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Successful use of sucrosomial iron in an anemic patient with sepsis in the early postoperative period
No full textThe following study presents a case of a 71-year-old female patient who was admitted to theintensive care unit (ICU) due to acute respiratory failure caused by pneumonia followinga laparotomy. Due to the presence of acute organ failure in the course of infection, the patientwas diagnosed with sepsis. The patient had multiple comorbidities: atrial fibrillation, hypertension,type 2 diabetes, hyperuricemia, and obesity (BMI 47 kg/m²). Upon admission tothe ICU, inflammatory anemia with iron deficiency was also diagnosed. Consequently, oralsupplementation with a new sucrosomal iron preparation was implemented. After seven days,significant improvement in hematological parameters was achieved. It is worth noting thatanemia is common in postoperative patients, increasing the risk of complications, prolonginghospitalization, and reducing quality of life. Postoperative anemia may result from blood loss,impaired erythropoiesis caused by surgical stress, and iron deficiency. Furthermore, systemicinflammation, associated with surgery or sepsis, may reduce iron absorption in the intestine.Sucrosomal iron may be an alternative to intravenous iron preparations for patients with asystemic inflammatory response. Due to its easier absorption and better tolerance, this form ofiron also represents a promising alternative to traditional oral iron preparations in patientswithout signs of systemic inflammation
When the mind pulls the hair: a narrative case study of stress-induced alopecia areata in a medical resident
No full textIntroduction: Working in the medical field involves considerable stress, and when this stress exceeds an individual’s coping capacity, it can contribute to the development of autoimmune conditions such as alopecia areata (AA). Although it has a solid biological foundation, very little is understood regarding the actual psychological experience that precedes its onset, particularly among individuals who work in stressful medical settings.
Objective: This narrative case study aims to examine how emotional strain and personal meaning-making may relate to the onset of AA in a young medical resident.
Material and methods: The case involves a 28-year-old woman who developed sudden, patchy hair loss. Clinical dermatological and psychiatric assessments were conducted, and a semi-structured interview captured her subjective account of the experience. The interview material was examined using Braun and Clarke’s inductive thematic analysis.
Results: Four central themes emerged from the residents’ narrative: (1) her professional identity and competence, (2) the body reflecting emotional burden, (3) feeling alone and holding back distress, and (4) recovery as a process of reconnection. Together, these themes illustrate how occupational stress and emotional suppression may manifest physically.
Conclusions: The case highlights the importance of addressing psychological as well as medical aspects in the management of AA, especially in high-pressure professions. A biopsychosocial perspective may support early recognition of stress-related triggers and promote more holistic recovery
Remote home monitoring for patients with chronic heart failure — rationale of the project. The talking chair — SIRIO 10 Project
No full textHeart failure (HF) is a global health challenge affecting over 64 million people worldwide and is associated with high morbidity, mortality, and healthcare costs. Despite advances in therapy, outcomes remain poor, and the COVID-19 pandemic further worsened prognosis by limiting hospital access. Clinical trials demonstrated that RM improves quality of life and reduces HF-related hospitalizations, though effects on all-cause mortality remain inconsistent. The proposed project incorporates weight, blood pressure, fluid status, oxygen saturation, and two-lead ECG monitoring. Data are transmitted wirelessly to a central server, analyzed by AI algorithms, and are used to trigger automated feedback or medical intervention. This approach is supposed to minimize staff workload, enable personalized therapy adjustments, reduce costs, and provide emergency assistance. The SIRIO 10 Project represents an innovative, holistic strategy for managing chronic HF in large populations. By combining AI-powered analytics with user-friendly home-based monitoring, it has the potential to transform care delivery, improve outcomes, and enhance quality of life for patients with HF
Całkowita odpowiedź na olaparyb u chorej na przerzutowego raka trzustki z mutacją gBRCA2
No full textMetastatic pancreatic cancer (mPC) is usually diagnosed at an advanced stage, and systemic therapy is stillthe main treatment option. Pathological germline mutations in the BRCA1 or BRCA2 genes are present in aroun 4–7% of cases of pancreatic cancer (PC). The poly(adenosine diphosphate-ribose) polymerase (PARP) inhibitor olaparib has had antitumor activity in this population. Following the results of the phase III POLO trial, the PARP inhibitor olaparib was approved by the Food and Drug Administration (FDA) as a maintenance therapy in germline BRCA1- and BRCA2-mutated mPC patients whose cancers had not progressed on first-line platinum-based chemotherapy. Maintenance olaparib increased median progression-free survival by 3.6 months compared to the placebo control. In these case, we describe a patient with a germline BRCA2-mutated, mPC who has a complete response to maintenance olaparib therapy. As of June 2025, the patient has experienced a complete response to olaparib for 20 months, enjoying a very good quality of life throughout this period.Rak trzustki (PC) jest zazwyczaj rozpoznawany w stadium zaawansowanym choroby, a leczenie systemowe wciąż stanowi podstawową opcję terapeutyczną. Patologiczne mutacje w linii germinalnej w genach BRCA1 lub BRCA2 występują w 4–7% przypadków PC. Inhibitor poli(ADP-rybozo)polimerazy (PARP) — olaparyb — wykazał działanie przeciwnowotworowe w tej grupie chorych. Na podstawie wyników badania III fazy POLO olaparyb został zatwierdzony przez Agencję Żywności i Leków (FDA) jako terapia podtrzymująca u chorych na przerzutowego raka trzustki (mPC) z mutacjami BRCA1 i BRCA2 w linii germinalnej, u których nie doszło do progresji choroby po chemioterapii pierwszego rzutu opartej na pochodnych platyny. Zastosowanie olaparybu w leczeniu podtrzymującym zwiększyło medianę przeżycia wolnego od progresji choroby (mPFS) o 3,6 miesiąca w porównaniu z grupą kontrolną otrzymującą placebo. W poniższym opisie przypadku przedstawiono chorą na mPC z mutacją gBRCA2, u której uzyskano całkowitą odpowiedź na terapię podtrzymującą olaparybem. Do czerwca 2025 roku u chorej utrzymuje się całkowita odpowiedź na olaparyb trwająca od 20 miesięcy, przy jednoczesnym zachowaniu bardzo dobrej jakości życia
The use of a combination of betamethasone dipropionate and salicylic acid in the treatment of inflammatory dermatoses
No full textCombined preparations are commonly used in the topical treatment of many inflammatory skin diseases. The simultaneous use of two substances with different mechanisms of action can produce an additive effect, thereby increasing their effectiveness. Topical glucocorticosteroids are the basis of the treatment for many inflammatory, autoimmune, allergic, or hyperproliferative dermatological conditions. Betamethasone dipropionate is a potent glucocorticosteroid receptor agonist, classified as class III according to the World Health Organization (WHO) classification. Salicylic acid has keratolytic and anti-inflammatory properties and stimulates the regeneration process. Exfoliation of keratinocytes from areas affected by hyperkeratosis through the use of salicylic acid promotes the penetration of active substances deep into the skin, directly to sites of disease. The application of a combination preparation containing both betamethasone dipropionate and salicylic acid increases the effectiveness of pharmacotherapy for many inflammatory dermatoses, with particular emphasis on dermatological conditions with hyperproliferation.Combined preparations are commonly used in the topical treatment of many inflammatory skin diseases. The simultaneous use of two substances with different mechanisms of action can produce an additive effect, thereby increasing their effectiveness. Topical glucocorticosteroids are the basis of the treatment for many inflammatory, autoimmune, allergic, or hyperproliferative dermatological conditions. Betamethasone dipropionate is a potent glucocorticosteroid receptor agonist, classified as class III according to the World Health Organization (WHO) classification. Salicylic acid has keratolytic and anti-inflammatory properties and stimulates the regeneration process. Exfoliation of keratinocytes from areas affected by hyperkeratosis with the help of salicylic acid promotes the penetration of active substances deep into the skin, directly to the sites of disease. The application of a combination preparation containing both betamethasone dipropionate and salicylic acid increases the effectiveness of pharmacotherapy for many inflammatory dermatoses, with particular emphasis on dermatological conditions with hyperproliferation
Meta-analysis of the efficacy and safety of vaginal natural orifice transluminal endoscopic surgery, laparoscopy, and robot-assisted laparoscopic myomectomy for uterine fibroid removal
No full textObjectives: This study aims to explore the efficacy and safety of vaginal natural orifice transluminal endoscopic surgery(vNOTES), laparoscopy, and robot-assisted laparoscopic myomectomy (RALM) for uterine fibroid removal.Material and methods: Computer searches were conducted in the Cochrane Library, Embase, Web of Science, PubMed,China National Knowledge Infrastructure (CNKI), China Biology Medicine disc (CBM), Wanfang Database, and otherdatabases until May 2023. Randomized controlled trials, cohort studies, case-control studies, and other relevant stu-dies comparing the safety and efficacy of vNOTES, laparoscopy, and RALM for uterine fibroid treatment were included.Results: A total of 28 studies involving 3247 subjects were included. Fifteen studies compared laparoscopy and RALM,thirteen studies compared laparoscopy and vNOTES, and there were no direct comparisons between RALM and vNOTES.In terms of surgical time, vNOTES had significantly shorter surgical time than laparoscopy (MD = 29, 95% CI: 0.89–47) andRALM (MD = 60, 95% CI: 30–90). RALM had significantly shorter surgical time than laparoscopy (MD = –33, 95% CI: –56, –9).There was no significant difference in intraoperative blood loss among the three treatment methods. Regarding hospitalstay, vNOTES had a significantly shorter duration than laparoscopy (MD = 0.59, 95% CI: 0.32–0.89) and RALM (MD = 0.51,95% CI: 0.027–1.00). Laparoscopy had a significantly higher laparotomy rate than vNOTES (OR = 0.27, 95% CI: 0.64–8.4).The rate of postoperative complications was significantly higher in laparoscopy compared to vNOTES (OR = 0.54, 95%CI: 0.23–1.0) and RALM (OR = 0.39, 95% CI: 0.17–0.92).Conclusions: In patients with uterine fibroids, vNOTES demonstrated significantly shorter surgical time, shorter hospitalstay, lower laparotomy rate, and lower rate of postoperative complications compared to laparoscopy. However, vNOTESdid not show significant advantages over RALM, except for shorter surgical time
Rare case reports of immunological fetal hydrops and severe fetal anemia due to maternal sensitization with both anti-D and anti-C antibodies necessitating fetal intrauterine treatment
No full textRekomendacje Polskiego Towarzystwa Ginekologów i Położników oraz Polskiego Towarzystwa Neonatologicznego dotyczące kortykosteroidoterapii prenatalnej
No full textWpływ stosowania tirzepatydu na ciśnienie tętnicze krwi u pacjentów spożywających duże ilości soli
No full textCritical assessment of microscopy methods for detecting single- and double-strand DNA breaks
No full textA laboratory toolbox for detecting and quantifying DNA breaks in animal cells and tissues includes various methods that employ biochemical tests, DNA sequencing, or imaging approaches. Various methods based on microscopy were developed to detect DNA breaks in fixed and live cells, including the nick translation assay, TUNEL, STRIDE, and detection methods based on imaging of histone modifications (γH2A.X), recruitment of repair factors (XRCC1, PCNA, 53BP1, Rad51) or poly-ADP-ribosylation. This review discusses the advantages and limitations of various microscopy-based methods for the detection and quantification of single- and double-strand DNA breaks