Journal of Chemical Health Risks (Islamic Azad University, Iran)
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Investigation of the Phytochemical Composition and Cytotoxic Properties of Antidesma menasu (Tul.) Mull.Arg. Extract in Human Pancreatic Cancer Cells
No full textAntidesma menasu (Tul.) Mull.Arg. belongs to the family Phyllanthaceae. The plant is known for its anti-inflammatory and analgesic properties. Traditionally, the plant is used for the treatment and management of pain associated with arthritis and lower back pain. It is also used for the treatment of inflammatory swellings. In the present study, phytochemical analysis and assessment of cytotoxic activity of the ethanolic extract of A. menasu were carried out. The ethanolic extract was prepared by the cold extraction method and subjected to qualitative phytochemical analysis. The phytochemical investigations confirmed the presence of flavonoids, alkaloids, glycosides, steroids and terpenoids. The cytotoxic activity of the extract was evaluated by MTT assay against the human MiaPaCa-2 cell line. The ethanolic extract of A. menasu exhibited a significant cytotoxic activity against the human MiaPaCa-2 cell line with an IC50 value of 285.97 ± 1.78 μg/ml. Further studies are underway to explore the molecular mechanisms and identify the active phytochemical agents
Successful Ayurvedic Intervention in Post-Sclerotherapy Complications (Perianal Abscess): Evidence Based Case Report
No full textAnorectal abscesses are one of the debilitating diseases, among them perianal abscess is common. Sclerotherapy is one of the minimal invasive procedures for hemorrhoidal management but it is having post operative complications such as urinary retention, thrombosis, bleeding and infection. An anorectal abscess originates from an infection arising in the cryptoglandular epithelium lining of the anal canal spreading into adjacent spaces. A Perianal abscess presents with the symptoms like throbbing type of pain, swelling, redness and localised warmth around the anus. On the basis of clinical features, Perianal abscess can be considered as Guda Vidradhi. Vidradhi occurs when the dushita doshas affects twak, rakta, mamsa and meda resulting in the formation of shopha and ruja, the treatment of Guda vidradhi is adequate drainage. Acharya Sushrutha have explained shashtiupakramas (60 modalities of treatment) for vidradhi. Among them Bhedhana and Visravana is considered as surgical management for adequate drainiage of the abscess. Patradana, prakshalana and lepa were adapted as conservative mode of management for post operative wound. In this present case study a 75year old female patient visited Shalya Tantra OPD with the complaints of pain and swelling in perianal region since 1week along with mass per anum and burning sensation in the perianal region since 1 week and was selected for bhedana and visravana followed by prakshalana patradana and lepa application. The study was done for a period of 30days. Within the study period, result shows that the abscess cavity was filled with the healthy granulation and wound was completely healed
Salivomics: Unlocking New Frontiers in Non-Invasive Diagnostics
No full textSaliva, often termed as the "mirror of the body," is emerging as a valuable non- invasive diagnostic fluid reflecting a wide range of systemic and oral health conditions. The field of salivomics, which involves the comprehensive analysis of salivary biomarkers, has enhanced early disease detection across medical and dental disciplines. Rich in proteins, enzymes, hormones, cytokines, nucleic acids, and metabolites, saliva provides insights into various physiological and pathological states.
Technological advancements in genomics, proteomics and molecular biology have improved the accuracy and clinical applicability of salivary diagnostics. Key advantages include non-invasiveness, cost-effectiveness, patient compliance, and real- time monitoring capabilities. Salivomics shows promise in the detection and management of cancers, cardiovascular and autoimmune diseases, metabolic and neurological disorders and infections.
This review highlights the potential of saliva as a diagnostic tool and its increasing importance in making clinical diagnostics more accessible, efficient, and less invasive. It points toward a shift in routine healthcare, with saliva-based testing becoming a key part of future diagnostic methods
Comment on “Retear Rates After Rotator Cuff Surgery: A Systematic Review and Meta-analysis
No full textBackground: This comment highlights the strengths of the meta-analysis by Longo et al. and reflects on areas where greater clarity or methodological consistency could strengthen future work
Development and Evaluation of Flurbiprofen Nanogel Drug Delivery System
No full textIntroduction: Inflammation is a defensive mechanism in the body the immune system recognized damaged cells, irritant, and pathogens and protective response involving immune cell, blood vessel that serves as a mechanism initiating the elimination of noxious agent and of damage tissue inflammation is part of body’s immune response.
Objectives: The purpose of this study was to develop and evaluate nanogel for transdermal delivery of Flurbiprofen.
Methods: Nanogel was prepared by chemical cross-linked gel method. Nanogel was prepared by the following steps using chemical crosslinked gel method. First, Hyaluronic Acid (HA) (Different concentration like 1% w/v, 2%w/v, 3%w/v) were dissolved in distilled water at room temperature for 1 hr and Polyvinyl alcohol (PVA) (Different concentration like 2.5% w/v, 5%w/v, 7.5%w/v) were dissolved in distilled water at 50OC on magnetic stirrer for 12 hour (1 hour for dissolution and further 11hr for to achieve homogeneous solution).
Results: The Optimization of formulation has been carried out through 32 factorial designs with Hyaluronic acid and polyvinyl alcohol concentration (in percentage W/V) as an independent variables and particle size and percentage drug entrapment efficiency and gelling time as dependent variables.
Conclusions: Nanogels are a very promising carrier for the topical administration due to the enhanced delivery of drugs
The science of Rasayana: Unlocking Ayurveda\u27s secret to longevity
No full textAyurveda is the ancient system of medicine in the world. The science of life deals with every aspect of life. Ayurveda has two aims, i.e., maintaining the health of a healthy person and curing the diseased. Rasayana may be employed for fulfilling both of them. Rasayana are the ways of attaining longevity, memory, intelligence, freedom from disorders, young age, excellence of lusture, complexion and voice, ultimate strength of physique and sense organs, wisdom and successful words and brilliance. Rasayana is one among the Ashtanga Ayurveda. Rasayana drugs are those that are capable of importing Rasas to the body and toning up the system of healthy persons. Rasayana aids in increasing natural immunity, enhancing general well-being, improving the functioning of all the fundamental organs of the body and keeping the signs of early ageing at bay. Moreover, it involves two opposite processes that simultaneously come into operation, i.e., growth and atrophy. Ageing represents structural and functional changes of an organism over its entire life span. Rasayana is not a drug therapy, but it is a specialised procedure practised in the form of rejuvenate recipes, dietary regimes and special health-promoting conduct and behaviour, i.e., Achara Rasayana
Evaluation of Strain on Mandibular Molars Restored with Peek Endocrown -Experimental Study
No full textContext :Endocrowns are increasingly used as a restorative option for endodontically treated teeth, offering a conservative and esthetic alternative to traditional crowns. Polyetheretherketone (PEEK) has emerged as a promising biomaterial due to its favorable mechanical properties and biocompatibility. Understanding stress distribution is crucial for the longevity of such restorations. The aim of this study was to assess the stress distribution in mandibular molars restored with polyetheretherketone (PEEK) endocrowns.
Materials and Methods:
A total of 10 patients were selected for the study, which was conducted in the Department of Prosthodontics, Thai Moogambikai Dental College and Hospital, Chennai. Strain was measured using a strainmeter on the day of insertion, at one week, one month, six months, and one year.
Results:
The mean strain distribution was found to be highest one week after insertion (245.4 ± 5.68), followed by the day of insertion (236.70 ± 4.94). A gradual decrease in strain was observed over time, with values recorded at one month (190.0 ± 5.81), six months (134.80 ± 9.35), and one year (108.10 ± 5.08). Statistically significant differences were observed between several time intervals: one year and the day of insertion (p = 0.000*), six months and the day of insertion (p = 0.005*), one month and one week (p = 0.005*), six months and one week (p = 0.000*), one year and one week (p = 0.000*), and one year and one month (p = 0.005*).
Conclusion:The study concluded that mandibular molars restored with PEEK endocrowns exhibited a reduction in strain over time
Beal’s Fuzzy Relations and Its Applications in Decision Making Problems
No full textIntroduction: This study introduces the conception of Beal’s fuzzy relation (BFR), which will help to remove certain limitations associated with Pythagorean (PFR), fermatean (FFR) and intuitionistic fuzzy relation (IFR). Some basic operations in this regard are given for Beal’s fuzzy relations (BFR). The set of all Beal’s fuzzy relations leads to several algebric structures for these operations (semi-ring, and bounded distributive lattice). Additionally, an application of the designed approach is proposed for entropy measure orthopairean TOPSIS algorthim. Moreover, the comparative analysis of the proposed method with some existing ideas is also presented by given several examples to authenticate the feasibility and superiority of the proposed approach
Stromal Desmoplasia as a Predictor of Regional Lymph Node Metastasis in Histological Grades of Oral Squamous Cell Carcinoma- A Polarized Microscopic Study
No full textBackground: The tumour stroma, including ECM and stromal cells, contributes to OSCC progression through desmoplasia, marked by increased collagen deposition. Picrosirius red staining under polarized light distinguishes collagen maturity, offering insights into stromal remodeling and its link to tumour invasiveness and lymph node metastasis.
Methods
A cross-sectional analytical study of 31 OSCC cases used Picrosirius red staining to assess stromal desmoplasia. Collagen birefringence patterns were analysed in relation to histological grade and lymph node involvement.
Results
Collagen birefringence colour was significantly associated with histological grade (p = 0.05). Green-yellow was observed in 50% of node-positive cases, while red-orange (42%) and yellow-orange (38%) predominated in node-negative cases (p = 0.08
Exploring the Phytochemical Elements and Therapeutic Potential of Stephenia Hernandifolia Leaf Extract: Evaluation of Antioxidant and Anti-Inflammatory Properties
No full textIntroduction: Stephania hernandifolia (S. hernandifolia) is widely distributed across northeastern India, including Assam, Mizoram, Tripura, Arunachal Pradesh, Sikkim, Manipur, Nagaland, and Meghalaya. It holds great economic importance in the perfume industry, traditional medicine, and incense production, though its phytochemical composition varies with geography.Objectives: This study aimed to perform phytochemical screening and evaluate the antioxidant and anti-inflammatory activities of S. hernandifolia leaves collected from Ikishe and Tenyiphe villages, Chumoukedima district, Nagaland.
Methods: Leaf samples were subjected to qualitative phytochemical tests and GC-MS analysis of methanolic extracts. Antioxidant activity was determined using the DPPH radical scavenging assay, while anti-inflammatory potential was assessed through the egg albumin denaturation assay.Results: Phytochemical screening revealed the presence of phenols, flavonoids, and saponins in both extracts, whereas alkaloids, tannins, and terpenoids were absent in the Tenyiphe sample. GC-MS identified major constituents such as n-Hexadecanoic acid, 9,12-Octadecadienoic acid (Z,Z), and Strophanthidin. The Ikishe extract exhibited stronger antioxidant and anti-inflammatory activities.Conclusion: The methanolic extract of S. hernandifolia from Ikishe village demonstrates significant antioxidant and anti-inflammatory potential, suggesting its usefulness as a natural source of bioactive compounds for food and pharmaceutical applications