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Extra-gastrointestinal stromal tumor of the prostate — a case report and literature review
No full textExtra-gastrointestinal stromal tumors (EGISTs) primarily originate outside the gastrointestinal tract and are not associated with the walls of the stomach or intestines. They typically arise from the omentum, mesentery, peritoneum, retroperitoneum, and genitourinary regions. However, EGISTs originating from the prostate are exceedingly rare. Herein, a case is presented of an EGIST arising from prostatic tissue. The patient underwent radical prostatectomy. Histopathological examination revealed spindle-shaped tumor cells. Immunohistochemical analysis demonstrated positive expression of CD117, DOG-1, and CD34, leading to the diagnosis of a gastrointestinal stromal tumor (GIST). Radiologic staging showed no evidence of residual disease or metastasis; however, due to the high-risk nature of the tumor, adjuvant imatinib therapy was initiated. No recurrence or metastasis was observed during a one-year follow-up period, and the patient continues to be monitored regularly. This article also provides a comprehensive review of the clinical characteristics, histopathology, and treatment of EGIST cases reported in the literature
Ruptured mycotic coronary aneurysm after percutaneous coronary intervention, presenting as pericarditis and cardiac tamponade
No full textMethodological rigor in AI-based angiographic analysis: A commentary on “Comparative evaluation of a convolutional neural network and interventional cardiologists in the diagnosis of significant stenosis of coronary arteries”
No full textClinical and biochemical predictors of large for gestational age during pregnancy in women with type 1 diabetes mellitus — current insight
No full textObjectives: Large for gestational age (LGA) is defined as a birth weight equal to or higher than the 90th centile for a certain gestational age. Despite the efforts to optimize therapeutic goals to stabilize diabetes, there is still a high rate of LGA in type 1 diabetes mellitus (T1DM) mothers. The aim of this paper is a literature review of the data on predictors of LGA incidence in pregnancies complicated by type 1 diabetes mellitus.
Results: Potential LGA predictors in pregestational diabetes include glucose concentration during pregnancy, maternal age, diabetes duration, increased body weight both at the beginning of gestation and at the time of delivery, as well as the weight gain in pregnancy. LGA risk is also associated with the use of an insulin pump (CSII), especially without the support of a continuous glucose monitoring system (CGMS). Significant glycaemic control parameters among others include average fasting glycaemia in the 3rd trimester, HbA1c in the 1st and 3rd trimesters, and among CGMS parameters — shorter TIR (time in range), shorter TBR (time below range) in the 2nd and 3rd trimesters, longer TAR (time above range) > 140 and average glycaemia in each trimester of gestation.
Conclusions: There is still a need for identification of new predictors and theraputic goals in pregnancy in T1DM women to reduce the prevalence of LGA newborns
Von Hippel-Lindau syndrome from the urologist and oncologist perspective — literature review
Full text linkVon Hippel-Lindau (VHL) syndrome is a rare genetic disorder characterized by multiple retinal and cerebellar hemangioblastomas that tend to occur in a familial setting. The pattern of inheritance is autosomal dominant. Patients with VHL syndrome have an increased risk of clear cell renal cell carcinoma (ccRCC) as well as pancreatic and testicular cysts and cystadenomas. Tumors associated with VHL syndrome manifest at a young age.
This article presents diagnostic methods and discusses the treatment approaches for this syndrome based on a global literature review
Advances in oncology after the 2024 European Society for Medical Oncology (ESMO) congress
Full text linkThe European Society of Medical Oncology (ESMO) Congress is the most important and clinically relevant oncological conference in Europe. It provides a forum to share the latest advances in cancer research, diagnostics, and treatment. In this review, we present the most significant new data on cancer treatment, which may change future oncological and patient outcomes
Zakrzepica związana z przeciwciałami przeciwko czynnikowi płytkowemu 4. Nie tylko małopłytkowość poheparynowa
No full textPrzeciwciała skierowane przeciwko czynnikowi płytkowemu 4 (PF4, platelet factor 4) zostały opisane po raz pierwszy w kontekście małopłytkowości pohemarynowej w latach 80. XX wieku. W ciągu ostatnich kilku lat opisano podobne rzadkie zespoły małopłytkowości z towarzyszącą tendencją do zakrzepicy, będące wynikiem tworzenia autoprzeciwciał przeciwko PF4 po zastosowaniu wektorowych szczepionek przeciwko COVID-19, a także w przebiegu niektórych przypadków monoklonalnej gammapatii. Autoprzeciwciała skierowane przeciwko PF4 odpowiadają za stan prozakrzepowy związany z nadmierną aktywacją płytek krwi
Co-occurrence of melanoma and breast cancer – a case report.
No full textW ciągu ostatnich kilku dekad obserwuje się wzrost liczby zachorowań zarówno na czerniaka, jak i raka piersi, co jest wynikiem zmieniającego się stylu życia. Opisany przypadek, gdzie oba nowotwory występują jednocześnie, może dać cenne wskazówki postępowania oraz ułatwić praktykę kliniczną.Over the past few decades, melanoma and breast cancer increased in its occurrence, due to changing lifestyles. The described case, where both cancers occur simultaneously, may provide valuable guidance and facilitate clinical practice