Showa University Academic Resource Repository / 昭和大学学術業績リポジトリ
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Use of a multibending scope as a rescue scope in gastric endoscopic submucosal dissection: A retrospective study
Get PDFThe aim of this study was to identify factors associated with the use of a multibending scope （MBS） as a rescue instrument in gastric endoscopic submucosal dissection （ESD） for neoplasia. Between January 2015 and June 2023, 502 patients with gastric neoplasia underwent ESD at Showa University Hospital. The patients were classified into ESD with MBS （MB） and ESD with conventional scope only （C） groups. Significantly more cases in the MB group had prolonged procedural times （≥120min）（p＜0.001） and difficult ESD （p＜0.001） compared with the C group. Patients in the MB group had significantly higher rates of lesions located in the lesser curvature （p＜0.001）, larger than 20mm （p＜0.001）, located in the upper two-thirds of the stomach （p＝0.004）, and endoscopic ulceration findings （p＝0.02） compared with the C group. These factors were significant after adjustment in the multivariate analysis. Independent clinicopathological characteristics of superficial gastric neoplasms associated with MBS use as a rescue scope for gastric ESD were identified. These results indicate that using a MBS as the initial scope may be beneficial in certain cases.departmental bulletin pape
Nationwide cross-sectional survey for preferred brand-named oral anticancer drugs using prescription data based on a large chain of community pharmacies in Japan
Get PDFThe global cost of medications, including anticancer drugs, is rapidly increasing. However, the relationship between the pharmacological mechanisms of anticancer drugs and the percentage of patients who prefer brand-name drugs remains largely unexplored. This study aimed to assess the proportion of patients who chose brand-name drugs based on the type of oral anticancer drug prescribed and patient background factors that may influence generic drug use. We extracted data from patients who received oral anticancer drugs at a QOL pharmacy between April 1, 2019, and March 31, 2021. Patient characteristics included age, sex, percentage of health insurance co-payment percentage, presence of a home pharmacist, prescribing healthcare provider, and specific oral anticancer drug prescribed. A total of 17,746 patients with prescriptions for oral anticancer drugs that had generic alternatives were included in the study. Among them, 26.4％ （n＝4,682） opted for brand-name drugs. Our results showed that molecularly targeted drugs had higher brand-name preference rates, with imatinib （73.5％） and gefitinib （62.8％） showing the highest selection rates. Furthermore, Patient characteristics such as sex, age, type of medical institution, and drug type influenced the decision to use brand-name drugs instead of generics. Our findings suggest that targeted educational strategies based on the pharmacologic mechanisms of drugs, rather than a one-size-fits-all approach to promoting generics, may be more effective in encouraging the use of generic anticancer drugs.departmental bulletin pape
Information and Communication Technology as an effective screening tool for poor visuospatial cognitive function detection in infants with low birth weight
Get PDFPrevious studies have indicated an association between low-birth-weight infants （LBWIs） and delayed mental development compared with normal-birth-weight infants （NBWIs）, which can be identified through the difference in intelligence quotient （IQ） scores. We here evaluated the efficacy of the Information and Communication Technology （ICT） program called the “Kids’ Brain Balancer” （KBB）, which could predict cognitive function similar to other established neuropsychological tests. Using this application, we examined 393 children with three tasks. Results of the three tasks did not indicate a significant difference between the LBWI （n＝33） and NBWI （n＝360） groups. Further investigation may highlight the usefulness of ICT tools, including the KBB.departmental bulletin pape
Effect of renin–angiotensin system inhibitors on cardiovascular events in hemodialysis patients with hyperphosphatemia: A post hoc analysis of the LANDMARK trial
Get PDF昭和大学博士(医学)2024年度thesi
Febuxostat inhibits airway inflammation and lung fibrosis in a mouse model of lipopolysaccharide-induced lung injury
Get PDF昭和大学博士(医学)2024年度doctoral thesi
Immune Stress-induced Tumor Mutation Burden and Neoantigen Expression in 4T1 Mammary Cancer Cells: A Potential Mechanism for Long-term Survival in Patients Treated With Immune Checkpoint Inhibitors
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大腸管状腺癌および管状腺腫におけるCD71/transferrin receptor 1発現と病理組織診断への応用に関する臨床病理学的検討―腺腫内癌におけるCD71発現の比較検討を用いて―
Get PDF昭和大学博士(医学)2024年度doctoral thesi
