menggunakan PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) sebagai protokol review. Strategi pencarian data menggunakan search engine: science direct, google scholar dan pubmed. Kata kunci pencarian menggunkan kombinasi kata-kata dalam rumusan masalah dan menggunakan Boolean “OR” dan “AND”.
Hasil pencarian literatur yang relevan memperoleh 22 artikel yang memenuhi kriteria yang terdiri dari artikel senyawa kimia, aktivitas dan mekanisme antibakteri. Hasil SLR menunjukan daun telang berpotensi sebagai antibakteri dan memiliki mekanisme molekuler yaitu, menggangu permeabilitas membran sel, menghambat sintesis asam nukleat dan protein dan menghambat pembentukan biofilm. Senyawa kimia yang berpotensi sebagai agen antibakteri yaitu kaempferol, kuersetin, siklotida, b-sitosterol alkaloid dan tanin
TANTANGAN MENEMPUH PENDIDIKAN TINGGI: STUDI OPTIMISME DAN RESILIENSI AKADEMIK MAHASISWA PENERIMA BEASISWA BIDIKMISI
Get PDFStudents who want to continue their education at tertiary institutions certainly need a lot of money, many students are vying for scholarships to continue their studies. One of the scholarships that are in great demand is the Bidikmisi scholarship. Being a student who receives a Bidikmisi scholarship certainly has challenges and obstacles in lectures. To overcome these obstacles and demands, students who receive a Bidikmisi scholarship need to have good academic resilience. Optimism is one of the factors in the formation of academic resilience. With an attitude of optimism in students who receive Bidikmisi scholarships, it can make these students carry out their duties and responsibilities in the academic field well. The purpose of this study is to determine the relationship between optimism and academic resilience in students receiving Bidikmisi scholarships. The method used is a quantitative method with a correlational design. The total participants in this study were 110 students receiving Bidikmisi scholarships throughout Indonesia using the incidental sampling technique. This study used the Academic Resilience Scale (α = 0.869) and the Optimism Scale (α = 0.894). The results of this study indicate a positive relationship between optimism and academic resilience (r=0.366 and sig. = 0.000). That is, the higher the optimism of students, the higher the academic resilience of students receiving bidikmisi scholarships
JOB INVOLVEMENT AND SERVANT LEADERSHIP INFLUENCE ON ORGANIZATIONAL CITIZENSHIP BEHAVIOR (OCB) IN EMPLOYEES
No full textThis study aims to test job involvement and servant leadership influence on Organizational Citizenship Behavior (OCB) in employees. Participant in this research was 70 permanent employees in an "X" Automotive company in Yogyakarta who had worked a minimum of one year. The data collection used OCB, job involvement, and servant leadership scales. The research data were analyzed using multiple linear regression assisted by SPSS program V.21. The result of simultaneous data analysis indicates that job involvement and servant leadership could influence Organizational Citizenship Behavior (OCB) (F = 406.135, p = 0.000). The partial data analysis shows job involvement (Standardized Coefficients = 0.536, p = 0.000) and servant leadership (Standardized Coefficients = 0.440, p = 0.000), respectively, influence on Organizational Citizenship Behavior (OCB). Job involvement and servant leadership simultaneously contribute as much as 92 % to Organizational Citizenship Behavior (OCB). Job involvement contributes 51%, and servant leadership contributes 41%. Therefore, it can be concluded that an internal factor, job involvement, and an external factor, servant leadership, influence the formation of Organizational Citizenship Behavior (OCB). The internal factor of job involvement is more dominant than the external factor of servant leadership in affecting Organizational Citizenship Behavior (OCB).Penelitian ini bertujuan untuk menguji pengaruh job involvement dan servant leadership terhadap Organizational Citizenship Behavior (OCB) pada karyawan. Partisipan dalam penelitian ini adalah 70 karyawan tetap di sebuah perusahaan otomotif "X" di Yogyakarta yang telah bekerja minimal satu tahun. Pengumpulan data menggunakan skala OCB, keterlibatan kerja, dan servant leadership. Data penelitian dianalisis dengan menggunakan regresi linier berganda yang dibantu dengan program SPSS V.21. Hasil analisis data secara simultan menunjukkan bahwa keterlibatan kerja dan servant leadership berpengaruh terhadap Organizational Citizenship Behavior (OCB) (F=406,135, p=0,000). Hasil analisis data secara parsial menunjukkan keterlibatan kerja (Standardized Coefficients = 0.536, p = 0.000) dan servant leadership (Standardized Coefficients = 0.440, p = 0.000) berpengaruh terhadap Organizational Citizenship Behavior (OCB). Keterlibatan kerja dan servant leadership secara simultan memberikan kontribusi sebesar 92% terhadap Organizational Citizenship Behavior (OCB). Keterlibatan kerja memberikan kontribusi sebesar 51%, dan servant leadership memberikan kontribusi sebesar 41%. Oleh karena itu, dapat disimpulkan bahwa faktor internal yaitu job involvement dan faktor eksternal yaitu servant leadership berpengaruh terhadap terbentuknya Organizational Citizenship Behavior (OCB). Faktor internal job involvement lebih dominan dibandingkan dengan faktor eksternal servant leadership dalam mempengaruhi Organizational Citizenship Behavior (OCB)
Pengaruh Harga Paket Produk, Suasana Kafe Dan Lokasi Terhadap Minat Beli Konsumen Kafe Belikopi Kota Tegal
Get PDFBisnis kafe dan restoran saat ini sangat berkembang di Indonesia terutama di kota Tegal. Ditengah menjamurnya kafe dan resto di kota Tegal, Belikopi hadir ditengah-tengah persaingan dengan bisnis yang serupa. Tujuan penelitian ini menganalisis pengaruh harga paket produk, suasana kafe dan lokasi kafe terhadap minat beli konsumen. Jenis penelitian ini adalah kuantitatif. Teknik pengambilan sampling yang digunakan adalah non probability sampling. Penentuan jumlah sampel dengan accidental sampling sebanyak 100 responden konsumen Belikopi Kota Tegal.Hasil penelitian dengan uji t diperoleh Variabel Harga Paket Produk terhadap variabel Minat Beli nilai thitung sebesar 4,343 yang berarti thitung > ttabel yaitu 4,343 > 1,661 dengan nilai sig. = 0,000 < 0,05 artinya H1 diterima. Variabel Suasana Kafe terhadap variabel Minat Beli nilai thitung sebesar 2,251 yang berarti thitung > ttabel yaitu 2,251 > 1,661 dengan nilai sig. = 0,027 < 0,05 artinya H2 diterima. Variabel Lokasi Kafe terhadap variabel Minat Beli didapatkan nilai thitung sebesar 0,115 < 1,661 yang berarti thitung < ttabel yaitu dengan nilai sig. = 0,909 > 0,05, artinya H3 ditolak. Hasil uji F diperoleh Fhitung 24,386 yang artinya lebih besar dari Ftabel yaitu 24,386 > 2,669 dengan nilai sig. adalah 0,000 dengan kata lain sig. < 0,05 atau 0,000 < 0,05, sehingga dapat diartikan bahwa H4 diterima
Formulasi Nanogel Allantoin Menggunakan Nano Allantoin yang Dibuat Melalui Metode Ionic Gelation antara Kitosan dan Tripolifosfa
Get PDFAllantoin is a kind of chemical compound as an anti-irritant and wound healer. Allantoin has a safe component characteristic, have not toxic but is easily degraded when used orally. On the other hand, modified allantoin through nanogels can increase stability and provide a maximum therapeutic effect. This study aims to determine the effects of the tripolyphosphate different concentrations as a crosslinking way on the characteristics of nano allantoin, determine the physical characteristics, and stability of the selected formula allantoin nanogel.
Allantoin nanoparticles were prepared using the ionic gelation method between chitosan polymer and tripolyphosphate crosslinker. The concentration of allantoin used was 0.5%, chitosan was 0.2% in 1% glacial acetic acid, and tripolyphosphate made in 3 variations, consisted of 0.3%; 0.2%; and 0.1%. The characteristics of nanoparticles include particle size, zeta potential, and sorption efficiency. Hydroxypropyl methylcellulose (HPMC) was used as a gelling material. The characteristics of nanogels include organoleptic, homogeneity, spreadability, adhesion, and viscosity.
The results of the nano allantoin characteristic test showed the lower the tripolyphosphate concentration, the smaller the particle size, the stable zeta potential, and the higher the adsorption efficiency. Nano allantoin formula number 3 was chosen as the formula for the manufacture of nanogels, which had the smallest particle size (160.73±2.4 nm), stable zeta potential (31.27±2.76 mV), and the highest adsorption efficiency (60.01±0,5%. Formula 3 was proven to be able to be formulated in the form of nanogels and had good gel physical properties standards. The cycling test stability test showed that the preparation was stable during storage.Allantoin merupakan senyawa kimia yang berperan sebagai antiiritasi dan penyembuh luka. Allantoin memiliki sifat aman, tidak toksik tetapi mudah terdegradasi apabila digunakan secara oral, modifikasi allantoin dalam bentuk nanogel dapat meningkatkan stabilitas dan memberikan efek terapi maksimal. Penelitian ini bertujuan untuk mengetahui pengaruh perbedaan konsentrasi tripolifosfat sebagai agen penyambung silang terhadap karakteristik nano allantoin, mengetahui karakteristik sifat fisik, dan stabilitas nanogel allantoin formula terpilih.Nanopartikel allantoin dibuat menggunakan metode gelasi ionik antara polimer kitosan dan penyambung silang tripolifosfat. Konsentrasi allantoin yang digunakan sebesar 0,5%, kitosan 0,2% dalam 1% asam asetat glasial, dan tripolifosfat yang dibuat 3 variasi yaitu 0,3%; 0,2%; 0,1%. Karakteristik nanopartikel meliputi ukuran partikel, potensial zeta, dan efisiensi penjerapan. Hidroksipropil metilselulosa (HPMC) digunakan sebagai bahan pembentuk gel. Karakteristik nanogel meliputi organoleptik, homogenitas, daya sebar, daya lekat, dan viskositas.Hasil uji karakteristik nano allantoin menunjukkan semakin rendah konsentrasi tripolifosfat semakin kecil ukuran partikel, potensial zeta stabil, dan efisiensi penjerapan semakin tinggi. Nano allantoin formula 3 dipilih sebagai formula untuk pembuatan nanogel, memiliki ukuran partikel terkecil (160,73±2,4 nm), potensial zeta stabil (31,27±2,76 mV), dan efisiensi penjerapan tertinggi (60,01±0,5 %). Formula 3 terbukti dapat diformulasikan dalam bentuk nanogel dan memenuhi standar sifat fisik gel yang baik. Uji stabilitas cycling test menunjukkan sediaan tetap stabil selama penyimpanan
Efektivitas Terapi dan Kejadian Tidak Dikehendaki Penggunaan Regimen Pengobatan Jangka Pendek pada MultiDrug-Resistant Tuberculosis: a Scoping Review
Get PDFThe increase in Multidrug-resistant Tuberculosis (MDR-TB) is a global problem that must be addressed immediately. Duration of treatment, adverse events (ADRs) and medical costs can affect adherence and treatment success. This literature review was conducted to review the effectiveness and ADRs of short-term regimens (STR) in MDR-TB patients.
We used PubMed, ScienceDirect, and Google Scholar to retrieve the relevant original articles on MDR-TB treatment with STR in English-language, published from 2018 through 2022. The keywords used in the search for articles are "multi-drug-resistant tuberculosis", "short regimens" or "short-term regimens", effectiveness, safety" or "adverse events".
Of the 13 articles obtained, the all-oral regimen proved promising for implementation in the treatment of MDR-TB. Based on sputum conversion, cure rate, and percentage of patients who completed treatment, the regimen with the highest therapeutic effectiveness was 6KmMfxPtoCfzHEZ/5MfxCfzEZ at 92.9%, and the lowest was 4KmMfxPtoCfzHEZ/5MfxCfzEZ at 63.6%. The all-oral regimen with or without Bedaquilin showed a better average therapeutic effectiveness (87.04%) than regimen containing injection (78.43%). Meanwhile, the serious ADRs that emerged were death, cardiotoxicity, hepatotoxicity and ototoxicity. Apart from monitoring the safety, research needs to be expanded to a larger population and wider sites, to find more effective regimens because Mycobacterium tuberculosis are easily resistant.Peningkatan kasus Multidrug-Resistant Tuberculosis (TB-MDR) di dunia menjadi masalah yang harus segera ditangani. Durasi terapi, kejadian tidak dikehendaki (KTD), biaya dapat berpengaruh pada kepatuhan dan keberhasilan pengobatan. Literatur review ini dilakukan untuk mengulas tentang efektivitas terapi dan KTD pengobatan jangka pendek pada pasien TB-MDR.
Literatur review ini melaporkan hasil review artikel dari PubMed, ScienceDirect, dan Google Scholar berupa artikel penelitian berbahasa Inggris tentang terapi TB-MDR dengan pengobatan jangka pendek yang dipublikasikan pada tahun 2018-2022. Kata kunci yang digunakan dalam pencarian artikel adalah “multi-drug resistant tuberculosis”, “short regimens” or “short-term regimens”, effectiveness, safety” or “adverse events”.
Dari 13 artikel yang diperoleh, regimen all-oral terbukti menjanjikan untuk diimplementasikan dalam pengobatan TB-MDR. Berdasarkan konversi sputum, angka kesembuhan, dan persentase pasien yang menyelesaikan pengobatan, regimen dengan efektivitas terapi tertinggi adalah 6KmMfxPtoCfzHEZ/5MfxCfzEZ sebesar 92,9%, dan terendah 4KmMfxPtoCfzHEZ/5MfxCfzEZ sebesar 63,6%. Regimen all oral dengan atau tanpa Bedaquilin menunjukkan rata-rata efektivitas terapi yang lebih baik (87.04%) daripada regimen yang mengandung injeksi (78.43%). Sementara itu, KTD berat yang muncul adalah meninggal, kardiotoksisitas, hepatotoksisitas dan ototoksisitas. Selain pemantauan keamanan regimen, penelitian dengan regimen ini perlu dikembangkan ke populasi yang lebih besar dan site penelitian yang lebih luas, untuk menemukan regimen baru yang lebih efektif karena bakteri Mycobacterium tuberculosis mudah resisten