Dokkyo Medical University Repository / 獨協医科大学リポジトリ
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An Easy Z-score Imaging System for Discrimination Between Alzheimer's Disease and Dementia with Lewy Bodies Using Brain Perfusion SPECT
Get PDFObjective: We retrospectively examined whether easy Z-score imaging system (eZIS)-specific volume of interest analysis (SVA) using brain perfusion single photon emission computed tomography (SPECT) imaging or the cingulate island sign score (CIScore) could distinguish between Alzheimer's disease (AD) and dementia with Lewy bodies (DLB).
Methods: This study included 22 AD and 22 DLB patients who underwent 99mTc-ECD SPECT at Dokkyo Medical University Saitama Medical Center from November 2011 to February 2023.
Results: The SVA of AD and DLB patients showed that the threshold was exceeded in 77.3% for severity, 72.7% for extent, and 63.6% for ratio in AD, and in 86.4% for severity, 77.3% for extent, and 72.7% for ratio in DLB, with no significant difference between the two patient groups. The CIScore threshold of 0.281 allowed DLB to be discriminated from AD with an accuracy, sensitivity, and specificity of 63.6%, 77.2%, and 50.0%, respectively. The mean CIScore was significantly lower in DLB patients than in AD patients (p = 0.028, Mann-Whitney U test). A significant positive correlation was found between the CIScore and age of AD and DLB patients by Spearman's rank correlation coefficient analysis.
Conclusion: SVA is useful for the diagnosis of dementia with AD and DLB. CIScore is an adjunctive assessment method to distinguish between AD and DLB. Although CIScore can distinguish AD and DLB, it was strongly affected by age.journal articl
Dietary counseling based on artificial intelligence for patients with nonalcoholic fatty liver disease
Get PDF獨協医科大学博士（医学）令和4年度doctoral thesi
Safe Performance of Track Dilation and Bile Aspiration with ERCP Catheter in EUS-Guided Hepaticogastrostomy with Plastic Stents: A Retrospective Multicenter Study
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The role of anti-elastin antibodies in a mouse model of asthma
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Giant Tumefactive Perivascular Spaces with Obstructive Hydrocephalus: A Case Report
Get PDFThe perivascular space is a normal anatomical structure that forms around perforating arteries and is filled with cerebrospinal fluid. In rare cases, the perivascular space is enlarged and form multiocular cysts measuring 1.5 cm or larger, which are called giant tumefactive perivascular spaces. Seventy-four cases who harbored tumefactive perivascular spaces have been reported to date, and about half of them required CSF diversion. The treatment for multiocular cysts themselves has been reported as being unnecessary. Herein, we report a case of a giant tumefactive perivascular space that caused obstructive hydrocephalus. In the case of obstructive hydrocephalus due to giant tumefactive perivascular spaces, the surgical intervention for the hydrocephalus, such as third ventriculostomy or ventricle-peritoneal shunt, would be the therapeutic choice. Thus, it is crucial to understand the characteristic imaging findings of giant tumefactive perivascular spaces; the signal of the lesions is isointense to the cerebrospinal fluid on each MRI sequence with minimum perifocal edema.journal articl
Pulmonary Metastasis from Renal Cell Carcinoma Noted during Resection under Artificial Cardiopulmonary Support Showing Intra-atrial Extension into Left Atrium
Get PDFA 73-year-old female underwent a left knee arthroplasty procedure. Postoperative fever persisted and a chest computed tomography (CT) and positron emission tomography (PET) examination was performed, which showed a mass shadow in the right lower lobe of lung and a mass in the left atrium. Based on these findings, we suspected intracardiac extension of the lung tumor or another mass in the left atrium, and surgery was planned. Initially, a right lower lobectomy was performed under a video assisted thoracoscopic surgical procedure. The interlobar plane was separated, then the inferior lobe pulmonary artery was dissected, followed by dissection of the lower trunk of bronchus. A tumor was found on the cranial side of the right inferior pulmonary vein. Next, the chest was opened through a median sternotomy and artificial cardiopulmonary support was started. The tumor was found to be extending from the right inferior pulmonary vein toward the mitral valve and extraction was performed from the left atrium. The entire mass was moved to the right thoracic cavity, then the right lower lobe and mass were removed en bloc. Described herein is a rare case of pulmonary metastasis associated with a renal cell carcinoma extending into the left atrium.journal articl
