Universitas Negeri Manado, Jurusan Kimia: Open Journal Systems
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Production of Liquid Organic Fertilizer from Pineapple Peel Waste Using EM4 as a Bioactivator
Get PDFPineapple peel waste is an abundant agricultural residue that remains underutilized. This study aims to produce liquid organic fertilizer (LOF) from pineapple peels using EM4 bioactivator, cow manure, rice-washing water, and palm sugar through a 30-day fermentation process. Fermentation performance was monitored via daily temperature and pH, along with nutrient content analysis including nitrogen (N), phosphorus (P), potassium (K), and organic carbon (C-organic). The results showed temperature ranged from 27.9–32.3°C and pH between 3.0–4.0, within the optimal range for microbial activity. However, nutrient concentrations of N (0.153%), P (0.116%), K (0.105%), and C-organic (1.58%) did not meet the Indonesian National Standard (SNI 261/2019). This indicates that pineapple peel alone requires nutrient-rich additives to produce standard-compliant LOF. This study highlights the potential of pineapple peel waste as an eco-friendly LOF source, emphasizing the need for further formula optimization
Bioprospecting and Chemical Potential of Bioactive Compounds of Medicinal Plants of the Baduy Tribe of Banten Province
Get PDFBioprospecting is the exploration, collection, research, and utilization of genetic and biological resources to obtain chemical compounds, genes, organisms, and other natural products. Bioprospection of medicinal plants is an exploration activity to have added value from both a scientific and an economic perspective. Indonesia is one of the archipelago countries that has the potential for cultivating various plants. The objective of this research was to find bioactive compounds from plants in Baduy and the chemical potential of bioactive compounds as drugs. White Ginger (Curcuma zedoria Rosc) is included in the family of medicinal plants (TOGA) is a plant in the family Zingiberaceae. This plant is widely found in Baduy. The method used in this research is descriptive qualitative, by describing the quality of bioactive compounds contained in traditional medicinal plants in the Baduy tribe. The research results showed that the yields obtained from the extraction using 70% ethanol solvent, water, and steeping water of white rhizome powder were 24.51%, 9.65%, and 12.22%, respectively. 70% ethanol medicinal plant extract and hot water at a concentration of 300 ppm did not have an inhibitory power on the activity of the enzyme tyrosine kinase, while the crude extract of 300 ppm aquadest had an inhibitory power of 7.23%. At a higher extract concentration, which is 700 ppm, 70% ethanol extract has the highest inhibitory power of 27.77%. The inhibition power of 700 ppm aqueous extract is 26.13% and 700 ppm hot water extract is 24.50%
Pengembangan Laboratorium Virtual dan Animasi 3 Dimensi (Le Chatelier Virtual Laboratory) Pada Materi Kesetimbangan Kimia
Get PDFThe digital era requires teachers and prospective teachers to innovate in the development of effective, efficient and not boring learning media. This study aims to develop interactive learning media based on virtual laboratories and 3-dimensional animation on chemical equilibrium material called Le Chatelier Virtual Laboratory. The research and development method used is 4D. The research study was used to determine the feasibility and student responses to virtual laboratory-based interactive learning media and 3D animation on chemical equilibrium. Product validation results were performed by experts using Aiken's V data analysis. The validity result reached a value of 0.91, a category with high validity. The small-scale trial produced a fairly good response with an overall quality percentage of 83.46%. This study concluded that learning media can be used in the learning process and further research can be carried out at the disseminate stage (large scale implementation).Era digital mewajibkan guru untuk melakukan inovasi dalam pengembangan media pembelajaran yang efektif, efisien dan tidak membosankan. Penelitian ini bertujuan mengembangkan media pembelajaran interaktif berbasis laboratorium virtual dan animasi 3 dimensi pada materi kesetimbangan kimia yang diberi nama Le Chatelier Virtual Laboratory. Metode penelitian yang digunakan adalah Research and Development (R&D) dengan model pengembangan 4D dari Thiagarajan. Kajian penelitian digunakan untuk mengetahui kelayakan dan respon siswa terhadap media pembelajaran interaktif berbasis laboratorium virtual dan animasi 3 dimensi pada materi kesetimbangan kimia. Hasil validasi produk dilakukan oleh para ahli dengan menggunakan analisis data Aiken’s V. Hasil validitas memperoleh nilai sebesar 0,91 dengan kategori kevalidan yang tinggi. Uji coba skala kecil menghasilkan respon yang cukup baik dengan persentase kualitas secara keseluruhan 83,46%. Penelitian ini memperoleh kesimpulan bahwa media pembelajaran dapat digunakan dalam proses pembelajaran dan dapat dilakukan penelitian lebih lanjut pada tahap disseminate (implementasi skala besar)
PENGARUH MEDIA PEMBELAJARAN WEB WORDWALL TERHADAP HASIL BELAJAR SISWA PADA MATERI TERMOKIMIA DI SMA KOSGORO TOMOHON
Get PDFA study has been conducted on the influence of web-based learning media Wordwall on student learning outcomes in thermochemistry material at SMA Kosgoro Tomohon. The research method used is Pretest-Posttest Control Group Design, involving 15 students of class XI A as the experimental class and 15 students of class XI B as the control class, while the t-test is carried out. Wordwall media is applied in the learning process to improve student understanding and involvement interactively in the experimental class. Based on the results of the study and discussion, it shows that the use of Wordwall has an effect on student learning outcomes, as shown through the research data, namely the average value of the experimental class of 76.19 is higher than the control class with an average of 65.96 and continued with a t-test with the help of SPSS software, a significance level value of 0.012 <α (0.05) was obtained. Therefore, this study shows a significant influence between Wordwall web media on student learning outcomes in thermochemistry material at SMA Kosgoro Tomohon. Therefore, Wordwall learning media is recommended as an innovative alternative to support the learning of complex chemical materials such as thermochemistry.Telah dilakukan penelitian tentang pengaruh media pembelajaran berbasis web Wordwall terhadap hasil belajar siswa pada materi termokimia di SMA Kosgoro Tomohon. Metode penelitian yang digunakan adalah Pretest-Posttest Control Group Design, melibatkan siswa kelas XI A dengan jumlah 15 orang sebagai kelas eksperimen dan kelas XI B dengan jumlah 15 orang sebagai kelas kontrol, sedangkan analisis dilakukan dengan uji-t. Media Wordwall diaplikasikan dalam proses pembelajaran untuk meningkatkan pemahaman dan keterlibatan siswa secara interaktif di kelas ekperimen. Berdasarkan hasil penelitian dan pembahasan menunjukkan bahwa penggunaan Wordwall memberikan pengaruh terhadap hasil belajar siswa, ditunjukkan melalui data hasil penelitian yaitu nilai rata-rata kelas eksperimen sebesar 76,19 lebih tinggi dibandingkan dengan kelas kontrol dengan rata-rata sebesar 65,96 dan dilanjutkan dengan uji-t dengan bantuan software SPSS, diperoleh nilai taraf siknifikansi sebesar 0,012 < α (0,05). Oleh karna itu, penelitian ini menujukan pengaruh media pembelajaran web Wordwall terhadap hasil belajar siswa pada materi termokimia di SMA Kosgoro Tomohon. Dengan demikian, media pembelajaran Wordwall direkomendasikan sebagai alternatif inovatif untuk mendukung pembelajaran materi kimia yang kompleks seperti termokimi
Molecular Docking Of Cyclosenegalin A As Anticancer
Get PDFCancer is recognized as a leading cause of death globally, responsible for approximately 14.5% of all deaths,. Cyclosenegalin A showed activity against DU-145 human prostate cancer cell line with IC50 of54.92.35μM. This study aims to investigate whether the cyclosenegalin A compound can interact with the target receptors 4IEH and potentially act as an anticancer candidate. The results of the study show that the docking of cyclosenegalin A with the 4IEH receptor yielded the best results, with an affinity value of -8.88 kcal/mol. The hydrogen bonding at the GLY 104, ASP 70, VAL 92, and GLU 95 amino acids was identical to that observed in the standard ligand, n-heteroarilsulfonamides. The interaction between cyclosenegalin A and the target receptor is effective, indicating that cyclosenegalin A holds potential as an anti-cancer candidate
Pengembangan E-Modul Laju Reaksi Discovery Learning Berbasis Blog Untuk Meningkatkan Motivasi Belajar dan Komunikasi Siswa: Analisis Kebutuhan
Get PDFThis research is a preliminary study of the development of blog-based reaction rate e-module media to increase student learning motivation and communication which was carried out by R&D. This study is a mixed-method of descriptive qualitative and quantitative methods. Data was collected through library research and questionnaires which were processed using the Rasch Model. The results of data collection were then processed in a qualitative descriptive manner. The purpose of this study is to find out, describe and explain the need for blog-based e-module development on the subject of reaction rates and the advantages and disadvantages of blog media. The literature study was carried out by reviewing journals relevant to the research (library research) and questionnaire data collection was carried out online using the Google form. Based on the results of the questionnaire analysis for the development of blog-based reaction rate e-modules to increase student learning motivation and communication using the Rasch Model, the results obtained from reviewing journals and distributing questionnaires can be concluded that blogger media is classified as effective for use as an alternative learning media for students because it is easy to use, inexpensive and interactive. The use of blog media is able to increase student learning motivation because of the in-depth presentation of material. The advantage of using blog media compared to print media is the sub-microscopic presentation. The blog-based module is able to describe abstract sub-microscopic materials on reaction rates in detail and is not boring because it is animated. Along with the development of learning motivation, students’ mathematical communication and communication in the learning process will increase.Penelitian ini merupakan penelitian pendahulun dari pengembangan media e-modul laju reaksi berbasis blog untuk meningkatkan motivasi belajar dan komunikasi siswa yang dilakukan secara R&D. Studi ini merupakan mixed-method dari metode kualitatif deskriptif dan kuantitatif. Data dikumpulkan melalui riset pustaka dan angket yang diolah dengan Rasch Model. Hasil pengumpulan dats kemudian diolah secara kualitatif deskriptif. Tujuan studi ini adalah adalah untuk mengetahui, menggambarkan dan menjelaskan tentang kebutuhan pengembangan e-modul berbasis blog pada materi laju reaksi serta keuntungan dan kelebihan media blog. Studi pustaka dilakukan dilakukan dengan cara me-review jurnal-jurnal yang relevan dengan penelitian (library research) dan pengambilan data angket dilakukan secara online menggunakan google form. Berdasarkan hasil analisis angket pengembangan e-modul laju reaksi berbasis blog untuk meningkatkan motivasi belajar dan komunikasi siswa menggunakan Rasch Model, diperoleh hasil review jurnal-jurnal dan penyebaran angket dapat disimpulkan bahwa media blogger tergolong efektif untuk digunakan sebagai media belajar alternatif siswa karena mudah digunakan, murah dan bersifat interaktif. Penggunaan media blog mampu meningkatkan motivasi belajar siswa karena penyajian materi yang mendalam. Keuntungan menggunakan media blog dibandingkan dengan media cetak yaitu penyajian sub mikroskopiknya. Pada modul berbasis blog mampu menggambarkan sub mikroskopik yang bersifat abstrak pada materi laju reaksi secara terperinci serta tidak membosankan karena bersifat animasi. Seiring dengan berkembangnya motivasi belajar maka komunikasi matematis siswa dan komunikasi pada proses pembelajaran akan meningkat
Pengaruh Ekstraksi Bertingkat Terhadap Kadar Flavonoid Total Ekstrak Binahong (Anredera cordifolia (Ten) Steenis)
Get PDFBinahong ( Anredera cordifolia (Ten.) Steenis) merupakan tumbuhan yang memiliki banyak khasiat dan sering digunakan untuk mengobati berbagai macam penyakit. Salah satu kandungan senyawa yang terdapat dalam daun binahong adalah flavonoid yang berfungsi sebagai obat tradisional. Penelitian ini bertujuan untuk mengetahui pengaruh ekstraksi maserasi bertingkat terhadap kadar total flavonoid ekstrak binahong. Metode yang digunakan dalam penelitian ini adalah eksperimental. Daun binahong di ekstraksi secara maserasi bertingkat dengan menggunakan pelarut yang memiliki kepolaran berbeda. Pelarut yang digunakan terdiri atas pelarut n-heksana (nonpolar), etil asetat (semi polar), dan etanol 96% (polar). Analisis kualitatif pada penelitian ini menggunakan uji tabung dan analisis kuantitatif menggunakan metode spektrofotometri UV-Vis pada panjang gelombang maksimum 417,5 nm dengan pembanding standar rutin. Hasil analisis kualitatif ekstrak n-heksan, ekstrak etil asetat, dan ekstrak etanol 96% mengandung flavonoid positif. Berdasarkan pengujian kuantitatif diperoleh kadar flavonoid total ekstrak n-heksan, etil asetat, dan etanol 96% berturut-turut yakni sebesar 2,3102%; 3,6124%; dan 1,0264%. Hal ini menunjukkan bahwa penggunaan ekstraksi maserasi bertingkat memberikan pengaruh terhadap kadar total flavonoid yang dihasilkan pada masing-masing ekstrak
Potensi Flavonoid Dalam Daun Pepaya (Carica papaya L.) Sebagai Antiinflamasi Secara In Silico
Get PDFPenatalaksaan inflamasi di Indonesia saat ini menggunakan obat golongan AINS (Antiinflamasi Non Steroid) maupun AIS (Antiinflamasi Steroid). Mekanisme kerja obat tersebut berhubungan dengan biosintesis prostaglandin, yaitu menghambat kerja enzim siklooksigense yang menyebabkan penurunan sintesa prostaglandin. Akan tetapi, penggunaan obat-obatan tersebut menunjukkan berbagai efek samping seperti tukak lambung, dispepsia, cushing, osteoporosis dan immunosuppresif. Penelitian ini merupakan penelitian eksperimental secara in silico pada daun papaya (Carica papaya L.) yang mengandung flavonoid diduga sebagai senyawa antiinflamasi. Tujuan penelitian ini untuk mengetahui interaksi senyawa flavonoid dengan COX-2 secara in silico. Hasil penelitian menunjukkan senyawa flavonoid diduga sebagai antiinflamasi dengan menghasilkan nilai ∆G antara COX-2 dengan flavonoid sebesar -44,92 kcal/mol. Interaksi yang terjadi antara reseptor COX-2 dengan flavonoid, yaitu terjadinya ikatan hidrogen antara atom O dari flavonoid dengan beberapa residu asam amino dari COX-2, yaitu Aspargarin 39, Lisin 469 dan Sistein 47
Impact of different heating duration on water content in ore samples: analysis, regression insights, and implications for sustainable energy sources
Get PDFThis study investigates the impact of heating duration on the water content of five different ore samples (ore_A, ore_B, ore_C, ore_D, ore_E) using a systematic experimental approach and advanced data analysis techniques. The ore samples were homogenized and subjected to heating at 105°C for durations of 2, 4, 6, and 8 hours. Water content was determined gravimetrically, with the data showing that water content generally increased with heating time. For example, ore_A's water content rose from 22.00% ± 7.94 after 2 hours to 40.00% ± 7.94 after 8 hours, while ore_B's water content increased from 6.50% ± 10.54 to 29.00% ± 10.54 over the same period. Statistical analyses, including Shapiro-Wilk normality tests, ANOVA (F-statistic = 4.706, p-value = 0.0116), and Tukey's HSD post-hoc tests, revealed significant differences in water content among certain ore samples. Linear regression analysis showed a strong relationship between heating duration and water content, with R-squared values ranging from 0.83 (ore_A) to 0.99 (ore_D), confirming the robustness of the model. These findings provide valuable insights into the thermal properties of ores, with implications for optimizing processing conditions in ore treatment
Separation and Characterization of Silica from Rice Husk with Varying Heating Times
Get PDFRice husk is a by-product of rice processing that has many uses but is rarely used by most people. Rice husk has abundant silica content which can be used as an adsorbent. This research was conducted to separate silica from rice husk by using the alkali fusion method with varying heating times (30, 60, 120, and 180 minutes) and to characterize silica using FTIR, XRD, and SEM-EDS. the maximum silica yield achieved was 50.75% after heating 60 minutes. The results of XRD characterization showed the presence of a spectrum in the 22o region at an angle of 2θ with a non-sharp spectral shape which is an amorphous nature of silica. In the FTIR test, there is a typical absorption of the silanol group in the absorption area of 1099.48 cm-1, while the results of the SEM-EDS analysis show the percentage of silica mass is 34.39%