Soka University Repository / 創価大学機関リポジトリ
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Japanese Acquisition of Proverbs “suru” and “yaru” : the Cohesion of Discourse and the Substitute
Get PDF日本語学習者は，同じ動詞を繰り返さず代わりになる動詞「する」を用いて効率よく話を進めていくという談話能力をどのように習得していくのだろうか。本稿では，日本語学習者が談話において代動詞「する」と「やる」をどう使用しているのか，レベル別の特徴は何かを明らかにするため，「多言語母語の日本語学習者横断コーパス：I-JAS」を利用し，初級，中級，上級の使用について調査した。その結果，レベルが上がるにつれてサ変動詞や動詞句以外にも実質動詞の代用ができるようになり，その単位も動詞一語から文，文脈と広がっていくことがわかった。また，初級では「する」の代わりに「ある」を用いる誤用が，中級以降では指示語と「する」「やる」の結びつきの可否を間違える誤用が見られた。departmental bulletin pape
Semantic and pragmatic characteristics of NP+demo in Japanese: Interface between ‘adversative conditionals’ and ‘exemplification’
Get PDF名詞句を受ける「でも」は，「逆条件」と「例示」という，一見，関連性を認めにくい用法をもつ。「例示」の「でも」は，適切な候補を暫定的に提示する用法を典型とするが，これとは異なるタイプの例示用法をもつ。すなわち，実現を阻む状況や懸念・危惧される状況において，それに対抗するための極端な手段の例示や，話し手の懸念・危惧の心情について断定を避け例示的・婉曲に述べるような用法である。後者の例示は，状況と話し手の期待の対立関係を表す点で，「例示」と「逆条件」の接点の存在を窺わせる用法と考えられ，一見，異質に見える「でも」の２用法を統一的に捉える可能性を示唆するものである。departmental bulletin pape
Foregrounding of Nampo Kagaku (Southeast Asian Science) and Nampo Shigen Kagaku Kenkyujo (Institute of Southeast Asian Resources), Tokyo Imperial University
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A Study of Academic Questions Leading Tsunesaburo Makiguchi’s Thoughts on Soka Education: Using Ikeda’s Thought as a Clue
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Mechanism of castration-resistant acquisition via 3-O-sulfated heparan sulfate in prostate cancer
Get PDF創価大学博士（工学）Androgen deprivation therapy is commonly administered to suppress the growth of prostate cancer. However, despite this treatment, certain cells continue growing independently of hormones, leading to the development of castration-resistant prostate cancer (CRPC). Prostate cancer proliferates through androgen receptor (AR) signaling. However, in the case of CRPC, signaling pathways other than AR signaling are involved in the proliferation. Sulfated glycosaminoglycans function as co-receptors to promote ligand binding to receptors in signaling pathway, but their specific role in CRPC has remained unclear. In this study, we used the human prostate cancer cell line C4-2, which can proliferate under both hormone-dependent and hormone-independent conditions, as CRPC model. We have found that when hormones were depleted, epidermal growth factor (EGF) triggers the activation of EGFR-ERK1/2 signaling through 3-O-sulfated heparan sulfate (3-OS HS) in C4-2 cells. By suppressing the expression of HS3ST1 in C4-2 cells, we were able to inhibit the activation of EGFR-ERK1/2 signaling and hormone-independent growth. Furthermore, treatment with gefitinib, an EGFR inhibitor, significantly suppressed the growth of xenografted C4-2 tumors in castrated mice. In summary, our study has revealed a mechanism of castration-resistant acquisition via 3-OS HS in prostate cancer. These findings contribute to our understanding of CRPC and pave the way for potential therapeutic approaches targeting this mechanism.doctoral thesi
Seeking Further Opportunities for Japanese ILO Multi-bilateral Cooperation in the Context of Promoting Decent Work in Lao PDR:A Case Study on Employment Projects for Lao PDR
Get PDFPromoting decent work (DW) for all, which is a target of the eight goal among the sustainable development goals (SDGs), is regarded as a focal point to be discussed globally. Additionally, each policy making and Official Development Assistance (ODA) is bei ng increasingly developed to address various labour issues. In this context, numerous labour issues, including employment issues, have been highlighted in Lao PDR, which is in a geographically important location of the Association of Southeast Asian Nation s (ASEAN) and has close diplomatic relations with Japan, and the Lao government has set policy goals for promoting DW accordingly. Conversely, the number of foreign direct investments from Japanese companies to the country has increased every year. To inco rporate market growth in Asia, labour issues in the region such as Lao PDR would constitute a serious concern. Hence, the Japanese government has engaged in various efforts towards promoting DW. Given the need for promoting DW in Lao PDR and the requiremen ts for the Japanese government to implement an effective ODA for DW in the country, this article seeks further opportunities for Japanese ILO multi bilateral cooperation in Lao PDR, which is a cooperation method to combine the technical expertise of ILO wi th financial support from the Ministry of Health, Labour and Social Welfare of Japan, while referring to recent cases of employment projects by ILO nationwide. Specifically, this article focuses on three perspectives (1: whether there are actual needs for such cooperation in the country, 2: whether Japanese ILO multi-bilateral cooperation effectively works in the country, 3: whether Japanese ILO multi bilateral cooperation contributes to being present in international society) to confirm whether Japanese ILO multi bilateral cooperation is possible in Lao PDR.departmental bulletin pape