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DYNAMIC ANALYSIS OF PREDATOR-PREY MODEL WITH CANNIBALISM INTERVENTION AND DISEASE INFECTION IN PREY USING HOLLING TYPE II RESPONSE FUNCTION
Get PDFThis study discusses the intervention of cannibalism and disease spread with Holling Type II response function in the predator-prey model. It is assumed that disease infection is limited to the prey population and cannot be cured so that in this model there are three subpopulations namely susceptible prey, infected prey and predators. In addition, there is cannibalism in the predator population. The objectives of this study include constructing a predator-prey model with cannibalism intervention and disease infection in prey using Holling Type II response function, identifying the stability of the equilibrium point of the model and interpreting the model based on simulation results. Analysis of the stability of the equilibrium point is carried out with a linearization approach and the Routh-Hurwitz criterion was used to determine equilibrium stability. Based on the stability analysis, 5 (five) equilibrium points are obtained, namely population extinction, susceptible prey exists, predator extinction, infected prey extinction and population exists where the population extinction equilibrium point is unstable and the other equilibrium points are stable with the certain conditions. From the simulation, it is obtained that the numerical results are in accordance with the analytical results of the stability analysis of the equilibrium point of the model and for infinite time, there will be no population extinction while the state of susceptible prey exists, predator extinction, infected prey extinction and population exists can occur if the stability conditions are met. Based on the numerical simulations, it was found that changes in the parameter values of the rate of change of susceptible prey to infected prey and the coefficient of predator cannibalism in day-1 can cause changes in the type of stability of the equilibrium point. Thus, rate of change susceptible prey to infected prey and the coefficient of predator cannibalism affects the population of prey and predator
Formulasi Es Krim Nabati Berbasis Sari Kedelai dan Sari Sorgum dengan Pengental Xanthan Gum
Get PDFThe trend of low-fat consumption is not only limited to main meals, but also to desserts. Ice cream, which is usually made from milk, is replaced by plant-based ingredients that have low fat content but high protein such as soybean juice and sorghum juice. The purpose of this study was to obtain the best plant-based ice cream formulation with the ratio of soybean juice and sorghum juice and the use of xanthan gum as a stabilizer. The method in this study was a completely randomized design with two treatments, namely three ratios of soybean juice and sorghum juice (30:70; 50:50; 70:30) and two concentrations of xanthan gum (0.3% and 0.5%). Physical quality parameters observed were overrun and melting time, chemical quality parameters were proximate and sensory quality parameter which were taste, aroma, texture and overall acceptance. The three best treatments were then analyzed for functional value in the form of total phenolics, flavonoids and antioxidant activity. Statistical analysis used One Way ANOVA with Duncan's difference test. The results showed that the ratio of soybean juice and sorghum juice and the concentration of xanthan gum had a significant effect on physical, chemical and sensory parameters. Ice cream with a ratio of 30:70 and a concentration of 0.3% xanthan gum produced the highest overrun value of 39.71% but the longest melting time was obtained in the treatment of a ratio of 50: 50 and 0.5% xanthan gum concentration of 1005.98 seconds or 16.77 minutes. Based on functional analysis, the highest total phenolics, flavonoids and antioxidant activity were obtained in the ice cream treatment of soybean juice and sorghum juice 50:50 with the addition of xanthan gum as much as 0.5% as a stabilizer
Investigation of Pharmacokinetics, Molecular Docking, and Dynamics of Xanthomicrol-Derived Compounds Against Various Mutated Proteins in Lung Cancer Cells
Get PDFLung cancer remains one of the leading causes of global mortality, primarily due to drug resistance and the adverse effects of conventional therapies. Therefore, the discovery of novel compounds that are both effective and safe is crucial for the development of alternative treatments. This study employed a computational approach to evaluate the therapeutic potential of Xanthomicrol-derived compounds targeting mutated proteins commonly associated with lung cancer. Four derivatives (u1a, u2a, u3a, and u4a) were assessed using pharmacokinetic (ADMET) predictions, molecular docking, and molecular dynamics simulations against ten mutated lung cancer-related proteins (1nq1, 1x2j, 4b3z, 4j97, 5l2q, 6pwa, 6usx, 7pgk, 7pgl, and 7r7k). ADMET predictions revealed that all compounds had good gastrointestinal absorption, did not cross the blood–brain barrier, and exhibited favourable safety profiles. Among them, compound u3a showed the highest binding affinity toward seven mutated proteins, with docking scores ranging from -5.9 to -9.4 kcal/mol. Molecular dynamics simulations further supported the stability of u3a protein interactions, indicated by low RMSF values and an optimal radius of gyration. These results suggest that u3a is a promising candidate for targeted lung cancer therapy and warrants further experimental validation
Monte Carlo-Expected Tail Loss for Analyzing Risk of Commodity Futures Based on Holt-Winters Model
Get PDFFuture, an agreement to buy or sell an asset at a certain price and a certain time in the future, is one of the market derivatives because the underlying assets influence the price of futures. In general, futures divide into financial futures and commodity futures. Each of the futures has different risks, so risk measures are needed to improve the effectiveness and efficiency of investment management. For example, we have the London Metal Exchange (LME) in the metal scope of commodity futures. Therefore, we propose the Holt-Winters Model for estimating commodity prices in this study. Hereafter, The Expected Tail Loss (ETL) with Monte Carlo process will use to analyze risk measures. We took six commodity futures in LME to implement the method as a sample, such as Zinc, Lead, Aluminum, Copper, Nickel, and Tin. Based on the analysis, each commodity has a different mean ETL value, where Nickel has the most significant risk with an ETL value of 0.036. This value means that the possibility of the expected loss to be borne by investors is 3.6%
GAMBARAN KARAKTERISTIK PASIEN BEDAH ANAK YANG DIRAWAT DI RSUD PIRU TAHUN 2023
Get PDFTindakan pembedahan pada pasien anak merupakan prosedur pembedahan yang dilakukan untuk menangani berbagai macam penyakit pada pasien anak-anak, termasuk janin, bayi yang terlahir prematur atau cukup bulan, balita, hingga remaja dibawah usia 18 tahun mulai dari kelainan organ dalam hingga tumor. Sebagian besar kasus bedah anak disebabkan oleh kondisi darurat yang memerlukan intervensi darurat. Pembedahan pada pasien anak masih merupakan masalah yang pelik dan kasus bedah anak merupakan salah satu kasus yang sering dijumpai pada praktik klinis, baik kasus emergensi atau kelainan bawaan. Penelitian ini bertujuan untuk melihat gambaran karakteristik pasien bedah anak di RSUD Piru. Penelitian ini merupakan penelitian deskriptif dengan pendekatan cross sectional study yang dilakukan di RSUD Piru. Penelitian ini dilakukan pada bulan Oktober sampai November 2024. Populasi dalam penelitian ini adalah seluruh rekam medis pasien bedah anak di RSUD Piru Tahun 2023 sebanyak 87 responden. Teknik pengambilan sampel menggunakan metode total sampling. Hasil penelitian menunjukkan bahwa sebagian besar pasien bedah anak di RSUD piru berjenis kelamin laki-laki dengan rata-rata usia Pasien bedah anak 6-15 Tahun. Berdasarkan diagnosis pasien tersebut diketahui bahwa sebagian besar pasien mengalami cedera yang terdapat sebanyak 54,02% dan hanya terdapat 2,30% diagnosis dengan kasus kongenital, dalam kasus ini pasien terdiagnosis Hidrosepalus dan Hirschsprung. Diharapkan bahwa RSUD piru memiliki dokter Spesialis Bedah anak, agar kedepannya kasus-kasus bedah anak tersebut dapat ditangani sehingga dapat mengurangi angka morbiditas dan mortalitas
FORECASTING STOCK PRICES OF PT. BANK RAKYAT INDONESIA USING THE HYBRID ARIMA-BACKPROPAGATION NEURAL NETWORK METHOD
Get PDFPT. Bank Rakyat Indonesia (Persero) Tbk is classified as a blue-chip stock. Although investing in BRI shares has the potential to generate profits, stock price fluctuations can pose risks, making forecasting necessary. The ARIMA model is frequently used to predict such fluctuations, but struggles to capture non-linear patterns. ARIMA is combined with an Artificial Neural Network (ANN), specifically the Backpropagation Neural Network, to address this issue and improve forecasting accuracy. Although Backpropagation is weak in slow convergence, this can be overcome using the Conjugate Gradient Powell Beale (CGB) algorithm. The research results show that the closing stock price data of BRI from January 2023 to February 2024 produced an ARIMA (1,1,1)-Backpropagation [4-4-1] model with higher accuracy, achieving a MAPE of 2.516% and RMSE of 200.1592, Relative to the standalone ARIMA (1,1,1) model, which had a MAPE of 6.203% and RMSE of 421.5896
PENINGKATAN HASIL BELAJAR IPAS MELALUI PEMBELAJARAN BERDIFERENSIASI GAYA BELAJAR PESERTA DIDIK
Get PDFGuru menghadapi tantangan dalam menciptakan pembelajaran yang efektif karena berbagai gaya belajar peserta didik, termasuk kinestetik, visual, dan auditori. Pendekatan pembelajaran berdiferensiasi berdasarkan gaya hadir sebagai solusi untuk memenuhi kebutuhan individu peserta didik dan meningkatkan hasil belajar mereka. Tujuan penelitian ini adalah untuk mengetahui bagaimana penerapan pembelajaran berdiferensiasi dapat meningkatkan hasil belajar peserta didik dalam mata pelajaran Ilmu Pengetahuan Alam (IPAS) kelas III B di SDN Pandeanlamper 03. Metode penelitian menggunakan metode mix method atau metode campuran. Pendekatan kuantitatif digunakan untuk mengukur hasil belajar peserta didik melalui pretest dan posttest. Sedangkan, Pendekatan kualitatif mengukur pengalaman peserta didik melalui observasi dan wawancara. Hasil Penelitian menunjukan bahwa pembelajaran berdiferensiasi gaya belajar menjadikan peserta didik aktif dan antusias dalam proses pembelajaran. Pretes dan posttest menunjukan dapat meningkatkan hasil belajar peserta didik. Pada hasil pretest tuntas belajar 21% sementara hasil posttest peserta didik tuntas belajar 92%. Jadi besar persentase peningkatan hasil belajar IPAS peserta didik adalah 70%
PENGARUH PENGGUNAAN LKPD BERBASIS PENDEKATAN STEM TERHADAP KEMAMPUAN BERPIKIR KRITIS PADA PEMBELAJARAN IPAS PESERTA DIDIK KELAS IV SEKOLAH DASAR
Get PDFMasalah dalam penelitian ini adalah rendahnya kemampuan berpikir kritis peserta didik kelas IV SD Negeri 5 Metro Pusat. Penelitian ini bertujuan untuk mengetahui pengaruh dari penggunaan LKPD (Lembar Kerja Peserta Didik) berbasis pendekatan STEM (Science,Technology, Engineering, Mathematics) terhadap kemampuan berpikir kritis peserta didik dan perbedaan kemampuan berpikir kritis peserta didik pada pembelajaran IPAS antara kelas eksperimen dan kelas kontrol. Jenis penelitian menggunakan penelitian kuantitatif dengan metode quasi eksperimental dan desain penelitian non equivalent control group design. Populasi dan sampel dalam penelitian ini diperoleh melalui teknik purposive samplingdengan jumlah sampel sebanyak 54 orang peserta didik. Data dianalisis menggunakan uji regresi sederhana dan uji t. Hasil penelitian menujukkan bahwa terdapat pengaruh penggunaan LKPD berbasis pendekatan STEM terhadap kemampuan berpikir kritis pada pembelajaran IPAS dan terdapat perbedaan kemampuan berpikir kritis pada pembelajaran IPAS antara kelas ekspeirmen dan kelas kontrol peserta didik kelas IV SD Negeri 5 Metro Pusat tahun pelajaran 2024/2025
DAYA DUKUNG DAN INDEKS KESESUAIAN WISATA DI PANTAI JERMAN DAN PANTAI SEGARA, KECAMATAN KUTA, KABUPATEN BADUNG, PROVINSI BALI
Get PDFSegara Beach and German Beach are one of the beaches located in Kuta District, Badung Regency, Bali. Segara Beach and German Beach have tourist destinations such as swimming, sunbathing, seeing the scenery, and sitting back, so that local and foreign tourists can enjoy the tourist attractions at Segara Beach and German Beach. Tourism development must be based on the principle of sustainable development (Sustainable Development Goals). Tourism development has a direct impact on the environment and can reduce the sustainability of existing natural resources, therefore it is necessary to know the carrying capacity of the tourism area (DDK) and the tourism suitability index (IKW) in order for further development to be very important based on the availability of data or information about carrying capacity and suitability index and evaluation of the potential conditions of tourist attractions at Segara Beach and German Beach, so it is very urgent to do. Data collection was carried out in March-April 2024 using quantitative and qualitative descriptive methods. The data analysis method uses carrying capacity analysis and tourism suitability index by calculating the type of beach, basic water material, beach width, water depth, water clarity, current speed, beach slope, land cover, dangerous biota, and fresh water availability. Based on the results of the tourism suitability index analysis, the results obtained at stations 1, 2, and 3 were 2.9, which is included in the very suitable category with a carrying capacity for the swimming category of 980 people/day, the viewing category of 6,971 people/day, the sitting and relaxing category of 5,346 people/day, and the sunbathing category of 4,386 people/day
Therapeutic Effect of Pulai Bark Extract (Alstonia scholaris L. R. Br) on Body Weight of Streptozotocin-Induced Mice (Mus musculus)
No full textType 1 and type 2 diabetes mellitus are metabolic disorders characterized by elevated blood sugar levels (hyperglycemia) due to the body’s inability to produce insulin effectively. Sustained hyperglycemia can affect various physiological parameters, including changes in body weight. Alstonia scholaris L. R. Br is a plant widely found in Southeast Asia. Alstonia scholaris stem bark extract contains bioactive compounds of flavonoids, saponins, and polyphenols that can be antidiabetic. This study aims to determine the therapeutic effect of pulai bark extract (Alstonia scholaris L. R. Br) on the body weight of mice (Mus musculus) induced by Streptozotocin. This research is experimental. A total of 18 mice were divided into 6 groups, namely the normal control group (KN), negative control group (K-), positive control group (K+), and DM mice group given the extract at a dose of 0.4 ml/mencit/day (P1), a dose of 0.8/ml/mencit/day (P2) and 1.6 ml/mencit/day (P3). Before treatment, all mice were weighed, and initial blood sugar levels were. After that, the K-, K+, P1, P2, and P3 groups were induced with streptozotocin mice at a dose of 0.3 ml for 14 days. Furthermore, suppose there is an increase in blood sugar levels. In that case, the K+ group is given the drug metformin, and the P1, P2, and P3 groups are given Alstonia scholaris stem bark extract at a predetermined dose. Data from the study were analyzed using an ANOVA test. The results showed that giving Alstonia scholaris stem bark extract can increase the body weight of DM mice