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Incorporación de la física del problema en la selección de características para la predicción de ocurrencia de ciclones tropicales: un enfoque híbrido basado en optimización
Get PDFEste Trabajo de Fin de Grado tiene como objetivo anticipar la formación de ciclones tropicales, debido a que resulta fundamental para reducir sus consecuencias y mejorar la planificación de medidas preventivas.
El proyecto, comenzará con el procesamiento y creación de las bases de datos, organizadas por tipo de características meteorológicas. A partir de las cuales se seleccionarán las variables más relevantes, utilizando técnicas avanzadas de selección de características. En concreto se empleará, el innovador método Wrapped conocido como CRO-SL (Coral Reefs Optimization with Substrate Layers), inspirado en procesos evolutivos naturales, y un método clásico basado en técnicas Filter, para posteriormente comparar el rendimiento de ambos métodos.
Además a ambos métodos, se ha integrado la física relacionada con el comportamiento estacional de los ciclones, con el objetivo de mejorar significativamente las capacidades predictivas.This thesis aims to anticipate the formation of tropical cyclones, as this is essential for reducing their consequences and improving the planning of preventive measures.
The project will begin with the processing and creation of databases, organized by type of meteorological features. From these, the most relevant variables will be selected using advanced feature selection techniques. Specifically, the innovative Wrapped method known as CRO-SL (Coral Reefs Optimization with Substrate Layers), inspired by natural evolutionary processes, and a classical method based on Filter techniques will be used to subsequently compare the performance of both methods.
In addition, the physics related to the seasonal behavior of cyclones has been integrated into both methods, with the aim of significantly improving their predictive capabilities.Grado en Ingeniería de Computadore
Differential expression of ferroptosis markers, circadian regulators, KLOTHO, and classical tumor suppressors in colorectal cancer according to tumor stage: Influence of age, anatomical location, and correlation patterns
Get PDF25 p.Colorectal cancer (CRC) is a leading cause of cancer-related mortality, with an incidence projected to rise significantly worldwide. While TNM staging remains the cornerstone of prognosis and treatment decisions, additional biomarkers are needed to enhance predictive accuracy and therapeutic targeting. Ferroptosis, an iron-dependent cell death pathway, has emerged as a key regulator of CRC progression and therapy resistance. Circadian rhythms, KLOTHO, and tumor suppressors, such as p53, CDKN1A (p21), and Rb, also play crucial roles in CRC biology. Integrating TNM staging with molecular markers and patient-specific variables offers a more precise, personalized approach to CRC management. In the present work, we analyze the histopathological expression of KLOTHO, ferroptosis markers (TFRC, ALOX-5, ACSL-4, and GPX-4), circadian regulators (CLOCK, BMAL1, PER1, and PER2), and classical tumor suppressors (p53, p21, and Rb) in a cohort of 63 patients diagnosed with CRC. Besides, we have considered important clinical variables, like sex, age, and anatomical location, in our statistical analysis; correlation with the protein expression of these markers was also included for each stage (T1, T2, and T3). Our study reveals that advanced CRC stages (primarily T3) exhibit increased expression of ferroptosis markers (TFRC, ALOX5, ACSL4, and GPX4) and tumor suppressors (p53, p21, and Rb), alongside reduced histopathological detection of KLOTHO and circadian markers (BMAL1, CLOCK, PER1, and PER2) compared with earlier stages. Age, but not sex, influenced the expression of several markers. Tumor location also played a role, with right-sided CRCs showing significant stage-related differences in ferroptosis, tumor suppressor, and BMAL1, whereas left-sided tumors exhibited variations primarily in circadian markers (CLOCK, PER1, and PER2). Correlation analyses across tumor stages indicate dynamic shifts, with tumor suppressors maintaining positive associations with ferroptosis markers and anti-aging/circadian markers showing stage-dependent changes. Despite the inherent limitations of our study, these findings highlight the evolving biomarker landscape in CRC progression, although further research is needed to elucidate their clinical implications.Comunidad de MadridProACapitalHALE KULANI, S. L
Short‐term effects in the treatment of episiotomy dehiscence in Physiotherapy: a novel approach in a case series report
Get PDF10 p.Background and Aims: Dehiscence is defined as the appearance of a hole or gap between the sutured edges of the episiotomy of more than 0.5cm. Episiotomy is a technique in which an incision is made in the perineum to reduce the incidence of severe perineal tears. The two most used are the midline in the USA and Canada and the postero‐lateral incision in Europe. In cases where the mother's BMI exceeds 35kg/m2, the risk of infection and dehiscence increases. Reoperation is the usual choice and may be accompanied by other symptoms such as purulent discharge in 22.2%, perineal pain in 23.6% and 26.2% suffering from both. Radiofrequency and magnetotherapy are common treatments in physiotherapy that have been shown to have positive effects on tissue regeneration with indications for scarring processes. Methods/Results: The following case series report proposes a detailed treatment protocol for episiotomy dehiscence with excellent results and no adverse effects in all cases. All patients had a 50% pain relief and total recovery in 1 week. Conclusions: This is a novel treatment which needs future clinical trials to evaluate, analyze, and determine its effectiveness
Breaking bad news: translation of children's stories about cancer for spanish-speaking children in the United Kingdom
Get PDFLa diversidad cultural y lingüística del Reino Unido plantea retos en la comunicación sanitaria,
en especial en la oncología pediátrica, donde el impacto emocional de las malas noticias exige
recursos adaptados a la infancia. Además, el hecho de que estos materiales no estén disponibles
en español manifiesta una carencia que limita la accesibilidad y la inclusión de esta comunidad.
El objetivo de esta investigación es analizar la traducción de cuentos infantiles sobre el cáncer
como herramienta de apoyo en la transmisión de información médica sensible. Así, el estudio
se basa en una muestra de relatos en inglés y en la traducción sanitaria, la traducción de
literatura infantil y la comunicación de malas noticias. Por tanto, con los objetivos específicos
se busca examinar la transmisión de información sensible en los cuentos, las estrategias
narrativas que se emplean para suavizar su impacto, la presencia de protocolos de comunicación
que se incorporan y los principales problemas que surgen al traducirlos al español.
La metodología empleada es cualitativa y descriptiva, y parte de un análisis textual y narrativo
de las escenas clave y de la relación entre el texto y las imágenes. Los resultados muestran que
los cuentos infantiles constituyen un recurso útil para suavizar la transmisión de la información
médica sensible, siempre que su traducción garantice una mediación lingüística y cultural
adecuada.The cultural and linguistic diversity of the United Kingdom poses challenges for healthcare
communication, particularly in paediatric oncology, where the emotional impact of breaking
bad news requires resources adapted to children. Furthermore, the lack of such materials in
Spanish highlights a gap that limits accessibility and inclusion for this community.
The aim of this research is to analyse the translation of children’s stories about cancer as a
support tool in the transmission of sensitive medical information. The study is therefore based
on a sample of English-language stories and the fields of healthcare translation, children’s
literature translation and bad news communication. The specific objectives are to examine how
sensitive information is conveyed in these stories, to identify the narrative strategies used to
soften its impact, to assess the presence of communication protocols and to analyse the main
challenges that arise in their translation into Spanish.
The methodology is qualitative and descriptive, consisting of a textual and narrative analysis of
key scenes and of the relationship between text and images. The results show that children’s
stories can be a useful resource for mitigating the transmission of sensitive medical information,
provided that their translation ensures appropriate linguistic and cultural mediation.Máster Universitario en Comunicación Intercultural, Interpretación y Traducción en los Servicios Públicos. Especialidad en Inglés-Español (M198
Programación Didáctica. Educación Física. 2º ESO
Get PDFMáster Universitario en Formación del Profesorado de ESO, Bachillerato, Formación Profesional y Enseñanza de Idiomas. Especialidad en Educación Física (M091
International human rights standards in disciplinary proceedings : opportunities for member states to the American convention on human rights based on the experiences of Mexico
Get PDFEl presente trabajo busca identificar áreas de oportunidad normativas y prácticas para los Estados Parte de la Convención Americana sobre Derechos Humanos en materia de los procedimientos disciplinarios seguidos en contra de personas servidoras públicas. Con este propósito, se llevó a cabo un análisis sistemático de los precedentes interamericanos en la materia, contrastándolos con el marco jurídico de responsabilidades administrativas de México, así como con diversos criterios de sus órganos jurisdiccionales. A través de este ejercicio, se identificaron avances normativos relevantes, desafíos y oportunidades que pueden ser aplicables a otros Estados de la región. Los hallazgos de la investigación permiten proponer un ejercicio de due dilligence y diagnóstico de convencionalidad que oriente a las autoridades competentes para hacer una evaluación normativa y práctica, con el fin de promover reformas legislativas y de política pública orientadas al fortalecimiento del régimen disciplinario y al cumplimiento de las obligaciones emanadas derivadas de la Convención Americana.The research aims to identify normative and practical areas of opportunity for the States Parties to the American Convention on Human Rights regarding disciplinary proceedings brought against public officials. To this end, a systematic analysis of the relevant case law issued by the Inter-American Court of Human Rights was conducted, contrasting it with the mexican legal framework, as well as with various interpretative criteria issued by its judicial bodies. Through this exercise, relevant legal advances, persistent challenges, and opportunities applicable to other States in the region were identified. The findings of the research support the proposal of a due diligence exercise, aimed at guiding competent authorities in conducting both normative and practical evaluations. The ultimate goal is to promote legal and public policy reforms to strengthen the disciplinary regimes and ensure compliance with the obligations of the American Convention of Human Rights.Máster Universitario en Protección Internacional de los Derechos Humanos (M081
El módulo como principio: estrategia proyectual en la arquitectura de Manuel Barbero Rebolledo
Get PDF63 p.El siguiente Trabajo de Fin de Grado, “El Módulo como Principio: Estrategia Proyectual en la Arquitectura de Manuel Barbero Rebolledo”, explora la arquitectura modular como sistema constructivo y conceptual, tomando como caso de estudio la obra del arquitecto español Manuel Barbero Rebolledo. La investigación analiza las posibilidades del módulo como unidad base repetible, flexible y escalable, capaz de responder a desafíos sociales, económicos y técnicos, tanto en el contexto del siglo XX como en la actualidad.
El trabajo se articula en tres ejes principales: un marco teórico que revisa los orígenes y ventajas de la modulación en arquitectura, con especial atención al caso español; un recorrido por la biografía y obra de Barbero, centrada en su sistema de 1,60 × 1,60 metros; y un análisis comparativo con otros referentes, como el Módulo HELE de Rafael Leoz.
Un aspecto clave de la investigación es la reflexión sobre la autoría en la arquitectura modular: se plantea que el verdadero protagonista del proyecto no es tanto el arquitecto como figura individual, sino el módulo en sí mismo como principio generador. El arquitecto pasa así a ocupar un papel de mediador que articula decisiones en torno a un sistema objetivo y universalizable.
La tesis concluye que la modulación trasciende lo tecnológico y constituye una estrategia integral capaz de garantizar eficiencia, adaptabilidad y coherencia formal, reivindicando a Barbero Rebolledo como figura clave en los debates actuales sobre industrialización, sostenibilidad y humanización de la arquitectura.The following Thesis, “The Module as Principle: A Design Strategy in the Architecture of Manuel Barbero Rebolledo”, explores modular architecture as both a constructive and conceptual system, taking the work of Spanish architect Manuel Barbero Rebolledo as a case study. The research examines the possibilities of the module as a repeatable, flexible, and scalable base unit, capable of responding to social, economic, and technical challenges, both in the context of the 20th century and in the present day.
The work is structured around three main axes: a theoretical framework that reviews the origins and advantages of modulation in architecture, with special attention to the Spanish case; an overview of Barbero’s biography and work, focused on his 1.60 × 1.60 meter system; and a comparative analysis with other references, such as Rafael Leoz’s HELE Module.
A key aspect of the research is the reflection on authorship in modular architecture: it suggests that the true protagonist of the project is not so much the architect as an individual figure, but rather the module itself as the generative principle. The architect thus assumes the role of mediator, articulating design decisions through an objective and universalizable system.
The thesis concludes that modulation transcends technology to become an integral design strategy, capable of ensuring efficiency, adaptability, and formal coherence, while highlighting Barbero Rebolledo as a key figure in contemporary debates on industrialization, sustainability, and the humanization of architecture.Grado en Fundamentos de Arquitectura y Urbanism
Estudio sobre las arquitecturas orientadas a eventos
Get PDFEste Trabajo de Fin de Grado explora a fondo los principios, patrones y tecnologías asociados a la arquitectura orientada a eventos, con un enfoque especial en la arquitectura hexagonal, el event sourcing, distintos patrones, y las plataformas de mensajería RabbitMQ y Kafka.
El objetivo principal de este proyecto es analizar todo lo relacionado con este tipo de arquitectura y diseñar un sistema demostrativo o demo, que utilice esta arquitectura, aplicando todo o parte de lo estudiado si es posible.
La metodología adoptada incluye una revisión exhaustiva de la literatura, un análisis comparativo de diversas arquitecturas orientadas a eventos, y la implementación de una aplicación demo que ejemplifique el uso de estos patrones y tecnologías. Los resultados de la implementación serán analizados en términos de eficiencia, escalabilidad y adaptabilidad, proporcionando una base sólida para futuros trabajos y aplicaciones en el diseño de sistemas distribuidos modernos.This Final Degree Project explores in depth the principles, patterns and technologies associated with event-driven architecture, with a special focus on hexagonal architecture, event sourcing, different patterns, and the RabbitMQ and Kafka messaging platforms.
The main objective of this project is to analyze everything related to this type of architecture and to design a demonstration or demo system using this architecture, applying all or part of what has been studied if possible.
The methodology adopted includes an exhaustive literature review, a comparative analysis of various event-driven architectures, and the implementation of a demo application that exemplifies the use of these patterns and technologies. The results of the implementation will be analyzed in terms of efficiency, scalability, and adaptability, providing a solid basis for future work and applications in the design of modern distributed systems.Grado en Ingeniería de Computadore
