Central Food Technological Research Institute
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Comparative Optimization and Characterization of Extraction Techniques for Seaweed Polysaccharides with Antioxidant and Anti-cancer Evaluation
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Fabrication of Aloe vera gel-based nanoparticle loaded with Pigment carotenoid and its characterization
No full textBlueberry-derived extracellular vesicles facilitate intracellular sesamol delivery and modulate redox homeostasis in non-small cell lung carcinoma
No full textFormulation and physico-chemical characterization of high-protein cookies using groundnut seed cake
No full textDevelopment and performance evaluation of fixed-bed column for food industry wastewater treatment
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A study on incorporation of underutilized grains for enhanced nutritional value in waffles
No full textAnalytical method development and multi-residue analysis of pesticides in Indian Black Tea with implications for food safety and consumer protection
No full textA modified QuEChERS method was developed and validated for efficient extraction and accurate quantification of pesticide residues in black tea using GC-MS/ECD and LC-MS/MS techniques. Optimization of the clean-up sorbent composition, particularly the proportion of graphitized carbon black, significantly improved recovery efficiency. The method showed acceptable linearity, selectivity, trueness, precision, recovery, limits of quantification, and measurement uncertainty, meeting internationally recognized validation criteria. Using this approach, 36 commercial black tea samples from India were analyzed for 78 pesticide residues, including those regulated by FSSAI. Eleven pesticides were detected in 28 samples, with monocrotophos most frequent, followed by acetamiprid, acephate, imidacloprid, cypermethrin, and captafol. Methomyl, dinotefuran, simazine, 4,4′-DDT, and γ-BHC appeared in fewer than 10 % of samples. Although 26 samples exceeded Indian MRLs, none surpassed Codex Alimentarius limits. Dietary risk assessment based on Estimated Daily Intake, Hazard Quotient, and Hazard Index values indicated negligible acute risk for adults and children. However, the recurring detection of multiple residues, even at trace levels, suggests potential chronic exposure concerns. Continuous monitoring and the adoption of safer pest management strategies are essential to safeguard consumer health
Mango ginger-derived exosome-like nanovesicles promotes diabetic wound healing via inducing the promigratory protein, follistatin-like 1.
No full textChronic non-healing wounds are major threat in diabetes leading to lower extremity amputation. Lack of ker-
atinocyte migration over the wound bed is a causal factor for non-healing wounds. Topical therapeutics with pro-
migratory growth factors faces limited success due to the protease rich wound milieu. Plant-derived nanovesicles
(PDNVs) are exosome-mimetic vesicles isolated from edible plants with bioavailable presence of several key plant
bioactives with therapeutic value. Herein, using in vitro scratch wound model to mimic keratinocyte migration,
we screened a panel of seven PDNVs from Zingiberaceae and Citrus plants and found Mango ginger-derived
PDNVs (MGDNV) to promote wound healing in vitro. In streptozotocin-induced diabetic mice model, topical
application of MGDNVs, formulated as hydrogel, rescued delayed wound healing caused by diabetes. Mecha-
nistically, MGDNVs promote keratinocyte migration via induction of follistatin-like 1 (FSTL1) protein both in
vitro and in vivo. FSTL1 is a key pro-migratory factor expressed in healing wounds, and failure to induce FSTL1
in keratinocytes leads to lack of cell migration in diabetic wounds. Considering MGDNVs also displayed
percutaneous penetration in porcine skin, which is similar to human skin, and exhibited immunomodulatory
properties, MGDNVs could be natural and cost-effective topical alternative to conventional biological agents for
the treatment of chronic wounds