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TOI-4860 b, a short-period giant planet transiting an M3.5 dwarf
No full textWe report the discovery and characterisation of a giant transiting planet orbiting a nearby M3.5V dwarf (d = 80.4pc, G = 15.1 mag, K=11.2mag, R* = 0.358 ± 0.015 R⊙, M* = 0.340 ± 0.009 M⊙). Using the photometric time series from TESS sectors 10, 36, 46, and 63 and near-infrared spectrophotometry from ExTrA, we measured a planetary radius of 0.77 ± 0.03 RJ and an orbital period of 1.52 days. With high-resolution spectroscopy taken by the CFHT/SPIRou and ESO/ESPRESSO spectrographs, we refined the host star parameters ([Fe/H] = 0.27 ± 0.12) and measured the mass of the planet (0.273 ± 0.006 MJ). Based on these measurements, TOI-4860 b joins the small set of massive planets (>80 ME) found around mid to late M dwarfs (<0.4 R⊙), providing both an interesting challenge to planet formation theory and a favourable target for further atmospheric studies with transmission spectroscopy. We identified an additional signal in the radial velocity data that we attribute to an eccentric planet candidate (e = 0.66 ± 0.09) with an orbital period of 427 ± 7 days and a minimum mass of 1.66 ± 0.26 MJ, but additional data would be needed to confirm thi
Ruckus in the rentals, seeking new arrangements : investigating and mitigating the impact of home-sharing property use on urban noise
No full textDrawing underutilized residential assets into the tourism economy, home-sharing platforms create tremendous economic value for their owners and users. They also, however, generate negative externalities. This study examines the impact of home-sharing property use on an externality which has been increasingly understood to have adverse consequences for human health and wellbeing – noise. Based on empirical analyses using a large sample of transactions from a popular platform, we show that property use increases noise which adversely affects neighbours. More interestingly, we show that the increase in noise is mitigated when property use is spatially or temporally concentrated. A high concentration of property use, our analyses reveal, can enhance the effectiveness of deterrence created through enforcement action against noise complaints. We further conduct empirically informed simulation experiments and propose a nudging algorithm which helps platforms mitigate noise externalities while also fulfilling user preferences and maintaining revenue growth. Contributing to the burgeoning literature on platform externalities, our work highlights the need for further research on potential complementarities between platform and regulatory governance and provides platforms with an alternative approach to the reputationally expensive guest penalties for addressing noise externalities
Sex differences in the association between short sleep duration and obesity : a systematic-review and meta-analysis
No full textAims
Obesity is a leading contributor to global morbidity and mortality. Short sleep duration is significantly associated with the incidence of obesity, however, it remains unclear whether this relationship is influenced by sex. The purpose of this meta-analysis was to systematically evaluate the evidence of whether the association between short sleep duration and obesity differs between males and females.
Data synthesis
The protocol was registered with PROSPERO (CRD42023374205). From inception through June 2023, Medline, Embase and Web of Science databases were searched for longitudinal cohort studies with minimum 12 months of observation. The quality of studies was assessed using the Newcastle-Ottawa Quality Assessment for Cohort Studies. Results were pooled using a random effects model. Results are expressed as ratio of odds ratios (ROR) with 95% confidence interval (CI). ROR directly estimates the relative strength of the association of interest (measured as odds ratio [OR] between females and males). Sensitivity analysis was performed and inconsistency between studies was assessed using I2 statistics. A total of 4,582 articles were retrieved with the search strategy, of which 6 were included. The meta-analysis indicated that the association between short sleep duration and obesity incidence was statistically significant in both men [OR 1.26 (95% CI 1.13 – 1.40)] and women [OR 1.36 (95% CI 1.16 – 1.59)]. However, it did not differ significantly between sexes ROR (women/men) 1.04 (95%CI 0.79 – 1.36; I2 20.1%).
Conclusions
This meta-analysis indicates that women and men who subjectively report short sleep duration have similarly increased risks of incident obesity
The Extended Pillar Integration Process (ePIP) : a data integration method allowing the systematic synthesis of findings from three different sources
Get PDFMixed methods research requires data integration from multiple sources. Existing techniques are restricted to integrating a maximum of two data sources, do not provide step-by-step guidance or can be cumbersome where many data need to be integrated. We have solved these limitations through the development of the extended Pillar Integration Process (ePIP), a method which contributes to the field of mixed methods by being the first data integration method providing explicit steps on how to integrate data from three data sources. The ePIP provides greater transparency, validity and consistency compared to existing methods. We provide two worked examples from health sciences and automotive human factors, highlighting its value as a mixed methods integration tool
Evaluation of the “take time to think” safer gambling message : a randomised, online experimental study
Get PDFIn October 2021, a majority of the UK gambling industry implemented a new UK safer gambling message, ‘take time to think’, which features on gambling advertising and websites. An effective safer gambling message could plausibly affect several relevant gambling behaviours, with previous research suggesting that message effectiveness is maximised via messages that are displayed prominently immediately prior to gambling. We experimentally tested this message's effect on four contemporaneous gambling behaviours (the proportion of available funds bet, clicks for help service information, the mean speed of play, and the total number of roulette spins made) in an incentivised online roulette game in a sample of UK-based online gamblers. Participants (n = 2,305) were randomly allocated to either (a) ‘no-message’ control, (b) ‘message’ shown throughout the condition or (c) a ‘message+’ condition, where the message was shown throughout and also via a popup immediately prior to the roulette game. Overall, the results showed no credible effects across the four outcome measures when comparing either of the message conditions to the no-message control. Even the prominent display of the ‘take time to think’ message did not lead to credible beneficial effects on a range of contemporaneous gambling behaviours
Tracing curves in the plane : geometric-invariant learning from human demonstrations
Get PDFThe empirical laws governing human-curvilinear movements have been studied using various relationships, including minimum jerk, the 2/3 power law, and the piecewise power law. These laws quantify the speed-curvature relationships of human movements during curve tracing using critical speed and curvature as regressors. In this work, we provide a reservoir computing-based framework that can learn and reproduce human-like movements. Specifically, the geometric invariance of the observations, i.e., lateral distance from the closest point on the curve, instantaneous velocity, and curvature, when viewed from the moving frame of reference, are exploited to train the reservoir system. The artificially produced movements are evaluated using the power law to assess whether they are indistinguishable from their human counterparts. The generalisation capabilities of the trained reservoir to curves that have not been used during training are also shown
Diagnosis and management of endometrial hyperplasia : a UK national audit of adherence to national guidance 2012–2020
Get PDFBackground: Endometrial hyperplasia (EH) is a precusor lesion for endometrial cancer (EC), the commonest gynaecological malignancy in high-income countries. EH is a proliferation of glandular tissue, classified as either non-atypical endometrial hyperplasia (NEH) or, if the cytological features are abnormal, atypical endometrial hyperplasia (AEH). The clinical significance of AEH is that patients face both a high risk of having occult EC and a high risk of progression to EC if untreated. Recommendations on the care of women with EH were introduced by United Kingdom–wide guidance (Green-top Guide No. 67, 2016). National adherence to guidance is unknown. We aimed to describe the care of patients with EH; to compare the patterns of care for those with EH with national guidance to identify opportunities for quality improvement; and to compare patterns of care prior to and following the introduction of national guidance to understand its impact. Methods and findings: In this UK-wide patient-level clinical audit, we included 3,307 women who received a new histological diagnosis of EH through a gynaecology service between 1 January 2012 and 30 June 2020. We described first-line management, management at 2 years, and surgical characteristics prior to and following national guidance for EH using proportions and 95% confidence intervals (CIs) and compared process measures between time periods using multilevel Poisson regression. Of the 3,307 patients, 1,570 had NEH and 1,511 had AEH between 2012 and 2019. An additional 85 patients had NEH and 141 had AEH during 2020. Prior to national guidance, 9% (95% CI [6%, 15%]) received no initial treatment for NEH compared with 3% (95% CI [1%, 5%]) post-guidance; 31% (95% CI [26%, 36%]) and 48% (95% CI [43% 53%]) received an intrauterine progestogen, respectively, in the same periods. The predominant management of women with AEH did not differ, with 68% (95% CI [61%, 74%]) and 67% (95 CI [63%, 71%]) receiving first-line hysterectomy, respectively. By 2 years, follow-up to histological regression without hysterectomy increased from 38% (95% CI [33%, 43%]) to 52% (95% CI [47%, 58%]) for those with NEH (rate ratio (RR) 1.38, 95% CI [1.18, 1.63] p < 0.001). We observed an increase in the use of total laparoscopic hysterectomy among those with AEH (RR 1.26, 95% CI [1.04, 1.52]). In the later period, 37% (95% CI [29%, 44%]) of women initially diagnosed with AEH who underwent a first-line hysterectomy, received an upgraded diagnosis of EC. Study limitations included retrospective data collection from routine clinical documentation and the inability to comprehensively understand the shared decision-making process where care differed from guidance. Conclusions: The care of patients with EH has changed in accordance with national guidance. More women received first-line medical management of NEH and were followed up to histological regression. The follow-up of those with AEH who do not undergo hysterectomy must be improved, given their very high risk of coexistent cancer and high risk of developing cancer
Structural validation of the Manchester-Oxford Foot Questionnaire for use in foot and ankle surgery
No full textThe Manchester-Oxford Foot Questionnaire (MOxFQ) is an anatomically specific patient-reported outcome measure (PROM) currently used to assess a wide variety of foot and ankle pathology. It consists of 16 items across three subscales measuring distinct but related traits: walking/standing ability, pain, and social interaction. It is the most used foot and ankle PROM in the UK. Initial MOxFQ validation involved analysis of 100 individuals undergoing hallux valgus surgery. This project aimed to establish whether an individual's response to the MOxFQ varies with anatomical region of disease (measurement invariance), and to explore structural validity of the factor structure (subscale items) of the MOxFQ. This was a single-centre, prospective cohort study involving 6,637 patients (mean age 52 years (SD 17.79)) presenting with a wide range of foot and ankle pathologies between January 2013 and December 2021. To assess whether the MOxFQ responses vary by anatomical region of foot and ankle disease, we performed multigroup confirmatory factor analysis. To assess the structural validity of the subscale items, exploratory and confirmatory factor analyses were performed. Measurement invariance by pathology was confirmed, suggesting the same model can be used across all foot and ankle anatomical regions. Exploratory factor analysis demonstrated a two- to three-factor model, and suggested that item 13 (inability to carry out work/everyday activities) and item 14 (inability to undertake social/recreational activities) loaded more positively onto the "walking/standing" subscale than their original "social interaction" subscale. This large cohort study supports the current widespread use of the MOxFQ across a broad range of foot and ankle pathologies. Our analyses found indications that could support alterations to the original factor structure (items 13 and 14 might be moved from the "social interaction" to the "walking/standing" subscale). However, this requires further work to confirm. [Abstract copyright: © 2024 The British Editorial Society of Bone & Joint Surgery.
An analytically tractable, age-structured model of the impact of vector control on mosquito-transmitted infections
Get PDFVector control is a vital tool utilised by malaria control and elimination programmes worldwide, and as such it is important that we can accurately quantify the expected public health impact of these methods. There are very few previous models that consider vector-control-induced changes in the age-structure of the vector population and the resulting impact on transmission. We analytically derive the steady-state solution of a novel age-structured deterministic compartmental model describing the mosquito feeding cycle, with mosquito age represented discretely by parity—the number of cycles (or successful bloodmeals) completed. Our key model output comprises an explicit, analytically tractable solution that can be used to directly quantify key transmission statistics, such as the effective reproductive ratio under control, Rc, and investigate the age-structured impact of vector control. Application of this model reinforces current knowledge that adult-acting interventions, such as indoor residual spraying of insecticides (IRS) or long-lasting insecticidal nets (LLINs), can be highly effective at reducing transmission, due to the dual effects of repelling and killing mosquitoes. We also demonstrate how larval measures can be implemented in addition to adult-acting measures to reduce Rc and mitigate the impact of waning insecticidal efficacy, as well as how mid-ranges of LLIN coverage are likely to experience the largest effect of reduced net integrity on transmission. We conclude that whilst well-maintained adult-acting vector control measures are substantially more effective than larval-based interventions, incorporating larval control in existing LLIN or IRS programmes could substantially reduce transmission and help mitigate any waning effects of adult-acting measures