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Transcriptomics and Network Analysis; NCRM, UKHLS and ICLS Autumn School 2016: The use of biomarkers in social science research. Speaker: Adam Stevens
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No full textThis presentation was recorded at the NCRM event on Approaches to Analysing Qualitative Data: Archaeology as a Metaphor for Method. 18 October 2016, Foundling Museum, Londo
Genome-wide analysis identified 12 loci influencing human reproductive behaviour
Get PDFThe genetic architecture of human reproductive behavior—age at first birth (AFB) and number of children ever born (NEB)—has a strong relationship with fitness, human development, infertility and risk of neuropsychiatric disorders. However, very few genetic loci have been identified, and the underlying mechanisms of AFB and NEB are poorly understood. We report a large genome-wide association study of both sexes including 251,151 individuals for AFB and 343,072 individuals for NEB. We identified 12 independent loci that are significantly associated with AFB and/or NEB in a SNP-based genome-wide association study and 4 additional loci associated in a gene-based effort. These loci harbor genes that are likely to have a role, either directly or by affecting non-local gene expression, in human reproduction and infertility, thereby increasing understanding of these complex traits
MethodsNews 2016: 2
Get PDFIn this issue:
- Looking forward to the 7th ESRC Research Methods Festival
- It’s all in the sample: report of the inquiry into the 2015 British general election
- Putting data science in the service of social science
- What is the impact of fieldwork effort on subpopulation estimates?
- Implementing mixed mode surveys in Europe: opportunities and challenges
- Is the educational ‘what works’ agenda working?
- ‘Operationalising’ reflexivity - qualitative ethics in practice
- NCRM training and event
