Central Food Technological Research Institute
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Amino acid derivative as a nitrogen source for freshwater microalgae Haematococcus pluvialis
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Investigating curcuminoid encapsulation in β-cyclodextrin: Insights from NMR spectroscopy and MD simulations
No full textCurcuminoids, key bioactive compounds in turmeric, exhibit significant health benefits but suffer from poor
bioavailability, limiting their therapeutic potential. Cyclodextrin (CD) encapsulation is a promising strategy to
enhance bioavailability, yet studies primarily focus on curcumin (CUR), with limited exploration of other major
curcuminoids such as demethoxycurcumin (DMC) and bisdemethoxycurcumin (BDMC). This study provides a
comprehensive comparative analysis of the encapsulation behavior of CUR, DMC, and BDMC within β-cyclodextrin (β-CD) using a combination of phase solubility analysis, NMR spectroscopy (1D-1H NMR, 2D-NOESY and DOSY), and molecular dynamics (MD) simulations. 1H NMR, NOESY spectra and diffusion studies revealed the strongest inclusion complex formation for BDMC, confirmed by phase stability constants (K). Molecular dynamics simulations further quantified the interaction strength through radial distribution functions (RDFs), close contact analyses, and hydrogen bonding patterns, highlighting the absence of -OCH3 groups in BDMC as a key factor for enhanced interaction. These findings provide crucial mechanistic insights into curcuminoids encap
sulation, suggesting BDMC as a superior candidate for β-CD formulations, with implications for developing more
effective nutraceutical and drug delivery syste
Sustainable fish oil extraction from catfish visceral biomass: A comparative study between high-shear homogenization and high-frequency ultrasound on wet rendering process
No full textTraditional wet rendering leads to the degradation of polyunsaturated fatty acids in fish oil. Therefore, we combined this method with high-shear homogenization and high-frequency ultrasound to extract oil from Clarias magur visceral biomass. This way, we aimed to achieve higher oil yield, shorter extraction times, and a better preservation of polyunsaturated fatty acids. High-shear homogenization and high-frequency ultrasound increased the oil yields by 9.17 and 10.55%, respectively, compared to traditional wet rendering. The oil quality was also improved, with lower acid and peroxide values. Scanning electron microscopy
confirmed enhanced cell disruption for increasing the oil extraction efficiency. Fourier transfer infrared spectroscopy also
proved the efficacy of homogenization and ultrasound pretreatment in enhancing the extraction of polyunsaturated fatty acids
from C. magur visceral biomass. Their content showed a significant variation among different extraction methods. Specifically,
the high-frequency ultrasound method resulted in a notable 15.1% increase, while the high-shear homogenization method de-
monstrated a significant 13.3% increase, compared to the wet rendering method (control). The oil extracted by the high-frequency
ultrasound method demonstrated a 7.5% increase in eicosatetraenoic acid and a 11.7% increase in docosahexaenoic acid, as
compared to the oil obtained from the control method. High-shear homogenization and high-frequency ultrasound shortened the
extraction time and reduced the temperature requirements for oil extraction from wet biomass.
These techniques have potential for efficient fish oil extraction, valuable in the healthcare and food industries
