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Genomic medicine, precision medicine, and personalized medicine: A survey of Turkish physicians’ perspectives on new paradigms in medicine
Full text linkAdvances in medicine and new approaches are transforming health services. How these new approaches affect clinicians' decision-making is still unclear. This research aimed to evaluate the reflections of the concepts of personalized, genomic and precision medicine, which are new approaches in medicine, among physicians, and to discuss these practices together with their theoretical, practical and moral dimensions. In this study, a questionnaire was used to question the theoretical, practical utility and necessity, and moral perspectives of clinicians about the applications of genomic medicine, precision medicine, and personalized medicine. The questionnaire also questioned the clinical decision-making processes of these clinicians. In the study, 58.7 (n=186) of the physicians participating in the study thought that planning treatment according to genetic medicine would solve many problems and that the medicine of the future would advance in this direction. In the study, 49.5% (n=157) of the physicians participating in the study stated that there is no objection to genomic and precision medicine applications. It has been stated that 39.1% (n=124) of the physicians have concerns that a new area of exploitation may occur in the medical profession. On the other hand, 20.1% (n= 64) of the physicians stated that such practices would distract the medical profession from evidence-based practices. On the other hand, 68.5% (n=217) of the physicians stated that they wanted to receive training on personalized, genomic and precision medicine. The results of the study show that although clinicians think that genomic and precision medicine applications are the medicine of the future, the majority of them have reservations. Before these applications become widespread in all medical fields, their theoretical, practical and moral frameworks should be established
Optimization of the jar testing process with the internetof things and machine learning
Full text linkDünya yüzeyinin %71'i suyla kaplı olmasına rağmen, bunun yalnızca %2,5'i tatlı sudur. Dünya sağlık örgütü'nün verilerine göre, yaklaşık 844 milyon insan güvenilir içme suyu kaynağına erişememekte, 159 milyon insan ise yüzey sularını kullanmaktadır. Bu durum, içme suyu kalitesinin sürekli izlenmesini ve iyileştirilmesini zorunlu kılmaktadır. İçme suyu kalitesinin değerlendirilmesinde su kalite indeksi yaygın olarak kullanılmakta olup, çeşitli fiziksel ve kimyasal parametrelerin ölçümüne dayanmaktadır. Bu çalışmada, Türkiye'nin Zonguldak ili Ereğli ilçesindeki içme suyu arıtma tesisi örnek alınarak, klasik jar testi sürecinin dijitalleştirilmesi ve optimize edilmesi hedeflenmiştir. Geliştirilen sistem; iot, fog bilişim ve bulut tabanlı makine öğrenmesi altyapılarıyla entegre bir şekilde tasarlanmıştır. IoT katmanında kullanılan sensörler ile giriş suyuna ait bulanıklık, ph, tds, sıcaklık, su seviyesi ve yağmur durumu gibi parametreler 5 dakikalık aralıklarla ölçülmüş ve mqtt protokolü ile nodemcu esp8266 üzerinden raspberry pi cihazına iletilmiştir. Raspberry pi üzerinde çalışan nodered uygulaması ile veriler influxdb bulut veritabanına kaydedilmiş, aynı zamanda grafana arayüzüyle görselleştirilmiştir. Bu yapı sayesinde sistemin uzaktan izlenebilirliği artırılmış, müdahale süreleri azaltılarak operasyonel güvenlik sağlanmıştır. Laboratuvar ortamında yapılan jar testleri, web tabanlı bir arayüz ile dijital ortama aktarılmış ve bu veriler makine öğrenmesi algoritmalarıyla analiz edilmiştir. Özellikle destek vektör regresyonu algoritması, 502 örnek üzerinde yapılan testlerde en yüksek performansı göstermiştir (MAE: 0.29, MAPE: 0.11, MSE: 0.16, RMSE: 0.40, R²: 0.61). Modelin yalnızca 1.27 saniyede sonuç üretmesi, gerçek zamanlı tahmin uygulamaları için yeterli olduğunu göstermektedir. Web tabanlı kullanıcı arayüzü sayesinde operatörler, giriş parametrelerini girerek çıkış bulanıklığını anlık olarak görebilmekte; ayrıca sistemde yer alan "eğitimi başlat" modülüyle model yeni verilerle otomatik olarak güncellenebilmektedir.Although 71% of the Earth's surface is covered by water, only 2.5% of it is freshwater. According to the World Health Organization, approximately 844 million people do not have access to a safe drinking water source, while 159 million people use surface water. This situation necessitates continuous monitoring and improvement of drinking water quality. The water quality index is widely used in the assessment of drinking water quality and is based on the measurement of various physical and chemical parameters. In this study, taking the drinking water treatment plant in Ereğli district of Zonguldak province of Turkey as an example, it is aimed to digitize and optimize the classical jar testing process. The system is designed to be integrated with iot, fog computing and cloud-based machine learning infrastructures. With the sensors used in the iot layer, parameters such as turbidity, ph, tds, temperature, water level and rainfall status of the inlet water were measured at 5-minute intervals and transmitted to the raspberry pi device via nodemcu esp8266 via mqtt protocol. With the nodered application running on the raspberry pi, the data was saved to the influxdb cloud database and visualized with the grafana interface. Thanks to this structure, the remote traceability of the system has been increased, intervention times have been reduced and operational security has been ensured. The jar tests performed in the laboratory environment were digitized with a web-based interface and these data were analyzed with machine learning algorithms. In particular, the support vector regression algorithm showed the highest performance in tests on 502 samples (MAE: 0.29, MAPE: 0.11, MSE: 0.16, RMSE: 0.40, R²: 0.61). The fact that the model produces results in only 1.27 seconds shows that it is sufficient for real-time forecasting applications. The web-based user interface allows operators to enter input parameters and see the output turbidity instantly, and the "start training" module in the system allows the model to be updated automatically with new data
PROPERTIES OF TITANIUM DIOXIDE SUBSTITUTED TRANSLUCENT CEMENT MORTARS
Full text linkYarı saydam beton, ışık geçirgenliğini sağlamak amacıyla, özel olarak yerleştirilen optik lifler ile güçlendirilmiş, geleneksel betonun opak doğasını kırarak ışığın belirli bir oranda yapı elemanları boyunca iletilmesine olanak sağlayan özel bir beton türüdür. TiO2 ise havayı ve betonu temizleyen, yüksek fotokatalitik aktiviteye sahip, zayıf güneş ışığı altında etkili iyi bir fotokatalizördür. Bu çalışmada, %3 oranında TiO2 çimento ikamesi ile yüzey hacminin %0 (Referans), %9, %20 ve %36 oranlarında optik fiber ilaveleri kullanılarak yarı saydam çimento harç numuneleri üretilmiştir. Üretilen numuneler üzerinde taze harç deneylerinden; kıvam tayini deneyi, priz süresi tayini ve yayılma tablası deneyi ile sertleşmiş harç deneylerinden; kuru birim ağırlık deneyi, su emme deneyi, basınç dayanımı deneyi, ışık geçirgenliği deneyi ve kendi kendini temizleme deneyi (Rhodamine-B deneyi) ile birlikte SEM (scanning electron microscope) – EDS analizleri yapılmıştır. Çalışmanın sonucunda; referans numune ile karşılaştırıldığında yüzey hacimce %9, %20, %36 oranlarında optik fiber ve %3 oranında TiO2 ikameli çimento harç numunelerinde basınç dayanımının %12.99-%23.05 oranlarında arttığı tespit edilmiştir. Optik fiber ilavesinin numunelerde 3.14lux-32.04lux aralığında ışık geçirimi ve %3 oranında TiO2 ikamesinin kendi kendini temizleme özelliği sağladığı belirlenmiştir. Elde dilen sonuçlar, yüzey hacimce %20 optik fiber ve %3 oranında TiO2 ikameli çimento harç numunelerinin optimum performansı sağladığını göstermiştir. Bu özellikler yapılarda ışık geçirimi sağlayan, çevre dostu çimento harç karışımlarının geliştirilmesi konusunda önemli bir potansiyel sunmaktadır.Translucent concrete is a special type of concrete reinforced with optical fibers strategically placed to break the opaque nature of conventional concrete, allowing light to be transmitted through structural elements to a certain extent. TiO2, on the other hand, is an efficient photocatalyst with high photocatalytic activity, capable of purifying both air and concrete, and performs effectively under low sunlight conditions. In this study, translucent cement mortar samples were produced by using %3 TiO₂ cement replacement and optical fiber additions at surface volume ratios of %0 (Reference), %9, %20, and %36. Fresh mortar tests, including consistency determination, setting time determination, and flow table tests, as well as hardened mortar tests such as dry unit weight, water absorption, compressive strength, light transmittance, and self-cleaning tests (Rhodamine-B test), were conducted on the produced samples. Additionally, SEM (scanning electron microscope) and EDS (energy dispersive X-ray spectroscopy) analyses were performed. The results of the study revealed that, compared to the reference sample, cement mortar samples containing %9, %20, and %36 optical fiber and %3 TiO₂ replacement exhibited an increase in compressive strength in the range of %12.99-%23.05. It was determined that the addition of optical fibers enabled light transmittance in the range of 3.14 lux to 32.04 lux, and the %3 TiO₂ replacement provided self-cleaning properties. The findings indicated that the optimum performance was achieved in cement mortar samples with %20 optical fiber by surface volume and %3 TiO₂ replacement. These properties present significant potential for the development of environmentally friendly cement mortar mixtures that allow light transmission in structures
Lumbar radiculopathy
Full text linkLow back pain is one of the most common musculoskeletal complaints in clinical practice. The differential diagnosis of low back pain is broad and should include lumbosacral radiculopathy. Radiculopathy is a term that covers sensory and motor deficits and paresthetic complaints resulting from the pathology of the nerve roots. Lumbar radicular pain is neuropathic pain caused by disc compression of the lumbar spinal nerve root, resulting in radiating pain in a dermatomal pattern. The most common causes of radicular pain are intervertebral disc herniation and lumbar spinal stenosis. Diseases such as neoplasms affecting the nerve roots, epidural abscesses, Herpes zoster, and Lyme disease can also cause radicular pain. The diagnosis of lumbar radicular pain due to disc compression/stenosis can be made by a history and physical examination. However, imaging and electrodiagnostic studies should be performed to exclude other possible causes of radicular symptoms. Urgent imaging and rapid intervention are important if 'red flag' symptoms or signs such as cauda equina syndrome, malignancy, vertebral fracture, vertebral osteomyelitis, and epidural abscess are present. Conservative treatment is the first-line treatment for radicular pain. However, in the presence of progressive neurologic deficit or cauda equina syndrome following radicular pain, surgical planning should be made according to the etiology and the current condition of the patient. © 2025 Elsevier B.V., All rights reserved
The role of organizational commitment in reducing turnover intention: Evidence from the hotel industry in Turkey
Full text linkEnsuring that employees, who are one of the most important assets of organizations, identify with the organization they work for and receive support from their supervisors can reduce their turnover intentions as well as making them more committed employees.The purpose of this study is to investigate the mediating role of organizational commitment in the relationship between organizational identification and turnover intention, and perceived supervisor support and turnover intention. Methodologically, the study is based on social exchange, organizational equilibrium and social identity theories. Among the key research methods are structural equation modelling, as well as exploratory and confirmatory factor analysis. An empirical study was conducted in a family business that owns two hotels operating in Istanbul,Turkey. Data gathered in November-December, 2023 from 314 employees were analysed with SPSS Statistics and PROCESS Macro statistical tool. The findings revealed that organizational identification and perceived supervisor support positively related to organizational commitment, and organizational commitment was negatively associated with turnover intention, which indicates that employees who commit to their organization will likely remain there. The results also proved that organizational commitment demonstrated the mediating effect on the relationship between organizational identification and turnover intention, along with perceived supervisor support and turnover intention. The findings show that hoteliers should focus on employees' identification within the organization as this construct helps prevent their intention to leave. To provide organizational identification, hoteliers can give importance to organizational communication, sharing information, providing feedback, and concentrating on the single purpose
4E analysis and operational vibration in domestic refrigeration systems: Effects of refrigerant charge and thermal load
Full text linkRefrigeration is an essential part of both domestic comfort and many industrial processes in which cooling is required for preserving goods like food, drugs etc., and the safe operation of heat-producing machines and appliances. Domestic refrigeration requires more than performance and reliability such as environmental sustainability, economic viability, low noise emission and vibration levels. Vibration in refrigeration system components can also lead to mechanical damage over time which may also increase energy consumption, resulting in further performance losses. A domestic-type vapor compression refrigeration system (VCRS) was comprehensively tested for different refrigerant mass (42 to 102 g with 10 g increments) and thermal load levels (0 to 75 W with 25 W increments) to conduct energy, exergy, environmental, and economic (4E) analyses, as well as the corresponding operational vibration levels. Experimental results showed that energy consumption, isentropic efficiency of the compressor and operational vibration levels increase with increasing refrigerant mass and thermal load, while the coefficient of performance (COP) and exergy efficiency decrease with increasing refrigerant mass and thermal load. The results revealed that the amount of refrigerant and thermal load of the refrigerator play a significant role in the system's overall performance and operational vibrations
Enhanced photoluminescence stability in mixed halide perovskite quantum dots via zinc doping
Full text linkDoped metal halide perovskite quantum dots (PQDs) have attracted significant attention due to their unique properties, to be applied in potential fields such as energy and optoelectronics. In this study, we investigate the influence of Zn on the structures of both CsPb(Cl/Br)3 and CsPb(Br/I)3 PQDs. The first principle calculations show that Zn doping creates an indirect band gap in the structures and increases the structures' dielectric constant. The experimental results show that Zn doping increases the durability of PQDs against both time and UV light exposure and decreases the probability of nonradiative recombination. In addition, thermal expansion and exciton redistribution mechanisms are observed in Zn doped CsPb(Cl/Br)3 PQDs, whereas, a blue-shifted concentration dependant photoluminescence spectra is observed in CsPb(Br/I)3 PQDs. This study provides insights into the effect of Zn doping on the structures of halide perovskite PQDs and offers new potentials for exploiting Zn-doped perovskite PQDs' unique properties in numerous applications
Evaluation of varicella zoster virus IgM, IgG and avidity results used in the diagnosis of varicella zoster virus
Full text linkAim: Varicella zoster virus (VZV) is a disease that is rapidly transmitted through the respiratory tract and has a high seroprevalence worldwide. This study aimed to evaluate the results of VZV IgM, VZV IgG and VZV avidity serological tests studied in our laboratory. Methods: In this study, the VZV IgM, VZV IgG, and VZV avidity test results in serum samples sent to our laboratory for preliminary diagnosis or screening of chickenpox between November 2019 and December 2024 were retrospectively examined. Kruskal-Wallis and Chi-Square tests were used to evaluate the results according to mean age, gender, and years. Results: In this study, VZV IgG positivity was found to be 88.5% (2721/3074) and VZV IgM positivity was found to be 5.2% (51/990). VZV IgG negativity was found to be 7.8% (122/1569) in females of childbearing age, and 7% (4/57) in elderly individuals over 65 years of age. In only three of the 29 samples in which both IgG and IgM were requested and both were found positive, the avidity test was performed and found to be high avidity. No low avidity result was detected. No statistical significant difference was detected between the patients whose VZV IgM and VZV IgG results were positive, negative or borderline values according to gender and age means. In addition, no statistical significant difference was detected between the years in terms of VZV IgM and VZV IgG results. Conclusion: Despite the high positivity of VZV IgG, antibody screening with VZV IgG can be recommended for high-risk groups. In addition, it was considered appropriate to study the VZV avidity test as a reflex test in laboratories
İstilacı Xylosandrus compactus'un (Coleoptera: Curculionidae: Scolytinae) moleküler ve morfolojik tanısı ve Türkiye için yeni konukçu bitki kayıtları
Full text linkThe polyphagous invasive pest Xylosandrus compactus (Eichhoff) (Coleoptera: Curculionidae: Scolytinae) has recently been reported in Türkiye. This species causes economic losses for woody ornamental and agricultural plants and forest trees in the lands where it invaded and settled. It should be considered that this pest has a pretty high rate of spread, and its control relies on accurate identification. This species could be distinguished from other ambrosia beetles using both morphological and molecular characteristics provided by the present study. The mtDNA gene region from some specimens collected in Türkiye was used for molecular identification and compared to "barcode" sequences already present in NCBI databases. COI sequences from X. compactus individuals obtained from eight distinct host plant species were used in phylogenetic analysis. More research into the genetic diversity of this ambrosia beetle's native and introduced areas is required to understand the origin of this biological invasion in Türkiye. Since its definition in Türkiye, X. compactus has been detected in 32 host plant species, and this study has increased that number to 40 by identifying eight new host plant species. Except Hydrangea macrophylla (Thunb.) Ser. and Fraxinus ornus L., six new species have been added to the world host plant species list for X. compactus. © 2025 Elsevier B.V., All rights reserved
Supine and Prone Positions in Percutaneous Nephrolithotomy: Exploring Their Roles in Operative Efficiency and Patient Comfort
Full text linkAim: This study aimed to compare the effects of supine and prone positions during percutaneous nephrolithotomy (PCNL) on operative characteristics, patient out-comes and postoperative quality of recovery. Material and Methods: A retrospective analysis was conducted on 78 patients who underwent PCNL for renal stones ≥2 cm at a single center between December 2022 and August 2024. Patients were divided into two groups: 41 treated in the mini-PCNL (mPCNL) supine position and 37 in the standart PCNL (sPCNL) prone position. Demographic data, operative time, hospital stay duration, complication rates, postoperative pain and analgesic requirements and quality of recovery scores (QoR) were compared. Treatment efficacy was assessed based on residual stone presence at 2 months postoperatively, with <2 mm considered stone-free. Results: Operative and access times were significantly shorter in the supine group and these patients had a reduced hospital stay. Quality of recovery improvement was more pronounced in the supine group with lower postoperative pain and analgesic requirements. Additionally, supine-positioned patients had a lower rate of residual stones compared to the prone group, suggesting enhanced treatment efficacy. Conclusion: The supine position in mPCNL offers advantages over the prone position in terms of operative efficiency, patient comfort and postoperative quality of recovery. Given these benefits the supine position may be a preferable choice for PCNL procedures. Further multicenter studies are recommended to validate these findings across broader patient populations