Showa University Academic Resource Repository / 昭和大学学術業績リポジトリ
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Examination of cerebral blood flow prediction using signals from magnetic resonance angiography: A comparison with cerebral blood flow using 123I-IMP
Get PDFCarotid artery stenting （CAS） is a procedure used in the treatment of internal carotid artery stenosis, a condition that can lead to cerebral infarction. Cerebral hyperperfusion syndrome is among the post-CAS complications. Thus, to ensure postoperative control, understanding the cerebral blood flow is warranted. Nuclear medicine scan is used for the quantitative assessment of cerebral blood flow; however, since magnetic resonance imaging allows assessment of the cerebral artery, it is often used pre- and postoperatively. In the present study, we compared magnetic resonance angiography （MRA） with nuclear medicine scan to determine if MRA can delineate the cerebral blood flow in patients with CAS. The correlation coefficient between the predicted regional cerebral blood flow obtained from MRA and 123I-IMP was 0.68. Moreover, the concordance rate was high. As a result, the MRA test may be used as an alternative imaging study, and it was found to be a reference value in clinical practice.departmental bulletin pape
Gamma-delta T cells are optimal immune cell carrier vehicles for adenovirus vector-based gene therapy
Get PDFGene therapy is a promising technique for treating malignant tumors. The efficacy of gene therapy with Ad5 is not high although adenovirus type 5 （Ad5） is a common vector, and this may be linked to the low gene transduction rate of Ad5 vectors. The rate of target transduction by Ad has enhanced with the invention of fiber-modified Ad （Ad5/F35）; nevertheless, a carrier system for Ad5/F35-based gene delivery is needed. Therefore, we evaluated the possibility of using γδ T cells, which portray high toxicity against cancer cells, as Ad5/F35 vector transporters. In vitro, γδ T cells were more efficient Ad5/F35 vector transporters than human peripheral blood mononuclear cells and natural killer cells tested. Moreover, they could transport the vector to the tumor site in a subcutaneous prostate cancer model in vivo. We conclude that virus-loaded γδ T-cells may aid systemic cancer virotherapy.departmental bulletin pape
Development of a penetratin-conjugated stapled peptide that inhibits Wnt/β-catenin signaling
Get PDF昭和大学博士(薬学)2022年度thesi
Development of a model predicting cardiac events in heart failure patients with decreased renal function: a retrospective study
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Relationship of mandibular condylar length and anterior disc displacement of the temporomandibular joint to facial asymmetry in orthodontic Class II patients
Get PDF昭和大学博士(歯学)2022年度doctoral thesi
Risk Factors Indicating Difficulty During Gastric Endoscopic Submucosal Dissection for Inexperienced Endoscopists: A Retrospective Study
Get PDF昭和大学博士(医学)2022年度doctoral thesi
Glycine and GABAA receptors suppressively regulate the inspiratory-related calcium rise in the thoracic inspiratory cells of the neonatal rat
Get PDF昭和大学博士(医学)2022年度doctoral thesi
