727 research outputs found
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Methane cycling in a eutrophic lake characterised by multiple stable isotope and flux measurements [data]
No full textRecent estimations demonstrate that methane (CH4) emissions from aquatic systems are responsible for up to half of global CH4 emissions. Lakes represent one of the largest CH4 sources, and emissions are predicted to increase due to global warming. However, there is a large uncertainty associated with CH4 emissions from freshwater environments to the atmosphere. Emissions result from the interplay between physical transport, CH4 production and consumption processes, which remain poorly understood. Especially the recently discovered CH4 production in oxic water layers (OMP) questions the traditional understanding of CH4 formation processes and might constitute a major driver of limnic CH4 emissions. However, the underlying mechanisms and pathways of OMP are largely unknown.
In the scope of this study, a combination of field measurements and laboratory incubation experiments as well as concentration measurements and stable isotope techniques were conducted to disentangle the complex processes involved in the CH4 cycle of small, seasonally stratified, eutrophic Lake Willersinnweiher, which is situated in south-west Germany. Methane oversaturation in the water column of Lake Willersinnweiher was found throughout the whole year. However, seasonal and spatial variations of dissolved CH4 depending on lake stratification were observed. Spatial disparities of epilimnic CH4 concentrations indicated that lateral input of CH4 originated mainly from a few selected shallow sites and not from the whole littoral area of the lake. Inflowing groundwater characterised by high CH4 concentrations, which were unusually enriched in 13C and deuterium (2H), further contributed to CH4 supersaturation in the water column. During the stratification period, accumulation of CH4 just below the thermocline coincided with chlorophyll-a peaks, thus indicating the potential presence of OMP in connection with phytoplankton blooms at Lake Willersinnweiher. The potential occurrence of OMP was further validated by a mass-balance approach and by identifying methyl phosphonate, methylamine, and methionine as three potential precursor compounds of CH4 in the oxic water column. In the sediment, the stable carbon (δ13C-CH4) and stable hydrogen (δ2H-CH4) isotope values of CH4 revealed the contribution of different pathways of methanogenic CH4 production depending on water depth. However, sulphate (SO42-)-dependent anaerobic methane oxidation (AOM), revealed by flux measurements, stable isotope evidence of CH4 and dissolved inorganic carbon (DIC) acted as a sink of sedimentary CH4 that substantially diminished CH4 fluxes from the sediment into bottom waters. Furthermore, CH4 from the anoxic CH4-rich hypolimnion was largely depleted by aerobic methane oxidation (MOx) at the oxic-anoxic interface. Methane fluxes from the water column to the atmosphere as well as its stable isotopic values showed strong seasonal dependence and variations, with CH4 being more enriched in 13C and 2H during the mixing period in winter compared to the stratification period in summer. While diffusive CH4 fluxes dominated total CH4 emissions during the mixing period, ebullition was the main contributor to CH4 emissions during the stratification period. Furthermore, the recently introduced isotope indicator Δ(2,13) was applied to characterise CH4 sources at Lake Willersinnweiher. Δ(2,13) values implied that littoral and groundwater inputs of CH4 mainly contributed to CH4 supersaturation at Lake Willersinnweiher during the mixing period. However, lateral and vertical CH4 inputs alone could not explain CH4 supersaturation during the stratification period. Therefore, OMP might be another important CH4 source. This study shows that all investigated sinks and sources of CH4 are subject to strong variations based on lake stratification, physicochemical conditions, and lake depth. Hence, the results of this study suggest that a combination of dual isotope and concentration measurements of CH4 is a promising tool in order to untangle seasonal and spatial dynamics of CH4 sources and sinks in the complex CH4 cycle of lakes
Cyclodimers and Cyclotrimers of 2,3-Bisalkynylated Anthracenes, Phenazines and Diazatetracenes [Data]
No full textResearch Data associated with the related publication
The Abbott PanBio WHO emergency use listed, rapid, antigen-detecting point-of-care diagnostic test for SARS-CoV-2 - Evaluation of the accuracy and ease-of-use [Research Data]
No full textThis repository includes data from a prospective, multi-centre diagnostic accuracy study. The study was conducted at two sites in Germany, Heidelberg and Berlin. Following routine testing with reverse-transcriptase polymerase chain reaction (RT-PCR), a second study-exclusive swab was performed for Ag-RDT testing. Routine swabs were nasopharyngeal (NP) or combined NP/oropharyngeal (OP) whereas the study-exclusive swabs were NP. To evaluate performance, sensitivity and specificity were assessed overall and in predefined sub analyses accordingly to cycle-threshold values, days of symptoms, disease severity and study site. In addition, further data from the participants were collected during interviews
A framework for assessing import costs of medical supplies and results for a tuberculosis program in Karakalpakstan, Uzbekistan [Research Data]
No full textBackground: Import of medical supplies is common, but limited knowledge about import costs and their structure introduces uncertainty to budget planning, cost management, and cost-effectiveness analysis of health programs. We aimed to estimate the import costs of a tuberculosis (TB) program in Uzbekistan, including the import costs of specific imported items.
Methods: We developed a framework that applies costing and cost accounting to import costs. First, transport costs, customs-related costs, cargo weight, unit weights, and quantities ordered were gathered for a major shipment of medical supplies from the Médecins Sans Frontières (MSF) Procurement Unit in Amsterdam, the Netherlands, to a TB program in Karakalpakstan, Uzbekistan, in 2016. Second, air freight, land freight, and customs clearance cost totals were estimated. Third, total import costs were allocated to different cargos (standard, cool, and frozen), items (e.g., TB drugs), and units (e.g., one tablet) based on imported weight and quantity. Data sources were order invoices, waybills, the local MSF logistics department, and an MSF standard product list.
Results: The shipment contained 1.8 million units of 85 medical items of standard, cool, and frozen cargo. The average import cost for the TB program was 9.0% of the shipment value. Import cost varied substantially between cargos (8.9–28% of the cargo value) and items (interquartile range 4.5–35% of the item value). The largest portion of the total import cost was caused by transport (82–99% of the cargo import cost) and allocated based on imported weight. Ten (14%) of the 69 items imported as standard cargo were associated with 85% of the standard cargo import cost. Standard cargo items could be grouped based on contributing to import costs predominantly through unit weight (e.g., fluids), imported quantity (e.g., tablets), or the combination of unit weight and imported quantity (e.g., items in powder form).
Conclusion: The cost of importing medical supplies to a TB program in Karakalpakstan, Uzbekistan, was sizable, variable, and driven by a subset of imported items. The framework used to measure and account import costs can be adapted to other health programs
Image-based screening for stress granule regulators
No full textThe supplied macro provides the opportunity to analyse large-scale image datasets, derived from image-based screening approaches. It can be used as a base for the segmentation of individual cells, referred as regions of interest (ROIs), and the detection and quantification of the stress granule (SG) response within those ROIs
Timer-based proteomic profiling of the ubiquitin-proteasome system reveals a substrate receptor of the GID ubiquitin ligase [Dataset]
No full textData accompanying the paper "Timer-based proteomic profiling of the ubiquitin-proteasome system reveals a substrate receptor of the GID ubiquitin ligase"
Ergänzungsmaterial zu: Stone tool analysis and context of a new late Middle Paleolithic site in western central Europe – Pouch-Terrassenpfeiler, Ldkr. Anhalt-Bitterfeld, Germany
No full textEine neue spätmittelpaläolithische Fundstelle im westlichen Mitteleuropa – Pouch-Terrassenpfeiler, Ldkr. Anhalt-Bitterfeld, Deutschland. Steinartefaktanalyse und mitteldeutscher Kontex
Biographical music therapy in palliative care [dataset]
No full text1. PURPOSE: Awareness for the importance of psychological and spiritual needs in patients with terminal diseases has increased in recent years. While clinical trials have demonstrated the potential of psychosocial interventions in cancer populations, it remains a challenge to transfer existing protocols to end-of-life situations. The present study aims to investigate the efficacy of the innovative biographical music therapy intervention “Song of Life” (SOL) regarding the emotional and psycho-spiritual dimensions of quality of life in palliative care patients.
2. PATIENTS AND METHODS: 104 inpatients from two palliative care units were randomly assigned to three sessions of either SOL music therapy (experimental group, EG) or relaxation as an active control group (CG). The primary outcome was the pre-to-post intervention change in psychological quality of life. Secondary outcomes included spiritual well-being, ego-integrity, momentary distress, and global quality of life. A feedback questionnaire was used as an explorative measure of treatment satisfaction in both a patient and family member version. Analysis of covariance with multiply imputed data was used for primary analysis. Sensitivity analysis was performed with all available data using multilevel modeling.
3. RESULTS: No significant differences were found regarding psychological and global quality of life, but SOL participants reported significantly higher spiritual well-being (p = .039) and ego-integrity (p
4. CONCLUSION: Our findings provide evidence that SOL is an effective biographical music therapy intervention to facilitate psycho-spiritual integration in terminally ill patients
Self-reported & Revealed Trust: Experimental Evidence [Dataset and Replication Code]
No full textI study the relationship between self-declared trust attitudes - using a well-recognised and established personality questionnaire - and trust choices in an induced infinitely repeated trust game. I find that self-reported trust measures are significantly related with trust choices as long as trust is part of equilibrium strategies. I find that questions regarding others' intentions is a missing component in previous work that studies self-reports of trust. An important aspect of the design is that first movers are not privy to the choices made by their partners. This design feature, coupled with an uncertainty element introduced in determining the first mover's final payoff, allows me to analyse how first movers react to bad outcomes. Trusting individuals are more likely to give the benefit of doubt to others. Analysis of the incentivised subjective beliefs reveals that the effect of personality traits on trust choices is not through the formation of beliefs
ARCHITRAVE [map visualization : data & software]
No full textThe dataset includes cartographic visualization data and software designed, implemented, and published for the ARCHITRAVE research project website. The research focused on the edition, executed in German and French, of six travelogues by German travelers of the Baroque period who visited Paris and Versailles. The edited texts are published in the Textgrid repository. For all further information on the content and objectives of the research, please refer to the website (https://architrave.eu/) and given literature.
Three visualizations were created for the website:
the travel stops of five of the travelers on their way to Paris and Versailles
the sites in Europe mentioned in the six travelogues
the sites in Paris described by the six travelers
The visualizations were implemented with Leaflet.js.
The dataset contains
scripts for data crunching
processed geodata
scripts for leaflet.js
License
README
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