Journal of Drug Delivery and Therapeutics (JDDT)
Not a member yet
4948 research outputs found
Sort by
Formulation and Evaluation of Niosomal Gel for Treatment of Acne
Get PDFA skin disease, like acne, is very common and normally happens to everyone at least once in their lifetime. The structure of the stratum corneum is often compared with a brick wall, with corneocytes surrounded by the mortar of the intercellular lipid lamellae. Acne vulgaris is a chronic inflammatory dermatosis which is notable for open and/or closed comedones (blackheads and whiteheads), and inflammatory lesions including papules, pustules, or nodules. It is a disorder of sebaceous follicles which are special pilosebaceous units located on the face, chest, and back. Skin is one of the most readily available organs on human body for topical management and is the major route of topical drug delivery system. Topical drug administration is a localized drug delivery system everywhere in the body during ophthalmic, vaginal, rectal and skin as topical routes. SA niosomes gel delivery system (SANG1 to SANG5) as a dispersed system, which consists of small droplets and well distributed in to immiscible vehicle. Niosome salicylic acid was prepared by Reverse phase evaporation method using cholesterol and span 80 and tween 20. Niosome were evaluated for vesicle shape, size determination, Entrapment efficiency and in-vitro drug release study. The result concluded that SANG5 was best formulation with Carbopol 940 (2g), PVP, nutmeg oil base. The drug release profile and release kinetics are two important characteristics of the dosage forms, which play an important role for describing dissolution profile of dosage form.
Keywords: Topical drug delivery, Acne vulgaris, Niosomes, Gel, Carbopol 940, nutmeg oi
Effect of andaliman (Zanthoxylum acanthopodium DC.) ethanol extract on doxorubicin-induced toxicity on hematology in male rats
Get PDFIntroduction: Doxorubicin is one of the chemotherapy drugs that have harmful effects on blood hematology. Blood hematological diseases are caused by its adverse effects and anticancer properties. The antioxidant properties of several plants have been reported to be closely related to reduced toxicity in blood hematology. Andaliman (Zanthoxylum acanthopodium) ethanolic extract (AEE) is thought to reduce the toxicity of doxorubicin due to the antioxidant properties of its secondary metabolite content. This study aimed to determine the effect of AEE on doxorubicin-induced rats and its effect on blood cells. Materials and Method: A total of 24 male rats were divided into 6 groups: (1) Normal group; (2) 0.5% Na-CMC group; (3) 50 mg/kg BW quercetin group; (4) AEE 75 mg/kg BW group; (5) AEE 150 mg/kg BW group; and (6) AEE group 300 mg/kg BW administered orally for 9 days. On days 8 and 9, doxorubicin 10 mg/kg BW was administered. Rats were sacrificed for blood collection, and measured at the Integrated Laboratory of the USU Hospital. Results: AEE reduces the toxicity of doxorubicin on blood parameters. Furthermore, it affects Hb, white blood cells, platelet cells, monocytes, lymphocytes, neutrophils, and several related protein metabolisms as well as organ damage. Dose 150 or 300 mg/kg AEE reduce all blood toxins to near-normal levels and decrease the lymphocyte and neutrophil suppressive activity of doxorubicin. Conclusion: Andaliman ethanol extract can improve Hb count, white blood cells, platelet cells, monocytes, lymphocytes, neutrophils, protein metabolism, and organ damage. Furthermore, AEE can be used in combination with doxorubicin to reduce its hematological toxicity.
Keywords: toxicity, hematology, doxorubicin, andaliman, Zanthoxylum acanthopodium, extrac
Herbal Drug Standardization: A Systemic Review
Get PDFThe demand for herbal medicinal products and materials is rising, and maintaining their quality is therefore becoming increasingly important. Numerous physical, chemical, and geographical factors that affect these materials\u27 quality also affect the quality of the herbals. In addition, the quality of herbal materials is becoming increasingly a concern due to adulteration. The quality characteristics of the herbal material the herbal pharmaceuticals are assessed using a variety of chemical and phytochemical tests, analytical techniques, and hyphenated analytical techniques. Formulations made from herbs are now widely accepted as effective treatments for many ailments. the creation of reliable analytical techniques, such as quantitative assessments of marker/bioactive chemicals and other techniques, that can accurately profile the phytochemical makeup. For the manufacture and manufacturing of herbal medications, standardisation is a crucial step in establishing a uniform biological activity, consistent chemical profile, or even just a quality assurance programme. It is crucial to follow WHO-specific recommendations for evaluating the quality, safety, and efficacy of herbal medicines as a condition for worldwide harmonisation. An overview of the numerous methods used for the extraction, characterisation, and standardisation of herbal nanomedicines is presented.
Keywords: herbal drugs, standardization, herbal formulation, quality contro
Novel Drug Delivery System: Brief Review
Get PDFCurrent developments in our knowledge of the pharmacokinetic and pharmacodynamics behaviour of drugs provide a more logical framework for designing the best possible drug delivery system. It is understandable that multidisciplinary efforts will play a major role in the success of drug delivery research in the future. Any therapeutic agent that has the potential to be safer, more effective, and use an enhanced drug delivery mechanism offers pharmaceutical companies significant marketing prospects as well as advancements in the treatment of illnesses. Since ancient times, humans have utilized plants as food and medicine, viewing them as nature\u27s solutions. The underlying idea is that every sickness has a remedy that is concealed in better ways using ayurvedic, homeopathic and allopathic. However, in order to promote sustained release, improve patient compliance, etc., the way herbal medications are delivered must also be modified. Because of challenges with processing, standardizing, extracting, and identifying them, herbal medications had historically been unable to draw scientists\u27 attention to the development of novel drug delivery methods. However, with today\u27s technological advancements, the development of herbal revolutionary drug delivery systems is made possible by novel drug delivery systems (NDDS). It is possible to achieve protection against toxicity, stability enhancement, enhanced bioavailability, and protection against chemical and physical degradation of herbal formulations through the application of advanced procedures which must give the result in better or faster way. In this review we will get the method of preparations of NDDS and the Application of NDDS.
Keywords: Herbal Drugs, Enhanced drug delivery, Phytosomes, Nanoparticles, liposomes
An outline of endocrine disrupting chemicals and the influencing hormones: what the human society ought to know?
Get PDFEndocrine-disrupting chemicals (EDCs) are exogenous chemicals that interfere with hormones action, thereby increasing the risk of adverse health outcomes, including cancer, reproductive impairment, cognitive deficits and obesity. A complex literature of mechanistic studies provides evidence on the hazards of EDC exposure, yet there is no widely accepted systematic method to integrate these data to help identify EDC hazards. Significant advances in research into endocrine-disrupting chemicals (EDCs) and their health effects have elevated concerns in recent years about these chemicals among a number of international scientific and health organizations. The research reviewed here provides knowledge about EDC’s that health scientists can use to inform their research and decision-making processes.
Keywords: Endocrine disrupting chemicals, hormones action, cancer, reproductive impairment, cognitive deficits and obesit
A Review of Repercussions of Lithium Amalgamated with Antipsychotics for the Remedy of Bipolar Disorder
Get PDFBipolar disorder is a brain illness that causes mood, energy, and ability to function variations. Bipolar illness patients have extreme emotional states that often occur over a period of days to weeks, referred to as mood episodes. Manic/hypomanic (abnormally cheerful or angry mood) or depressed (sad mood) mood episodes are classified. People with bipolar disorder frequently have periods of neutral mood. People with bipolar disorder can live long and productive lives if they are treated. The management of BD may be summarized into 2 phases, acute treatment and long-term prevention. Lithium was observed to have a unique therapeutic profile, including mood-stabilizing effects, as well as anti-suicidal and neuroprotective properties.13 It is available in many different salt forms, namely lithium carbonate, lithium citrate, lithium chloride, and lithium sulfate. A meta-analysis discovered that a combination regimen of haloperidol, olanzapine, risperidone, and quetiapine was substantially more effective in treating BD manic episodes than monotherapy with a mood stabiliser, but the combination regimen was less well tolerated than monotherapy.
Keywords: Bipolar Disorder, Lithium, Monotherapy, Combination therapy, Adverse effects
Formulation and evaluation of Transdermal Patch for the treatment of Migraine
Get PDFA migraine is a specific kind of headache disorder that primarily affects the head. It can range in severity from mild to severe and is often accompanied by other symptoms like vomiting, nausea, illness, dizziness that gets worse with movement, photophobia, sonophobia, severe disability, or other types of nature. Triptans that are administered intravenously can be used to treat migraines and irritated injection sites. Transdermal delivery means that the medications will be administered through the skin in a precise, regulated manner. Our study aims to identify all possible transdermal patch combination and application for the treatment of migraines. The drug rizatriptan belongs to a group of drugs known as selective serotonin receptor agonists. It functions by constricting blood vessels in the brain, preventing the transmission of pain signals to the brain, and preventing the production of several naturally occurring compounds that produce pain, nausea, and other migraine symptoms. Verapamil belongs to the group of drugs known as calcium-channel blockers. It works by relaxing the blood vessels in order to reduce the workload of the heart. The Lambda max Rizatriptan and Verapamil is 278.9nm and 228nm respectively. They are soluble in most of the solvents. When used with verapamil, rizatriptan\u27s transdermal patch improves patient compliance in those with hypertension. P2 patch shows the optimized results.
Keywords: Migraine, Rizatriptan, Verapamil, Bioavailability, Transdermal patch
Toxicity and anti-diabetic effectiveness of polymeric nanoparticles containing natural compounds
Get PDFObjective: To develop the nanoparticle formulations, characterization and evaluation of safety and in vivo anti diabetic potential by using experimental animal model.
Methods: Different nano formulations such as Cur-nanoparticles, Pip-nanoparticles as well as Cur-Pip dual drug loaded nanoparticles were developed by nano co-precipitation method. The developed formulations were subjected for FT-IR analysis to determine the drug-drug and drug-polymer interaction. The Differential Scanning Colorimetric (DSC) study was carried out to observe the glass transition. Surface topography of nano formulations were carried out by Scanning Electron Microscopy (SEM). X-ray diffraction study was carried out to determine the crystalline properties of different formulations. Particle size of the polymeric nanoparticles was evaluated by Zeta sizer of nanoseries. Toxicity of nanoformulation was evaluated as per OECD guideline-407. For evaluation of therapeutic effectiveness, in-vivo anti-diabetic potential of nano formulations, the Streptozotocin (STZ) induced diabetes model was considered.
Results: The developed formulations were spherical in shape and smooth surfaced. There were no interaction between the drugs and polymers. The result of toxicity study revealed that, there were no changes in behavior, food intake; hematology as well as biochemical parameters were observed that indicates the developed formulation is completely safe. The anti-diabetic effect of different formulations was screened against Streptozotocin induced diabetes in experimental animals. All the formulations were proved as effective in restoring blood glucose level however, Cu+Pi NP (184.15) group showed highest anti diabetic activity in comparison to control group (207.93)
Conclusions: From this study, it was observed that, Curcumin-Piperine dual drug loaded nanoparticles exhibit better anti diabetic potential in comparison to control and Curcumin-NP treated group.
Keywords: Nanoparticles, Streptozotocin, anti-diabetes, toxicity, hematology, biochemica
Innovative Nanosuspension Formulation for Prochlorperazine and In-vitro Evaluation
Get PDFProchlorperazine is a dopamine antagonist and is used to control nausea and vomiting. It is a BCS class II drug which has low aqueous solubility and high permeability. The present study is aimed to formulate and evaluate prochlorperazine nanosuspension to improve solubility and enhance dissolution of Prochlorperazine with varying concentrations of stabilizers such as Tween 80, PVP K30, Poloxamer 188 by using nanoprecipitation method. The developed formulations were characterized for particle size and polydispersity index, total drug content, SEM, Zeta Potential and FTIR. The invitro drug release studies and invitro drug release kinetics were performed for all formulations. FTIR studies revealed that drug is compatible with the excipients. The particle size and poly dispersity index of optimized formulation was found to be 162nm and the zeta potential was found to be -30.2 mV and concluded that the system had sufficient stability. The invitro drug release was found within their acceptable ranges. The rate of dissolution of best batch was enhanced to 93.24 in 120min. Stability studies proved that nanosuspensions were more stable with no significant changes in particle size distribution. Thus the formulated nanosuspension of prochlorperazine offers a superior conventional dosage forms for drug release
Keywords: Prochlorperazine, Nanosuspension, Solubility, Dissolutio
Potential activity of Stevia rebaudiana Bert. in Inhibiting Cyclooxygenase and Lipooxygenase Enzymes as Anti-inflammatory Candidates: A Molecular Docking Study and ADMET Prediction
Get PDFStevia rebaudiana Bert. is one of the plants that has been traditionally used to treat inflammation. Numerous articles have reported scientific evidence of the anti-inflammatory activity of Stevia rebaudiana Bert. However, research regarding the bioactive contributing to its anti-inflammatory activity has never been discovered. This study was implemented to identify the molecules regulating the anti-inflammatory activity of Stevia rebaudiana Bert. and assess their pharmacokinetics and toxicological profile. The potent phytochemical derived from Stevia rebaudiana Bert. was screened via a molecular docking approach using autodock 4.2 assisted by ADT interface to COX-1, COX-2, and 5-LOX. The ADMET assessment was undertaken via biosig pkCSM web server. Molecular docking results revealed that β-sitosterol, campesterol, and stigmasterol exhibited high affinity to COX-1, COX-2, and 5-LOX with free energy of binding value of -11.12, -11.43, and -10.62 kcal/mol for COX-1, -11.45, -11.34, and -11.84 kcal/mol for COX-2, and -5.95, -11.34, and -9.08 kcal/mol for 5-LOX, respectively. The ADMET prediction also indicated those bioactive have an excellent pharmacokinetics and toxicity profile. Therefore, β-sitosterol, campesterol, and stigmasterol can be considered to be developed as anti-inflammation agents. However, further research regarding their anti-inflammatory activities including in vitro and in vivo assays is necessary to be implemented.
Keywords: anti-inflammation, molecular docking, Stevia rebaudiana Bert