Karamanoğlu Mehmetbey University
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A fluorescent chemoprobe based on carbazole for hypochlorite with fast response: design and its applications in test strips, water samples and living cells
No full textHypochlorite (ClO−) has been widely used as the main component of cleaning agents, and is also used in the treatment of disinfect water. The concentration of ClO− is critical for living organisms andthe environment. Hence, it is essential to develop reliable, sensitive and user-friendly molecular sensors to determine ClO−. In this context, the synthesized probe 2,4-di-tert-butyl-6-((E)-(((E)-(9-pentyl-9H-carbazol-3-yl)methylene) hydrazono) methyl) phenol (TBCP) can detect ClO− with rapid response (1 min), low detection limit (0.28 µM) and high sensitivity. Also, the sensor is utilized at wide pH range (4–10) for the determination of ClO−. TBCP showed outstanding selectivity for ClO− over other competing analytes via a fluorescent response change from colorless to orange, and its response mechanism was based on a deprotonation phenomenon. The ClO− level was successfully determined by TBCP on test kits, cotton swabs and in real samples. Fluorescent bio-imaging of ClO− in HEPG2 cells was also carried out in the presence of TBCP. Furthermore, DFT calculations were performed successfully for TBCP and TBCP + ClO− complex. © 2025 Elsevier B.V
The effect of watching videos with virtual reality glasses on pain and fear in children who undergoing suturing in the emergency department: A randomized controlled trial
No full textPurpose: This study was conducted to examine the effects of watching videos with virtual reality glasses on pain and fear in children aged 7-12 who applied to the emergency room for suturing.
Design and methods: This study randomized controlled design was conducted in the emergency department of a public hospital between October 2022 and November 2024. 84 children aged 7-12 years were assigned to two different groups using block randomization method. The child, parent, and researcher assessed pain using the Wong-Baker FACES Pain Rating Scale, and fear using the Children's Fear Scale. The study data were analyzed using the Chi-square and independent Sample t-tests.
Results: The groups were similar in clinical and demographic characteristics. The pain and fear scores of the group watching the video with the virtual reality glasses during and after the procedure were lower than those of the control group. Children who watched the video with virtual reality glasses had lower pain scores during the procedure (n = 37; 2.54 ± 2.09, p < 0.001), after the procedure (1.35 ± 1.57; p < 0.001), and fear scores during the procedure (1,68 ± 1.40; p < 0.001), after procedure (0.59 ± 1.07; p < 0.001) than the control group.
Conclusion: This study found that watching videos with virtual reality glasses was effective in reducing pain and fear in children aged 7-12 who undergoing sutures.
Practice implications: The cost-effective, easily accessible and effective (reducing pain and fear) video viewing technique with virtual reality glasses during the suturing procedure can be used safely in children between the ages of 7 and 12. Clinical Trials ID:NCT05543876
Investigation of the validity, reliability and psychometric properties of the turkish version of the ottawa sitting scale in patients with parkinson's disease
Get PDFThe Ottawa Sitting Scale is a tool for the multidimensional assessment of sitting balance. This study aimed to investigate the validity, reliability, and psychometric properties of the Turkish version of the Ottawa Sitting Scale (OSS-TR) in Turkish-speaking patients with Parkinson's disease (PD). The study included 56 patients diagnosed with PD based on the UK Brain Bank Criteria. Construct validity of the OSS-TR was established through the evaluation of structural and convergent validity. Explanatory factor analysis and confirmatory factor analysis (CFA) were carried out to determine the structural validity. Convergent validity was analysed by examining the relationships between OSS-TR with the Berg Balance Scale (BBS) and Trunk Impairment Scale (TIS). The test-retest reliability of the scale was assessed by intraclass correlation coefficient (ICC) and internal consistency was assessed by Cronbach's alpha coefficient. The good fit determined according to the model fit criteria based on the CFA results confirmed the structural validity. Furthermore, the high associations between OSS-TR with the BBS (r = 0.766) and TIS (r = 0.720) supported convergent validity (p < 0.05). Test-retest reliability of the OSS-TR was excellent (ICC = 0.867). Moreover, internal consistency was high (Cronbach's alpha = 0.948). The OSS-TR is a valid and reliable instrument for assessing sitting balance in Turkish-speaking PD patients. Regarding the results of the study, OSS-TR can be considered useful in the evaluation of sitting balance among PD patients in clinical and research settings
Cardiovascular disease markers in schizophrenia during negative symptoms and remission periods
No full textObjectives: This study aims to investigate cardiovascular disease markers in patients with schizophrenia and to contribute to the early indication of asymptomatic cardiovascular diseases in these patients. In our study, there are three groups: schizophrenia with negative symptoms (SCH-N), schizophrenia in remission (SCH-R), and a healthy control group (HC). In these groups, there were compared parameters such as lipid panel, Atherogenic Index (AIP), Triglyceride-glucose (TyG) index, Castelli Risk Index-1 (CRI-I), Castelli Risk Index-2 (CRI-II), and Atherogenic Coefficient (AC), which are associated with the risk of cardiovascular disease. Methods: The participants of the study were from the HC group and schizophrenia patients aged between 18 and 65 who were followed up at the Psychiatry Clinic of Karaman Hospital. This cross-sectional case-control study consists of the SCH-N (n:20), the SCH-R (n:23), and the HC (n:21) groups. Those with cardiovascular, endocrine, and inflammatory diseases, those with alcohol and substance addiction, those using drugs other than psychiatric drugs, and those lacking informed consent were excluded from the study. Patients in active psychotic episodes were also excluded from the study due to communication difficulties. All data were analyzed using SPSS 25.0 package program in a computer environment. The conformity of continuous data to normal distribution was evaluated with normality test value, q-q plot, skewness, and kurtosis. For significant results in the ANOVA test, pairwise comparisons were conducted using the post hoc Bonferroni correction when variances were homogeneously distributed. Similarly, for significant results in the Kruskal-Wallis Test, pairwise comparisons were performed using the Dunn-Bonferroni test. In this study, values less than p < 0.05 were considered statistically significant. Results: When all groups were compared, the increase in the TGs, TyG index, AIP, CRI-I, CRI-II, and AC values in the SCH-R group compared to the HC group was found to be statistically significant (p < 0.001, p < 0.001, p < 0.001, p < 0.001, p = 0.015, p < 0.001; sequentially). Conclusions: This study revealed that cardiovascular risk markers in schizophrenia patients showed significant differences. In particular, the elevation in parameters such as TGs, TyG index, AIP, CRI-I, CRI-II, and AC indicates that schizophrenia patients have an increased risk for cardiovascular diseases. Therefore, it is recommended that schizophrenia patients be closely monitored for cardiovascular risk factors and to intervene early
Sensory properties, textural analysis, and some physical analysis of enriched extruded products produced from different grain products
No full textA functional product has been produced from a mixture of whole wheat flour and corn semolina, which can be consumed as a healthy snack compared to oily and additive-laden chip products. Extruded products were obtained at various output die temperatures (130, 150, and 170 °C) in a twin-screw extruder from mixtures prepared with different raw material humidity (12, 14, and 16%) from the mixtures of whole wheat flour, corn semolina, and D-glucose. The water binding capacity increased with increasing raw material humidity and output die temperature. Expansion index value was founded corn semolina had the highest value (3.11 ± 0.22), whereas whole wheat flour with D-glucose added had the lowest value (2.10 ± 0.34). Through sensory investigation, the most popular product groupings were determined to be whole wheat flour and corn semolina-extruded products. It is expected that this study will be able to produce extruded products from whole wheat flour and corn semolina and will set an example for the development of new functional products
A study on the morphometry and classification of variations of the suprascapular notch using computed tomography
No full textThe suprascapular notch is one of the anatomical sites most commonly exposed to compressive and traction injuries of the suprascapular nerve. In this preliminary study, we aimed to evaluate the morphological and morphometric features of the notch to enhance the diagnostic accuracy and therapeutic outcomes of nerve compression. This retrospective study was conducted using computed tomography images of the scapula obtained between January 1, 2022, and August 30, 2024. A total of 852 scapulae were evaluated, of which 448 belonged to males and 404 to females. Morphometric measurements included superior transverse diameter, middle transverse diameter, and maximal depth of the notch. In addition, the notch was classified using both the Polguj and Rengachary classification systems. When the measurement parameters were compared between genders, the values were higher in males; however, only the maximal depth showed a statistically significant difference (p < 0.05). According to the Polguj classification, Type 3 was the most common (63.38%). Based on the Rengachary classification, the U-shaped form was the most frequently observed (65.02%), while the J-shaped form was the rarest (3.41%). The foramen shape was detected in 5.75% of cases. The J-shaped variant was found to be approximately four times more common in males than in females. Knowledge of the anatomical variations of the notch is likely to be beneficial for both endoscopic and open surgical interventions in the suprascapular region. In particular, three-dimensional computed tomography imaging may be useful in preoperative planning for arthroscopic resection of ossified ligament. © The Author(s), under exclusive licence to Japanese Association of Anatomists 2025
The correlation between vitamin d levels and thyroid functions in early pregnancy
Get PDFVitamin D deficiency (serum vitamin D <10 ng/ml) and thyroid dysfunctions are prevalent issues globally, particularly during pregnancy. Evidence suggests a potential link between thyroid function and vitamin D levels. This study aims to investigate the correlation between serum vitamin D levels and thyroid functions in wome n during the first trimester of pregnancy. The study was conducted retrospectively at a University Education and Research Hospital’s pregnancy clinic, covering data from August 2023 to March 2024. The sample group consisted of first-trimester pregnant women who attended routine pregnancy check-ups and had complete vitamin D levels and thyroid function tests (n=185). The sociodemographic data form and blood serum level assessment forms were used as data collection tools. The data were analyzed using descriptive statistics and correlation analysis. The average age of the pregnant women participating i n our study was 27.6±4.9 years, and the Body Mass Index (BMI) was 25.4±4.8 (overweight). The mean number of pregnancies was 1.13±0.3, and the gestational week was 8.19±1.8. Of the participants, 35 had subclinical hypothyroidism, 37 had thyroiditis, and 113 had normal thyroid functions. The study identified 36 women with normal/adequate vitamin D levels (≥20 ng/ml), 113 with vitamin D insufficiency (10–20 ng/ml), and 36 with vitamin D deficiency (<10 ng/ml). The correlation analysis revealed no significant relationship between the thyroid function tests and vitamin D levels of the pregnant women. It was determined that vitamin D levels do not affect thyroid gland function in the first trimester. © 2025, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved
Machine learning modeling and response surface methodology driven antioxidant and anticancer activities of chitosan nanoparticle-mediated extracts of bacopa monnieri
No full textThis study investigates the potential of chitosan nanoparticles (CNPs) in enhancing the bioavailability and efficacy of Bacopa monnieri extracts, known for their neuroprotective, antioxidant, and anticancer properties. Different concentrations of CNPs were added to the culture medium for in vitro shoot regeneration. Antioxidant activity (DPPH free radical scavenging and H2O2 removal assays) and cytotoxicity assay (LDH release and XTT viability) were performed. The results demonstrated the highest DPPH radical scavenging activity of 95.60 % at 125 mu g/mL CNPs from methanol extract. Whereas, H2O2 scavenging activity increased with higher extract concentrations, and the maximum was recorded from methanol extract when used at 1000 mu g/mL. Cytotoxicity assays revealed a dose-dependent increase in LDH activity and XTT reduction, and water-based extracts demonstrated the strongest cytotoxic effects. IC50 analysis indicated that CNP-enriched methanol and water extracts were significantly more cytotoxic to HeLa cells as compared to ethanol extracts. Response surface regression analysis and ML models confirmed the reliability of the experimental data, with the multilayer perceptron (MLP) model exhibiting the best predictive accuracy, followed by the random forest (RF) model. It can be concluded that CNP enrichment significantly improved the antioxidant and anticancer properties of B. monnieri extracts, highlighting the potential of CNP-based formulations for future studies
Extending the shelf life of stuffed pasta (manti) using cold smoking for different times
Get PDFSmoking treatments are widely used to impart desirable properties and to extend their shelf life to some foods, especially meat and meat products. A perfect combination of meat and cereal products, stuffed pasta (manti) is preserved in fresh and dried forms. Fresh manti has a short shelf life and a high risk of food poisoning due to the ground beef content. In this study, the new process was studied using cold smoking techniques to ensure the sustainability of the quality of manti. Within the scope of this study, a suitable smoking system was constructed and applied (cold smoking durations of 15, 30, and 45 min) to the fresh manti samples. Then some physicochemical (moisture, pH, color, ash, texture, Thiobarbituric acid), total phenol, sensory, and microbiological (total mesophilic aerobic bacteria, total aerobic, mold, and yeast) load of the samples were determined and compared to control samples at the beginning of the storage process (0. day) and throughout storage (21. day). There was initially no significant difference (p > 0.05) in the pH, ash, texture, Thiobarbituric acid values, and microbiological (total mesophilic aerobic bacteria, total aerobic, mold, and yeast) load of the manti samples. Initially and during the storage process, there was a difference in the color values of manti samples depending on the application time of cold smoking, but no negative effect of cold smoking on the color values of manti was detected. The total phenolic contents of the smoked manti samples were initially higher than the control sample, and the values obtained were statistically significant. During the storage process, the moisture level, TBA value, and microbiological (total mesophilic aerobic bacteria, total aerobic, mold, and yeast) load were found to be high in the control samples, and the values obtained were statistically significant (p < 0.05). As a result of the study, it was noted that 15 min of cold smoking treatment have significantly (p < 0.05) preserved sensory quality and color (L, a∗, b∗) values, total phenol content, microbiological load, texture, and Thiobarbituric acid values of the manti samples. In addition, it was found that smoking treatment prolonged the shelf life of manti by 25 days and increased its total phenol content. It was concluded that this technique could be improved further and used as an alternative preservation technique in the food industry. © 2024 The Author(s
Metaheuristic optimization of an organic rankine cycle using advanced exergy analysis and artificial bee colony algorithm
No full textIn optimizing thermodynamic cycles, selecting the objective function is crucial, and including advanced methods in addition to classical approaches can provide significant advantages to the optimization process. In this study, the condenser temperature, evaporator temperature, and turbine inlet pressure are considered as variables to be optimized in an organic Rankine cycle that extracts heat from a low-temperature geothermal water source. Total unavoidable exergy destruction, thermal efficiency, second-law efficiency, and network output are optimized individually. The artificial bee colony algorithm, a metaheuristic approach, is employed as the optimization method. R123, R11, and R245ca are considered to be the working fluids, and each objective function is applied individually. A total of 12 different optimization processes are conducted, and the achieved objective values are compared. Thus, not only identifying the fluid with the best potential, but also the selection of the most advantageous objective function is determined. In this study, it is observed that selecting R11 as the working fluid and applying total unavoidable exergy minimization optimization result in the best values for all objectives. While other fluids show relatively successful outcomes under different objectives, choosing total unavoidable exergy destruction as the objective function has consistently led to successful results in almost all cases. Maximum work output value was obtained with R11 as 298.45 kW