Karamanoğlu Mehmetbey University
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Antimicrobial, antioxidant and antifungal properties of Artemisia absinthium L. and Plantago major
No full textFarklı coğrafi bölgelerden toplanan bitkilerin biyolojik aktivitelerinin de çeşitlilik gösterdiği bilindiği için bu çalışmada Karaman yöresinden Ağustos 2022 yılında toplanan Artemisia absinthium L. ve Plantago major özütünün antimikrobiyal aktivitesi disk difüzyon ve minimum inhibitör konsantrasyon (MİK) testleri ile değerlendirilmiştir. Bitkinin antioksidan kapasitesi ise 2,2-difenil-1-pikrilhidrazil (DPPH) radikal süpürme aktivitesi yöntemi ile ölçülmüştür. Sonuçlara göre soxhlet yöntemi ile elde edilen özütlerin etken maddesinin disk difüzyon yönteminde diskten yayılmadığı, dolayısıyla test edilen tüm mikroorganizmalar için sadece disk etrafında temiz alan oluşturduğu (6mm) gözlemlenmiştir. Aynı mikroorganizmalar için gerçekleştirilen MİK testlerinde ise; A. absinthium L. için MİK değerlerinin Staphylococcus aureus ve Escherichia coli için 400 µg/mL, Bacillus cereus için 100 µg/mL, Pseudomonas aeruginosa ve Candida albicans için ise >400 µg/mL olduğu tespit edilmiştir. Aynı mikroorganizmalarda P. major için MİK değerleri ise >400 µg/mL olarak tespit edilmiştir. DPPH radikal süpürme aktivitesinde A. absinthium L. için en düşük medyan inhibitör konsantrasyonu (IC₅₀) değeri 79,93 µg/mL P.major için IC₅₀ değeri 618 µg/mL olarak hesaplanmıştır. Sonuç olarak, A. absinthium L. ve P.major sahip olduğu antimikrobiyal ve antioksidan aktiviteler, enfeksiyonlar ve oksidatif stresle ilişkili durumlar için doğal tedavilerin geliştirilmesinde değerli bir terapötik ajan potansiyeli taşımaktadır.Since it is known that the biological activities of plants collected from different geographical regions vary, in this study, the antimicrobial activity of Artemisia absinthium L. and Plantago major extracts collected from the Karaman region in August 2022 was evaluated by disk diffusion and minimum inhibitory concentration (MIC) tests. The antioxidant capacity of the plants was measured by the 2,2 diphenyl-1-picrylhydrazl (DPPH) radical scavenging activity method. According to the results, it was observed that the active ingredient of the extracts obtained by the Soxhlet method did not spread from the disk in the disk diffusion method, thus creating a clean area only around the disk (6 mm) for all tested microorganisms. In MIC tests performed for the same microorganisms; The MIC values for A. absinthium L. were determined to be 400 µg/mL for Staphylococcus aureus and Escherichia coli, 100 µg/mL for Bacillus cereus, and >400 µg/mL for Pseudomonas aeruginosa and Candida albicans. In the same microorganisms, MIC values for P. major were determined as >400 µg/mL. In DPPH radical scavenging activity, the lowest median inhibitory concentration (IC50) value for A. absinthium L. was calculated as 79.93 µg/mL, and the IC50 value for P. major was 618 µg/mL. In conclusion, the antimicrobial and antioxidant activities possessed by A. absinthium L. and P. major carry the potential as a valuable therapeutic agent in the development of natural treatments for infections and oxidative stress-related conditions
Bilateral cross hashing image retrieval based on principal component analysis
No full textImage retrieval (IR) has become a crucial challenge in computer vision with the exponential growth of digital imagery. The existing methods employ a single hash source, which may overlook deep details in the image, and they struggle to handle the complexity and diversity of modern visual data. This study addresses this limitation by proposing a novel deep hashing-based IR method named bilateral cross hashing based on principal component analysis (BCHP). Bilateral cross hashing based on principal component analysis-image retrieval (BCHP-IR) employs the feature extraction capabilities of residual network-50 (ResNet-50) and the dimensionality reduction and information preservation properties of principal component analysis (PCA). The method extracts high-level features from query images using ResNet-50 and then compresses both features and class labels using PCA. The compressed data undergoes quantization to generate binary codes. These "bilateral" hash codes are combined to capture deep features and compared with image codes in the database. The BCHP-IR's effectiveness is demonstrated through extensive comparative analysis against reported methods, achieving superior performance metrics. On the MS-COCO dataset, BCHP-IR achieves mAP scores that are higher than the average of other benchmark algorithms by 6.3, 6.4, 6.2 and 5.0 at hash lengths of 16, 32, 48 and 64, respectively. These enhancements at those hash lengths are 4.6, 4.7, 4.8 and 4.3 for the NUS-WIDE dataset and 3.9, 2.9, 2.5 and 2.1 for the ImageNet dataset. Therefore, the proposed BCHP-IR method harnesses the power of ResNet-50 and PCA and offers a promising solution for efficient and effective image retrieval
A machine learning-based real-time remaining useful life estimation and fair pricing strategy for electric vehicle battery swapping stations
No full textThe increasing adoption of electric vehicles (EVs) has led to the widespread implementation of battery swapping stations. However, ensuring fairness in battery pricing remains a significant challenge since variations in battery health and performance among swapped batteries can result in user dissatisfaction and operational inefficiencies. This paper introduces a novel approach to enhance fairness in battery swapping by integrating a machine learning-based real-time prediction model with a pricing strategy based on remaining useful life (RUL) estimation to address this issue. The proposed solution comprises a real-time RUL estimation system and a dynamic pricing mechanism that ensures fair pricing based on battery health and performance. This integrated approach aims to improve user satisfaction and the operational efficiency of swapping stations. The paper evaluates various machine learning algorithms for real-time RUL estimation regarding accuracy, computation time, and memory usage. The results suggest that XGBoost provides the most suitable balance between accuracy and efficiency, making it an effective solution for real-world applications. Comparative analysis shows that the XGBoost model outperforms the second-best method (Random Forest) with a lower error (3.50 vs 3.79) while maintaining competitive computational efficiency (9.75 vs 8.52 seconds) and memory usage (2.12 vs 2.32 MB) when solving a typical numerical case study problem. The proposed approach has the potential to accelerate the adoption of electric vehicles and contribute to sustainability goals by promoting efficient battery utilization and fair pricing mechanisms
Fragmentation in the sense of community comparison in housing estate and single-family housing residential areas
Full text linkPlanning has the power to prevent or reduce many physical and social problems associated with urban regeneration. By addressing issues such as poor infrastructure, lack of public space, and social inequality, planning can also help prevent potential future social problems. As a result, neighborhoods play a fundamental role in finding solutions to these problems. Unfortunately, recent rent-oriented urban regeneration practices carried out in Turkey have exacerbated these issues. This makes it even more critical to prioritize thoughtful planning in future urban development. This study aimed to test the theoretical assumption that different spatial designs produce distinct forms of neighborhood-level relationships through a sense of community in Eskisehir Neighborhood (Turkey). Firstly, we analyzed the effect of neighbor relations on the sense of community in residential areas within an urban regeneration project. Next, we examined a neighborhood located in the same area where the demolition process has not yet begun, and which still maintains its traditional characteristics. According to our findings we concluded that the sense of community has an impact on social interaction, community attachment, and community identity in single-family housing areas, whereas neighbor relations in housing estate areas only affect community attachment
Acquiring stereospecific new pseudosugars: Obtaining rac-decahydro-1,4-epoxynaphthalene-2,3,5,6,7,8-hexaols from the Diels-Alder reaction and investigating their biological effects
No full textIn this study, Diels–Alder reaction was performed to sulfolene and endo/exo-diacetate compounds. After a series of reactions, new conduritol A and F analogs containing oxo-bridge and naphthalene rings in their structures were synthesized. To the starting compound, bromination, elimination, singlet oxygen reaction, acetylation, selective oxidation with osmium tetroxide (OsO4), and m-chloroperbenzoic acid (m-CPBA), re-acetylation, and finally hydrolysis of the compounds by NH3(g)/MeOH reactions were carried out. 1H NMR, 13C NMR, IR, and elemental analysis elucidated the structures of all synthesized compounds. The ?, ?-glucosidase, and ?-amylase inhibitory potentials of the new polycyclitols, conduritol A and F analogs, were examined for biological activity. Also, enzyme kinetic studies of well-active compounds were carried out. Compound 30 showed the best inhibition activity against ?, ?-glucosidase, and ?-amylase enzymes. Compound 28a showed the best activity against L929 and Capan-1 cell lines, and compound 22 showed the best activity against the A549 fibroblast cell line. Moreover, hemolysis (ASTM F756 standard) and genotoxicity test results were recorded. © 2024 Elsevier Inc.Türkiye Bilimsel ve Teknolojik Araştırma Kurumu, TÜBİTAK, (TBAG-104T396, 113Z699, 115Z446, 217Z043); Türkiye Bilimsel ve Teknolojik Araştırma Kurumu, TÜBİTA
Childhood psychological maltreatment, psychological flexibility, family conflict, and subjective happiness in university students: a serial mediation model
No full textChildhood psychological maltreatment has psychological, behavioral, and emotional repercussions on individuals in adulthood. These reflections play a role in both the internal distress of individuals and the deterioration of their interpersonal relationships. The aim of this study was to examine the serial mediating role of psychological flexibility and family conflict in the relationship between childhood psychological maltreatment and subjective happiness. The study was conducted with 493 university students (61.7% female, 38.3% male), with ages ranging from 18 to 53 years (M-age = 24.02, SD = 6.342). The data of this research was analyzed using structural equation modeling. The findings of the study indicate that psychological flexibility and family conflict have a serial mediating role in the relationship between childhood psychological maltreatment and subjective happiness. The results demonstrated that to improve the subjective happiness of people who have been psychologically abused as children, it is necessary to make them more psychologically flexible and teach them how to deal with family conflict. Overall, these findings emphasize the importance of fostering psychological flexibility and conflict resolution skills as key intervention targets to mitigate the long-term negative effects of childhood psychological maltreatment on subjective happiness. The findings of the study were discussed and interpreted in detail in the light of the relevant literature
Risk factors associated with neonatal pneumothorax in the neonatal intensive care unit: 10 years of experience in a single-center
No full textBackground: We aimed to evaluate the epidemiological characteristics, risk factors and prognostic factors affecting the clinical follow-up of patients who underwent tube thoracostomy due to pneumothorax in the neonatal intensive care unit of our hospital. Methods: In our study; 54 cases with neonatal pneumothorax underwent tube thoracostomy followed up in the neonatal intensive care unit between April 2014 and March 2023 were retrospectively analyzed. Results: The gestational age of the cases was between 28 and 38 weeks; 24 (44.4%) were premature and 30 (55.6%) were 36 weeks and above. Of the cases included in the study, 35 (64.8%) had primary lung disease and 19 (35.2%) had other anomalies accompanying pneumothorax. Mechanical ventilation was needed in 35 (64.8%) of the 54 cases included in the study. While all patients who did not require mechanical ventilation recovered, 10 of 35 patients (28.6%) who required mechanical ventilation died. The body weight of 10 of these 35 cases (28.6%) was 2500 g or less. Conclusion: It was determined that accompanying primary lung disease, the need to connect to a ventilator, and bilateral pneumothorax significantly affected mortality and prognosis in premature babies, especially those weighing less than 2500 g, who were followed in the neonatal intensive care unit. © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2024
The relationship between fibromyalgianess and clinical features, disease activity in patients with systemic lupus erythematosus
No full textIntroduction: Fibromyalgia (FM) is a chronic syndrome characterised by widespread pain, fatigue, and symptoms such as sleep disturbances, cognitive impairment, and mood disorders. FM prevalence is notably higher among systemic lupus erythematosus (SLE) patients compared with the general population, often leading to diagnostic challenges. Misinterpreting FM as SLE activity can result in overtreatment. This study aimed to evaluate fibromyalgianess and its relationship with the clinical and immunological characteristics of SLE patients using comprehensive scoring methods for better diagnostic accuracy. Materials and Methods: This cross-sectional study included 50 SLE patients meeting the 2019 EULAR/ACR classification criteria. Patients with coexisting autoimmune diseases or severe systemic conditions were excluded. Clinical data, SLEDAI scores, and fibromyalgianess severity were assessed using the Polysymptomatic Distress Scale (PSDS). Patients were categorised into groups based on fibromyalgia diagnostic criteria: widespread pain and SLE-FM. Statistical analysis was performed using SPSS, with p < 0.05 considered significant. Results: Among 50 patients (45 female, 5 male; mean age 42.04 +/- 12.5), 24% had fibromyalgianess, and 18% experienced widespread pain. Female patients exhibited significantly higher PSDS scores (p < 0.05). While NSAID use was associated with increased PSDS scores (p < 0.001), no significant relationship was found between fibromyalgianess and SLEDAI scores or organ involvement. Conclusion: Fibromyalgianess in SLE patients primarily reflects heightened pain sensitivity and symptom severity rather than disease activity. Incorporating fibromyalgianess assessment into routine SLE management may prevent diagnostic and therapeutic pitfalls and improve treatment outcomes. Multidisciplinary approaches, including pharmacological and non-pharmacological strategies, are essential for effective care
Electrospun graphene-cellulose acetate/paulschulzia pseudovolvox (algae) modified photoelectrodes generating electricity via harnessing solar energy: a novel biosensing design for photoelectrochemical pesticide detection via photosynthesis inhibition
No full textThis article explores the possibility of biophotovoltaic devices (BPVs) as a sustainable solution to the global energy issue and climate change mitigation. BPVs produce renewable power by harnessing sunshine and water, employing the photosynthetic processes of biological photocatalysts such as green algae and cyanobacteria. Carbon-based electrodes, particularly graphene (Gr), are distinguished as advantageous alternatives owing to their affordability, electrical conductivity, and mechanical robustness. While reduced graphene oxide is frequently utilized, non-oxidized graphene has not been extensively studied until recent researches emphasized its remarkable current-harvesting abilities. Moreover, one-dimensional structured nanomaterials, such as electrospun nanofibers, present opportunities for enhancing electron transit and augmenting charge collecting efficiency. A novel photoanode design has been developed, using Paulschulzia pseudovolvox sp. (green algae) immobilized on a graphene-cellulose acetate electrospun matrix. This mat offers a porous structure that facilitates suitable algal attachment and effective electron transfer. The cathode is linked to a gold electrode surface coated with Poly (4-(2,5-di(thiophen-2-yl)-1H-pyrrol-1-yl)benzamine), P(SNS-NH2) electrochemically, on which the bilirubin oxidase (BOx) enzyme gets immobilized via glutaraldehyde activation. The algae-based system employs light to oxidize and dissociate water at the photoanode, producing oxygen. At the same time oxygen is converted to water at the cathode through bioelectrocatalysis. Optimizations were carried out to improve electron transport and promote electron transfer, hence achieving high photocurrent. Under optimal conditions, the BPV attained a peak power output of 55.2 mW/m² at a steady state with a current density of 125 mA/m². In addition to conversion of light energy to electricity, the system was applied as a pesticide biosensor. The BPV system effectively detected atrazine and diuron, with analytical characterisation performed for atrazine within the 0.1–1.2 μM range and diuron within the 0.01–0.15 μM range. The detection limits were significantly low, measuring 7.5 nM for atrazine and 0.29 nM for diuron. Furthermore, recovery studies were also performed to evaluate the pesticide biosensor capabilities of BPV. © 2025 Elsevier Lt
Recurrent hepatocellular carcinoma is associated with the enrichment of MYC targets gene sets, elevated high confidence deleterious mutations and alternative splicing of DDB2 and BRCA1 transcripts
No full textPurpose: Recurrence is the main cause of hepatocellular carcinoma (HCC) related deaths. Underlying recurrence biology can be better understood by comparative analysis of the complete set of transcripts between recurrent and non-recurrent HCC. In this study, transcriptomic data (GSE56545) from 21 male patients diagnosed with either recurrent or non-recurrent HCC were reanalyzed to identify deregulated pathways, somatic mutations, fusion transcripts, alternative splicing events, and the immune context in recurrent HCC. Materials and methods: DESeq2 was used for differential expression analysis, Mutect2 for somatic mutation analysis, Arriba and STAR-Fusion for fusion transcript analysis, and rMATs for alternative splicing analysis. Results: The results revealed that MYC targets gene sets (Hallmark_MYC_targets_V1 and Hallmark_MYC_targets_V2) were significantly enriched in recurrent HCC. Among the MYC targets, CBX3, NOP56, CDK4, NPM1, MCM5, MCM4 and PA2G4 upregulation was significantly associated with poor survival. Somatic mutation analysis demonstrated that the numbers of high confidence deleterious mutations were significantly increased in recurrent HCC. Alternative splicing-mediated production of non-functional DDB2 and oncogenic BRCA1 D11q were discovered in recurrent HCC. Finally, CD8+ T-cells were significantly decreased in recurrent HCC. Conclusions: These results indicated that the enrichment of MYC targets gene sets is one of the most critical factors that leads to the development of recurrent HCC. In addition, elevated deleterious mutation numbers and alternative spliced DDB2 and BRCA1 isoforms have been identified as prominent contributors to increasing genomic instability in male patients with recurrent HCC. © 2024 Medical University of Bialysto