Sumathi Publications (E-Journals)
Not a member yet
381 research outputs found
Sort by
Prevalence of Musculoskeletal Disorders in Workers In An Industry in Ahmednagar District, Maharashtra.
Get PDFIntroduction: Musculoskeletal disorders are a major public health problem in industrialized and developing countries. The present study was aimed to find out the prevalence of acute and chronic WMSD’s in Industrial workers. Methodology: This cross-sectional observational study was carried out in 60 workers of the Adon Block department workers of the electrical & automation industry, Ahmednagar. Pre-structured occupational Performa was filled by asking questions in the worker’s local language. The Nordic pain Questionnaire was filled by asking the subjects to mark the sites of pain on body chart paper. The risk factors for work-related musculoskeletal problems were assessed by the working posture of workers and repetitive movements in industrial set up. The data collected were interpreted and analyzed. Results: In the present study, 60 workers were selected, of which a number of females were 39 (65%) while males were 21 (35%). The Neck (20.2%) followed by the shoulder (14.9%), elbow (14.4%) and knee (14.4%) were most commonly involved. There was a statistically significant variation in the number of workers involved according to the posture (sitting vs standing) and part of the MSK system involved. Conclusion: The WMSD’s are common in Adon block department workers. The involvement of neck, shoulder, lower back and arm was common in sitting position, while the involvement of upper back, elbow and knee were common in standing position. The disorders are commonly seen in workers irrespective of their duration of work and gender.
Keywords: Musculoskeletal disorders; Industry Workers; Nordic pain Questionnaire; Ahmednagar
Hematological Profile and Serum Potassium Level in Patients of Chronic Renal Failure at a Tertiary Health Care Center
Get PDFBackground: Chronic Kidney Disease (CKD) can be defined as an estimated glomerular Filtration Rate (eGFR) of less than ml/min/1.73 m2 for a minimum period of three months. CKD is commonly associated with various hematological abnormalities especially anemia. Aim: The present study was planned to assess the hematological variations in CKD patients as compared to healthy subjects. Method: Fifty patients diagnosed with CKD were enrolled for the study. Fifty age and sex-matched healthy subjects constituted the control group. Result: On comparison of the hematological profile, it was observed that all enrolled CKD patients were anemic with hemoglobin (Hb) less than 13g/dL in males and less than 12 g/dL in females. The mean Hb levels were as low as 7.50 + 1.55 g/dL (P< 0.0001). Correspondingly, the total RBC count of CKD patients was also low. It was also observed that the platelet count was slightly low among CKD patients. However, the mean level was comparable with the control group (P=NS). On further analysis, it was observed that among fifty CKD patients, 46% (n=23) suffered from severe anemia i.e. Hb < 7 gm/dL whereas 48% had moderate anemia i.e. Hb between 7-9.9 gm/dL. However, only 12 % (n=6) CKD patients suffered from thrombocytopenia i.e. platelets count < 1.50 lack/ cmm. Conclusion: Hematological abnormalities may lead to several associated morbidities and may pose a challenge for the maintenance of overall health status for CKD patients. Hence, there is a need to monitor the hematological profile of CKD patients especially those on dialysis so that any abnormality can be detected and managed accordingly.
Keywords: Chronic kidney disease, Anemia, Hematological changes, Potassium, Platelets
SUBLINGUAL VITAMIN D3 DRUG THERAPY IN VITAMIN D DEFICIENCY PATIENTS AT PRAVARA RURAL HOSPITAL
Get PDFThe present study was aimed to study the effect of Sublingual Vitamin D3 on Serum Vitamin D level in Vitamin D deficiency patients. This was a cross-sectional and interventional study. All the Vitamin D deficiency patients of age 18-60years and either gender, willing to participate in the study were included. Patients who had greater than 20 ng/ml were excluded from the study. The total number of participants in our study was 200, out of these 111 males and 89 females, the mean age in our study was 51.07 ± 7.39Yrs. All volunteers were given sublingual vitamin D3 (60,000IU) in six doses every fifteen days of follow up for 3 months. The subject’s serum 25(OH)D levels were estimated before and after the treatment of sublingual vitamin D3. There was a statistically significant difference in serum vitamin D3 level before 16.61±6.71 ng/ml and after 35.80±7.80 ng/ml after treatment with Sublingual Vitamin D3. Six doses of 60,000IU of Vitamin D3 sublingual route having improved the role of serum 25(OH)D levels in the treatment of Vitamin D3 deficiency patients.Keywords: Vitamin D3; Sublingual rout
Differentiating transudative and exudative pleural effusion by pleural fluid cholesterol
Get PDFBackground: Pleural effusion is one of the common condition encountered in day to day practise. Pleural effusions represent a very common diagnostic task to the physician. A correct diagnosis of the underlying disease is essential to rational management. Today there are a number of laboratory tests available to differentiate exudates and transudates which are considered cost effective to the patients, so this study was designed for the measurement of pleural fluid cholesterol to differentiate transudative and exudative pleural effusions (sensitivity-97.8%, specificity-100%) with the advantage that a contemporary blood sample is not required, thereby lowering cost of diagnostic procedure. Objectives: To study the diagnostic value of Pleural fluid Cholesterol in differentiating transudative and exudative pleural effusions. Methodology: This cross sectional descriptive study was conducted on patients of pleural effusion (n=60)age >18 years patients with definitive clinical diagnosis and evidenced by radiological diagnosis of pleural effusion were taken as inclusion criteria. Results: The results showed majority of the patients were males (63.3%) and females (36.7%). According to lights criteria 46 patients were exudates and 14 patients were transudates and according to Pleural fluid Cholesterol criteria 45 patients were exudates and 15 patients were transudates with sensitivity of 97.8% and specificity of 100% and accuracy of 98.3%. Conclusion: The pleural fluid cholesterol criteria were found to be the most efficient criteria. Since this parameter involves the measurement of only pleural fluid values of cholesterol, it has following advantages-Economically it reduces number of biochemical tests and Simpler as there is no need to take simultaneous blood sample at the time of thoracocentesis
Medically Important Coagulase Negative Staphylococci
Get PDFIn recent years, coagulase negative Staphylococci (CONS) are increasingly recognized as one of the major causes of health care associated infections (HCAI). CONS infections are one of the major causes of morbidity and mortality in hospitalized patients. As CONS colonize various parts of the skin and mucous membranes, most of infections are endogenous in origin. However, they are also transmitted exogenously via various medical/ surgical procedures. The aim of present review article is to update and summarize the information available on medically important CONS with special reference to epidemiology, laboratory diagnosis and antibiotic resistance
Fetal Umblical Artery Doppler Indices in Healthy Pregnant Women in Yenagoa, Nigeria.
No full textIntroduction: The measurement of fetal umbilical blood flow using Doppler ultrasound is a well-established tool in the management of high-risk pregnancies and has resulted in improved outcome. However, there is paucity of data concerning the normal parameters in Nigeria. This study is aimed at assessing the fetal umbilical artery indices in pregnant Nigerian women. Methods: This was a cross sectional prospective study carried out at the Niger delta university teaching hospital, silhouette radio diagnostic consultants Yenagoa and federal medical centre. A total of 400 pregnant women between the gestational ages of 20 – 40 weeks were evaluated within a one-year period using a 2014 Philips HD 11 ultrasound machine equipped with a 3.5Mhz curvilinear probe having colour, pulsed wave and power Doppler facilities. Results: The mean age and BMI were 30 ± 6 years and 29.9±5.76 kg/m2 respectively while the mean umbilical artery systolic velocity and end diastolic velocities were 40.07± 8.99m/s and 17.44±6.37m respectively. The mean resistivity index (RI) is 0.57. There was a negative correlation of RI with Gestational age (P<0.05). Conclusion: Fetal umbilical artery Doppler parameters are essential tool in management of high-risk pregnancies and has resulted in an improved outcome. This study is to serve as a baseline for further studies with a larger sample size.
Keywords: Fetal; Umbilical; Artery; Doppler; Pregnancies
Biomarkers to Assess Liver Function in Various Types of Liver Diseases
Get PDFBackground: It is estimated that liver diseases are among the top ten killer diseases in India, causing deaths every year. Besides, there are those who suffered from chronic liver problems needing recurrent hospitalization and prolonged medical attention, which leaves them physically, mentally, emotionally and financially devastated. Methodology: The study included (n=80) various liver disease patients admitted to the General Medicine department and controls (n=20) subjects were having normal health within the age group of 30-55 years. Serum levels of bilirubin, Aspartate Transaminase, Alanine Amino Transferase, Alkaline Phosphatase and Gamma Glutamyl Transferase parameters were studied among the subjects suffering from cirrhosis, alcoholic liver disease, viral hepatitis, obstructive jaundice type of liver diseases. Result: The results of this study showed that the increase in serum levels of Bilirubin, AST, ALT, ALP and GGT in various types of liver diseases i.e Obstructive jaundice, Cirrhosis of the liver, Viral hepatitis, Alcoholic Liver disease when compared with controls. Conclusion: Biochemistry laboratory investigations i.e. Liver Function Test (LFT) are a simple, easy measure of tools which can early diagnose the various types of liver diseases.
Keywords: Liver diseases; Liver Bio-markers; Liver Function Test
IN SILICO DESIGN OF POTENTIAL 1, 5-BENZOTHIAZEPINE DERIVATIVES AS AN ANTI - CONVULSANT AGENT BY MOLECULAR DOCKING STUDIES
Get PDFEpilepsy is characterized by the presence of recurrent seizures. A seizure can be defined as “an episodic disturbance of movement, feeling, or consciousness caused by sudden synchronous, inappropriate, and excessive electrical discharges in the cerebral cortex”. One in every three patients with epilepsy is probable to be severely disabled. It is continuing this scenario as an attempt to develop potent and nontoxic anti-convulsant agents. Recently the discovery of benzothiazepine derivatives as an anticonvulsant agent is a significant area for research in medicinal chemistry as it is free from all side effects which is shown by a developed as an anticonvulsant agent. In this paper, we have presented results of 2D, and 3D docking poses studies of a series of 300 (Three series) molecules containing 1,5-benzothiazepine pharmacophore as anti-convulsant agents. Docking analysis was utilized to predict the mechanism of action of the designed derivatives for anticonvulsant potential. All the molecules exhibited a binding score in the range of -82.61 to - 118.25 kcal/mol. Most active molecules from Series 1, 2 and 3 exhibited hydrogen bond interactions with LEU282B, LEU282B and LEU282B. Also for the selected standard sodium phenytoin showed the hydrogen bond interaction with LYS637A. It was noted that the docking score of 1a to 10a, 101b to 110b and 201c to 210c was almost the same as that of selected standard sodium phenytoin. The protein showed hydrogen bonding with all synthesized compound showed potential against epilepsy with GABA nergic mechanism.
Keywords: Anti-convulsant; 1,5-benzothiazepine; V-Life MDS 4.3
Role of Udvartana, a diurnal Ayurveda practice in the prevention and management of diabetes mellitus
No full textDiabetes is among the most common lifestyle disorders of the modern era. The current approach towards its prevention and management is largely based on diet and lifestyle modifications. As increased body weight and serum lipids have been implicated in the risk factors of diabetes, measures to reduce them have a significant role to play. Udvartana described as a diurnal practice for health maintenance in Ayurveda plays an important role in the prevention and management of diabetes. Clinical studies have shown that Udvartana helps in reducing body weight as well as serum lipids. A review of the role of Udvartana in the prevention and management of diabetes is attempted here.
Keywords: Diabetes; Udvartana; Body weight; Serum lipids
Comparison of the force deterioration of different orthodontic elastomeric materials in artificial saliva: An in vitro study
Get PDFThe orthodontist must be able to choose an elastic band with force-extension characteristics that are most suitable for the particular tooth movement required. From a clinician view it would be mandatory not only to know the clinical aspect of these elastics but also their basic properties, in order to extract the most out of these polymers. Stretching of elastics are thought to be the primary cause of force degradation of orthodontic elastics but there is evidence of increased force degradation of elastics when exposed to various types of substances like artificial saliva, phosphoric acid and citric acid. Orthodontic elastics have received mixed reactions of practitioners as reported by the vendors of orthodontic supplies. The present study is designed to compare the force deterioration of different orthodontic elastomeric materials in artificial saliva medium. There was a force deterioration over time in all materials, being greatest on the seventh day of the experiment, especially more in the chains; From the third to the fourth week there was no noticeable force degradation in either group; By the end of the experiment, modules showed less deterioration of the force compared to the chains and threads