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CITADEL: Computational Investigation of the Topographical and Architectural Designs in an Evolving Landscape (Research Data)
No full textThe data found in this repository contain the basis for the historical, architectural, and geo-spatial analyses discussed in the dissertation entitled: CITADEL – Computation Investigation of the Topographical and Architectural Designs in an Evolving Landscape. These data include the following categories.
1. Photogrammetric Data: all photos, calibration information, and Agisoft Metashape projects for the four sites. All post-processed 3D models of the photogrammetric process and their associated perspectives from which orthophotos were generated for the construction research.
2. Laserscan Data: all raw data and calibration information pertaining the four sites as recorded by the Riegl VZ-400 laser scanner, and all post-processed 3D models of the sites.
3. GIS Data: all historical maps that were geo-referenced in the project, the entire QGIS project file with all associated layers, all raster and vector data saved as individual files, and all shapefiles saved as individual files.
4. Graph Database: all spreadsheets containing the base information drawn from the charters provided by online and analog sources. The entire Cypher Script as well as instruction for importing the data into Neo4j. The rubric outlining how the status and administration positions of the individuals in the charters were ranked relative to one another. The cognitive development of the database’s structure represented by graph schemas over time.
5. Architectural Plans: the roombook outlining every wall, architectural element, and building phase of the four sites. All 76 architectural plans of the construction research using orthophotos of the photogrammetric models.</p
Substituted Cyclopentannulated Tetraazapentacenes [data]
No full textBrominated pentannulated dihydrotetraazapentacenes were prepared by gold- or palladium-catalyzed 5-endo-dig cyclization of TIPS-ethynylated dihydrotetraazaacenes (TIPS = triisopropylsilyl). Post-functionalization was demonstrated by Sonogashira alkynylation and Rosenmund-von Braun cyanation. Calculations predict these species to act as n-type semiconductors, which was verified for two derivates through characterization in organic field-effect transistors
Complex irradiation history of chondrules and matrix – a study of CR2 and some other meteorites - Tables 1-6
No full textExcesses of cosmic-ray produced nuclei in individual components of meteorites indicate “pre-irradiation”, either in the surface region of their parent bodies (PBs) or as free-floating small particles in the early Solar System (ESS), and several cases of pre-irradiation of chondrules have been inferred in previous studies. We expand on our earlier work (Beyersdorf-Kuis et al., 2015) and report a study of cosmic-ray produced He and Ne in chondrules and “matrix” material of several CR2 and CV meteorites as well as the highly primitive, unique, carbonaceous chondrite Acfer 094. In order to avoid artifacts in the interpretation due to poorly known target element abundances in the analyzed material, we performed instrumental neutron activation analysis (INAA) on the very samples subsequently used for noble gas analysis. In accordance with previous work, no evidence for pre-irradiation was found for CV3 Allende, while for CV3 Vigarano evidence for pre-irradiation is marginal at best. Chondrules from Acfer 082 (CV) exhibit both excesses and deficits relative to matrix, which points to pre-irradiation of not only chondrules, but also matrix material. A similar case may be Renazzo (CR2), where, however, the identification is complicated by the presence of abundant pre-solar Ne-E. A large number of chondrules (ten) were studied from CR2 El Djouf 001, which yielded slightly variable, small but consistent, excesses relative to matrix, corresponding to “nominal” (i.e., irradiation by galactic cosmic rays in 4 Pi geometry) excess ages of 1 to 2 Ma. Modelling based on cosmogenic 22Ne/21Ne suggest contributions from irradiation in the parent body regolith by SCR as well as GCR, where the latter dominates. The individual contributions are difficult to quantify, but variations of the GCR component may be the major cause of the variations in nominal CRE ages. Very large excesses - corresponding to nominal excess exposure ages >30 Ma - were found in two chondrules from the solar-wind-rich CR2 NWA 852, in agreement with reports in the literature. The case shows similarity to El Djouf 001 except for the much larger size of the effects, and the situation may be common among meteorites with a regolith origin. With independent information on the CRE age, SCR and GCR parent body contributions may be disentangled, providing constraints on regolith dynamics. Reevaluating the large variations previously identified in chondrules from QUE 99177 we suggest either a very different regolith history compared to that of El Djouf 001 or, more likely, pre-irradiation in the ESS as suggested by Beyersdorf et al. (2015). The single chondrule from unique Acfer 094 that we studied has a cosmic ray exposure indistinguishable from the one we found for matrix material
German funders' data sharing policies - A qualitative interview study [interview excerpts]
No full textBackground
Data sharing is commonly seen as beneficial for science, but is not yet common practice. Research funding agencies are known to play a key role in promoting data sharing, but German funders’ data sharing policies appear to lag behind in international comparison. This study aims to answer the question of how German data sharing experts inside and outside funding agencies perceive and evaluate German funders’ data sharing policies and overall efforts to promote data sharing.
Methods
This study is based on sixteen guideline-structured interviews with representatives of German funding agencies and German research data experts from other organisations, who shared their perceptions of German’ funders efforts to promote data sharing. By applying the method of qualitative content analysis to our interview data, we categorise and describe noteworthy aspects of the German data sharing policy landscape and illustrate our findings with interview passages.
Research data
This dataset contains summaries from interviews with data sharing and funding policy experts from German funding agencies and what we call "stakeholder organisations" (e.g., universities, research data infrastructure providers, etc.). We asked the interviewees about their perspectives on German funders' data sharing policies, for example regarding the actual status quo, their expectations about the potential role that funders can play in promoting data sharing, as well as general developments in this area.
Supplement_1_Interview_guideline_funders.pdf and Supplement_2_Interview_guideline_stakeholders.pdf provide supplemental information in the form of the (german) interview guidelines used in this study.
Supplement_3_Transcription_and_coding_guideline.pdf lays out the rules we followed in our transcription and coding process.
Supplement_4_Category_system.pdf describes the underlying category system of the qualitative content analysis we conducted
Feature-Oriented CBCT Self-Calibration Parameter Estimator for Arbitrary Trajectories: FORCAST-EST [data]
No full textData for the Paper: "Feature-Oriented CBCT Self-Calibration Parameter Estimator for Arbitrary Trajectories: FORCAST-EST"
https://doi.org/10.3390/app13169179
Abstract:
Background: For the reconstruction of Cone-Beam CT volumes, the exact position of
each projection is needed; however, in some situations, this information is missing.
Purpose: The
development of a self-calibration algorithm for arbitrary CBCT trajectories that does not need initial
positions.
Methods: Projections are simulated in a spherical grid around the center of rotation.
Through using feature detection and matching, an acquired projection is compared to each simulated
image in this grid. The position with the most matched features was used as a starting point for a
fine calibration with a state-of-the-art algorithm.
Evaluation: This approach is compared with the
calibration of nearly correct starting positions when using FORCASTER and CMA-ES minimization
with a normalized gradient information (NGI) objective function. The comparison metrics were the
normalized root mean squared error, structural similarity index, and the dice coefficient, which were
evaluated on the segmentation of a metal object.
Results: The parameter estimation for a regular
Cone-Beam CT with a 496 projection took 1:26 h with the following metric values: NRMSE = 0.0669;
SSIM = 0.992; NGI = 0.75; and Dice = 0.96. FORCASTER with parameter estimation took 3:28 h with
the following metrics: NRMSE = 0.0190; SSIM = 0.999; NGI = 0.92; and Dice = 0.99. CMA-ES with
parameter estimation took 5:39 h with the following metrics: NRMSE = 0.0037; SSIM = 1.0; NGI =
0.98; and Dice = 1.0.
Conclusions: The proposed algorithm can determine the parameters of the
projection orientations for arbitrary trajectories with enough accuracy to reconstruct a 3D volume
with low errors
Collagen breaks at weak sacrificial bonds taming its mechanoradicals [Data]
No full textThis dataset contains input files for MD simulations, derived breakage counts from these simulations that are used to generate the figures in the publication, and the experimental, uncropped SDS-PAGE gels of the presented results in the related publication.
Abstract of related publication:
Collagen is a force-bearing, hierarchical structural protein important to all connective tissue. In tendon collagen, high load even below macroscopic failure level creates mechanoradicals by homolytic bond scission, similar to polymers. The location and type of initial rupture sites critically decide on both the mechanical and chemical impact of these micro-ruptures on the tissue, but are yet to be explored. We
here use scale-bridging simulations supported by gel electrophoresis and mass spectrometry to determine breakage points in collagen. We find collagen crosslinks, as opposed to the backbone, to harbor the weakest bonds, with one particular bond in trivalent crosslinks as the most dominant rupture site. We identify this bond as sacrificial, rupturing prior to other bonds while maintaining the material’s integrity.
Also, collagen’s weak bonds funnel ruptures such that the potentially harmful mechanoradicals are readily stabilized. Our results suggest this unique failure mode of collagen to be tailored towards combatting an early onset of macroscopic failure and material ageing
Accurate classification of major brain cell types using in vivo imaging and neural network processing
No full textThis dataset accompanies the article of the same title in the journal Plos Biology. It includes a) Ground truth datasets for the training of the StarDist neuronal network for nucleus segmentation (StardistTraining.tar.gz) b) The trained Stardist nucleus segmentation model (StardistModel.tar.gz c) raw and segmented data for the training of the cell type classification (CelltypeClassification.tar.gz, CelltypeClassificationExcInhNeurons.tar.gz) d) the raw and segmented data for the results of the paper (RawdataResults.tar.gz) e) Ground truth data for the training of all classifiers (ClassificationTrainingDataSet.tab
Digital Appendix: Structural cerebrocortical changes in ageing and chronic neuropathic pain - a mouse study correlating magnetic resonance imaging and in vivo two-photon microscopy
No full textThis is the digital appendix to the dissertation by Livia Asan, titled "Structural cerebrocortical changes in ageing and chronic neuropathic pain - a mouse study correlating magnetic resonance imaging and in vivo two-photon microscopy", at the Faculty of Medicine, Heidelberg, Ruprecht-Karls-University
Allosteric Activation of Vinculin by Talin [data]
No full textThe talin-vinculin axis is a key mechanosensing component of cellular focal adhesions. How talin and vinculin respond to forces and regulate one another remains unclear. By combining single molecule magnetic tweezer experiments, Molecular Dynamics simulations, actin bundling assays, and adhesion assembly experiments in live cells, we here discover a two-ways allosteric network within vinculin as a regulator of the talin-vinculin interaction. We directly observe a maturation process of vinculin upon talin binding which reinforces the binding to talin at a rate of 0.03 s−1. This allosteric transition can compete with force-induced dissociation of vinculin from talin only at 7-10 pN. Mimicking the allosteric activation by mutation yields a vinculin molecule that bundles actin and localizes to focal adhesions in a force-independent manner. Hence, the allosteric switch confines talin-vinculin interactions and focal adhesion build-up to intermediate force levels. The ‘allosteric vinculin mutant’ is a valuable molecular tool to further dissect the mechanical and biochemical signalling circuits at focal adhesions and elsewhere
Ergänzungsmaterial zu: Siedlungsarchäologie im Alpenvorland XV. Die Pfahlbausiedlungen von Sipplingen-Osthafen am Bodensee I. Befunde und dendrochronologische Untersuchungen
No full textIm Band "Siedlungsarchäologie im Alpenvorland XV" werden die Ergebnisse der Grabungen und der dendrochronologischen Untersuchungen in der Pfahlbaustation Sipplingen-Osthafen am Bodensee vorgelegt sowie die Schlussfolgerungen zur Besiedlungsgeschichte und zur Siedlungs- und Hausbauweise diskutiert.
Als Ergänzungsmaterial zu Teil B "Dendroarchäologie in der Pfahlbaubucht von Sipplingen“ wird ein detaillierter Pfahlplan des Siedlungsareals online zur Verfügung gestellt. Verzeichnet sind nach Holzart und mit schematischem Querschnitt alle erfassten, dendrodatierten sowie undatierten Pfähle