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Direct and indirect pathways to kindergartners' school adjustment: Roles of children's parent and friendship representations
Get PDFIn this study, we investigated the direct and indirect associations between children's attachment representations of parents and their representations of friendships with their reported feelings about school (school liking and avoidance). A story completion task was administered to 91 preschool children to assess attachment security with their parents. Approximately three months later, the children completed a story completion task about friendships and provided information about their feelings toward school. Children's attachment representations with their parents were positively associated with school liking and negatively associated with school avoidance. Similarly, attachment security with parents was associated with children's positive friendship representations. The indirect effects of children's positive friendship representations on the associations between attachment security with parents and school liking and avoidance were significant. These results revealed the potential importance of children's representations of close relationships for the development and maintenance of their adjustment to school
Evaluation of Urinary Incontinence Status of Women With Diabetes: Cross-Sectional Analytical Study
Get PDFThis study aimed to evaluate urinary incontinence and its impact on quality of life in women diagnosed with diabetes. Conductedas a cross-sectional analytical study, it included 217 women with diabetes who were admitted to a public hospital. Data werecollected through face-to-face interviews using the Descriptive Information Form and the Incontinence Quality of Life Scale(I- QOL), and statistical analyses were performed using SPSS 25.0. Significant differences were found between I- QOL total andsubscale scores and various incontinence-related factors, including pain during urination, amount of urine leakage, presenceof incontinence, coping strategies for incontinence, difficulty urinating, urinary tract infections in the last 6 months, inconti-nence episodes in the last 30 days, incontinence while urinating, frequency of urinary incontinence, frequent urination, use ofincontinence-related medication, and pad use (p < 0.01). Overall, the findings indicate that urinary incontinence is a prevalenthealth issue among women with diabetes and significantly impairs their quality of life, suggesting that addressing incontinencewithin diabetes management programs may help improve patient well-being.1 | IntroductionDiabetes is a chronic and metabolic disease that occurs due toinsufficient insulin production or the inability of insulin to entercells [1]. This condition leads to uncontrolled increases in bloodsugar levels, resulting in various systemic complications andnegatively affecting individuals' quality of life Turkish Societyof Endocrinology and Metabolism [2]. The prevalence of diabe-tes is steadily increasing worldwide, posing a significant publichealth concern [3].According to the International Diabetes Federation [3], thenumber of people with diabetes is expected to reach 643million by 2030 and 783 million by 2045. These projectionshighlight the urgent need for effective strategies in diabetesprevention and management. Turkey is among the countriesin Europe with the highest diabetes prevalence, with an esti-mated 6.6 million diabetic individuals according to the 2019IDF Diabetes Atlas. This number is expected to rise to 10 mil-lion by 2045, and Turkey is predicted to be among the top 10countries worldwide with the highest number of people livingwith diabetes [1].Diabetes is not only a metabolic disorder but also significantlyincreases individuals' susceptibility to infections [2]. The inci-dence of infections is higher in diabetic individuals comparedto non-diabetics, with urinary tract infections (UTIs) being oneof the most common infection types among diabetic patients [4].© 2025 British Association of Urological Nurses and John Wiley & Sons Ltd
The effects of sports and physical activity on quality of life in elderly individuals taking regular medication
No full textIn this applied study, the effects of medication use and regular sports and physical activity on quality of life in elderly individuals who regularly use medication were examined. In this study, 4972 people with different demographic characteristics participated in this research and data were collected with a questionnaire method consisting of a 5-point Likert scale. The data obtained were in order to understand the effects of demographic variables on medication use and quality of life. Within the framework of the study, the relationship between demographic factors such as age, gender, educational status, marital status and medication use, medication recommendation and the number of medications used analysed in detail. After statistical analyses using ANOVA and Chi-square analyses, it found that medication use differed especially according to age and marital status, while medication recommendation was significantly related to gender, educational status and marital status. In terms of other findings, in addition to demographic factors, regular physical activity and sports positive effects on medication use. It was also determined that the number of medication used was significantly related to loneliness and feeling of helplessness. It also found that the feeling of loneliness and medication use pattern were in a significant relationship in individuals engaged in sports and physical activity. In addition, it was found that there was a significant relationship between medication intake and quality of life in individuals engaged in sports and physical activity. After this study, it has been revealed that it is a very important source to understand the relationship between medication use and quality of life in elderly individuals who do sports and physical activity and the importance of encouraging elderly individuals to do more physical activity. © 2025, Campus EDUCA SPORTIS S.L.. All rights reserved
Sağlık çalışanlarının bisfenoller konusunda bilgi düzeyi oranlarının değerlendirilmesi
Get PDFSağlık çalışanlarının bisfenoller konusunda bilgi düzeyi oranlarının değerlendirilmesi amacıyla yapılan çalışma tanımlayıcı tiptedir. Araştırma 15 Nisan – 15 Eylül 2024 tarihleri arasında Gaziantep Üniversitesi Şahinbey Araştırma ve Uygulama Hastanesi'nde görev yapan 400 sağlık personeli (doktor, ebe, hemşire, sağlık teknikeri) ile gerçekleştirildi. Çalışmanın verileri, katılımcılardan bilgilendirilmiş onam alındıktan sonra araştırmacı tarafından yüz yüze görüşme yoluyla toplandı. Veri toplama aracı olarak araştırmaya katılan sağlık çalışanlarının sosyo-demografik özelliklerini değerlendiren form ile bisfenoller hakkında bilgi düzeyi oranlarını değerlendiren soru formu kullanıldı. Veriler Statistical Package for Social Sciences (SPSS) 25.0 programı kullanılarak analiz edildi. Sağlık çalışanlarının yaş aralığının 21 ile 56 arasında olduğu tespit edildi. Katılımcıların %31,7'sinin doktor, %29,2'sinin hemşire, %7,6'sının ebe ve %31,5'inin sağlık teknikeri olduğu tespit edildi. Çalışanların Bisfenol isimli kimyasal hakkındaki bilgi düzeylerine bakıldığında , %23.7'si daha önce duyduğunu, %58.7'si duymadığını ve %17.6'sı bu konuda bilgi sahibi olmadığı belirlendi. Sağlık Çalışanları için Bisfenol Bilgi Düzeyi Formu'ndan elde edilen verilere göre, ortalama madde puanı 0,30±0,27 (0-1), toplam puan ortalaması ise 3,90±3,48 (0-12) olarak bulundu. Bilgi düzeyi açısından yapılan değerlendirmeye göre, katılımcıların %82,6'sının Bisfenol bilgi düzeyinin yetersiz olduğu, %17,4'ünün ise yeterli bilgiye sahip olduğu tespit edildi. Bu bulgular, sağlık çalışanlarının büyük bir kısmının bisfenollerle ilgili bilgi düzeyinin yetersiz olduğunu gösterdi. Sağlık çalışanlarının bisfenoller konusunda bilgi düzeylerini artırmak ve bisfenollere maruz kalma riski taşıyan hastaları değerlendirmek amacıyla bisfenollerin olumsuz etkileri hakkında farkındalık eğitimlerinin düzenlenmesi gerektiği görüşüne, katılımcıların %70,5'i (n=282) katıldığını belirtirken, %1,5'i (n=6) gerekli olmadığını, %28,0'i (n=112) ise bu konuda bilgi sahibi olmadığını ifade etti. Çalışmamızın sonuçları, sağlık çalışanlarının endokrin bozucu özellikler taşıyan bisfenoller hakkında yeterli bilgiye sahip olmadığını göstermektedir. Bu durum, bisfenollerle ilgili farkındalık eğitimlerinin düzenlenmesi gerekliliğini ortaya koymaktadır. Yapılacak bu eğitimler, hem sağlık çalışanlarının hem de hastaların bisfenol maruziyetini en aza indirmeye katkı sağlayacaktır.This descriptive study was conducted to evaluate the knowledge levels of healthcare professionals regarding bisphenols. The research took place between April 15, 2024, and September 15, 2024, at Gaziantep University Şahinbey Research and Application Hospital, involving 400 healthcare professionals (doctors, midwives, nurses, and health technicians). Data were collected through face-to-face interviews conducted by the researcher after obtaining informed consent from the participants. Two forms were used as data collection tools: one assessing the socio-demographic characteristics of health professionals, and the other a questionnaire assessing their level of knowledge about bisphenols. The data were analyzed using the Statistical Package for Social Sciences (SPSS) version 25.0. The age range of the participants was found to be between 21 and 56. It was found that 31.7% of the participants were doctors, 29.2% were nurses, 7.6% were midwives and 31.5% were health technicians. When examining the participants' knowledge about bisphenols, it was found that 23.7% had heard of the chemical before, 58.7% had not, and 17.6% had no knowledge about it. According to the results of the Bisphenol Knowledge Level Assessment Form, the average item score was 0.30±0.27 (on a scale of 0 to 1), and the total average score was 3.90±3.48 (on a scale of 0 to 12). The analysis revealed that 82.6% of participants had insufficient knowledge about bisphenols, while 17.4% had sufficient knowledge. These findings indicate that most healthcare professionals lack adequate knowledge about bisphenols. Regarding the necessity of organizing awareness training on the harmful effects of bisphenols to improve healthcare workers' knowledge and assess patients at risk of exposure, 70.5% (n=282) of participants agreed, 1.5% (n=6) disagreed, and 28.0% (n=112) stated they had no opinion on the matter. The results of this study demonstrate that healthcare professionals do not have sufficient knowledge about bisphenols, which are known to have endocrine-disrupting properties. This underscores the need for awareness training on bisphenols. Such training programs could contribute to minimizing bisphenol exposure for both healthcare professionals and patients
Determination of the In Vitro Cytotoxic Activities of Several Coumarin Derivatives on Neuroblastoma Cell Lines With In Silico Inhibitory Effects on CDK9, VEGFR2 and EGFR Proteins and ADME Studies
No full textDue to their stable nature and medical applicability properties, coumarin derivatives have fascinated medicinal chemists in the discovery of novel therapeutics. In this study, the cytotoxic/anticancer properties of some newly synthesized coumarin derivatives were aimed at designing, synthesizing, and examining cultured human neuroblastoma cells. Moreover, molecular docking studies were carried out to determine the potential mechanism. In addition, ADMET properties were evaluated to examine the drug-likeness of newly designed coumarin derivatives. To detect the cytotoxic action of compounds, 3-(4,5-dimethylthiazol-2-yl)-2,5 2,5-diphenyltetrazolium bromide (MTT) and lactate dehydrogenase (LDH) release assays were carried out. In addition, Hoechst 33258 staining was used to detect abnormal nuclear structures. In silico, the estimates for all compounds (3a-3c) used in the study revealed that they possessed desirable physicochemical properties for bioavailability. The results of our study showed that all tested compounds exhibited remarkable cytotoxic effects on human neuroblastoma cell lines (p < 0.05). Additionally, among the compounds tested, 3a and 3c showed selective effects on neuroblastoma cells effectively at all tested concentrations. However, it was found that the selective feature of 3b, unlike the others, was concentration-dependent. Our findings clearly showed that novel coumarin derivatives exerted potent and selective anticancer effects. Results of molecular docking studies were in parallel with in vitro studies. Unlike the majority of hybrid coumarin derivatives reported in anticancer research, the present study introduces minimalist, heteroatom-free coumarins bearing bulky aliphatic substituents. These compounds demonstrated selective cytotoxicity against SH-SY5Y neuroblastoma cells and a favorable multi-target binding profile, highlighting a distinct hydrophobic volume-based SAR. As a result, the obtained data exhibited that all used molecules may be good multitarget drug alternatives for the treatment of neuroblastoma. © 2025 John Wiley & Sons Ltd
Biopsychosocial model-based exercise improves muscle strength, proprioception, pain, function, and quality of life in rheumatoid arthritis patients with knee involvement: a randomized controlled clinical tiral
Get PDFThis randomized controlled study aims to evaluate the effects of BETY (Bili & scedil;sel Egzersiz Terapi Yakla & scedil;& imath;m & imath;-Cognitive Exercise Therapy Approach in English) as a biopsychosocial model-based exercise approach on knee joint proprioception and other biopsychosocial characteristics through telerehabilitation in individuals with Rheumatoid Arthritis (RA). The study included 19 female (10 Training Group, 9 Control Group) individuals diagnosed with RA. Individuals participated in BETY group sessions via telerehabilitation for one hour, three days a week for three months. The primary outcome measures were the BETY-Biopsychosocial Questionnaire (BETY-BQ) and Proprioception assessment via Biodex System III Isokinetic Dynamometer and the secondary outcome measures were the McGill Pain Questionnaire- Short Form, Western Ontario-Mcmaster University Osteoarthritis Index, Health Assessment Questionnaire, Falls Efficacy Scale, World Health Organization Quality Of Life Scale-Short Form (WHOQOL-BREF), 6-Min Walk Test, Time Up And Go Test and 10-Step Stair Climbing Test were used. There were no differences between the groups in terms of demographic characteristics. Improvements were found in favor of the post-treatment training group in TUG, 10-SCT, 6MWT distance, BETY-BQ sleep, WHOQOL-BREF social relations, knee proprioception, and muscle strength measurements (p < 0.05). In this study, BETY was presented to the literature with its positive impact on muscle strength and proprioception, functional capacity, pain, mood, quality of life, and biopsychosocial status in RA patients with knee involvement
NGOs and the sociocultural adaptation of refugees: exploring challenges and impact
Get PDFThis study explores the role of non-governmental organisations (NGOs) in facilitating the sociocultural adaptation of Syrian refugees in Türkiye. Data were collected using both quantitative and qualitative methods, including a questionnaire featuring the Sociocultural Adaptation Scale – Revised, demographic and open-ended questions directed at refugees, and interviews with NGO representatives. The findings highlight both the successes and challenges associated with NGO-led programmes aimed at enhancing refugees’ sociocultural adaptation. While these initiatives have fostered environments that promote communication and mutual understanding between refugees and the host community, the study found that NGO programmes were positively associated primarily with language proficiency (LP), with beneficiaries demonstrating higher LP scores compared to non-participants. However, NGO programmes did not significantly influence overall sociocultural adaptation, and socio-demographic factors such as age and employment status were independently associated with LP outcomes. Respondents identified organisational deficiencies, a lack of expertise among training personnel, and the short duration of programmes as key obstacles. Language barriers were particularly challenging, exacerbated by economic pressures that hindered full-time educational engagement. Additionally, perceptions of non-acceptance from the host community, fuelled by political rhetoric and negative media portrayals, further complicated integration efforts. The study underscores the importance of multisectoral collaboration, to ensure more comprehensive integration
Clinical and laboratory aspects of patients diagnosed with various inherited platelet disorders
Get PDFBackground: Inherited platelet disorders (IPDs) are characterized by thrombocytopenia, platelet dysfunction, or both, leading to recurrent bleeding and diagnostic challenges. Advances in genetic testing have significantly improved early and accurate diagnoses. Objectives: This study aimed to evaluate the clinical and genetic spectrum of IPDs, identify diagnostic challenges, and assess outcomes of therapeutic interventions. Methods: We conducted a retrospective cohort study of 50 IPD patients. We performed clinical evaluations, peripheral smear analyses, and genetic testing to identify causative variants. Correlation between platelet counts, bleeding severity, and the effectiveness of treatments, such as hematopoietic stem cell transplantation and thrombopoietin receptor agonists, was analyzed. Results: A total of 54.5% of cases showed autosomal dominant inheritance. Diagnostic delays were common, with many patients initially misdiagnosed as having immune thrombocytopenic purpura (ITP). There was a moderate, negative, statistically significant correlation between platelet counts and bleeding severity. Peripheral smear findings, such as stomatocytosis and macrothrombocytopenia, provided critical diagnostic clues. We identified novel mutations in GP1BA, ITGB3, NBEAL2, WAS, and MPL genes, which expanded our understanding of IPDs. Different treatment modalities were used. Hematopoietic stem cell transplantation was performed in severe systemic cases, such as Wiskott–Aldrich syndrome. Sitosterolemia was treated with ezetimibe. Thrombopoietin receptor agonists reduced bleeding in some patients. Conclusion: Integrating genetic, clinical, and laboratory findings is essential in providing accurate diagnoses and management of IPDs. Early genetic diagnosis and personalized therapeutic strategies improve outcomes. Future research should focus on functional studies of novel mutations and refining treatment protocols to enhance care for this complex population. © 2025 The Author(s
Modeling PISA 2022 student performance with interpretable fuzzy methods: a comparison of FPM and ANFIS
Get PDFThis study explores the potential of the Fuzzy Propositional Model (FPM) for predicting student achievement using process data from the PISA 2022 mathematics tasks in the Turkish sample. The model interprets students’ problem-solving behaviours through rulebased reasoning and triangular membership functions, providing insights into how learning processes unfold rather than focusing solely on correctness. The results indicate that the FPM yields pedagogically meaningful interpretations of behavioural indicators such as response time, number of actions, and task revisits, linking them to varying achievement levels. Although data-driven models like ANFIS may achieve marginally higher numerical precision, the FPM stands out by offering transparent, interpretable rules that enhance educational understanding and support data-informed decision-making. These findings demonstrate that explainable fuzzy logic models can serve as practical tools in large-scale assessments, helping educators and policymakers transform process data into actionable insights about student learning
A novel intuitionistic fuzzy decision-making framework for sustainable site selection of solar panel waste recycling facilities
Get PDFIncreasing global energy demand makes the transition to efficient and clean energy sources, such as solar energy, necessary. However, decommissioned solar panels generate hazardous waste, creating significant environmental challenges. Establishing an optimal location for solar panel waste recycling facilities is crucial to ensuring sustainability and compliance with environmental regulations. This study identifies and evaluates a detailed set of criteria, including environmental, economic, social, and technical aspects, critical for the site selection of solar panel waste recycling plants. This study offers the first methodical approach for solar waste management in Türkiye, confirming that growing solar energy investments align with sustainable waste treatment strategies. To handle the complexities of this process, an integrated methodology combining an improved Intuitionistic Fuzzy Indifference Threshold-Based Attribute Ratio Analysis (IF-ITARA) and Intuitionistic Fuzzy Evaluation based on Distance from Average Solution (IF-EDAS) is proposed. IF-ITARA is developed and introduced to the literature to provide a more precise determination of criteria weights, while IF-EDAS ranks the five potential sites in Turkiye, including Izmir, Konya, Kayseri, Antalya, and Sanliurfa, based on these weights. This approach effectively manages uncertainties and subjectivity in decision-making by incorporating intuitionistic fuzzy logic, providing a robust and systematic evaluation. The findings show that the most significant factor in the site selection process of the solar panel waste recycling plant is the legal and regulatory environment. The results offer valuable insights for policymakers and stakeholders involved in solar waste management and sustainable infrastructure planning. This study not only advances the application of decision-making approaches but also contributes to the broader goal of promoting a circular economy in the renewable energy sector