The University of Kansas: Journals@KU
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Interactions between Pro-inflammatory Cytokines and Estrogen Receptors in Endometrial Cancer
Get PDFEndometrial cancer (EC) is a hormone-driven malignancy in which estrogen receptor (ER) signaling plays a central role. Meanwhile, chronic inflammation, particularly mediated by pro-inflammatory cytokines such as interleukin-6 (IL-6) and interleukin-17 (IL-17), has emerged as a key contributor to endometrial cancer progression. This review examines the interplay between IL-6, IL-17, and estrogen receptors (ERα and ERβ) in endometrial cancer cells, highlighting how these cytokines regulate ER expression and function through multiple signaling pathways, including the Janus kinase/signal transducer and activator of transcription (JAK/STAT), nuclear factor-κB (NF-κB), and mitogen-activated protein kinase (MAPK) pathways. IL-6 and IL-17 have been shown to upregulate ERα and suppress ERβ, thereby enhancing estrogen-mediated tumor proliferation and potentially contributing to hormonal therapy resistance. Moreover, evidence suggests a bidirectional feedback loop in which estrogen signaling further amplifies cytokine production, creating a self-sustaining inflammatory environment that promotes tumor progression. Understanding this cytokine–ER crosstalk provides novel insights into endometrial cancer pathogenesis and reveals potential therapeutic targets. Strategies that combine endocrine therapy with anti-inflammatory agents or cytokine pathway inhibitors may help overcome resistance and improve clinical outcomes in selected patients. Further mechanistic studies and clinical trials are needed to validate the prognostic and therapeutic relevance of IL-6 and IL-17 in hormone-responsive endometrial cancer
Call for nomination 2025 USCACA/AFCR Youth Award
No full textThe USCACA Junior Faculty Awards will recognize 3 to 6 outstanding junior Chinese faculty for their significant contributions to translational or clinical cancer research. Eligibility is open to junior Chinese faculty currently engaged in translational or clinical cancer research, holding the rank of Associate Professor (or equivalent) in China, or Instructor or Assistant Professor (or equivalent) in the United States. In addition, candidates in China must have obtained training in the US and subsequently returned to China within the last three years or confirmed to return China by the end of 2025, and are currently active in (or will be continue their) translational and clinical cancer research in China
First record of Centris (Paracentris) lanosa (Apidae: Centridini) in Georgia, United States
Get PDFCentris (Paracentris) lanosa Cresson, the wooly oil-digger bee, is a specialized oil-collecting species associated with Krameria lanceolata (Torrey) (Krameriaceae). The species is known from two disjunct populations in the southeastern and southwestern United States, with southeastern records previously limited to northern Florida. Here, we report the first occurrence of C. lanosa in Georgia. On 13 May 2024, we collected a female specimen of C. lanosa in a blue vane trap located in a mixed pine-hardwood riparian buffer within privately owned timberland in Treutlen County, Georgia. This new record extends the known range of the species northward by more than 250 km
Evaluating the Evidence: Public Awareness of the Association Between Alcohol and Cancer in the US
Get PDFFirst record of Forsten\u27s Cat Snake, Boiga forsteni (Duméril, Bibron, and Duméril 1854), in Himachal Pradesh: Extending the known range in northern India
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