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Green Extraction Enhances Antioxidant and Cytotoxic Properties of Pomegranate By-Products Against Human Cancer Cell Lines
Full text linkThe aim of this study was to determine the anticancer effects of extract obtained from pomegranate by-products by green extraction (ultrafiltration and enzymatic extraction) (GE) on prostate (LNCaP), ovarian (A2780), breast (MCF-7), and colon (Caco-2) cancer cell lines compared to the traditional extraction (TE) and pomegranate juice (PJ). The GE sample demonstrated the highest total or individual phenolic content, and antioxidant activity. The major phenolics in all samples were determined to be ellagic acid, punicalagin A and punicalagin B. The 50% and 100% doses of the PJ exhibited a significant reduction in the viability of all cancer cells except LNCaP cells (only 100%) (p < 0.05). The TE sample showed a significant decrease in the viability of all cancer cells except the MCF-7 cell line (at all doses) at doses other than 1 M (p < 0.05). The GE sample caused a significant decrease in all cancer cells at all doses (1, 5, 25, 50, 100 and 150 M) (p < 0.05). Consequently, the GE sample applied with the green method was effective at all doses in reducing the viability of cancer cells
Bidirectional positive associations between problematic pornography use and body dissatisfaction in women and men: Findings among Hungarian young adults in a one-year longitudinal study
Full text linkPrevious studies have established a positive link between pornography use and body dissatisfaction (BD). Nevertheless, previous empirical studies have yielded inconsistent associations between pornography use and BD when taking into account different forms of pornography use (e.g., pornography use frequency or problematic pornography use) or potential gender differences. Given that problematic pornography use (PPU, out-of-control use with negative consequences) differs from general pornography use, the associations between PPU and BD warrant further examination using a longitudinal design and large sample, which the current literature lacks. Given these limitations, this study examined the associations between PPU and BD cross-sectionally and longitudinally in a sample of Hungarian young adults. Among a sample of 2801 adults (Mage = 28 years, SD = 4.75, 47.69 % men and 52.30 % women), we performed an autoregressive cross-lagged analysis with a multi-group approach. According to the findings, greater levels of PPU were cross-sectionally associated with higher BD among men and women. Longitudinally, we observed bidirectional positive associations between PPU and BD over time among men and women as well. Based on the present findings, clinicians should implement systematic screening procedures for BD symptoms among individuals exhibiting signs of PPU. Similarly, individuals presenting with BD should be assessed for PPU. This dual-screening approach will enable timely intervention and the development of comprehensive treatment plans
Human plasma-derived plasminogen replacement in type 1 plasminogen deficiency: a pediatric case with multisystemic manifestation
Full text linkThe article by D€onmez-Demir et al., ‘Novel plasminogen
gene mutations in Turkish patients with type I plasminogen deficiency’, recently published in Blood Coagulation
and Fibrinolysis[1], was read with great interest. The
study’s authors expanded the mutational spectrum of
the PLG gene in the Turkish population and emphasized
the clinical heterogeneity and the timely recognition of
this rare disorder. As highlighted in the discussion, treatment options for type 1 plasminogen deficiency remain
limited, and management strategies, including plasminogen replacement therapy, are of particular clinical relevance. In this context, we wish to present our paediatric
case demonstrating a multisystemic phenotype and
favourable clinical response to human plasma-derived
plasminogen replacement
Automatic and Rapid Measurement in Artificial Intelligence-Aided Microstructure Analysis: A Deep Learning Approach Applied to AlSi9 Alloys
Full text linkThis study showcases a proof-of-concept of an artificial intelligence-driven analytical technique that facilitates the automated extraction of significant quantitative data from microstructural images. Semantic segmentation and classification were conducted on eutectic Si particles and dendritic architectures utilizing microscopic images of AlSi9 alloys with varying Sr ratios. Following segmentation, characteristics including area, aspect ratio, maximum Feret diameter, circularity and SDAS were assessed automatically, and the resulting values were compared with both literature and manual measurements. The samples were effectively categorized based on their alteration levels using a CNN-based classification algorithm. This technology provides significant temporal and financial benefits for microstructural investigation by executing the entire procedure autonomously and expeditiously. The minimal error rates and elevated accuracy findings demonstrate the usefulness and dependability of the devised method for automated microstructural analysis. This paper exemplifies the application of artificial intelligence-driven microstructural analysis techniques in materials science, addressing a significant gap in the literature
Multifokal intraoküler lens implantasyonu sonrası nöroadaptasyonun stimülasyonu için uygulanan göz egzersizlerinin görme fonksiyonu ve yaşam kalitesi üzerine etkisi
Full text linkBu çalışma multifokal intraoküler lens (IOL) implantasyonu sonrası nöroadaptasyonu stimüle etmek amacıyla uygulanan göz egzersizlerinin, hastaların görme fonksiyonu ve yaşam kalitesi üzerindeki etkilerini incelemek amacıyla yapıldı. Çalışmada 74 birey basit rastgele yöntem ile Çalışma Grubu (ÇG) (n=37) ve Kontrol Grubu (KG) (n=37) olmak üzere iki gruba ayrıldı. Çalışma grubu Multifokal İOL implantsayonunu takiben hastanın durumu stabil olduktan sonra her gün en az bir seans (~30 dk.) toplam 12 hafta boyunca yoga göz egzersizlerini ev temelli olarak uygularken, kontrol grubuna ise sadece değerlendirme planlandı. Değerlendirmeler her iki grup için cerrahiden önce, cerrahiyi takiben 1. ve 3. ayda olmak üzere toplam üç kez yapıldı. Hastaların sosyodemografik verileri için araştırmacı tarafından hazırlanan Sosyodemografik Veri Formu, okuma performansları için Zamanlı Okuma Testi, görme ile ilişkili yaşam kalitesi için Ulusal Göz Sağlığı Enstitüsü Görme İşlevi Ölçeği (NEİ-VFQ 25), anksiyete düzeyleri için Durumluk ve Sürekli Anksiyete Ölçeği (STAI), bilişsel performansları için Standardize Mini Mental Test (SMMT) kullanıldı. Ayrıca göz hastalıkları uzmanı tarafından hastaların refraksiyon hatası, görme keskinliği, kontrast duyarlılığı, göz içi basınç, pupilla çapı ve kappa açısı ölçümleri yapıldı. İlk değerlendirmeden elde edilen veriler, çalışma ve kontrol gruplarının sosyodemografik, fiziksel (yaş, boy, ağırlık, BKİ), fizyolojik (pupilla çapı, kappa açısı) ve bilişsel (SMMT) açıdan benzer olduğunu gösterdi (p>0.05). Yoga göz egzersizleri sonrasında çalışma grubunda göz içi basıncı, okuma performansı, yaşam kalitesi ve anksiyete düzeylerinde kontrol grubuna göre anlamlı iyileşmeler gözlendi (p0,05). Sonuç olarak, bu çalışma, multifokal İOL implantasyonu sonrası uygulanan yoga göz egzersizlerinin hastaların görme fonksiyonları ve görme ile ilişkili yaşam kalitelerini artırabileceğini göstermektedir. Ayrıca, bu egzersizlerin okuma performansı ve anksiyete düzeylerinde olumlu değişimlere yol açtığı, ancak görme keskinliği ve kontrast duyarlılık üzerinde sınırlı bir etkisinin olduğu anlaşılmıştır. Fizyoterapi alanında, görme fonksiyonu ve yaşam kalitesini artırmaya yönelik bu tür tamamlayıcı egzersiz programlarının uygulanması, bireylerin günlük yaşam becerilerini geliştirmek ve rehabilitasyon süreçlerini desteklemek için yenilikçi bir yaklaşım sunabilir. Özellikle, nöroadaptasyonu teşvik eden ve görme fonksiyonlarını destekleyen egzersizlerin, göz sağlığı rehabilitasyonunda standart protokollere entegre edilmesi önemlidir.This study was conducted to examine the effects of eye exercises aimed at stimulating neuroadaptation following multifocal intraocular lens (Multifocal IOL) implantation on patients' visual function and quality of life. In the study, 74 individuals were randomly assigned to two groups: the Study Group (SG) (n=37) and the Control Group (CG) (n=37). The Study Group performed home-based yoga eye exercises for at least one session (~30 minutes) daily for a total of 12 weeks after the patients' condition stabilized following multifocal IOL implantation, while the Control Group was scheduled for assessments only. Assessments were conducted three times for both groups: preoperatively and at the first and third months postoperatively. The Sociodemographic Data Form, prepared by the researchers, was used to collect participants' sociodemographic data; the Timed Reading Test was employed to assess reading performance; the National Eye Institute Visual Function Questionnaire (NEI-VFQ 25) was utilized to evaluate vision-related quality of life; the State-Trait Anxiety Inventory (STAI) measured anxiety levels; and the Standardized Mini-Mental Test (SMMT) was used to assess cognitive performance. In addition, an ophthalmologist performed measurements of refractive error, visual acuity, contrast sensitivity, intraocular pressure, pupil diameter, and kappa angle. Data from the initial assessment showed that the Study and Control Groups were similar in terms of sociodemographic, physical (age, height, weight, BMI), physiological (pupil diameter, kappa angle), and cognitive (SMMT) characteristics (p>0.05). Following the yoga eye exercises, the Study Group demonstrated significant improvements in intraocular pressure, reading performance, quality of life, and anxiety levels compared to the Control Group (p0.05). In conclusion, this study demonstrates that yoga eye exercises performed after multifocal IOL implantation can improve patients' visual function and vision-related quality of life. Furthermore, these exercises contribute to positive changes in reading performance and anxiety levels, although their effects on visual acuity and contrast sensitivity appear to be limited. In the field of physiotherapy, the implementation of such complementary exercise programs aimed at enhancing visual function and quality of life offers an innovative approach to improving daily living skills and supporting rehabilitation processes. The integration of exercises that promote neuroadaptation and support visual function into standard protocols for ocular health rehabilitation is particularly important
The Effect of a Pulmonary Care Bundle Implemented WithCardiac Surgery Patients on Recovery
Full text linkBackground Various care bundles have been used with cardiac surgery patients in order to improve recovery by reducing complication rates. Pulmonary complications are frequent in cardiac surgery patients. The number of studies examining care bundles aimed at preventing pulmonary complications is limited. Further studies in this field may support the recovery of patients. Aim The primary aim of this study was to examine the effect of a pulmonary care bundle (PCB) on the recovery of patients undergoing cardiac surgery. Study Design In this quasi-experimental study, 103 patients were divided into control and study groups. The control group received standard care. A PCB was administered to the study group by nurses in a Cardiovascular Surgery Clinic in Turkey. The Descriptive Characteristics Data Form, Pulmonary Care Bundle Implementation and Evaluation Form, Respiratory Patterns Follow-up Form and Quality of Recovery Questionnaire-40 were applied to the patients. After data collection, the Quality of Recovery Questionnaire-40 scores and respiratory patterns of the patients in the study and control groups were compared. In addition, the nurses' rate of using the care bundle was examined, and their rate of compliance with the bundle was evaluated. Results The Quality of Recovery Questionnaire-40 scores of the study group (177.70 +/- 10.77) were higher than those of the control group (165.28 +/- 15.63) (p < 0.05). The study group's scores for cough and pathologic pulmonary sound were lower than those of the control group. The oxygen saturation level was higher in the study group than in the control group (p < 0.05). Conclusion The PCB had positive effects on recovery. The respiratory pattern findings were better, and the incidence of respiratory complications was lower in patients who received the care bundle. Relevance to Clinical Practice The PCB supported the patients' recovery. This care bundle can be used to prevent pulmonary complications
Genetic and clinical characterization of factor VII deficiency: insights from 34 Turkish patients
Full text linkBackground Factor VII (FVII) deficiency is a rare autosomal recessive bleeding disorder caused by pathogenic variants in the F7 gene. Clinical manifestations vary widely, ranging from asymptomatic cases to severe bleeding episodes, including gastrointestinal bleeding and intracranial hemorrhage. Objective This study aims to evaluate the clinical and molecular characteristics of Turkish patients diagnosed with FVII deficiency and explore genotype-phenotype correlations. Methods A cohort of 34 patients with FVII deficiency was examined. Clinical symptoms were documented, and genetic analysis of the F7 gene was performed to identify pathogenic variants. Results A total of 16 different variants were identified, including four novel variants: c.-5_4delTCinsCA, c.686T>C (p.Leu229Pro), c.728T>C (p.Ile243Thr), c.733delA (p.Thr245ProfsTer20). Monoallelic variants were found in 50% of patients, while biallelic pathogenic variants were detected in 20.6%. No pathogenic variants were identified in 29.4% of the patients. There was a poor correlation between FVII activity levels and clinical severity. Conclusion This study highlights the importance of molecular diagnostics in the management of FVII deficiency, providing valuable insights into genotype-phenotype relationships. Our findings contribute to the understanding of the genetic diversity and clinical spectrum of FVII deficiency, particularly within the Turkish population. Copyright (c) 2025 Wolters Kluwer Health, Inc. All rights reserved
Lumbar spondilolisteziste egzersiz eğitimi ve ortez kulanımının ağrı, kinezyofobi ve yaşam kalitesi üzerine etkilerinin araştırılması
Full text linkLumbar spondilolistezis, istmik ya da dejeneratif nedenlerle, bir vertebranın alttaki vertebraya göre yer değiştirmesiyle ortaya çıkan patolojik bir durumdur. Bu çalışmanın amacı, lumbar spondilolisteziste egzersiz eğitimi ve lumbar ortez kullanımının ağrı, kinezyofobi ve yaşam kalitesi üzerine etkisini araştırmaktı. Bu amaçla grade 1 ve grade 2 spondilolistezis tanısı olan, 16 yaş üstü, çalışmaya engel ortopedik ve nörolojik defisiti olmayan 34 birey çalışmaya dahil edildi. Çalışmaya dahil edilen bireyler, basit randomizasyon yöntemi ile çalışma (n=17) ve kontrol grubu (n=17) olarak 2 gruba ayrıldı. Çalışma grubuna dahil edilen bireylere, lumbar stabilizasyon egzersiz programı oluşturuldu ve haftada 4 gün ve 30 dakika süre ile bu egzersizleri yapmaları istendi. Aynı zamanda gün içinde uzun süre ayakta kalmaları veya efor gerektiren işler yapmaları durumunda spinal ortez desteği kullanmaları önerildi. Kontrol grubuna dahil edilen bireylere ise, lumbar spondilolistezis hakkında detaylı bilgilendirme yapıldı, günlük yaşamda dikkat etmeleri gereken hususlarla ilgili genel önerilerde bulunuldu. Her iki grup, başlangıçta ve 6 haftanın sonunda Visual Analog Skalası (VAS) ile ağrı seviyesi, McGill Ağrı Anketi; Kısa Form (MAA-KF) ile ağrının karakteri, Tampa Kinezyofobi Ölçeği (TKÖ) ile hareket korkusu, Oswestry Bel Ağrısı Engellik Anketi (OBAEA) ile ağrı nedeniyle oluşan engellilik durumu, Short Form-36 (SF-36) ile genel sağlığın iyilik hali değerlendirildi. Çalışma sonunda yapılan, VAS, MAA-KF, TKÖ, OBAEA değerlendirme anketlerinde çalışma grubunda anlamlı iyileşme elde edilirken (p<0,05) kontrol grubunda herhangi bir değişiklik gözlenmedi (p>0,05). Çalışma sonunda yapılan, SF-36 değerlendirme anketinde ise çalışma ve kontrol grubunda herhangi bir değişiklik gözlenmedi (p>0,05). Sonuç olarak, grade 1 ve grade 2 spondilolistezisin tedavi planlamasında, ağrının azalması, kinezyofobi ve engelliliğin iyileşmesi amacıyla stabilizasyon egzersizleri ve spinal ortez desteği kolay ulaşılabilir ve uygulanabilir bir seçenek olarak önerilebilir. Egzersiz ve ortezin birlikte kullanımının spondilolistezisin grade 3 ve 4 gibi diğer aşamalarında ve uzunlamasına tedavi sonuçlarının gösterileceği araştırmalara ihtiyaç vardır.Lumbar spondylolisthesis is a pathological condition that occurs when a vertebra is displaced relative to the vertebra below it due to isthmic or degenerative reasons. The aim of this study was to investigate the effects of exercise training and lumbar orthosis use on pain, kinesiophobia and quality of life in lumbar spondylolisthesis. For this purpose, 34 individuals diagnosed with grade 1 and grade 2 spondylolisthesis, over the age of 16, and without any orthopedic or neurological deficits that would prevent the study were included in the study. The individuals included in the study were divided into 2 groups as the study (n=17) and the control group (n=17) by simple randomization method. A lumbar stabilization exercise program was created for the individuals included in the study group and they were asked to do these exercises for 30 minutes, 4 days a week. They were also advised to use spinal orthosis support if they had to stand for long periods during the day or do work that required effort. Individuals included in the control group were given detailed information about lumbar spondylolisthesis and general recommendations were made about the issues they should pay attention to in daily life. Both groups were evaluated at the beginning and at the end of 6 weeks with the Visual Analog Scale (VAS) for pain level, the McGill Pain Questionnaire; Short Form (MAA-KF) for pain character, the Tampa Kinesiophobia Scale (TKS) for fear of movement, the Oswestry Low Back Pain Disability Questionnaire (OBAEA) for disability due to pain, and the Short Form-36 (SF-36) for general health well-being. At the end of the study, significant improvement was achieved in the study group in the VAS, MAA-KF, TKO, OBAEA assessment questionnaires (p<0.05), while no change was observed in the control group (p>0.05). At the end of the study, no change was observed in the study and control groups in the SF-36 assessment questionnaire (p>0.05). As a result, in the treatment planning of grade 1 and grade 2 spondylolisthesis, stabilization exercises and spinal orthosis support can be recommended as an easily accessible and applicable option for the purpose of reducing pain, improving kinesiophobia and disability. There is a need for studies that will show the longitudinal treatment results of the combined use of exercise and orthosis in other stages of spondylolisthesis such as grade 3 and 4
The Effect of Waiting Time on the Surgical Stretcher in the Operating Room for Urological Surgery on Anxiety and Surgical Fear: A Comparative Cross-sectional Study
Full text linkThis study was conducted to examine the effect of operating room waiting time on surgical fear and preoperative anxiety in patients undergoing urinary system surgery. Design: This study was conducted as a comparative cross-sectional. Methods: This study was conducted with 150 patients undergoing urinary system surgery at a state hospital in Turkey between December 2023 and July 2024. Data were collected using a Descriptive Characteristics Form, the Visual Analog Scale, and the Surgical Fear Questionnaire at two time points: before entering the operating room (T0) and before being placed on the surgical table (T1). Patients were divided into 2 groups based on waiting time: group A (<30 minutes) and group B (≥30 minutes). Statistical analysis was performed with SPSS 27.0 at a significance level of P less than .05. Findings: Patients in groups A and B were similar in terms of descriptive characteristics and T0 assessment. However, at T1 assessment, patients in group B had significantly higher levels of anxiety (P = .002), short-term fear (P = .001), and total fear (P = .001) compared to group A. Waiting time had a significant effect on anxiety (β = 0.637, P = .001), short-term fear (β = 0.788, P = .001), and total fear (β = 0.536, P = .001). Conclusions: Prolonged waiting time in the operating room significantly increases psychological burden by significantly increasing anxiety, short-term fear, and total fear levels in patients. © 2025 The American Society of PeriAnesthesia Nurse