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HERMITE–HADAMARD TYPE INEQUALITIES FOR INTERVAL-VALUED COORDINATED LR-CONVEXITY VIA GENERALIZED FRACTIONAL INTEGRALS
Full text linkWe first obtain some new Hermite–Hadamard-type inequalities for interval-valued LR-convex functions. Afterwards, we investigate Hermite–Hadamard-type inequalities for interval-valued coordinated LRconvex functions. New results are obtained by making special choices in newly established inequalities in the case of interval-valued LR-convex functions and interval-valued coordinated LR-convex functions. It is also shown that the newly established inequalities are extensions of comparable results in the literature. © 2025 Elsevier B.V., All rights reserved
Alien species of Ipomoea in Greece, Türkiye and Iran: distribution, impacts and management
Full text linkNew introductions of alien Ipomoea species and their negative impacts have increased in Greece, T & uuml;rkiye, and Iran. However, little is known about their current status, distribution, impacts, and management. Here, we provide a detailed overview of Ipomoea species in these countries and discuss the current and proposed management options for restoring invaded plant communities. We report on four alien Ipomoea species in Greece (three naturalized and one casual), 10 in T & uuml;rkiye (eight naturalized and two casual), and 11 in Iran (eight naturalized of which two are invasive and three casual). Their most significant negative impact was detected in agricultural areas, especially in spring crops like soybean, cotton, and maize, with I. hederacea, I. purpurea, and I. triloba being the most troublesome weeds. Native plants are mainly threatened by I. indica, I. leucantha, and I. triloba. The management of Ipomoea species differs according to the habitats invaded; in agricultural areas, the management is more dependent on the host crop and the available registered herbicides, whereas in areas with natural habitats, other management options such as mechanical and biological measures are more appropriate. The information from this work will be useful for the early detection of Ipomoea species in countries neighboring the already invaded ones.Gorgan University of Agricultural Sciences and Natural Resources (GUASNR), Iran [01-474-15]Czech Science Foundation [19-28807X]Czech Academy of Sciences [RVO 67985939]Gorgan University of Agricultural Sciences and Natural Resources (GUASNR) , Iran supported this research (project no. 01-474-15) . PP and AK were supported by EXPRO grant no. 19-28807X (Czech Science Foundation) and by the long-term research development project RVO 67985939 (Czech Academy of Sciences)
College graduates’ foreign language needs in employment
Full text linkEnglish, as a lingua franca, is the common language of science, education, industry, business, and many other fields, and has become a prominent research interest. In Türkiye, English is taught as a foreign language, including K12 and tertiary levels to prepare individuals for international work life. However, the English First English Proficiency Index (2023) ranks show that Türkiye is the 33rd with ―low proficiency‖ among 34 European countries, which suggests questioning the efficiency of English language teaching, and the degree to which the needs of the graduates could be met. Therefore, this qualitative research, within a research project conducted at a Turkish state university, has been designed to obtain data from college graduate employees regarding their English needs at the workplace. Firstly, people working in the industry and commerce sectors in Düzce were asked to fill out a 16-item open-ended questionnaire, and 48 of them responded. 6 of them were interviewed to triangulate the data. The questions focused on the use of language skills and the role of English proficiency in business life. Research findings revealed that employees use their writing skills mainly to write e-mails and reports, their reading skills to read e-mails, software program messages and instructions, and their listening and speaking skills to participate and present in multinational meetings and negotiate with foreign clients. Being a proficient English user is reported to be important in employment and being promoted in work life. The study is expected to contribute to identifying the English language needs at the workplace in Türkiye and suggestions for further research. © 2025 Elsevier B.V., All rights reserved
Salicylic acid priming before cadmium exposure increases wheat growth but does not uniformly reverse cadmium effects on membrane glycerolipids
Full text linkCadmium (Cd) is an abiotic stressor negatively affecting plant growth and reducing crop productivity. The effects of Cd (25 mu M) and of pre-soaking seeds with salicylic acid (SA) (500 mu M) on morphological, physiological, and glycerolipid changes in two cultivars of wheat (Triticum aestivum L. 'Tosunbey' and 'Cumhuriyet') were explored. Parameters measured were length, fresh and dry biomass, Cd concentration, osmotic potential (psi), lipid peroxidation, and polar lipid species in roots and leaves, as well as leaf chlorophyll a, carotenoids, and fv/fm. Fresh biomass of roots and leaves and leaf length were strongly depressed by Cd treatment compared to the control, but significantly increased with SA + Cd compared to Cd alone. Cd reduced leaf levels of chlorophyll a, carotenoids, and fv/fm, compared to controls. Treatment with SA + Cd increased pigment levels and fv/fm compared to Cd alone. Cd treatment led to a decrease in DW of total membrane lipids in leaves and depressed levels of monogalactosyldiacylglycerol and phosphatidic acid in leaves and roots of both cultivars. The effects of SA priming and SA + Cd treatment on lipid content and composition were cultivar-specific, suggesting that lipid metabolism may not be a primary target underlying SA remediation of the damaging effects of Cd on wheat growth and development.National Science Foundation (the Major Research Instrumentation program) [10427]Research Fund of Karadeniz Technical University in TurkeyNational Science Foundation [DBI-1726527]Major Research Instrumentation program [P20GM103418]Kansas-IDeA Networks of Biomedical Research Excellence (INBRE) of National Institutes of Health [7001195]USDA National Institute of Food and Agriculture (Hatch/Multi-State project)Kansas State UniversityThe support of the Research Fund of Karadeniz Technical University in Turkey (Project Number 10427) is greatly appreciated. The lipid analyses described in this work were performed at the Kansas Lipidomics Research Center Analytical Laboratory. Instrument acquisition and lipidomics method development were supported by the National Science Foundation (including support from the Major Research Instrumentation program; most recent award DBI-1726527), Kansas-IDeA Networks of Biomedical Research Excellence (INBRE) of National Institutes of Health (P20GM103418), USDA National Institute of Food and Agriculture (Hatch/Multi-State project 7001195), and Kansas State University
Manufacture and characterisation of sustainable biocomposites reinforced with waste walnut shell powder
Full text linkAgricultural production brings along huge amounts of agro-industrial waste, result in environmental problems such as storage and disposal. Today, it is crucial to use waste as a source of raw materials in order to reduce environmental pollution, promote a circular economy, and support sustainable waste management. Biocomposite materials are one of the important approaches to sustainable waste management. Natural fibre reinforcements have been attracted attention in the development of biocomposites due to their biodegradability and renewability. In the study, waste walnut shells were ground in the range of -154/+77 mu m so they were used as a reinforcing element. The micro powders were mixed with bio-resin at different rates (2%, 4%, 6%, 8%) to produce a biocomposite material. Tensile, three-point bending, izod impact and hardness tests were run to determine the mechanical properties of the biocomposite materials. Moreover, water absorption test, thermogravimetric analysis (TGA), differential thermal analysis (DTA) and SEM analysis were performed on the biocomposite samples. The highest tensile strength was obtained in biocomposite materials produced by adding 2% waste walnut shell powder. When the modulus of elasticity of all biocomposites was compared with the base material (BM), increases of approximately 100% were determined. As rate of the reinforcing element increased in biocomposite materials, micro powders agglomerated in the matrix.Dzce University Research Fund [2022.11.01.1369]This study was funded by Duezce University Research Fund. Project Number: 2022.11.01.1369
Retrospective Examination of the PECARN Algorithm in Pediatric Patients with Minor Head Trauma
Full text linkObjective: We aimed to retrospectively evaluate and examine pediatric head trauma cases according to PECARN in the light of their neurological and clinical conditions. We wanted to contribute to the detection of TBI with minimum CT imaging rates in order to avoid radiation-related carcinogenesis. Method: 108 pediatric patients who were admitted to the emergency department due to minor head trauma and were admitted to the neurosurgery clinic were evaluated retrospectively. Results: During follow-up, 9 patients required intensive care and 5 patients underwent neurosurgical surgery. The most common trauma etiology was falling from one's own level with 53.7%. The most common tomography pathology was non-displaced fracture. According to the evaluations made in accordance with the PECARN algorithm, CT was recommended in 18 cases (16.7%); CT was not recommended for 32 cases. Conclusions: The clinician's goal is to quickly and accurately diagnose clinically significant TBI while avoiding unnecessary CT imaging to protect against the adverse effects of radiation. We recommend using the PECARN algorithm for this purpose
Endoluminal radiofrequency ablation with stenting versus stenting alone in patients with malignant biliary obstruction: a meta-analysis of randomized trials
Full text linkBackground: Endoluminal radiofrequency ablation (RFA) is a palliative treatment for patients suffering from malignant biliary obstruction (MBO). We aimed to conduct a meta-analysis to evaluate the impact of RFA on stent patency, patient survival, and adverse events. Methods: Major databases were searched through December 2023 for patients who had undergone stenting with or without RFA for extrahepatic MBO. A random-effects model was used for analysis, with results expressed as relative risk ratios (RRs) with 95%CIs. Results: Nine RCTs involving 750 subjects with MBO (374 RFA plus stent vs. 376 stent only) were included. Meta-analysis revealed similar risks of stent patency at 3 months (RR 1.01, 95%CI 0.92-1.11; I (2) = 4%) for RFA plus stenting vs. stent only. Meta-analysis showed improved survival at 6 months (RR 0.84, 95%CI 0.73-0.96; I (2) = 21%; P = 0.01) for RFA plus stenting vs. stent only. Subgroup analysis comparing plastic vs. uncovered metal stents showed that stent patency was unaffected at 3 months (RR 1.06, 95%CI 0.91-1.23; I (2) = 17%). Subgroup analysis showed that patients with cholangiocarcinoma experienced an overall survival benefit with RFA plus stenting vs. stenting alone (P < 0.001); however, stent patency remained unaffected (P = 0.08). An increased incidence of cholecystitis was noted with RFA plus stenting vs. stenting alone (5.1% [95%CI 3.1%-7.8%] vs. 0.3% [95%CI 0.01%-1.5%], respectively). Conclusion: Combining endoluminal RFA and stenting may improve overall survival in patients with MBO. RFA did not significantly impact stent patency
A retrospective analysis of adverse events in multiple myeloma patients receiving lenalidomide based therapy
Full text linkÇalışmanın amacı, lenalidomid bazlı tedavi almakta olan Multiple Myelom hastalarında gelişen ve lenalidomid ile ilişkilendirilmiş yan etkileri detaylı bir şekilde incelemektir. Bu retrospektif çalışma, 1 Ocak 2014-31 Aralık 2024 tarihleri arasında hastanemiz hematoloji polikliniğinde takip edilmiş olan ve lenalidomid bazlı tedavi rejimleri almış olan MM hastaları üzerinde gerçekleştirilmiştir. Çalışmaya toplam 75 hasta dahil edilmiştir. Hastaların yaş, cinsiyet, performans durumu, miyelom tipi, hastalık evresi, kemik tutulumu ve plazmositom varlığı, başvuru anındaki laboratuvar verileri, hastaların aldığı tedaviler, OKİT (otolog kök hücre nakli) yapılıp yapılmadığı, yapılamayan hastalarda yapılamama nedenleri, lenalidomid idame ve maruziyet süreleri, lenalidomid tedavisine bağlı gelişen yan etkiler, tedavi sırasında doz azaltma gerekip gerekmediği, doz azaltma nedenleri, lenalidomid tedavisinin kesilmesi gerektiği durumlarda kesilme nedenleri değerlendirilmiştir. Çalışma kapsamında lenalidomid + deksametazon (LenDex), bortezomib + lenalidomid + deksametazon (VRd), karfilzomib + lenalidomid + deksametazon (KRd), daratumumab + lenalidomid + deksametazon (DRd), iksazomib + lenalidomid + deksametazon (İxaLenDex), lenalidomid + siklofosfamid + deksametazon (RCD) ve idame lenalidomid tedavileri sırasında gelişen ve litaratürde lenalidomid ile ilişkilendirilmiş hematolojik, gastrointestinal, dermatolojik, nörolojik, tromboembolik ve sekonder malignite olan yan etkilerin gelişimi değerlendirilmiştir. Çalışmamız sonucunda hastaların epidemiyolojik ve demografik verileri, lenalidomid ilişkili yan etkilerin gelişme sıklığı literatürle uyumlu saptanmıştır. Lenalidomid içeren farklı tedavi rejimlerinde gelişen yan etkiler birbirleriyle kıyaslanmış olup gelişen enfeksiyonlar dışında rejimler arası anlamlı bir fark saptanmadı. Söz konusu yan etkilerin lenalidomid dozunun düşürülmesine veya tedavinin kesilmesine yol açabileceği saptandı.The aim of this study is to comprehensively investigate the adverse effects associated with lenalidomide in patients with multiple myeloma (MM) receiving lenalidomide-based treatment regimens. This retrospective study was conducted on MM patients who were treated in the hematology outpatient clinic of our hospital between January 1, 2014, and December 31, 2024, and who received lenalidomide-based therapies. A total of 75 patients were included in the study. Collected data included patients' age, sex, performance status, type of myeloma, disease stage, presence of bone involvement and plasmacytoma, laboratory parameters at diagnosis, treatment regimens received, whether autologous stem cell transplantation (ASCT) was performed, reasons for not undergoing ASCT in non-eligible patients, duration of lenalidomide maintenance and total exposure, adverse effects associated with lenalidomide therapy, need for dose modification during treatment, reasons for dose modification or treatment termination evaluated. Within the scope of the study, adverse effects that developed during treatment with lenalidomide + dexamethasone (LenDex), bortezomib + lenalidomide + dexamethasone (VRd), carfilzomib + lenalidomide + dexamethasone (KRd), daratumumab + lenalidomide + dexamethasone (DRd), ixazomib + lenalidomide + dexamethasone (IxaLenDex), lenalidomide + cyclophosphamide + dexamethasone (RCD), and lenalidomide maintenance were evaluated. Specifically, hematological, gastrointestinal, dermatological, neurological, thromboembolic adverse effects and secondary malignancies previously reported in the literature to be associated with lenalidomide were assessed. The epidemiological and demographic characteristics of the patients, as well as the incidence of lenalidomide associated adverse events, were found to be consistent with data reported in the literature. No statistically significant differences were observed in the adverse event profiles, except enfections among different lenalidomide based treatment regimens. However, the observed adverse effects were determined to potentially necessitate dose reductions or termination of lenalidomide therapy
Modeling the potential distribution areas of castanea sativa mill. within the boundaries of the bolu regional directorate of forestry based on climate variables
Full text linkCastanea sativa Bu çalışma, Türkiye'nin kuzeybatısında yer alan Bolu Orman Bölge Müdürlüğü sınırlarında, iklim değişikliğinin Castanea sativa (kestane) türünün habitat uygunluğu üzerindeki potansiyel etkilerini değerlendirmeyi amaçlamaktadır. Tür dağılım modellemesinde MaxEnt algoritması kullanılmış olup, 2050, 2070 ve 2090 yılları için Orta Yol (SSP2-4.5) ve Yüksek Emisyon (SSP5-8.5) senaryoları temel alınmıştır. Biyoklimatik ve topografik çevresel değişkenler, çoklu doğrusallığı en aza indirmek amacıyla korelasyon analizi ve ekolojik anlamlılık kriterlerine göre seçilmiştir. Modelin doğruluk değerlendirmesi, eğitim verileri için 0,961 ve test verileri için 0,959 AUC (Area Under Curve) değerleriyle yüksek bir performans sergilemiştir. Model çıktıları, Castanea sativa dağılımı üzerinde en belirleyici çevresel değişkenin %42,2 katkı oranıyla en kurak çeyrek dönemin yağışı (Bio17) olduğunu; bunu sırasıyla yağış mevsimselliği (Bio15, %27,6) ve sıcaklık mevsimselliği (Bio4, %15,7) değişkenlerinin izlediğini ortaya koymaktadır. SSP5-8.5 senaryosuna göre, tür için uygun olmayan alanların 2050 yılı itibarıyla 907.585,92 hektardan 910.104,16 hektara, 2070'te 911.058,07 hektara ve 2090'da 909.943,00 hektara yükseleceği öngörülmektedir. Yüksek uygunluklu habitatların ise 310,92 hektardan 266,47 hektara düşerek nispeten sabit bir seyir izlediği belirlenmiştir. Öte yandan, SSP2-4.5 senaryosu altında yüksek uygunluklu alanlarda daha belirgin bir daralma yaşanacağı ve bu alanların 2090 yılına kadar 133,26 hektara kadar gerileyeceği öngörülmektedir. Bu senaryo kapsamında uygun olmayan alanların genişliği 912.802,41 hektara ulaşırken, orta düzey uygunluk gösteren habitatlarda 34.584,00 hektardan 36.261,46 hektara kadar bir artış söz konusu olup geçiş zonlarının önemine işaret etmektedir. Yükseklik dağılımı açısından değerlendirildiğinde, Castanea sativa bireylerinin büyük oranda 1000 metrenin altındaki rakımlarda bulunduğu, ayrıca mevcut uygun habitatların %20,2'sinin 0–100 metre aralığında yer aldığı tespit edilmiştir. Gelecek senaryoları altında türün daha düşük rakımlara doğru yayılım göstereceği ve özellikle SSP5-8.5 senaryosu kapsamında yüksek uygunluklu alanların alt rakımlarda yoğunlaşacağı öngörülmektedir. Elde edilen bulgular, Castanea sativa türü başta olmak üzere benzer ekolojik gereksinimlere sahip türlerin sürdürülebilirliği açısından, iklim değişikliğine uyumlu ormancılık uygulamaları ve etkin koruma stratejilerinin geliştirilmesinin kritik önem taşıdığını ortaya koymaktadır.This study aims to assess the potential impacts of climate change on habitat suitability of Castanea sativa (chestnut) species in Bolu Regional Directorate of Forestry in northwestern Turkey. The MaxEnt algorithm was used for species distribution modeling, based on the Medium Pathway (SSP2-4.5) and High Emission (SSP5-8.5) scenarios for the years 2050, 2070 and 2090. Bioclimatic and topographic environmental variables were selected based on correlation analysis and ecological significance criteria to minimize multicollinearity. The accuracy assessment of the model showed a high performance with AUC (Area Under Curve) values of 0.961 for training data and 0.959 for test data. The model outputs reveal that the most determinant environmental variable on Castanea sativa distribution is the precipitation of the driest quarter (Bio17) with a contribution of 42.2%, followed by rainfall seasonality (Bio15, 27.6%) and temperature seasonality (Bio4, 15.7%). According to the SSP5-8.5 scenario, unsuitable areas for the species are projected to increase from 907,585.92 hectares to 910,104.16 hectares by 2050, 911,058.07 hectares by 2070 and 909,943.00 hectares by 2090. High suitability habitats, on the other hand, have followed a relatively stable course, decreasing from 310.92 hectares to 266.47 hectares. On the other hand, under the SSP2-4.5 scenario, there will be a more significant shrinkage in high suitability areas and these areas are projected to decrease to 133.26 hectares by 2090. Under this scenario, the extent of unsuitable areas reaches 912,802.41 hectares, while habitats of medium suitability increase from 34,584.00 to 36,261.46 hectares, indicating the importance of transition zones. In terms of elevation distribution, Castanea sativa individuals are mostly found at altitudes below 1000 meters, and 20.2% of the available suitable habitats are located between 0-100 meters. Under future scenarios, it is predicted that the species will spread to lower altitudes and especially under the SSP5-8.5 scenario, high suitability areas will be concentrated at lower elevations. The findings reveal that the development of climate change compatible forestry practices and effective conservation strategies are critical for the sustainability of species with similar ecological requirements, especially Castanea sativa species
Assessment of clean production approaches in the textile sector through indoor environmental quality and lighting systems
Full text linkEndüstriyel işletmeler üretim süreçlerinde, üretilen ürünlerin kalitesi, verimliliği ve niceliği konuları üzerinde durmaktadırlar. Üretim süreçlerinde çalışanların farklı motivasyon kaynakları olsa da işin verimliliği açısından göz önünde bulundurulması gereken önemli bir konuda endüstriyel firmaların üretim yaptıkları iç ortam kalitesinin çalışanlar açısından değerlendirilmesidir. İç ortam durumu, iç ortam hava kalitesi, iç ortamdaki gürültü kirliliği ve iç ortam aydınlatma etkinliği gibi parametreler ile değerlendirilmektedir. Literatürde çeşitli endüstriyel firmalar için iç ortam durumunun belirlendiği parametrelerin ayrı ayrı incelendiği çalışmalar bulunmaktadır. Ancak, iç ortam durumunun bütünsel olarak incelendiği çalışmaların kısıtlı olduğu görülmüştür. Bu tez çalışmasında da tekstil ürün üretimi yapan bir firmanın iç ortam hava kalitesi CO2 parametresi olarak, iç ortam gürültü kirliliği dB olarak, iç ortam aydınlatma etkinliği ise Iux olarak tespit edilmiştir. Çalışmada ayrıca, Python yazılımı kullanılarak işletmenin söz konusu parametreleri için haritalama yapılmış ve elde edilen veriler Ülkemizde yayınlanmış olan yönetmelikler ve dünyadaki asgari limitler kapsamında değerlendirilmiştir. İncelenen firmada üretim sahası toplam 10 bölgeye bölünmüştür. Bu bölgelerde en yoğun CO2 kirliliğinin, gürültü kirliliğinin ve aydınlatma etkinliğinin oluştuğu dikimhane ve yemekhane bölgesinde ilgili yönetmelikler ve genel asgari limitler açısından herhangi olumsuz durumun olmadığı tespit edilmiştir. Özellikle, aydınlatma etkinliğinin belirlendiği çalışma için firmanın çatısına yenilenebilir enerji kaynağı olan güneş panelleri yapılması durumunda elde edilecek olan enerji teorik olarak belirlenmiş ve aydınlatma verimliliğine etkisi çevresel sürdürülebilirlik parametresi olan temiz üretim çalışması olarak önerilmiştir. Ayrıca, aydınlatma etkinliğinin işletmelerde kolaylıkla tespit edilebilmesi için bir yazılım geliştirilmiştir.In industrial enterprises, production processes primarily focus on product quality, productivity, and quantity. Although employees in production environments may be driven by different motivational factors, an important issue that should be considered in terms of operational efficiency is the evaluation of the indoor environmental quality of the production areas from the perspective of the workers. Indoor environmental conditions are assessed based on parameters such as indoor air quality, noise pollution, and lighting efficiency. In the literature, various studies have examined these parameters individually for different industrial firms. However, studies that investigate indoor environmental conditions in a holistic manner appear to be limited. In this thesis study, the indoor air quality of a textile manufacturing company was assessed using CO₂ concentration as the key parameter, indoor noise pollution was measured in decibels (dB), and indoor lighting efficiency was evaluated in lux (lx). In addition, mapping of these parameters within the production area was performed using Python software. The obtained data were then evaluated according to national regulations published in Türkiye and minimum international standards. The production area of the studied firm was divided into ten zones. It was determined that the zones with the highest concentrations of CO₂, noise pollution, and lighting levels were the sewing workshop and cafeteria. However, no negative conditions were identified in these areas with respect to the relevant regulations and general minimum standards. Specifically, regarding the assessment of lighting efficiency, the theoretical amount of energy that could be generated by installing solar panels—a renewable energy source—on the company's roof was calculated, and its potential contribution to lighting efficiency was proposed as a clean production strategy, contributing to environmental sustainability. Moreover, a dedicated software tool was developed to facilitate the easy determination of lighting efficiency within industrial facilities