Advanced Emergency Medicine (E-Journal)
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Clinical Treatment of Gastroenterology in Patients with Chronic Atrophic Gastritis
Get PDFObjective: To observe the clinical manifestations of selected patients with chronic atrophic gastritis, and to collect data to explore the clinical treatment effect of tepredone in the Department of Gastroenterology in patients with chronic atrophic gastritis. Methods: A total of 160 patients with chronic atrophic gastritis were selected among the patients admitted to the hospital for treatment from August 2019 to August 2022, and a total of 160 patients were selected as the experimental subjects of this clinical treatment study of gastroenterology in patients with chronic atrophic gastritis. 160 patients with chronic atrophic gastritis will be randomly divided into two groups, 80 cases in each group, to ensure that the difference between the study group and the control group is statistically significant to ensure the availability of experimental data. In the experiment, 80 patients with chronic atrophic gastritis in the control group received triple therapy with conventional treatment in gastroenterology, while 80 patients with chronic atrophic gastritis in the study group added tipredone therapy to the triple therapy of conventional treatment in gastroenterology. A two-week treatment cycle compares the effects of treatment between the study and control groups, collects data and draws corresponding conclusions. Results: After treatment, the total effective rate of treatment in the study group was 97.5%, which was higher than that in the control group, and the difference was statistically significant. Conclusion: In patients with chronic atrophic gastritis, on the basis of conventional treatment in gastroenterology, the addition of tepredone therapy has positive significance for the treatment effect of chronic atrophic gastritis, and can be promoted
Clinical Observation on the Treatment of Chronic Hypertrophic Rhinitis with Endoscopic Nasal Dilatation
Get PDFObjective: To observe the clinical efect of endoscopic nasal dilatation in the treatment of chronic hypertrophic rhinitis. Methods: Atotal of 100 patients who received treatment in the Department of Otolaryngology of our hospital from January 2019 to January 2021 were selected as the study subjects. Patients were divided into a control group and an experimental group using the method of numerical random allocation. There are 50 patients in each group. Patients in the control group were treated with medication, while patients in the experimental group were treated with endoscopic nasal dilatation. Compare the diferences in the efcacy, nasal congestion symptoms, and nasal resistance between the two groups of patients after treatment. Results The total efective rate of treatment in the experimental group (98.00%) was high-er than that in the control group (69.00%), with a statistically signifcant diference (
COVID-19 Patients with Concurrent Acute Angle-Closure Glaucoma: A Retrospective Hospital Study.”
Get PDFThis retrospective study investigates the interaction between COVID-19 and Acute Angle-Closure Glaucoma (AACG), analyzing clinical features, laboratory fndings, and OCTAimages in 20 patients diagnosed with both conditions. Elevated Intraocular Pressure (IOP) levels and a decrease in the deep capillary plexus (DCP) and choriocapillaris (CC) foveal vessel density were observed, with infammation and coagulation markers also elevated. These fndings suggest that the physiological changes induced by COVID-19 may exacerbate AACG symptoms. Despite the study’s limitations, including a small sample size and retrospective design, these insights are pivotal for clinicians and underline the importance of careful ocular monitoring in COVID-19 patients. Further research is warranted to explore the long-term implica-tions of these fndings and the mechanistic pathways underlying the interaction between COVID-19 andAACG
Antitumor Activity of Celery Loaded Lipid PLGA-TPGS Nanoparticles in Glioblastoma
Get PDFGlioblastoma (GBM) is a highly aggressive brain tumor characterized by high recurrence and poor prognosis. Natural compounds are good alternatives for treating glioblastoma and are less toxic than synthetic drugs. Apigenin (AGN) is an effective phytochemical with strong antioxidant and anticancer potential. However, due to its high lipophilicity, the therapeutic effect is limited. Therefore, apigenin lipid polymer hybrid nanoparticles (LPHyNPs) were prepared and characterized according to various parameters in this study. The mean particle size (234.100±23.320 nm), PDI (0.330±0.098), zeta potential (-5.403±0.650 mV), EE (54.99±4.13%), etc. Besides, Morphological analysis by SEM showed that the spherical NP had dark nuclei, indicating that the drug was embedded in the nucleus. In vitro release studies showed that continuous release of AGN from LPHyNPs significantly increased the suspension level of AGN (P<0.05). Cell proliferation and apoptosis experiments showed that LPHyNPs could significantly inhibit cell proliferation and promote cell apoptosis. Therefore, the LPHyNPs developed may be an effective therapeutic system for the management of GBM
Therapeutic Effect of Azithromycin on Clinical Gynecological Mycoplasma Infection
Get PDFObjective: To explore the therapeutic effect of Azithromycin on gynecological mycoplasma infection. Method: Forty patients with gynecological mycoplasma infection who underwent examination and treatment in our hospital from June 2021 to June 2022 were selected as the study subjects. These 40 patients were divided into a control group and an experimental group, with 20 patients in each group. Among them, the experimental group was treated with Azithromycin, and the patients in the control group were treated with cefoxitin sodium. The effects, satisfaction and adverse reactions of the two groups were compared. Result: Through experimental comparison, it can be seen that the total effective rate of treatment in the experimental group is better than that in the control group, and the difference between the two is statistically significant (P<0.05); After receiving treatment, the IL-10 and TNF levels in two experimental groups of patients- α, CRP and other levels all decreased, and in the observation group, patients' IL-10 and TNF- α. The CRP level will be lower than the control group, and the difference between the two is statistically significant (P<0.05). After the experiment, the satisfaction of patients in the observation group will be higher than that in the control group, and the difference between the two is statistically significant (P<0.05). Conclusion: The treatment effect of Azithromycin for clinical gynaecological mycoplasma infection will be better. With this treatment method, the clinical symptoms of patients can be effectively improved. At the same time, the treatment compliance and satisfaction of patients can be further improved, and the probability of various adverse reactions can be reduced. It can be popularized and applied to clinical practice
Effect of Progesterone Combined with Low Molecular Weight Heparin Sodium in the Treatment of Recurrent Miscarriage
Get PDFObjective: To analyze the effect of progesterone combined with low molecular weight heparin sodium in the treatment of recurrent miscarriage. Methods: A total of 68 patients with recurrent miscarriage admitted to our hospital within 1 year from 2022.04 to 2023.04 were selected as research subjects, and they were divided into control group (34 cases, treated with progesterone) and observation group (34 cases, treated with low molecular weight heparin sodium combined with progesterone) according to the random number table method. The treatment effects of the two groups were analyzed. Results: Both groups achieved certain results after treatment, but the coagulation indexes, sex hormone levels and delivery outcomes of the observation group were better than those in the control group after treatment with progesterone combined with low molecular weight heparin sodium (P<0.05). Conclusion: Progesterone combined with low molecular weight heparin sodium can effectively improve the coagulation effect, regulate the level of sex hormones, and improve the outcome of childbirth in patients with recurrent miscarriage
The Possible Relationship and Drug Targets of Ischemic Stroke and Dementia in Oxidative Stress
Get PDFThere are multiple mechanisms of pathogenic factors in dementia and ischemic-reperfusion injury, such as oxidative stress (OS) and the reactive oxygen species (ROS). NADPH oxidases (NOXs) have a broad distribution in brain and participate in the oxidative stress and inflammatory responses. It may be efficient to treat this specific target of NOX to establish a balance between reactive oxygen species and antioxidants. This review will elaborate the possible relationship and mechanism between the occurrence of stroke and its complications and focus on NOXs, ROS and inflammatory responses to figure out the possible signaling pathway in the perspective of oxidative stress. And NOX2 will be focused to demonstrate the relationship between ischemia-reperfusion and pathogenic factors of dementia via the NOX2/ROS signaling pathway. And considering the upstream and downstream elements and the end results of this signaling pathway, inhibiting NOX2 activity can reduce oxidative damage and inflammatory responses, NOX2 can be considered as a drug target to treat stroke development to reduce the risk of severe dementia
An Experimental Study on the Effects of Deep Touch Pressure on Emotion Soothing
Get PDFStress, anxiety, and depression are normal reactions to a variety of stressors and have a detrimental effect on mental or physical well-being. An experimental study on the effects of deep touch pressure on emotion soothing was carried out. The study used an automated pressure vest and measured participants' vital signs and emotions before and after being exposed to a stressor. Secondly, an automatic pressure vest was used to explore the effects of deep touch pressure on emotion soothing. The State-Trait Anxiety Inventory, a self-rating anxiety scale, and electroencephalogram (EEG) readings measure deep touch pressure effects on anxiety reduction. The research found that the pressure vest helped to reduce stress and improve relaxation. It also found that the pressure vest induced a high theta in the prefrontal lobe of the brain, indicating that the participants became more relaxed. The study suggests that deep touch pressure may be an effective, non-pharmacological method for reducing stress, anxiety, and depression
Multi-Slice Spiral CT Diagnosis of Septic Pulmonary Embolism Caused by Infective Endocarditis
Get PDFObjective: To analyze the multi-slice spiral CT manifestations of septic pulmonary embolism caused by infective endocarditis, and improve the understanding and imaging diagnostic ability of this disease. Method: 50 infected SPE patients who visited our hospital from January 2020 to January 2021 were selected. Through detailed analysis of the CT diagnosis results of the patients, the characteristics of SPT under multi-slice spiral CT scanning were understood, the pulmonary artery manifestations of the patients were observed, and the pulmonary display of the patients' primary heart disease and vegetations was determined. Result: There were 19 fungal pulmonary aneurysms in 16 cases, of which 5 were solitary, with 10 cystic, 6 irregular edges, and 4 thickened walls. The filling defects were located in 4 peripheral and 3 distal segments, and 4 were more common in the outer basal segment of the lower lobe and the inner segment of the right middle lobe. There were 2 proximal and 3 middle segments of the pulmonary artery. Three cases showed halo signs around the aneurysm, and four cases had rapid enlargement of the pulmonary artery contour during the acute phase. Among them, three cases shrank and became thinner after anti infection treatment. Before treatment, 5 cases had slightly thickened pulmonary arteries due to embolism. 20 cases of electrocardiographically gated whole chest cardiac large vessel CT angiography were able to clearly display cardiac lesions, with 15 cases showing pulmonary endarteritis, which showed rough and irregular thickening of the pulmonary artery wall, including 10 cases of local swelling. 11 cases showed vegetations. 5 cases underwent chest enhancement scan, showing 5 cases of cardiac lesions and 5 cases of vegetations. All 50 cases had multiple and multiple forms of lesions in both lungs, including patchy infiltrative shadows, wedge-shaped shadows, nodules, and cords. The first three may be accompanied by cavities and airbags, while wedge-shaped shadows and nodules may be accompanied by nutrient vessel signs, mainly distributed around the lungs. Conclusion: For patients with SPE, the use of multi-slice spiral CT for diagnosis is more efficient, and this method is currently the best method for examining the disease
Clinical Effect of Endoscopic Sinus Surgery on Fungal Sinusitis
Get PDFObjective: To investigate the clinical effect of endoscopic sinus surgery on fungal sinusitis. Methods: 100 patients who came to our hospital for treatment from January 2019 to January 2022 were selected as the study subjects. The patients were divided into two groups using a random number table method, with 50 patients in each group. They were the experimental group and the control group. Patients in the control group can be treated with traditional Caldwell Luc surgery. The experimental group was treated with endoscopic sinus surgery. The total effective rate, specific airway resistance, olfactory function, incidence of postoperative infection, and recurrence rate of the two groups were compared. Results: The total effective rate of surgery in the experimental group reached 98%. Compared with the control group, the total effective rate of surgery was 78%. The difference was statistically significant (P<0.05). There was no statistically significant difference between the postoperative infection rate (2.53% vs 8.57%) and recurrence rate (2.86% vs 5.71%) between the two groups (P>0.05). Conclusion The treatment of fungal sinusitis with endoscopic sinus surgery is effective, which can significantly reduce nasal airway resistance, improve patients' olfactory function, and reduce postoperative infection and recurrence