727 research outputs found
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Glyco-STORM: Nanoscale Mapping of the Cellular Glycosylation Landscape
No full textThis project utilizes lectin staining combined with multiplexed super-resolution microscopy to explore the glycosylation patterns within different cellular contexts, such as brain tissue, hippocampal neurons, and U2OS cells. This repository contains widefield and super-resolution (dSTORM) data showcasing cellular glycosylation
Psychobiological Stress Regulation Through Group Music Therapy in Depressive Women
No full textAbstract
Background. Major Depressive Disorder (MDD) is known as a stress-related disease which affects women more often than men. Music therapy (MT) has been shown to be effective in the treatment of MDD. However, clinical trials investigating the effects of MT on psychological and psychobiological stress-related outcomes in women suffering from MDD are still scarce.
Methods. This study was conducted as a randomized controlled trial, with participants assigned to either an intervention group (IG), which received group MT (GMT), or a waitlist control group (CG) which received GMT 6 months later. The primary objective was to assess the impact of GMT on psychological stress outcomes (chronic stress, stress coping, and stress experienced in daily life) and psychobiological stress markers (diurnal salivary cortisol levels and circadian heart rate variability), considering the effects of both group allocation and time. Outcome measurements were taken before, immediately after, and for some variables, 10 weeks following the intervention period.
Results. A total of 102 women between 18 and 65 years diagnosed with current MDD took part in the study. Overall, the IG demonstrated more substantial stress-reducing effects compared to the CG. Significant improvements were observed in general stress coping, positive thinking, daily life stress, and cortisol.
Conclusion. GMT is a cost-effective and non-invasive approach to effectively address the stress-related psychological and psychobiological burden associated with MDD. To demonstrate long-term effects and gain a better understanding of the underlying mechanisms, further methodologically robust studies are needed
ComCog - Encapsulation
No full textEye Tracking Data comparing Encapsulation and Coreference across different levels of informativity of the referential expression
Soft X-ray tomography reveals variations in B.subtilis biofilm structure upon tasA deletion [Data]
No full textBacterial biofilms are complex communities of cells within a self-produced extracellular matrix. They play crucial roles in healthcare, nutrition, agriculture and environmental research, yet an analysis of their elaborate 3D architecture remains challenging. In our work, we developed a “biofilm-in-capillary” growth method compatible with full-rotation soft X-ray tomography, providing high-resolution 3D imaging of bacterial cells and their surrounding extracellular matrix during biofilm formation, without drying or fixation steps. These datasets are reconstructed 3D volumes obtained by soft X-ray tomography of WT and ΔtasA mutants, including rescue with TasA protein.
The data is organized in individual *.tif files with prefixes as follows:
for single-cell suspension WT "Diehl_Biofilm_Bacillus_subtilis_WT_GFP_0h_10797";
for single-cell suspension ΔtasA mutants "Diehl_Biofilm_Bacillus_subtilis_tasA_GFP_0h_10801_";
for WT biofilm formed after 22h "Diehl_Biofilm_Bacillus_subtilis_WT_GFP_10479";for ΔtasA biofilm formed after 22h "Diehl_Biofilm_Bacillus_subtilis_tasA_GFP_10517";for ΔtasA biofilm formed after 44h "Diehl_Biofilm_Bacillus_subtilis_tasA_GFP_ctrl_44h_10815";for ΔtasA biofilm with the addition of TasA protein formed after 44h "Diehl_Biofilm_Bacillus_subtilis_tasA_GFP_rescue_44h_10821"</ul
Peer-led revision course of the subject ‚Medical Psychology and Sociology‘ for preclinical international medical students [data]
No full textIn this study we evaluated the objective improvement of international preclinical medical students' knowledge in the subject 'Medical Psychology and Sociology' after attending a 3-day peer-led revision course. Using a pre-post-test-design, we found a significant improvement of post-results, compared to pre-results. This data verse contains our collected data as well as the R code used for statistical analysis. We also provide a RMarkdown file with our results. All participants are anonymised
Autobiographical Narratives in Major Depression: Changes in Memory Specificity During Outpatient Psychodynamic Psychotherapy [Analysis]
No full textThis dataset contains the code for the analysis in SPSS and R that was used to calculate the results for the study "Autobiographical Narratives in Major Depression: Changes in Memory Specificity During Outpatient Psychodynamic Psychotherapy"
LIDO-Handbuch für die Erfassung und Publikation von Metadaten zu kulturellen Objekten - Band 3: Architektur und andere ortsfeste Werke [Anwendungsbeispiele]
No full textLIDO (Lightweight Information Describing Objects) ist ein XML-Schema für die standardkonforme Bereitstellung von Metadaten über kulturelle Objekte in einer Vielzahl von digitalen Kontexten. Basierend auf diesem internationalen Standard dient das "LIDO-Handbuch für die Erfassung und Publikation von Metadaten zu kulturellen Objekten, Band 3: Architektur und andere ortsfeste Werke" als Anleitung für die schlüssige Strukturierung von Informationen über Werke der Architektur und andere ortsfeste Strukturen in lokalen Sammlungsmanagement-Systemen.
In dem hier vorliegenden Datenset werden LIDO-XML-Beispieldatensätze für die Version LIDO v1.1 zur Verfügung gestellt, die unmittelbar bei der Vorbereitung eines Datenexports aus einem lokalen System als Anschauungsmaterial dienen können. Das Dataset umfasst vollständige LIDO-XML-Datensätze mit unterschiedlichen dokumentarischen und informationstechnischen Schwerpunkten.
Erfolgt die Bereitstellung von XML-Datensätzen über kulturelle Objekte gemäß den im LIDO XML-Schema definierten Regeln, so wird eine wesentliche Voraussetzung dafür geschaffen, dass die Daten rechtlich und technisch optimal durch Dritte nachgenutzt werden können. Außerdem werden Suchergebnisse in sammlungsübergreifenden Anwendungen hinsichtlich Recall und Precision verbessert. Informationen können so vernetzt werden, dass ein Mehrwert durch die Generierung von Wissen entsteht.
Das Handbuch und dieses begleitende Datenset entstanden im Rahmen zweier
Projekte: Das Konzept für die Ausrichtung und publikationstechnische Umsetzung des Handbuchs wurde im Zuge des Projekts "KONDA - Kontinuierliches Qualitätsmanagement von dynamischen Forschungsdaten zu Objekten der materiellen Kultur unter Nutzung des LIDO-Standards", gefördert vom Bundesministerium für Bildung und Forschung (BMBF), entwickelt. Wesentlich mitgetragen und finanziert wurde das Handbuch-Projekt zudem durch NFDI4Culture – Konsortium für Forschungsdaten zu materiellen und immateriellen Kulturgütern, Arbeitsbereich Standards, Datenqualität und Kuratierung, gefördert von der Deutschen Forschungsgemeinschaft (Fördernummer 441958017)
Natural abiotic iron-mediated formation of C1 and C2 compounds from environmentally important methyl-substituted substrates and their implication for nature (Digital Appendix)
No full textOrganic and inorganic compounds with one or two carbon atoms (C1 and C2) are continuously produced through natural processes, including methane, ethane, methanol, formaldehyde, methyl chloride, and carbon dioxide. These compounds act as greenhouse gases, control the oxidation capacity of the atmosphere, and play an important role in atmospheric chemistry and physics.
A recent study has provided compelling evidence for the oxic and abiotic formation of C1 and C2 compounds through the cleavage of methyl groups from environmentally relevant organic substrates with sulfur-, nitrogen-, phosphorus-, and oxygen-bonded methyl groups using iron-oxo species.
The results show that these processes are a significant source of C1 and C2 compounds, influencing the global carbon cycle. In particular, the demethoxylation of lignin monomers and other aromatic methoxy compounds is an important process occurring in natural environments such as soil.
This discovery highlights the importance of abiotic processes for the production of C1 and C2 compounds and their impact on the chemical and physical properties of natural environments
Exploring Gender differences with Natural Language Processing: Language Characteristics of male and female patients in psychodynamic psychotherapy [data]
No full textThis dataset contains the R code for the analysis and results of the study "Exploring Gender differences with Natural Language Processing: Language characteristics of male and female patients in psychodynamic psychotherapy". Furthermore, it contains the transcription rules.
Introduction: To improve psychotherapeutic treatment, gender differences regarding psychological processes in psychotherapy need to be understood. As language is the basis for communication and the relationship between patient and psychotherapist, the impact of gender on psychotherapeutic treatment can be investigated through the analysis of language patterns of male and female patients in psychotherapy sessions.
Methods: For this retrospective, exploratory study 250 psychotherapy sessions of 125 patients treated at a psychodynamic psychotherapy institute were verbatim transcribed. The psychodynamic psychotherapies took place at the Heidelberg Institute for Psychotherapy (HIP). Using computational methods of Natural Language Processing, different language parameters were extracted from these transcripts and language differences between male and female patients were analysed.
Results: We were able to identify several gender differences: Male patients showed a higher lexical verbosity, used longer words and more nouns and adjectives than female patients. Moreover, in sessions with male patients, interruptions occurred more often. In comparison, female patients spoke words that refer to their mother more often and also used terms of endearment to talk about their parents. Additionally, they used personal pronouns and first-person plural pronouns more frequently than male patients. No significant gender difference was found for word count, simultaneous speaking and insertions.
Discussion: Our study demonstrated that gender impacts language patterns in psychodynamic psychotherapy. Male patients use a more complex, formal and directive language, while the language of female patients indicates more emotional proximity, especially in relationships. Our results serve as a first account of gender-specific language characteristics in psychotherapy
Hugo Helbing in München und Berlin. Eine quantitative Analyse digitalisierter Auktionskataloge (1916-1932) [Forschungsdaten]
No full textHeiData Description – MA Thesis Schneider, Madeleine
Die Untersuchungseinheit der Masterarbeit bilden die digitalisierten Auktionskataloge der Galerie Helbing und der Berliner Auktionsgemeinschaft mit dem Berliner Kunsthändler Paul Cassirer innerhalb der beiden Kooperationsphasen (Phase I: 1916–1919 und Phase II: 1924–1932). Der Datensatz stellt die Arbeitsgrundlage der quantitativen Erhebungen dar, die im Text näher analysiert werden. Tabelle 1 enthält die Berliner Auktionskataloge von Cassirer und Helbing. Tabelle 2 umfasst die Kataloge der Münchner Galerie Hugo Helbing. Die Metadaten umfassen Katalog- und Auktionsnummer, Jahr, Tag und Monat, Titel, Herkunft, Konvolut, Besitzverhältnis, Konvolutsanzahl, Gattungen sowie Gattungsanzahl. Die Daten wurden von der Autorin erfasst; nur in gekennzeichneten Feldern wurden Angaben aus der Sekundärliteratur übernommen. Die Tabellen enthalten zudem Informationen, die nicht umfassend in die Analyse eingeflossen sind: z.B. Notizen zu Auffälligkeiten und in Tabelle 1 auch seitengenaue Verweise auf die eingesehenen Auktionsberichte. Nähere Erläuterungen finden sich in der Master-Thesis.
The research unit of the master’s thesis consists of the digitised auction catalogues of Galerie Helbing and the partnership with the Berlin art dealer Paul Cassirer, covering the two cooperation phases (Phase I: 1916–1919 and Phase II: 1924–1932). The dataset forms the basis for the quantitative analysis described in the text. Table 1 contains the Berlin auction catalogues of Cassirer and Helbing, while Table 2 includes the catalogues of the Munich Galerie Hugo Helbing. The metadata comprises catalogue and auction numbers, year, day and month, title, provenance of the lot, ownership status, number of lots, genres, and number of genres. The data was collected by the author; only in marked fields information was taken from secondary literature. The tables also contain information that was not fully included in the analysis, e.g., notes on irregularities and, in Table 1, page‑specific references to the auction reports consulted. Further details can be found in the master’s thesis.</p