727 research outputs found
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Camera Work. A Photographic Quarterly – Eine digitale Edition
No full textCamera Work is an American journal dedicated to art and photography published by Alfred Stieglitz in New York between 1903 and 1917.
Fifty regular quarterly issues and three special numbers were printed in editions of 1,000 copies and distributed to varying numbers of subscribers. In the history of photography, but also in the broad field of artistic movements, Camera Work holds the status of a modern icon.
Here you will find the TEI transcription of all issues, as well as TEI index files on persons, places and institutions, which were created according to the guidelines of heiEDITIONS
Programme costs of longer and shorter tuberculosis drug regimens and drug import: a modelling study for Karakalpakstan, Uzbekistan [Research Data]
No full textBackground: The introduction of new and often shorter tuberculosis (TB) drug regimens affects the cost of TB programmes.
Methods: We modelled drug purchase and import costs for 20-month, 9-month and 4- to 6-month TB drug regimens based on 2016–2020 treatment numbers from a TB programme in Karakalpakstan, Uzbekistan, and 2021 Global Drug Facility prices.
Results: On average, 2225±374 (±sd) people per year started TB treatment, 30±2.1% of whom were diagnosed with drug-resistant forms of TB. Transitioning from a 6-month to a 4-month drug-susceptible (DS)-TB drug regimen increased the TB programme's annual DS-TB drug cost from USD 65±10 K to USD 357±56 K (p<0.001) and its drug import cost from USD 6.4±1.0 K to USD 9.3±1.4 K (p=0.008). Transitioning from a 20-month all-oral multidrug-resistant (MDR)-TB drug regimen to a 9-month MDR-TB drug regimen with an injectable antibiotic decreased the TB programme's annual MDR-TB drug cost from USD 1336±265 K to USD 266±53 K (p<0.001) and had no significant effect on the drug import cost (USD 28±5.5 K versus USD 27±5.4 K; p=0.88). Purchasing (USD 577±114 K) and importing (USD 3.0±0.59 K) the 6-month all-oral MDR-TB drug regimen cost more than procuring the 9-month MDR-TB drug regimen but less than the 20-month all-oral MDR-TB drug regimen (both p<0.01).
Conclusion: Introducing new and shorter TB drug regimens could increase the cost of TB programmes with low drug resistance rates and decrease the cost of TB programmes with high drug resistance rates
In Situ Fabrication of Constraints for Multicellular Micro-Spheroids Using Two-Photon Lithography [data]
No full text2-photon polymerization is a promising technology for creating complex, microscale 3D matrices for biomedical and also bioprinting applications. Cancer research provides compelling uses for this strategy, in particular, for generating a 3D constraint around multicellular spheroids. Because these spheroids are inhomogeneous in size and shape, the ability to target a spheroid composed of a few living cells requires geometrical control of the printing shape in situ. In this study, it is presented that two-photon lithography can be used to study complex phenomena involved in cancer progression, such as collective 3D cell migration in situ in vitro. This method allows the spatial and temporal control of cancer cell migration from single spheroids, using dome-shaped confinements with micrometer-sized openings. The confinement of the spheroids leads to a decreased migration speed and affects actin dynamics. Furthermore, this methodology provides a novel way of analyzing the behavior of specific regions of multicellular structures, by enabling the separation of multicellular structures, while keeping them alive. Ultimately, this study demonstrates a new way to use two-photon lithography for controlling the growth, migration and morphological cues of live cells, thus opening new avenues toward the dynamic in situ control of living 3D structures
Developmental origins and evolution of pallial cell types and structures in birds - Data
No full textThe advanced cognitive abilities of birds rival those of mammals and have been attributed to evolutionary innovations in the pallium. However, a comprehensive cellular characterization of this brain region in birds has been lacking. We scrutinized the structures, cell types and evolutionary origins of the avian pallium based on single-cell and spatial transcriptomics atlases for the adult and developing chicken, and comparisons to corresponding data from mammals and non-avian reptiles. We found that the avian pallium shares most inhibitory neuron types with other amniotes. While excitatory neuron repertoires in the (medial) hippocampal formation show high conservation, they substantially diverged in other pallial regions during avian evolution, defining novel structures like the avian-specific (dorsal) hyperpallium, whose neuronal gene expression identities partly converge during late development with those of the (ventral) nidopallium. Our work also unveils the evolutionary relationships of pallial structures across amniotes, like the previously unknown homology between avian (lateral) mesopallial and mammalian deep layer cortical neurons
Closed-Loop Recyclable Silica-Based Nanocomposites with Multifunctional Properties and Versatile Processability [data]
No full textMost plastics originate from limited petroleum reserves and cannot be effectively recycled at the end of their life cycle, making them a significant threat to the environment and human health. Closed-loop chemical recycling, by depolymerizing plastics into monomers that can be repolymerized, offers a promising solution for recycling otherwise wasted plastics. However, most current chemically recyclable polymers may only be prepared at the gram scale, and their depolymerization typically requires harsh conditions and high energy consumption. Herein, it reports less petroleum-dependent closed-loop recyclable silica-based nanocomposites that can be prepared on a large scale and have a fully reversible polymerization/depolymerization capability at room temperature, based on catalysis of free aminopropyl groups with the assistance of diethylamine or ethylenediamine. The nanocomposites show glass-like hardness yet plastic-like light weight and toughness, exhibiting the highest specific mechanical strength superior even to common materials such as poly(methyl methacrylate), glass, and ZrO2 ceramic, as well as demonstrating multifunctionality such as anti-fouling, low thermal conductivity, and flame retardancy. Meanwhile, these nanocomposites can be easily processed by various plastic-like scalable manufacturing methods, such as compression molding and 3D printing. These nanocomposites are expected to provide an alternative to petroleum-based plastics and contribute to a closed-loop materials economy
Ergänzungsmaterial zu: Population trend in the Merovingian era in Western and Southern Germany
No full textData on Early Medieval population growth in Western and Southern Germany, based on the number of cemeteries and on the number of archaeologically dated graves
Stable Azaheptacenes
No full textwe have developed a novel access to stable azaheptacenes and investigated both their (air-stable) radical anions as well as dianions. The two azaheptacenes are significantly more stable than reported examples. We identified their structure through NMR, IR, MS and X-ray crystallography, and evaluated their stability through UV-Vis characterization.
The raw-data (NMR, IR, UV-Vis, MS, CV and EPR spectra) concerning the intermediates and final products are uploaded to the dataset
Relationship of Thermostability and Binding Affinity in Metal-binding WW-Domain Minireceptors [Research Data]
No full textThe design of metallo-miniproteins advances our understanding of the structural and functional roles of metals in proteins. We recently designed a metal-binding WW domain, WW-CA-Nle, which displays three histidine residues on its surface for coordination of divalent metals Ni(II), Zn(II) and Cu(II). However, WW-CA-Nle is a molten globule in the apo state and thus showed only moderate binding affinities with Kd values in the μM regime. In this report, we hypothesize that improved thermal stability of the apo state of the metal binding WW-domain scaffold should lead to improved preorganization of the metal-binding site and consequently to higher metal-binding affinities. By redesigning WW-CA-Nle, we obtained WW-CA variants, WW-CA-min and WW-CA-ANG, which were fully folded in the apo states and displayed moderate to excellent thermostabilities in the apo and holo states. We were able to show that the improved thermal stabilities led to improved metal binding, which was reflected in Kd values that were at least one order of magnitude lower compared to WW-CA-Nle. EPR spectroscopy and ITC measurements revealed a better defined and predisposed metal binding site in WW-CA-ANG
Influence of N-Introduction in Pentacene on the Electronic Structure and Excited Electronic States [data]
No full textUnderlying data for figures in the paper "Influence of N-Introduction in Pentacene on the Electronic Structure and Excited Electronic States
Multimaterial 3D Laser Printing of Cell-Adhesive and Cell-Repellent Hydrogels [data]
No full textThis study introduces a straightforward method for manufacturing 3D microstructured cell-adhesive and cell-repellent multimaterials using two-photon laser printing. Compared to existing strategies, this approach offers bottom-up molecular control, high customizability and rapid and precise 3D fabrication. The printable cell-adhesive PEG-based material includes an RGD-containing peptide synthesized through solid-phase peptide synthesis, allowing for precise control of the peptide design. Remarkably, minimal amounts of RGD peptide (< 0.1 wt%) suffice for imparting cell-adhesiveness, while maintaining identical mechanical properties in the 3D printed microstructures to those of the cell-repellent, PEG-based material. Fluorescent labeling of the RGD peptide facilitates visualization of its presence in cell-adhesive areas. To demonstrate the broad applicability of our system, we showcase the fabrication of cell-adhesive 2.5D and 3D structures, fostering the adhesion of fibroblast cells within these architectures. Thus, this approach allows for the printing of high-resolution, true 3D structures suitable for diverse applications, including cellular studies in complex environments