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Study of serum high sensitivity C- reactive protein and lipid profile in ischemic and hemorrhagic stroke
No full textIntroduction: Stroke is the neurological deficit of abrupt onset attributable to focal vascular cause and makes a considerable contribution to morbidity and mortality. High sensitivity C reactive protein (hsCRP) is an acute-phase reactant tends to increase at the onset of inflammation. Atherosclerosis, a major risk factor for cerebrovascular diseases involves inflammation which is triggered by dyslipidaemia. Objective: To estimate and compare levels of serum hs-CRP and lipid profile in patients with ischemic and haemorrhagic stroke. Methods: Present study comprised of 90 subjects, 30 ischemic stroke, 30 haemorrhagic stroke and 30 as apparently healthy control. Blood samples obtained within 24 hours of presentation were analysed for serum hsCRP and lipid profile. Results: In the present study Median age was 52 years, 52.5 years and 54 years in control, ischemic stroke and haemorrhagic stroke respectively. Hs-CRP levels were raised in ischemic and haemorrhagic stroke compared to normal control (F-value=96.78; p<0.0001). Total cholesterol, triglyceride and LDL- cholesterol levels were significantly raised while HDL- cholesterol levels were low in ischemic stroke and haemorrhagic stroke than control (p<0.05). Conclusion: Increased serum hs-CRP levels and dyslipidemia were observed in ischemic and haemorrhagic stroke. But serum hs-CRP cannot differentiate type of stroke.
Keywords: Ischemic stroke; Haemorrhagic stroke; hs-CRP; Lipid profile
Competency based undergraduate curriculum in Pharmacology for the Indian medical graduate: Challenges in assessment.
Get PDFImpact of PowerPoint and Chalkboard teaching in Physiotherapy Undergraduates.
Get PDFBackground: A teacher\u27s basic tool for displaying lectures are through blackboards, pegboards, bulletin boards, transparencies with an overhead projector (TOHP), PowerPoint presentation and walk and talk. Nowadays PowerPoint presentation is commonly used as it has ability to present the information in a clear, organized and simpler manner. The present study was carried out to find out the best method of teaching amongst the undergraduate Physiotherapy students. Objective: To compare the impact of the PowerPoint multimedia presentation and chalkboard in teaching by assessing the knowledge based on the marks obtained in the pretest and posttest. Methodology: 40 students were divided into two groups and a selected content-based lecture in pharmacology was delivered. For one group lecture was delivered using PowerPoint presentation, for second group using Chalkboard. Single - best Multiple Choice Questions [MCQs] paper was used for assessing the knowledge gained. The differences in the marks obtained in the two groups were analyzed Results: Students who attended the class on chalkboard obtained significantly higher score in single best MCQ examination compared to those students who attended the same content based lecture on the PowerPoint. Conclusion: The chalkboard method of teaching was found more suitable tool of teaching and learning than PowerPoint for small group
Awareness and effect of Janani Suraksha Yojana on antenatal care and institutional deliveries in rural, urban & tribal areas of Ahmednagar district
Get PDFJanani Suraksha Yojana (JSY) is a centrally sponsored scheme which is being implemented with the objective of reducing maternal and infant mortality by promoting institutional delivery among pregnant women. The Government of India introduced the JSY (safe motherhood program) based on the principles of CCT. Under JSY, cash assistance was given to pregnant women receiving at least three antenatal check-ups (ANCs) and delivering at institutions. The study is undertaken to establish if there is any co-relation of level of awareness about the scheme and its impact on ANC and institutional deliveries in the rural, urban and tribal area of Ahmednagar district. Method: The JSY beneficiaries were asked demographic characteristics, area of residency, educational levels, Category and place of delivery were noted. A set of question (self-designed and pretested) and their responses were noted. Result: Out of 825 JSY beneficiaries, there were total 781 (94.7%) Hindu, Muslim 23(2.8%) and Christian 21 (2.5%) beneficiaries. Majority of Hindu religion JSY beneficiaries. Only few member from BPL JSY beneficiaries have opted for delivery at private hospital. Maximum deliveries taking place in civil hospital are from BPL category. It was observed that the awareness level about JSY is low in tribal area compared to the rural and urban area. It was also seen that 648 (78.54%) JSY beneficiaries availed free transport facility out of which 358 (55.24%) fall in high level of awareness category. There is a positive relation between age group and awareness about JSY. Conclusion: 46.8% women with high awareness about JSY scheme, it is a programme for pregnant women which aims at safe institutional delivery. Other factors such as education of mother, religion, culture, area of residence, family type played important role in utilization of available maternal health scheme
MODIFIED TREATMENT TOLERABILITY EVALUATION SCORE IN PATIENTS UNDERGOING TEMPORARY ANCHORAGE DEVICES (TAD) UNDER TOPICAL LIGNOCAINE AEROSOL 15% WITH LIGNOCAINE WITH OR WITHOUT ADRENALINE INFILTRATION DURING ORTHODONTIC TREATMENT
Get PDFIntroduction: This study was undertaken primarily to compare the efficacy and safety of topical Lignocaine aerosol 15%, Lignocaine 2% with or without Adrenaline (1:80000) used in Temporary Anchorage Devices (TAD) placement in Orthodontic Treatment. Method: The study population included all patients of both gender and aged above 12 years, who were scheduled for placement of Temporary Anchorage Devices (TAD) in orthodontic treatment, and willing to participate in the study were included in the study. Depending on the local anaesthetic used, the patients were divided into Group 1 (Topical Lignocaine Aerosol 15% USP + Lignocaine 2% with Adrenaline), Group 2 (Lignocaine 2%) and Group 3 (Lignocaine 2% with Adrenaline). All the groups were assessed for immediate adverse drug reactions. The severity of adverse effects was graded by using Modified Treatment Tolerability Evaluation Score (MTTES) for the signs and symptoms Results: There was no statistically significant difference between age and gender of the three treatment groups. MTTES score was lowest in Group 2 followed by Group 3. It was significantly higher in Group 1. Conclusion: Group 1 (topical and infiltration lignocaine) and 3 combinations showed higher MTTES score for the adverse effect profile, whereas Group 2 appeared safer in terms of both the variables. Thus, use of topical and infiltration lignocaine raises concerns regarding safety of this combination.
 
Effects of α, β momorcharin extract of momordica charantia in intracellular free calcium on cancer cell lines.
Get PDFThe Momordica charantia L., (family: Cucurbitaceae) is a scientific name of the plant and its fruit. It is also known by other names, for instance in the USA it is known as Bitter gourd or balsam pear while its referred to as the African cucumber in many African countries. This study was specifically designed to investigate the cellular mechanisms whereby alpha, beta momorcharin an extract of M. charantiacan induce cell death measuring the elevation in intracellular free calcium concentrations in three different cancer cell lines 1321N1, Gos-3 and U-87. The results show that incubation of the three cancer cell lines 1321N1, Gos-3 and U-87 with α, β momorcharin can result in significant (p < 0.05) time-dependent increases in [Ca2+]i in all three cancer cell lines compared to control (untreated) cells. Maximal increases in [Ca2+]i was attained after 420 min of incubation.In control (untreated cell lines), [Ca2+]i remained more or less stable in both cell lines after 420 min. The results also show that the increase in [Ca2+]i in Gos-3 cell line was much more pronounced following incubation with α, β momorcharin compared to 1321N1 and U-87 cell line. The results show that incubation of the three cancer cell lines with momorcharin can result in significant (p < 0.05) time-dependent increases in [Ca2+]i in all three cancer cell lines compared to control (untreated) cells. Maximal increases in [Ca2+]i was attained after 420 min of incubation. In control (untreated cell lines), [Ca2+]i remained more or less stable in all three cell lines after 420 min. These results clearly show that α, β momorcharin extract of M. charantia is exerting its anti- cancer effect via an insult to the mitochondria resulting in apoptosis, calcium overloading and subsequently, cell death
Tibial Fracture in an Elderly Female Patient of Rheumatoid Arthritis: A Preventable Iatrogenic Injury
Get PDFOral systemic glucocorticoids widely used in the medical practice to treat various diseases like asthma, systemic connective tissue diseases, other autoimmune diseases and in transplantology, are considered the main cause of secondary and iatrogenic osteoporosis. The pathogenesis of glucocorticoid induced bone loss is multifactorial and complex. The exact mechanism remains undefined. The present report describes a case of 65 yr old female presenting with fracture in mid shaft of tibia after a very low velocity trauma. On medical history elicitation, she was found to be treated for rheumatoid arthritis with oral glucocorticoids. Causality, severity and preventability assessment was done for the reaction. Potentiality of glucocorticoids causing fractures is often neglected by professionals and ignored by patient and their caregivers. Given the potential for rapid bone loss with glucocorticoid therapy, frequent monitoring is warranted while bearing in mind that BMD is a surrogate marker for fracture risk and patients on glucocorticoids fracture at higher BMD than other patients. Once treatment is initiated, BMD should be monitored annually to ensure compliance and efficacy
Correlation between Age, IPSS, Prostate size with histopathological findings and management of patients of prostatism
No full textIntroduction: Benign prostatic obstruction/enlargement (BPO/BPE) is one of the important aetiology for Bladder outlet obstruction (BOO) in men. Study has been planned to measure various parameters of bladder dysfunction by using Cystometry in patients of Prostatism and to find out correlation between various parameters like age, prostate size, IPSS, management of patients with Prostatism, choice of operative procedure performed and various histopathological findings. Methods: This was observational study. Total 75 patients with age> 50 year and IPSS > 19 having symptoms of Prostatism were included in the study. Patient detailed history was taken and demographic parameters with IPSS, histopathological findings, management plan, Ultrasonography findings were recorded in structured proforma. Results: It is seen that the maximum i.e. 39 (52%) cases of prostatism are observed in the age group of 60 to 70 years. The average age was 67.29 years. Maximum i.e. 31 (41.33%) cases of prostatism had prostate size in 50-70 gms.36 patients were managed by catheterisation while surgery was performed in remaining 39 patients. Transurethral resection of prostate (TURP) was performed in 36 of 39 patients. IPSS was decreased significantly from average of 26 to average of 22 after 2 weeks of operation/catheterisation. Conclusion: Prevalence of BPE increases with age as there found to be positive correlation between age and Prostate size. TURP was preferred procedure in our tertiary centre for the treatment of BPE. Significant decrease in IPPS suggests improvement in symptoms of BPE after operation/catheterisation.
Keywords: Bladder outlet obstruction; Prostatism; International Prostate Symptom Score; Transurethral resection
Histopathological study of non-neoplastic lesions of nose, paransal sinuses and nasopharynx
Get PDFBackground: The various lesions of the nose, paranasal sinuses and nasopharynx were subjected to histopathological evaluation over a period of 5 years (2010 to 2015) at the Department of Pathology, in a rural based hospital. Total 84 specimens were studied over the time of 5 years. Methodology: The formalin fixed specimens were received with complete clinical and radiological features. Routine gross examination and required number of sections were taken and stained with hematoxylin and eosin. Result: In the study, 84 cases were of Inflammatory and Non neoplastic lesions. Nasal polyps were the most common lesions with 77 (91.67%) cases. Among the all Nasal polyps, 77 cases, 20 (25.97%) cases were of Allergic polyp, 50 (64.93%) cases were of inflammatory polyp, while 7 (9.09%) cases were of Antrochoanal polyp. 2 cases (2.38%) each of Sinusitis and Intradermal naevus. Rhinosporidiosis, Mucocele and Nasolabial cyst comprised of 1 (0.77%) case each respectively. Conclusion: In our study, most common lesions were Nasal Polyps. Most of the cases were presented in 2nd and 3rd decade of life with Male preponderance. Nasal obstruction was the most common clinical presentation in the present study
Prevalence of tobacco consumption among adolescents from rural area of Wardha district
Get PDFBackground: Globally adolescent population is around 1200 million and out of six person, every one person is in adolescence (aged10 to 19 years) period (1). Yet most of them are healthy, but premature death, illness and injury among them can hinder ability to grow and develop to their full potential. It is estimated that 1.2 million adolescents died in 2015 and mostly from preventable or treatable causes. Tobacco consumption is world\u27s leading cause of preventable morbidity and mortality. National Family Health Survey conducted in year 2016-17 reported tobacco consumption prevalence 38.9% in urban area and 48% in rural area of India. Method: It was a community based cross-sectional study conducted in eight villages of Wardha district adopted under Community Health Care program run by department of community medicine. Data was collected by interview from 485 adolescent in the age group of 10-19 years by domiciliary visits using pre-designed pre-tested questionnaire from the period October 2016 to October 2018. Results: Prevalence of tobacco use (all forms), smokeless tobacco use and smoking in rural adolescents were 20.82%, 20.41%, and 2.68%, respectively. Prevalence of tobacco use in boys (30.29%) was more than girls (4.49%). Higher Prevalence was found in late adolescent period. Bidi was commonly used form of smoke tobacco while Kharra was the preferred smokeless tobacco. Almost all smokers were male but few exceptions were there. Conclusion: The prevalence of tobacco use among rural adolescents was very high (20.82%) as compared to national prevalence of 14.6% according to the global youth tobacco survey India 2009. There is a need of early intervention for tobacco cessation as overall mean age of 1st experienced to tobacco consumption was 12.02 years and in male and female users it was 12.25 years and 10.88 years respectively. 42.10 % adolescents 1st time experienced any type of tobacco products when they were in the 12-14 years age and only 0.66% adolescents experienced at the age of 17 -19 years. Maximum male (42.19%) and female (41.67%) ever user experienced their 1st tobacco consumption when they were 12-14 years old