Dokkyo Medical University Repository / 獨協医科大学リポジトリ
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A Case of Conversion Hepatectomy for Hepatocellular Carcinoma with Vascular Invasion after Atezolizumab-bevacizumab Treatment
Get PDFWe report a hepatocellular carcinoma (HCC) case with vascular invasion successfully treated by conversion hepatectomy after treatment by atezolizumab-bevacizumab. A 74-year-old male patient was diagnosed with HCC and referred to our hospital. The tumor at the anterior section was 12.3 cm in diameter. It had invaded a portal vein branch of subsection 5 (S5) and peripheral branches of the middle hepatic vein. Serum alpha-fetoprotein (AFP) level was extremely high at 177408.3 ng/ml. The patient first received atezolizumab-bevacizumab treatment. After three cycles of atezolizumab-bevacizumab therapy, the tumor had decreased in size, the invasion into a portal and hepatic vein disappeared, the tumor enhancement completely vanished in the CT scan, and the tumor markers became within normal range. We decided to perform a conversion hepatectomy. The tumor was removed entirely by S5 partial resection, and pathological analyses showed a complete response to atezolizumab-bevacizumab treatment. There was no perioperative complication. The patient has survived for nine months without recurrence so far. Atezolizumab combined with bevacizumab might be an effective and appropriate option for the multidisciplinary treatment aiming for curative surgical resection.journal articl
Comparison of hemodynamics and root configurations between remodeling and reimplantation methods for valve-sparing aortic root replacement: A pulsatile flow study
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The mutational spectrum in whole exon of p53 in oral squamous cell carcinoma and its clinical implications
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Lung sound analysis in infants with risk factors for asthma development
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Thoracic kyphosis in light of lumbosacral alignment in thoracic adolescent idiopathic scoliosis: recognition of thoracic hypokyphosis and therapeutic implications
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Differences and similarities in cytokine profiles of macrophage activation syndrome in systemic lupus erythematosus and adult-onset Still’s disease
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Provocation and localization of arrhythmogenic triggers from persistent left superior vena cava in patients with atrial fibrillation
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Impending Rupture of Infected Aortic Aneurysm Due to Invasive Pulmonary Aspergillosis Occurring in Patient with Pulmonary Sequestration - Case Report
Get PDFWe present a case of impending rupture of an infected aortic aneurysm due to invasive pulmonary aspergillosis affecting an intralobar pulmonary sequestration. A 67-year-old man had acute lymphocytic leukemia and underwent chemotherapy, with complete remission. Previously, he had been diagnosed with asymptomatic pulmonary intralobar sequestration in the left lower lung. One month after chemotherapy, he complained chest and back pain, and was treated with antibiotics for one month. However, the pain continued and the patient was referred to our hospital. CT scan findings revealed an aortic aneurysm, which was diagnosed as an impending rupture of an infected aortic aneurysm with a maximum diameter of 9 cm, thus an emergency operation was performed. Aortic aneurysm was resected with both of a left lower lobe including the pulmonary sequestration and an aberrant feeding artery. Pathological study revealed invasive pulmonary aspergillosis originated from the pulmonary sequestration in left lower lobe.journal articl