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Bioprinting Revolution: Innovative Design of 3D Bioactive Scaffolds for Living Organs and Transdermal Tissues
No full textThe bioprinting revolution has opened new frontiers in the design and fabrication of
three-dimensional bioactive scaffolds for living organs and transdermal tissues. This
transformative technology enables the precise assembly of biomaterials and living
cells, creating structures that mimic the complexity of natural tissues. Advances in
bioprinting have facilitated the development of personalized scaffolds for tissue
regeneration, wound healing, and transdermal drug delivery systems. This abstract
explores cutting-edge innovations in bioactive scaffold design, highlighting their
potential to replicate functional organ structures and support transdermal therapeutic
applications. Current challenges, such as achieving vascularization and mechanical
integrity, are discussed alongside emerging solutions and future directions for clinical
translation. Bioprinting stands poised to redefine the landscape of regenerative medicine
and transdermal therapeutics
Contributions of Economic Diplomacy to the Public Diplomacy Communication Model in Tiirkiye: An Evaluation of the Central Bank's Potential
No full textContemporary diplomacy is increasingly shaped by both the dernaruis of
the present and the historical contexts of states. The evolution of Turkish
public diplomacy exemplifies this interplay, drawing on Tiirkiye,s longstanding
state traditions as it enters its second century in 2023. This transition
marks a significant phase: in which Tlirl:::i.ye's public diplomacy is
being redefined to align with contemporary global standards and objectives.
The "Century of T\irkiye" initiative represents a strategic effort to
integrate the country's state structure, institutional frameworks, and economic
goals into its public diplomacy strategy
Story Point Estimation Using Transformer Based Agents
No full textReliable story-pointing is key to sprint planning, staffing, and capacity,
but traditional methods rely on tacit knowledge that fades. Automating and
standardizing with Large Language Models reduces bias and improves predictability.
Models like GPT-4 decompose tasks, solve subproblems, and propose candidates;
however, closed architectures limit real-time data and expert input, sometimes
causing hallucinations. Fine-tuning helps but requires rich domain data and custom
weights, risking weaker generalization.
We tackle these issues by enhancing agile story point estimation with extended positional
encoding and a multi-agent weighting scheme in the model head. In our
transformer model, we add a shared “knowledge pool” of specialized agents in the
environment, each trained on distinct facets of project data. Using 12,017 story
point records from 8 open source projects, we adopt an 80/20 train/holdout split;
from the holdout, 80% populates the knowledge pool and 20% is reserved for evaluation.
Our system uses hyperparameters (epochs = 3, batch size = 16, learning rate
= 2×10−5). The proposed architecture achieves 70.81% accuracy versus 42.62%
for standard BERT, a relative gain of ≈ 66.1%, indicating that domain-specialized
agents with refined encoding substantially improve Large Language Model-based
estimations and support AI-assisted agile management
Machine Learning Approaches for Predicting Diesel engine Emissions Using Waste tire Pyrolysis Oil – Hydrotreated Vegetable Oil Blends
No full textThis experimental study explores the use of blended Tire Pyrolysis Oil (TPO) with Hydrotreated Vegetable Oil
(HVO) as potential substitutes for diesel fuel in compression ignition engines. The assessment of the investigation
on the three blends of TPO with HVO as the varying %vol addition as 15 %, 30 % and 60 % under various engine
load conditions. The performance and emission characteristics are compared with the neat fuels like diesel oil,
HVO and neat TPO for conclusive results. Further to enhance the analysis and reduce dependency on extensive
physical testing, machine learning (ML) techniques were employed to model and predict engine out emissions.
Four machine learning models including Linear Regression (LR), k-Nearest Neighbors (KNN), Random Forest
(RF), and Gradient Boosting (GB) were developed to estimate these outputs. The performance of the models was
evaluated using R², Root Mean Square Error (RMSE), and Mean Absolute Error (MAE). Among the models,
Random Forest achieved the lowest RMSE, MAE values and highest R² across the target variables, followed by
Gradient Boosting, while KNN and Linear Regression demonstrated relatively lower R² and higher errors. The
findings emphasize the strength of ensemble-based models in accurately predicting engine behaviour under
varying fuel conditions. The experimental results shows that the engine operations with HVO as the working fuel
has improved brake thermal efficiency of 30.8 % with reduced emission formation. The addition of 15 % vol of
TPO with HVO also has the improved thermal efficiency of 28.2 % and with the consistent increase of TPO with
HVO as 30 and 60 %vol the brake thermal efficiency tends to decrease. The integration of experimental data with
machine learning provides a valuable framework for optimizing alternative fuel usage in diesel engines,
contributing to more sustainable energy systems
Abd Al-Jalīl Īsā and His Tafsir Titled Taysīr Al-Qur’ān Al-Karīm Lıl-Qırā’ah wal-Fahm Al-Mustaqīm
No full textGeçtiğimiz asırda Mısır’da yaşamış ilim adamlarından biri olan Abdülcelîl Îsâ, döneminde adından söz ettirmiş, ilim dünyasına önemli eserler ve izler bırakmış bir ilim adamıdır. İcra ettiği vazifelerin yanında kaleme aldığı eserler, yetiştirdiği ilim adamları onun ilmî birikim ve mirasının aktarılmasında önemli bir yere sahiptir. Yaşadığı dönem itibariyle önceki âlimler ile sonrakiler arasında bir geçiş dönemi âlimi olarak köprü vazifesi görmüş, çeşitli konularda kaleme aldığı eserleri ve özellikle de tefsiriyle ismini ilim dünyasına yazdırmıştır. Mısır’da ilim ehli arasında belirli bir üne sahip olan Abdülcelîl Îsâ’nın Türkiye’de çok tanındığını söylemek zordur. Zira gerek Abdülcelîl Îsâ’nın hayatına dair gerekse eserleri ve bahusus tefsiri hakkında Türkçe bir çalışmaya rastlamamış bulunmaktayız. Bundan dolayı çalışmada, hem bir ilim adamı olarak Abdülcelîl Îsâ’nın hem de eserlerinin, özellikle de tefsirinin tanıtılmasına katkı sağlamak amaçlanmıştır. Bu gayeye matuf olarak önce merhumun biyografisi, eserleri, bazı fikirleri ve sonraki döneme etkisi genel olarak ele alınmış, akabinde “Teysîru’l-Kur’ân li’l-kırâ’e ve’l-fehmi’l-müstakîm” isimli tefsirine farklı yönlerden ışık tutulmaya çalışılmıştır. Bu bağlamda Abdülcelîl Îsâ’nın kaleme almış olduğu bu tefsir çalışması; telif edilme sebebi, istifade edilen kaynaklar, müellifin tefsirdeki üslûbu ve fikrî yaklaşımı, kelâmî yönden değerlendirilmesi, fıkhî yönden değerlendirilmesi gibi farklı açılardan ele alınmıştır. Teysîru’l-Kur’ân li’l-kırâ’e ve’l-fehmi’l-müstakîm isimli tefsir çalışma Kur’ân’ın Kur’ân’la tefsiri açısından örnek teşkil edecek niteliktedir. Eser aynı zamanda geçtiğimiz yüzyıl Mısır’ının da ilmî yapısını ve dokusunu barındırır mahiyettedir. Nitekim eserde genel olarak Ehl-i Sünnet çizgisi baskınken bazı meselelerde rasyonalist ve modernist eğilimlerin tezahürleri kendini göstermektedir. Müellifinin köklü tahsilde bulunması, gençlik yıllarından beri Mısır’da aktif bir hayat sürmesi, ilmî ve idârî alanlarda sorumluluklar üstlenmesi sebebiyle hem müellifin hem de kitabının Mısır’da belirli bir üne sahip olmasına olanak tanımıştır. Bu çalışmanın, müellifin biyografisini, tefsirini ve tefsirindeki yöntemini ele alması bakımından literatüre küçük bir katkı sunması amaçlanmıştır.Abdul Jalil Isa is an Egyptian scholar who lived in the last century and a figure who made a name for himself in his time and left his mark and works in the world of science. In addition to the duties he performed, the works he wrote and the scholars he educates have an important place in the transmission of his scientific knowledge and legacy. Considering the period in which he lived, he acted as a bridge between the previous and later scholars as a transitional scholar, and he made his name known in the world of science with his works on various subjects, especially his tafsir. It is difficult to say that Abd al-Jalīl Īsā, who had a certain reputation among the scholars in Egypt, was well known in Türkiye. I have not come across any Turkish studies on his life, his works and especially his tafsir. Therefore, this study aims to contribute to the introduction of both the life of Abd al-Jalīl Īsā as a scholar and his works, especially his tafsir. For this purpose, firstly his biography, his works, and some of his ideas and influences were discussed in general, and then an attempt was made to shed light on his tafsir titled “Taysīr Al-Qur’ān Al-Karīm Lil-Qirā’ah Wal-Fahm Al-Mustaqīm” from different aspects. In this context, this tafsir work written by Abdul Jalil Isa has been discussed in terms of the reason for its compilation, the sources used, the author's style and intellectual approach in tafsir, its theological evaluation, and its jurisprudential evaluation. The exegesis work titled “Taysīr Al-Qur’ān Al-Karīm Lil-Qirā’ah Wal-Fahm Al-Mustaqīm” is an exemplary work in terms of the interpretation of the Qur’an by the Qur’an. The work also contains the scientific structure and texture of Egypt in the last century. Indeed, while the Ahl al-Sunnah line is generally dominant in the work, manifestations of rationalist and modernist tendencies are evident in some issues. The author's deep education, his active life in Egypt since his youth, and his responsibilities in scientific and administrative fields have enabled both the author and his book to gain a certain reputation in Egypt. This study is intended to make a small contribution to the literature in terms of the author's biography, his tafsir and his methodology in his tafsir
Emerging Biomedical Applications of Surface-enhanced Raman Spectroscopy Integrated with Artificial Intelligence and Microfluidic Technologies
No full textThe integration of surface-enhanced Raman spectroscopy (SERS), artificial intelligence (AI), and microfluidics
represent a transformative approach for biomedical applications. By combining the molecular sensitivity of
SERS, AI-driven spectral analysis, and the precise sample handling of microfluidics, these novel integrated
systems enable ultrasensitive, label-free diagnostics with minimal sample processing. The development of
portable, cost-effective platforms could democratize advanced diagnostics for resource-limited settings. However,
challenges such as reproducibility, clinical validation, and system integration hinder widespread adoption.
This review explores these new integrated platforms, beginning with a discussion of SERS principles, their
biomedical applications, and the critical roles of AI and microfluidics in enhancing analytical performance. We
evaluate recent advances in the application of these integrated systems, while addressing key challenges such as
substrate scalability, biocompatibility, and point-of-care translation, with a focus on nanomaterials, AI models, and lab-on-chip designs. Finally, we outline future directions, including multimodal sensing, sustainable materials, and embedded AI for real-time diagnostics, to bridge the gap between technological innovation and clinical implementation
Cognitive Flexibility in Children and Adolescents with Autism Spectrum Disorder: Current Status and Research Directions
No full textObjectives: This study investigated cognitive flexibility (CF) in Turkish children and adolescents
with Autism Spectrum Disorder (ASD), examining the influence of key demographic and clinical
variables such as age, gender, autism severity, parental education, family income, and the presence
of additional disabilities.
Methods: The study included a sample of parents and teachers of 248 students with ASD from
various schools in Istanbul. Data were collected using two primary instruments: the Cognitive
Flexibility Scale (CFS) to assess CF and the Childhood Autism Rating Scale (CARS) to determine
autism severity.
Results: Gender was found to significantly differentiate CF, but only in the Routines/Rituals subdimension,
where males showed greater flexibility than females. Autism severity had a varied
impact: it was inversely related to flexibility in the Routines/Rituals and Generativity subdimensions
but directly related to flexibility in the Special Interests sub-dimension. The presence
of additional disabilities was associated with greater flexibility in Special Interests but less flexibility
in Generativity. No significant relationships were observed between CF and age, parental
education, or family income.
Conclusions: The findings suggest that CF in ASD is a multidimensional construct, with factors
like autism severity and additional disabilities exerting differential effects across its subdimensions.
This highlights the need for tailored and individualized interventions. The study also
underscores the importance of future research incorporating objective, performance-based
measures to overcome the limitations of parent-report data
Kitap’tan İnstagram’a Çocukları Kim Yetiştiriyor? Dijital Dünyada Aile
No full textThe role of media in shaping parenting practices has become increasingly important in contemporary society. Parents' decisions about raising children are shaped by a flood of information from various media sources. The rise of social media, in particular, has introduced new opportunities and challenges for parents by creating an alternative public sphere with interactive features. Among social platforms, Instagram stands out as a preferred source of information for digital parenting. This article examines how parents' sources of information on child-rearing have changed over time, with special attention to Generation Y (Millennials). A phenomenological study, the work draws on data collected through digital ethnography and interviews. The findings show that, while books continue to be regarded as a scientific and trustworthy source within traditional media, parents today may prefer social media for ease of access to information, real-time interactions, visual content, participation in parenting communities, and a sense of belonging and trust. At the same time, social media content is found to create insecurity in parents due to information overload, potential privacy violations, and feelings of inadequacy driven by influencers and peer pressure. This article aims to contribute to the literature by better understanding the dynamics between parents and media in the context of child-rearing.Medyanın ebeveynlik uygulamalarını şekillendirmedeki rolü çağdaş toplumda giderek daha önemli hale gelmiştir. Ebeveynlerin çocuk yetiştirme kararları çeşitli medya kaynaklarından gelen bir bilgi seliyle şekillenmektedir. Özellikle sosyal medyanın yükselişi, etkileşimli özelliklere sahip alternatif bir kamusal alan yaratarak ebeveynler için yeni fırsatlar ve zorluklar ortaya çıkarmıştır. Sosyal platformlar arasında Instagram, dijital ebeveynlik için tercih edilen bir bilgi kaynağı olarak öne çıkmaktadır. Bu makale, ebeveynlerin çocuk yetiştirme konusundaki bilgi kaynaklarının zaman içinde nasıl değiştiğini, özellikle Y Kuşağı'na (Milenyumlar) özel bir dikkat göstererek incelemektedir. Fenomenolojik bir çalışma olan araştırma, dijital etnografya ve görüşmeler yoluyla toplanan verilerden yararlanmaktadır. Bulgular, kitapların geleneksel medyada bilimsel ve güvenilir bir kaynak olarak görülmeye devam etmesine rağmen, günümüzde ebeveynlerin bilgiye kolay erişim, gerçek zamanlı etkileşim, görsel içerik, ebeveyn topluluklarına katılım ve aidiyet ve güven duygusu nedeniyle sosyal medyayı tercih edebileceğini göstermektedir. Aynı zamanda, sosyal medya içeriğinin, aşırı bilgi yükü, potansiyel gizlilik ihlalleri ve fenomenler ve akran baskısı tarafından yönlendirilen yetersizlik duyguları nedeniyle ebeveynlerde güvensizlik yarattığı bulunmuştur. Bu makale, çocuk yetiştirme bağlamında ebeveynler ve medya arasındaki dinamikleri daha iyi anlayarak literatüre katkıda bulunmayı amaçlamaktadır
Examination of the relation between styles of adult attachments and early maladaptive schemas
No full textBağlanma, çocuk ve bakım veren arasında gelişmiş olan ilişkide, bakım veren ile çocuğun ihtiyacı olan yakınlık arayışı sırasında ortaya çıkan, tutarlılık ve süreklilik içerisinde olan duygusal bir bağdır. Bağlanma kavramının geliştirilmesine yönelik çeşitli çalışmalar uzun yıllar boyunca yapılmış ve kavramla ilgili çeşitli modeller ortaya konulmuştur. Bu modeller, bireylerin yaşamlarının farklı dönemlerinde geliştirdikleri bağlanma stillerini anlamaya ve sınıflandırmaya olanak tanımaktadır. Yetişkinlikte bağlanma ise, bireyin kendisine fiziksel ve psikolojik güvenlik sağlayacak diğerleriyle etkileşimde bulunması ve bu kişilerle yakın ilişkilerini sürdürme eğilimidir. Bilişsel kuram çerçevesinde sıkça kullanılan şema kavramı ile bağlanma kuramı arasında kavramsal bir yakınlık söz konusudur. Şemalar, bireyin kendisi, diğerleri ve dünya hakkında geliştirdiği, bilişsel ve duygusal düzeyde organize olmuş yapılandırmalardır. Özellikle erken dönem uyumsuz şemalar, bireyin çocukluk dönemindeki temel duygusal ihtiyaçlarının yeterince karşılanmaması sonucu oluşan ve yaşam boyu işlevselliği etkileyen bilişsel-duygusal örüntülerdir. Dolayısıyla bu çalışmada yetişkin bağlanma stilleri ile erken dönem uyumsuz şemalar arasındaki ilişki incelenmiştir. Araştırma nicel bir araştırma olup ilişkisel tarama modeli kullanılmıştır. Çalışmanın araştırma grubunu 19-63 yaş aralığında bulunan 193 birey oluşturmaktadır. Katılımcıların %72,5'ini (n= 140) kadınlar, %27,5'ini (n= 53) erkekler oluşturmaktadır. Veriler kolayda örnekleme yoluyla dijital ortamda toplanmıştır. Araştırmada veri toplama aracı olarak kişisel bilgi formu, Yakın İlişkilerde Yaşantılar Envanteri-II ve Young Şema Ölçeği Kısa Form-3 kullanılmıştır. Araştırmanın analiz sonuçları incelendiğinde, yetişkin bağlanma stillerinin erken dönem uyumsuz şemalar ile ilişki içinde olduğu tespit edilmiştir. Bununla birlikte yetişkin bağlanma stilleri yaş ve cinsiyete göre anlamlı bir farklılık göstermez iken; romantik ilişki varlığı ve çocuklukta kim tarafından yetiştirildiği değişkenine göre anlamlı bir farklılık gösterdiği gözlemlenmiştir. Erken dönem uyumsuz şemalarda ise, yaş ve çocuklukta kim tarafından yetiştirildiği değişkenine göre anlamlı bir farklılık gözlenmediği; cinsiyet ve romantik ilişki varlığı değişkenin de anlamlı bir farklılık gözlendiği sonucuna ulaşılmıştır. Çalışmadan elde edilen bulgular literatür ışığında tartışılmış ve araştırmacılar ile uygulayıcılara yönelik önerilerde bulunulmuştur.Attachment is an emotional bond that develops within the relationship between a child and their caregiver, emerging in the context of the child's search for proximity to meet emotional and physical needs, and characterized by consistency and continuity. Over the years, numerous studies have been conducted to develop the concept of attachment, leading to the formulation of various models. These models have enabled researchers to understand and classify the attachment styles that individuals develop at different stages of life. The adult attachment refers to an individual's tendency to interact with others who provide physical and psychological security and to maintain close relationships with these individuals. Within the framework of cognitive theory, there is a conceptual proximity between the notion of schema and attachment theory. Schemas are cognitive and emotional structures organized around the individual's perception of themselves, others, and the world. In particular, early maladaptive schemas are defined as cognitive-emotional patterns that emerge when a child's core emotional needs are not adequately met during early developmental periods and persist throughout the individual's life, often impairing functionality. Accordingly, the present study examined the relationship between adult attachment styles and early maladaptive schemas. This is a quantitative study employing a relational screening model. The research sample consisted of 193 individuals aged between 19 and 63 years. Of the participants, 72.5% (n = 140) were female, and 27.5% (n = 53) were male. Data were collected online using convenience sampling. The data collection tools included a personal information form, the Experiences in Close Relationships-Revised (ECR-R), and the Young Schema Questionnaire-Short Form 3 (YSQ-SF3). The analysis of the data revealed that adult attachment styles are significantly associated with early maladaptive schemas. Furthermore, while adult attachment styles did not significantly differ by age or gender, they did show significant differences based on the presence of a romantic relationship and the identity of the primary caregiver during childhood. In contrast, early maladaptive schemas did not significantly differ according to age or the childhood caregiver variable, whereas significant differences were found in relation to gender and the presence of a romantic relationship. The findings of this study were discussed in light of the existing literature, and suggestions were provided for researchers and practitioners
The Effect of Using Quizlet in Teaching Vocabulary to Learners of Turkish as a Foreign Language
No full textYabancı dilde sözcük öğretiminde tercih edilen dijital araçlardan biri Quizlet’tir. Bu araştırmada yabancı dil olarak Türkçe öğrenenlere sözcük öğretiminde Quizlet’in etkisinin ne ve nasıl olduğunu belirlemek amaçlanmıştır. Çalışmada karma araştırma modeli kullanılmıştır. Çalışmanın nicel kısmı için yarı deneysel bir araştırma modeli seçilmiştir. Deney ve kontrol grubunu B1 seviyesinde Türkçe öğrenen 40 öğrenen oluşturmaktadır. Araştırma verileri ön test ve son test olarak araştırmacının oluşturduğu sözcük bilgisi testi ile toplanmıştır. Elde edilen veriler SPSS programıyla çözümlenmiştir. Araştırmanın nitel çalışma kısmında durum çalışması deseni kullanılmıştır. Veriler deney grubunu oluşturan 20 öğrenenden araştırmacı tarafından oluşturulan etkinlik değerlendirme formu aracılığıyla ve deney grubunda yer alan 4 öğrenenle odak grup görüşmesi yapılarak toplanmıştır. Elde edilen veriler içerik analiziyle çözümlenmiştir. Çalışmanın sonucunda yabancı dil olarak Türkçe öğrenenlerin sözcük öğretiminde Quizlet’in kullanımının öğrenenlerin sözcük bilgisini geliştirmede etkili olduğu ve bu etkinin olumlu yönde olduğu tespit edilmiştir.Quizlet is one of the preferred digital tools for teaching vocabulary in a foreign language. In this study, it is aimed to determine what and how the effect of Quizlet is on teaching vocabulary to learners of Turkish as a foreign language. Mixed research model was used in the study. A quasi-experimental research model was chosen for the quantitative part of the study. The experimental and control groups consisted of 40 Turkish learners at B1 level. The research data were collected as pre-test and post-test with a vocabulary knowledge test created by the researcher. The data obtained were analysed with the SPSS programme. Case study design was used in the qualitative part of the study. Data were collected from 20 learners in the experimental group through the activity evaluation form created by the researcher and focus group interviews with 4 learners in the experimental group. The data obtained were analysed by content analysis. As a result of the study, it was determined that the use of Quizlet in teaching vocabulary to learners of Turkish as a foreign language is effective in improving learners' vocabulary knowledge and this effect is positive