Advanced Emergency Medicine (E-Journal)
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Triphenylphosphonium (TPP) Cation as a Promising Strategy in Mitochondria-Targeting and the Current Studies of the TPP-Based Mitochondria-Targeting Medicines in Ischemia-Reperfusion Injury and Cancer
Get PDFMitochondria are known as the “powerhouse†of a cell, in charge of the generation of respiratory ATP. On the other hand, mitochondria are also involved in cell metabolism, the formation and regulation of reactive oxygen species (ROS), mitophagy, and cell signalling. As a result, diseases like ischemia-reperfusion (IR) injury, neurological disorders, diabetes, and cancer may be caused by mitochondrial malfunction. Hence, mitochondrial dysfunction treatment has become a great interest in the research direction for the therapeutic strategy. To treat the dysfunctional mitochondria and facilitate the transportation of drugs, we need to accomplish accurate mitochondria-targeting. In this review, I will discuss triphenylphosphonium (TPP) as one of the most prevalent strategies in targeting and facilitating the drugs into mitochondria. Furthermore, the current studies of TPP in IR injury and cancer resulting from mitochondria dysfunction will be reviewed
Investigation and Fabrication of Micromotors for Biomedical Applications
Get PDFThe research of micromotors have received extensive attention in recent years, and their iconic feature is the ability to utilize external energy to achieve autonomous motion then carry out various tasks. Micromotor for biological applications is a common type of micromotors, this specific type of micromotor is capable to be applied to drug delivery system and transportation of cells. The content of this article is to introduce examples, potential, and current problems of micromotors based on hydrogels or other kind of environment-friendly materials for cell culture and drug delivery, and to further explore the effects of hydrogels and micromotors on cells and drugs. In addition, methods and steps of the preparation of a four-sided, dual-power Sodium Alginate (SA) hydrogel micromotor is demonstrated and explicitized, the micromotor’s ability to achieve independent movement and its potential applications are also explored
Development and Validation of a Predictive Model for the Prognosis of Complications of Supracondylar Fractures of The Humerus in Children
Get PDFObjective: Informing patient consultations and healthcare choices, clinical predictive models can offer patients tailored projections of the outcome. The most frequent elbow fractures in children are supracondylar humerus fractures, and clinical prediction models were still largely underutilized in these cases. By developing and verifying a prediction model to lower the risk of postoperative problems in children with supracondylar humerus fractures, this research sought to evaluate independent risk variables connected with the incidence of complications of supracondylar humerus fractures in children. Methods: We retrospectively studied 411 children with supracondylar humerus fractures treated surgically at our hospital from 2015 to 2019, and explored the independent risk factors affecting the prognosis of supracondylar humerus fractures in children in the study group using univariate and multifactorial Cox regression analysis, respectively. In addition, a prediction model based on the independent factors was constructed, a nomogram was made and data from the two cohorts were used to verify the feasibility and reliability of the model and visualize the data. Results: Height, older than eight years, weight, nerve damage, fracture type and with joystick technology of the child as independent risk factors influenced the prognosis of pediatric supracondylar humerus fractures in the modeling constructed by the training cohort, respectively. The results of the validation cohort were further screened for older than eight years, nerve injury and fracture type as independent prognostic factors. Conclusions: We were able to construct a predictive model based on a large genuine data sample, and clinical characteristics in this model could be used as independent predictors for reducing the occurrence of postoperative complications in supracondylar fractures. Combining basic vital signs and clinical risk factors into a simple and clear nomogram was more likely to result in the best treatment plan
Research Progress of Laboratory Diagnosis of TB
Get PDFEarly, rapid, and accurate identification of Mycobacterium tuberculosis is crucial to the treatment and management of the disease, and laboratory diagnosis is an important means for its diagnosis, treatment, and prevention control. Common methods include pathogenic methods based on bacterial smear and culture, molecular methods based on polymerase chain reaction (PCR), immunological methods such as tuberculin skin test and gamma-interferon (IFN-γ) release test, and the latest emergence of molecular methods, such as Xpert MTB/RIF and CRISPR technology have provided new perspectives for TB diagnosis. This review focuses on the main research advances in laboratory diagnosis of TB
Telescoping Tubridge Flow Diverter Treatment in Giant Middle Cerebral Artery Fusiform Aneurysm
Get PDFGiant fusiform aneurysm of the middle cerebral artery is a rare lesion with a high risk of rupture and high mortality, which is more difficult to treat either surgically or endovascularly. We report a case of a giant middle cerebral artery (MCA) M1 segmental fusiform aneurysm treated with the Tubridge Flow Diverter (TFD) telescoping technique alone without coil embolization. The patient had a single TFD implanted initially after the accidental discovery of a giant left MCA fusiform aneurysm, and after 3 months of postoperative shortening of the proximal end of the TFD and no significant healing of the aneurysm, a second TFD was implanted in the second stage by Telescoping technique. the aneurysm healed completely at 6 and 18 months after procedure, with no significant complications during follow-up.Â
Research Progress of Platelets, Lymphocytes and Neutrophils in Sepsis
Get PDFSepsis is a life-threatening organ dysfunction syndrome caused by the body's disregulated response to infection [1]. Platelets, lymphocytes and neutrophils are important cells in the immune response process of sepsis and play an important role in the progression of sepsis. Recently, research has found that platelet can inhibit bacteria, mediate inflammatory reaction process and secrete pro-inflammatory factors in addition to coagulation function. Lymphocytes act as adaptive immune cells, and low lymphocyte count can be a manifestation of immunosuppression. Neutrophils are important innate immune cells and represent the first barrier of immunity. Moreover, neutrophils, platelets and lymphocytes are common clinical indicators, which can be obtained in blood routine examination. As a new inflammatory index, Platelet-lymphocyte ratio and Neutral-lymphocyte ratio have gradually become the focus of the inflammatory index in the immune response process. In this paper, the value of platelet, lymphocytes and neutrophils in sepsis is reviewed
Correlation Between CT Body Fat Distribution and Carotid Plaque Characteristics
Get PDFObjective: To analyze the relationship between CT body fat distribution and the characteristics of carotid artery plaques. Method: A retrospective analysis was conducted on the clinical and imaging data of 50 patients who underwent CT examination in our hospital. Within 2 weeks, 50 patients were required to undergo abdominal CT and head CTA examinations. Transfer various data to the workstation and conduct research and analysis on the type of carotid artery plaque and degree of stenosis evaluated by CT angiography of the patient's head and neck. Determine the type of carotid artery plaque in patients and divide them into stable plaque group and unstable plaque group. According to the degree of carotid artery stenosis, patients are divided into no/mild stenosis group and moderate/severe stenosis group. Compare clinical laboratory indicators separately. Use SPSS21.0 statistical software for data processing. The measurement data in line with normal distribution were compared between the two groups by t test; The measurement data of non normal distribution were compared between the two groups by Mann Whitney U test. The difference was statistically significant with P<0.05. The VFA/SFA ratio was higher in the unstable plaque group than in the stable plaque group, and the difference between the two groups was statistically significant (P=0.028); There was no statistically significant difference in VFA and SFA between the two groups (P=0.106, 0.695); The total cholesterol in the unstable plaque group was lower than that in the stable plaque group, and the difference was statistically significant (P=0.052). The incidence rate of coronary heart disease in patients with moderate/severe stenosis was higher than that in patients with no/mild stenosis, and the difference between the two groups was statistically significant (P=0.037); The quantitative parameters of CT body fat distribution (VFA, SFA, VFA/SFA ratio) showed no statistically significant differences between the no/mild stenosis group and the moderate/severe stenosis group (P values>0.05). Conclusion: The quantitative parameter VFA/SFA ratio of abdominal fat is closely related to the stability of carotid artery plaques. The higher the VFA/SFA ratio, the poorer the stability of plaques
Professor Wang Xiaoyan's Experience in Treating Dementia
Get PDFDementia is a common Psychiatric disease, especially in the elderly group of high incidence, Professor Wang Xiaoyan thinks that the pathogenesis of this disease is the deficiency of upper qi, Yang qi can not access the brain body, the etiology is divided into two categories, including deficiency syndrome is divided into weak temper, kidney essence deficiency, positive syndrome is divided into phlegm turbidity and upper confusion, Yang Ming dry heat, etc.Clinical patients are mostly mixed with deficiency and reality, need to distinguish the primary and secondary, dialectical treatment, remarkable effect
Analysis of the Effectiveness of Globe Incision Mammaplasty in the Treatment of Early Breast Cancer
Get PDFObjective: To observe the efficacy of different methods in the treatment of early stage breast cancer disease. Methods: 84 patients admitted from 2020.12 to 2022.8 were divided into groups I and II, 42 patients each, who received treatment after conventional breast-conserving and racket-shaped incision mammoplasty, respectively, and compared the surgical treatment of patients between groups. Results: The rates of cosmetic excellence and complications in group II were 95.2% and 7.1% respectively, compared with 73.8% and 35.7% in group I. The differences reached a significant level (X² 5.825,8.556 respectively, P equals 0.016,0.003 both <0.05). Conclusion: The treatment of early breast cancer patients with racket-shaped incisions for mammaplasty is cosmetically effective and safe, and is worth promoting
Analysis of the Clinical Characteristics of Malignant Tumor Patients with Rheumatic Symptoms and Rheumatic Disease Combined with Malignant Tumor Patients
Get PDFObjective: We study the relationship between rheumatic immune disease and malignant tumor to provide the basis for clinical diagnosis and treatment. Methods: We selected 53 patients who were hospitalized in our department from January 2013 to February 2020, including 26 patients with rheumatic immune disease combined with malignant tumor and 27 patients with malignant tumor with rheumatic symptoms. We retrospectively analyzed the relationship between gender, age, main clinical manifestations, tumor system distribution, metastasis rate, rheumatic immune disease type and tumor type. Results: Among the patients with rheumatic immune disease complicated with tumor, 26.1% were male and 66.7% were female. Among the tumor patients with rheumatic symptoms, 73.9% were male and 33.3% were female. There was a significant difference in gender composition between the two groups. Among the patients with rheumatic immune disease complicated with tumor, respiratory system tumor was the highest. Among the tumor patients with rheumatic symptoms, the incidence of hematological tumors was the highest. The distribution of tumor system was different between the two groups. The proportion of metastatic tumor in patients with rheumatic symptoms is higher than that in patients with rheumatic immune disease combined with malignant tumor. The percentage of concurrent tumor in three diseases in the same period was 0.363% for rheumatoid arthritis, 2.02% for polymyositis/ dermatomyositis and 0.24% for Sjogren's syndrome. This study shows that patients with polymyositis/ dermatomyositis are more likely to develop malignant tumors. Conclusion: There were significant differences in gender composition, distribution of tumor system and the proportion of metastatic tumor between patients with rheumatic immune disease complicated with malignant tumor and patients with rheumatic symptoms, and malignant tumor was more common in patients with polymyositis/ dermatomyositis