Bulletin of Siberian Medicine / Бюллетень сибирской медицины
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НАТРИЙ-КАЛИЙ-ХЛОР-КОТРАНСПОРТ В РЕГУЛЯЦИИ МИОГЕННОГО ТОНУСА СОСУДОВ
Get PDFThe article discusses the data on the functioning of Na+,K+,2Cl– cotransport – the carrier providing electroneutral symport of sodium, potassium and chloride, as well as molecular mechanisms of the regulation and physiological significance of this carrier. We analyzed the novel data on involvement of ubiquitous isoform of Na+,K+,2Cl–cotransporter (NKCC1) in regulation of vascular smooth muscle contraction, and role of this carrier in the regulation of cell volume and intracellular chloride concentration.В статье рассматриваются принципы функционирования Na+,K+,2Cl–-котранспорта – трансмембранного ионного переносчика, осуществляющего электронейтральный симпорт натрия, калия и хлора, молекулярные механизмы его регуляции и физиологическое значение. Приводятся новые данные о роли универсальной изоформы Na+,K+,2Cl–-котранспортера (NKCC1) в регуляции сокращения гладких мышц сосудов, объема клеток и внутриклеточной концентрации хлора
ОКРУЖНОСТЬ ТАЛИИ КАК ИНДИКАТОР КОМПОНЕНТОВ МЕТАБОЛИЧЕСКОГО СИНДРОМА В СИБИРСКОЙ ПОПУЛЯЦИИ
Get PDFObject of research: to determine the cut-off point of waist circumference (WC) identify the components of metabolic syndrome (MS) in a large industrial center of Western Siberia.In the period from 2003 to 2005 in the screening population surveyed 9362 people, including 4268 men (45.6%) and 5094 women (54.4%).The response rate was 61%. The study protocol included a sociodemographic data, measurement of blood pressure (BP), anthropometry (height, weight, WC), the definition of biochemical parameters. Statistical analysis was performed using the package SPSS. To determine the cut-off points of the used ROC model.In the group with ≥2 components of MS cut-off point WC from the men was 93.3 cm (sensitivity 72%, specificity 83%), women – 90.2 cm (sensitivity 72%, specificity 62%).The lowest cut-off point WC marked BP ≥ 130/85 mm Hg for men – 90 cm (sensitivity 66.8%, specificity 58.1%), for women – 86.5 cm (sensitivity 71.0%, specificity 55.7%). The highest cut-off point from the defined patients with diabetes for men was 99.0 cm (sensitivity 61%, specificity 70.2%), for women – cm (sensitivity 64.1%, specificity 65.9%).Conclusions: Cut-off point from the persons with the presence of ≥2 MS components in Siberian population 45–69 years, in accordance with the ROC analysis are 93.3 cm for men and 90.2 cm for women. The lowest cut-off point WC marked BP ≥ 130/85 mm Hg for men – 90 cm, for women – 86.5 cm. The highest cut-off point from the defined patients with diabetes for men was 99.0 cm, for women – 95 cm
ОСОБЕННОСТИ И ХАРАКТЕРИСТИКА ПОКАЗАТЕЛЕЙ ЗАБОЛЕВАЕМОСТИ РАКОМ ЩИТОВИДНОЙ ЖЕЛЕЗЫ У ЖИТЕЛЕЙ Г. ТОМСКА И ТОМСКОЙ ОБЛАСТИ
Get PDFThe analysis of thyroid cancer incidence and its structure among different populations of Tomsk region is presented. We studied the report documents, the database of the Tomsk regional oncologic dispensary for the period 2008 to 2012. The clinical characteristics of patients with thyroid cancer were summarizes according to sex, age and place of residence. The papillary cancer was the most often diagnosed. It was found that in young patients, thyroid cancer was diagnosed more often in the stage 1 and 2. On the other hand, in elderly patients (above 60 years), thyroid cancer diagnosed at stage 3 and 4. In the Tomsk region, as elsewhere in the world, thyroid cancer is detected more often in women.Представлены результаты анализа заболеваемости раком щитовидной железы среди жителей Томской области, особенности ее структуры среди различных контингентов населения. Были изучены база данных и отчетные документы Томского областного онкологического диспансера за период 2008–2012 гг. Обобщена клиническая характеристика больных раком щитовидной железы в зависимости от пола, возраста и места проживания. В результате анализа установлено, что лидирующее место в морфологической структуре рака щитовидной железы принадлежит папиллярному раку. Выявлено увеличение количества вновь выявленных больных, установлено, что рак щитовидной железы в молодом возрасте чаще диагностируется на ранних стадиях, стадии 3 и 4 при первичной диагностике встречаются преимущественно у лиц старше 60 лет. В Томской области, как и во всем мире, среди больных раком щитовидной железы превалируют женщины
УЛЬТРАЗВУКОВОЕ ИССЛЕДОВАНИЕ В ОЦЕНКЕ ПРОХОДИМОСТИ ШУНТА ПОСЛЕ ТИМПАНОСТОМИИ ПРИ ЭКССУДАТИВНОМ СРЕДНЕМ ОТИТЕ
Get PDFThe aim of this study was to improve the accuracy and sensitivity of methods for ventilation tube patency evaluation after timpanostomy. New method of one-dimensional ultrasound middle ear sonography was developed. We studied ventilation tubes patency in 40 patients with otitis media with effusion, after timpanostomy. All patients tympanometry and one-dimensional ultrasound sonography was obtained at 4, 7th and one month after surgery. After timpanostomy in children with the otitis media with effusion, at 4 days after the surgery one-dimensional ultrasound sonography detected normal function of ventilation tubes in 75% patients. At the same time, according to tympanometry ventilation tube patency was recorded in 80% patients. On 7th day after surgery one-dimensional ultrasound sonography detected normal function of ventilation tubes in 85% patients. According to tympanometry the 90% patients demonstrated normal ventilation tube function. One month after surgery one-dimensional ultrasound sonography detected normal function of ventilation tubes in 92.5% patients. At the same time, according to tympa nometry ventilation tube patency was recorded in 95% people. Calculation of ultrasound sonography sensitivity and specificity showed that the sensitivity of this process is 97.4%, specificity – 100%. The statistical significance of differences in ventilation tube patency assessment is not determined. Thus, we have proved one-dimensional ultrasound sonography the sensitive method for ventilation tubes patency validation. The method is simple, requires a bit of time for application, so it can be widely recommended for outpatient network
ПАЛЛИАТИВНЫЕ РЕЗЕКЦИИ ПЕЧЕНИ С ПРИМЕНЕНИЕМ КРИОДЕСТРУКЦИИ У БОЛЬНЫХ, ПОВТОРНО ОПЕРИРОВАННЫХ ПО ПОВОДУ АЛЬВЕОКОККОЗА
Get PDFОПРЕДЕЛЕНИЕ ИНДИВИДУАЛЬНЫХ ОСОБЕННОСТЕЙ ПРОЦЕССА УДЕРЖАНИЯ РАВНОВЕСИЯ У БОЛЬНЫХ ДЕТСКИМ ЦЕРЕБРАЛЬНЫМ ПАРАЛИЧОМ ПО РЕЗУЛЬТАТАМ СТАБИЛОМЕТРИЧЕСКОГО ТЕСТИРОВАНИЯ
Get PDFThe practical aim of the research is to develop a methodology for assessing the functional state of the musculoskeletal system in the case of complex human pathologies and associated injuries with the objective distinction of interdependent anatomical and functional disorders in the osteoarticular system, nervous and muscular subsystems, identification pathology severity in the separate subsystems and the degree of influence for each of them on the movement organization as a whole. In patients with cerebral palsy the neurological movement disturbance is a priority component, differentiation of which may by difficult due to lack of tools to evaluate objectively and display the features of functioning nervous system in normal and pathological conditions. The authors propose a set of interval indicators of stabilometric study and method to use it providing the more qualitative consideration individual characteristics and the formation of clinically interpretable representation of a visual results image as compared with the standard vector and frequency indicators
ЭФФЕКТИВНОСТЬ ВЛИЯНИЯ ОДНОКРАТНОЙ И ПРОДОЛЖИТЕЛЬНОЙ АУДИОВИЗУАЛЬНОЙ СТИМУЛЯЦИИ НА ВАРИАБЕЛЬНОСТЬ СЕРДЕЧНОГО РИТМА И МЕХАНИЗМЫ ВЕГЕТАТИВНОЙ РЕГУЛЯЦИИ У СПОРТСМЕНОВ-ЦИКЛИКОВ
Get PDFМЫШЛЕНИЕ В АСПЕКТЕ ТРАНСДИСЦИПЛИНАРНЫХ ИССЛЕДОВАНИЙ
Get PDFPhenomenon of thought and its’ interpretations at the different cultural and historical stages are in focus of the paper. The research is aimed at reasoning of new interpretation of thought revealed as a result of cognitive science and convergent technologies transdisciplinary research.Transdisciplinary research of thought in cognitive science is achieved with the unity of method, which is the systemic-evolutionary approach.The research is based on thought analysis in philosophy, cognitive psychology, cognitive linguistics, artificial intelligence science, thus mainly on transdisciplinary research of thought in cognitive science.The paper represents the approach of cognitive science and NBIC (Nano-, Bio-, Information and Cognitive) technologies implementing transdisciplinary research of thought and intelligence.It is shown that the transdisciplinary approach is based on new ontology, called holistic, and on nonclassical epistemology. Answering the raised question of the outcome of thought transdisciplinary research comparing to specifically scientific and philosophic, it is reasoned that cognitive science studies thought at the higher level of complexity, considering simultaneously several order parameters characterizing this complex nonlinear phenomenon
