The University of Kansas: Journals@KU
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Interactions between Pro-inflammatory Cytokines and Estrogen Receptors in Endometrial Cancer
Full text linkEndometrial cancer (EC) is a hormone-driven malignancy in which estrogen receptor (ER) signaling plays a central role. Meanwhile, chronic inflammation, particularly mediated by pro-inflammatory cytokines such as interleukin-6 (IL-6) and interleukin-17 (IL-17), has emerged as a key contributor to endometrial cancer progression. This review examines the interplay between IL-6, IL-17, and estrogen receptors (ERα and ERβ) in endometrial cancer cells, highlighting how these cytokines regulate ER expression and function through multiple signaling pathways, including the Janus kinase/signal transducer and activator of transcription (JAK/STAT), nuclear factor-κB (NF-κB), and mitogen-activated protein kinase (MAPK) pathways. IL-6 and IL-17 have been shown to upregulate ERα and suppress ERβ, thereby enhancing estrogen-mediated tumor proliferation and potentially contributing to hormonal therapy resistance. Moreover, evidence suggests a bidirectional feedback loop in which estrogen signaling further amplifies cytokine production, creating a self-sustaining inflammatory environment that promotes tumor progression. Understanding this cytokine–ER crosstalk provides novel insights into endometrial cancer pathogenesis and reveals potential therapeutic targets. Strategies that combine endocrine therapy with anti-inflammatory agents or cytokine pathway inhibitors may help overcome resistance and improve clinical outcomes in selected patients. Further mechanistic studies and clinical trials are needed to validate the prognostic and therapeutic relevance of IL-6 and IL-17 in hormone-responsive endometrial cancer
Call for nomination 2025 USCACA/AFCR Youth Award
No full textThe USCACA Junior Faculty Awards will recognize 3 to 6 outstanding junior Chinese faculty for their significant contributions to translational or clinical cancer research. Eligibility is open to junior Chinese faculty currently engaged in translational or clinical cancer research, holding the rank of Associate Professor (or equivalent) in China, or Instructor or Assistant Professor (or equivalent) in the United States. In addition, candidates in China must have obtained training in the US and subsequently returned to China within the last three years or confirmed to return China by the end of 2025, and are currently active in (or will be continue their) translational and clinical cancer research in China
Treatise Online no. 191: Part R, Revised, Volume 1, Illustrated Glossary of the Decapoda
No full textIdentifying Barriers to Mental Health Care For Canadian Student-Athletes: A Narrative Approach
Full text linkCanadian student-athletes and American college athletes face unique stressors related to their sport and have demanding schedules. Although there is limited research specifically focused on the mental health of Canadian student-athletes participating in university sports, existing studies indicate that Canadian student-athletes report increased levels of psychological distress and are more susceptible to mental health issues compared to the general student population. Despite this, many do not seek or receive the treatment they need. This study aimed to identify the barriers to mental health care for Canadian student-athletes competing in Canada. Using a narrative approach, participants identified barriers to mental health treatment, including cultural stigma and voluntary isolation, in addition to a lack of availability of mental health services and the suffering of Canadian student-athletes
Extended mate accompaniment and a novel context for female body-bridging in Pygmy Rattlesnakes, Sistrurus miliarius (Linnaeus 1766)
Full text linkA case of cannibalism in the Indian Spectacled Cobra (Naja naja) from Nagpur, Maharashtra, India
Full text linkAn observation of traumatic globe luxation in the African Red Toad, (Schismaderma carens) (Smith 1848), in KwaZulu-Natal
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Castoriadis’s Language of Radical Imagining, in light of Aristotle and Saussure on Signitive Imagination
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