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Cognitive dysfunction and depression in chemotherapy patients: a cross-sectional study from Turkey
Get PDFObjective This study investigates the relationship between cognitive function and depression in cancer patients receiving chemotherapy. Methods A cross-sectional study design was employed, involving 80 cancer patients undergoing chemotherapy. Data were collected using the Socio-Demographic Information Form, the Functional Assessment of Cancer TherapyCognitive Function (FACT-Cog), and the Beck Depression Inventory (BDI). Assessments were conducted prior to the second cycle of chemotherapy. Results Among participants, 72.8% were female and 47.5% aged 40–50. Moderate depressive symptoms were most common (45%). Cognitive dysfunction was inversely correlated with depression (r = -0.525, p < 0.001). Low income significantly predicted lower cognitive scores (p = 0.01). Conclusion Chemotherapy patients exhibit cognitive decline and elevated depression levels. Socioeconomic status exacerbates these effects. Psychosocial interventions should be integrated into oncological rehabilitation
Seasonal and annual precipitation characteristics of Türkiye and the influence of atmospheric-ocean interactions
Get PDFThis study explores the relationship between T & uuml;rkiye's precipitation series and major climate indices, including AMO, PDO, and Nino 3.4. The analysis reveals significant spatial variability in precipitation across T & uuml;rkiye, with coastal regions like the Black Sea and Mediterranean receiving higher rainfall compared to Central Anatolia. The seasonal distribution shows a distinct north-south gradient, with winter precipitation concentrated in the west and south, while summer precipitation is more intense in the southern and southeastern regions. Precipitation Concentration Index (PCI) and Coefficient of Variation (CV) analyses highlight the diverse hydroclimate across the country. Coastal areas, particularly in the south and west, exhibit high seasonal concentration and variability, while the Black Sea coast experiences more uniform precipitation year-round. Decadal analysis of the PCI reveals shifts in precipitation patterns over the past four decades, with notable changes in the 1980s, 2000s, and 2010s. Cross-Wavelet Transform (XWT) analyses show that the AMO (Atlantic Multidecadal Oscillation) exerts a long-term influence on precipitation, particularly in the Mediterranean and Eastern Anatolia regions, while the PDO (Pacific Decadal Oscillation) significantly impacts Southeastern Anatolia. However, Nino 3.4 exhibits more intermittent effects. Same-year correlations between these indices and precipitation are generally stronger than lagged correlations, indicating more immediate impacts. As a result of XWT, the post-2000 period shows shifts in climate dynamics and teleconnections, suggesting evolving influences on T & uuml;rkiye's precipitation, and underscoring the need for adaptive water management strategies
65 yaş ve üzeri tip 2 diabetes mellitus'lu bireylerde kor stabilizasyon egzersizlerinin denge ve düşme korkusu üzerine etkileri
Get PDFBu araştırma, 65 yaş ve üzeri Tip 2 diyabetli bireylerde kor stabilizasyon egzersizlerinin denge ve düşme korkusu üzerindeki etkilerini incelemek amacıyla yapıldı. Çalışmaya 2023 yılı Ocak ve Mart ayları arasında dahil edilen 61 birey rastgele yöntemle kor stabilizasyon egzersiz grubu (n=30) ve aerobik egzersiz grubu (n=31) olarak iki gruba ayrıldı. Kor stabilizasyon egzersiz grubuna haftada 2 gün, 1 saat sürecek şekilde ve toplamda 8 hafta boyunca kor stabilizasyon egzersizleri uygulandı. Aerobik egzersiz grubuna ise haftada 3 gün toplamda 150 dakika orta şiddette aerobik egzersiz programı uygulandı. Egzersiz öncesinde ve sonrasında katılımcıların dengeleri Berg Denge Testi (BDT), mobiliteleri Zamanlı Kalk ve Yürü Testi (ZKYT), düşme korkusu Uluslararası Düşme Etkinlik Skalası (UDES), kor stabilizasyon kaslarının enduransı, vücut kompozisyonları Vücut Kitle İndeksi, Bel Çevresi ve metabolik parametreleri ise HbA1c ile değerlendirildi. Gruplar karşılaştırıldığında egzersiz sonrası değerler açısından BDT skorlarının kor stabilizasyon egzersiz eğitimi grubunda anlamlı derecede iyi olduğu belirlendi(p=0,014). ZKYT değerlerinde istatistiksel açıdan anlamlı fark gözlenmedi (p=0,516). UDES skorları incelendiğinde gruplar arasında istatistiksel farklılık bulunmadı (p=0,08). Kor stabilizasyon kaslarının enduransı açısından bakıldığında kor stabilizasyon egzersiz grubunun daha üstün olduğu belirlendi (p<0,001). HbA1c değerlerindeki azalmanın ise kor stabilizasyon egzersizleri grubunda daha belirgin olduğu gözlendi (p=0,006). Sonuç olarak, kor stabilizasyon egzersiz programlarının, 65 yaş ve üzeri Tip 2 diyabetli bireylerde dengeyi iyileştirme, mobiliteyi arttırma, düşme korkusunu azaltma, vücut kompozisyonunu düzenleme ve metabolik kontrol sağlama açısından etkili olduğu sonucuna varılmıştır. Anahtar Kelimeler: Diabetes Mellitus, Kor Stabilizasyon, Denge, Düşme KorkusuThis study aimed to examine the effects of core stabilization exercises on balance and fear of falling in individuals aged 65 years and older with Type 2 diabetes. A total of 61 individuals were included in the study between January and March 2023 and were randomly assigned into two groups: the core stabilization exercise group (n=30) and the aerobic exercise group (n=31). The core stabilization exercise group performed core stabilization exercises twice a week, each session lasting approximately 1 hour, for a total of 8 weeks. The aerobic exercise group participated in a moderate-intensity aerobic exercise program for 150 minutes per week over three days. Before and after the exercise programs, participants' balance was assessed using the Berg Balance Test (BBT), mobility was evaluated using the Timed Up and Go Test (TUGT), fear of falling was measured using the International Falls Efficacy Scale (FES-I), core muscle endurance was assessed, and body composition parameters, such as Body Mass Index (BMI) and waist circumference, along with metabolic parameters, such as HbA1c levels, were recorded. When comparing the groups, post-exercise BBT scores were found to be significantly better in the core stabilization exercise group (p=0.014). No statistically significant difference was observed in TUGT values (p=0.516). Similarly, there was no significant difference in FES-I scores between the groups (p=0.08). Regarding core muscle endurance, the core stabilization exercise group demonstrated superior results (p<0.001). The reduction in HbA1c levels was also more pronounced in the core stabilization exercise group (p=0.006). In conclusion, core stabilization exercise programs were found to be effective in improving balance, enhancing mobility, reducing fear of falling, improving body composition, and achieving metabolic control in individuals aged 65 years and older with Type 2 diabetes. Keywords: Diabetes Mellitus, Type 2, Core Stabilization, Balance, Fear of Fallin
Determination of copper (II) in seafood and water samples by ICP-OES using magnetic titanium aluminum carbide nanocomposite for solid phase microextraction
Get PDFThis study presents a method for the quantitative determination of copper ions (Cu (II)) in various seafood using solid phase microextraction (SPME) with magnetized maximum phase titanium aluminum carbide (Ti3AlC2) nanocomposite (MAX phase-MSPE). The aim of this method is to separate copper from the complex matrix environment and ensure a measurable concentration level. Optimized extraction conditions were established, including pH, extraction time, sample volume, and eluent concentration. The analytical significant parameters of the MAX phase-MSPE method have been assessed through limit of detection (LOD), limit of quantification (LOQ), recovery (R%), and certified reference material studies to obtain high accuracy and sensitivity. The LOD, LOQ, preconcentration factor, and relative standard deviation were obtained as 0.37 and 1.2 µg/L, 10, and % 4.1, respectively. The developed method demonstrates high selectivity toward copper ions (Cu (II)) in both food and water samples. This makes the approach particularly suitable for applications in food safety monitoring and environmental analysis, where precise detection and quantification of copper ions are critical. © 2025 Elsevier Inc
Metabolic-Nutritional Associations with Depression in Elderly Chronic Kidney Disease Patients: Hemodialysis Versus Non-Dialysis Populations
Get PDFBackground/Objectives: This study aimed to evaluate the interrelationship between depression and nutritional-metabolic status in geriatric patients with chronic kidney disease (CKD), and to identify the contributing clinical and sociodemographic factors, with a particular focus on differences between patients receiving and not receiving hemodialysis treatment. Methods: This cross-sectional descriptive study was conducted between September 2023 and September 2024 in Gaziantep, Turkey. A total of 152 CKD patients aged 65 years and older were included, with 78 receiving hemodialysis and 74 managed without dialysis. Nutritional status was assessed using the Mini Nutritional Assessment-Short Form (MNA-SF), and depression levels were measured using the Geriatric Depression Scale-Short Form (GDS-SF). Laboratory parameters such as hemoglobin and serum albumin were also recorded. Results: A total of 152 geriatric CKD patients were included, with 78 (51.3%) undergoing hemodialysis and 74 (48.7%) not receiving dialysis. The non-dialysis group had significantly higher age (77.07 +/- 8.61 vs. 70.13 +/- 7.76 years, p = 0.001) and BMI (28.44 +/- 4.70 vs. 25.18 +/- 4.75, p = 0.001). Serum albumin levels were lower in non-dialysis patients (2.53 +/- 0.67 vs. 3.50 +/- 0.465 g/dL, p < 0.001), while hemoglobin (12.44 +/- 2.03 vs. 11.16 +/- 1.92 g/dL, p = 0.001) and ALT levels (17.16 +/- 13.06 vs. 8.53 +/- 4.31 U/L, p = 0.001) were higher. Malnutrition was more frequent among non-dialysis patients (20.3% vs. 9.0%, p = 0.033). Although depression was more common in this group, the difference was not statistically significant (p = 0.091). A moderate negative correlation was observed between MNA-SF and GDS-SF scores (r = -0.426, p < 0.01). Serum albumin positively correlated with MNA-SF (r = 0.374, p < 0.01) and negatively with GDS-SF (r = -0.323, p < 0.01). Conclusions: Malnutrition was more frequent among elderly CKD patients not receiving hemodialysis, whereas depression prevalence did not differ significantly between groups. A significant correlation between nutritional status (MNA-SF, serum albumin) and depressive symptoms (GDS-SF) was observed in the overall CKD cohort, underscoring the close interplay between metabolic and psychological health in this population. These results highlight the need for routine screening and integrated management of both nutrition and mental health in elderly CKD patients, and future longitudinal studies are warranted to determine causal pathways and predictive value
Factors influencing the intention of family members of patients admitted to emergency departments to commit violence against health care professionals: A multicenter cross-sectional study
Get PDFIntroduction: Information regarding the factors influencing the intention of family members of patients admitted to the emergency department to commit violence against health care professionals is limited. This study aimed to determine the factors affecting the intention of family members of patients admitted to the emergency department to commit violence against health care professionals. Methods: This multicenter cross-sectional study, conducted in 3 Turkish hospitals from December 2023 to May 2024, involved 872 family members of emergency department patients. Ethical approval was obtained (approval no: 2023/83). Data were collected through face-to-face surveys using the Intention to Commit Violence Against Healthcare Workers Scale and the Healthcare Access Experience Form. Analysis was performed with SPSS 22.0 using both parametric and nonparametric tests, with significance set at P<.05. Results: The participants' average age was 35.60 SD = 10.89, with 56.8% male and 61.5% having completed secondary education. Significant factors increasing the intention to commit violence included younger age (P = .001), lower education (P = .001), unemployment (P = .001), and being single (P = .001). Although the overall intention to commit violence was low, negative perceptions regarding health care access, such as lack of information about their relative's condition (P = .001), inability to see their relative during treatment (P = .001), and exclusion from care (P = .001), significantly heightened this intention. Discussion: This study reveals that the strongest factors influencing the intention to commit violence among family members of patients admitted to the emergency department are the lack of information about their relative and inadequate communication
Determining the decay of frictional shear bond strength in the fiber duct of a single straight steel fiber in cementitious composites using an experimental and numerical data calibration method
No full textWhen straight steel fibers (SSFs) are embedded in a cementitious matrix, the frictional shear bond strength increases the safety factor against brittle fractures in the fiber/matrix regime. This study presented three methods for evaluating the frictional shear bond strength performance based on the pullout work principle. First, theoretical approaches defined the SSF regime in concrete matrices using an analytical model. Second, experimental pullout tests were used to control the proposed theoretical approaches. Third, numerical simulations were used for validation purposes. These three methods were calibrated using an empirical decaying coefficient. Various parameters were used to evaluate the pullout work and frictional shear bond strength. The effects of the fiber geometry, such as the diameter, embedded length, and aspect ratio, were investigated. The results showed that increasing the diameter of the fibers by six times increased the pullout capacity by 3.75 times and decreased the frictional shear bond strength by 62.4%. Thus, decreasing the fiber diameter improved the resistance of the fiber duct against decay. However, increasing the embedment length and aspect ratio of the fibers by 1.8 times increased the pullout capacity by 2.1 times and decreased the shear bond strength by 7.9%. Therefore, increasing the embedded length of the fiber increased crumbling in the fiber duct. © 2025 American Society of Civil Engineers
Hydrazine imprinted electrochemical sensor based on cobalt-barium stannate nanoparticles incorporated-functionalized MWCNTs nanocomposite for hydrazine determination in tap water samples
Get PDFA hydrazine (HYD) detection method is presented based on molecularly imprinting polymers (MIPs) and cobalt-barium stannate nanoparticles incorporated-functionalized MWCNTs (CBSNPs/f-MWCNTs) nanocomposite. Firstly, co-precipitation and sonication techniques were applied to the preparations of CBSNPs and CBSNPs/f-MWCNTs nanocomposite, respectively. Since waste generation occurs at a minimum level in these techniques, an environmentally friendly nanocomposite was prepared. After the glassy carbon electrode modification with CBSNPs and CBSNPs/f-MWCNTs nanocomposite, HYD imprinted electrodes were fabricated using cyclic voltammetry (CV) with a dispersion containing 100.0 mM pyrrole (Py) monomer and 25.0 mM HYD molecule. The resulting electrochemical sensor demonstrated a detection span of 1.0 x 10-9 M to 1.0 x 10-8 M HYD and achieved a detection limit (LOD) of 3.0 x 10-10 M. Furthermore, the developed electrochemical sensor was used for actual tap water samples, and the obtained values close to 100.00% in recovery experiments showed the high accuracy of the developed sensor in real sample analysis. Finally, the selectivity, stability, and reproducibility of the created electrochemical sensor were investigated, and the developed sensor has been demonstrated to have high stability for at least 7 weeks, high reproducibility with a relative standard deviation (RSD) value of 0.14%, and high selectivity in real samples
Burdens of type 2 diabetes and cardiovascular disease attributable to sugar-sweetened beverages in 184 countries
Get PDFThe consumption of sugar-sweetened beverages (SSBs) is associated with type 2 diabetes (T2D) and cardiovascular diseases (CVD). However, an updated and comprehensive assessment of the global burden attributable to SSBs remains scarce. Here we estimated SSB-attributable T2D and CVD burdens across 184 countries in 1990 and 2020 globally, regionally and nationally, incorporating data from the Global Dietary Database, jointly stratified by age, sex, educational attainment and urbanicity. In 2020, 2.2 million (95% uncertainty interval 2.0–2.3) new T2D cases and 1.2 million (95% uncertainty interval 1.1–1.3) new CVD cases were attributable to SSBs worldwide, representing 9.8% and 3.1%, respectively, of all incident cases. Globally, proportional SSB-attributable burdens were higher among men versus women, younger versus older adults, higher- versus lower-educated adults, and adults in urban versus rural areas. By world region, the highest SSB-attributable percentage burdens were in Latin America and the Caribbean (T2D: 24.4%; CVD: 11.3%) and sub-Saharan Africa (T2D: 21.5%; CVD: 10.5%). From 1990 to 2020, the largest proportional increases in SSB-attributable incident T2D and CVD cases were in sub-Saharan Africa (+8.8% and +4.4%, respectively). Our study highlights the countries and subpopulations most affected by cardiometabolic disease associated with SSB consumption, assisting in shaping effective policies and interventions to reduce these burdens globally. © The Author(s) 2025