Advanced Emergency Medicine (E-Journal)
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The value of CRP and NLR in differential diagnosis of benign and malignant pulmonary nodules
Get PDFObjective: Evaluate CRP and NLR levels in benign vs. malignant pulmonary nodules for differential diagnosis. Methods: Selected
60 patients with benign nodules and 60 with lung cancer from a Hunan hospital from August 2022 to December 2023. Analyzed CRP and
NLR diagnostic value. Results: Significant differences in CRP, NLR levels between groups (
Study on the application of CBCT in the diagnosis of chronic periapical periodontitis with different depth of periodontal pocket
Get PDFObjective To investigate the application of conical beam CT(CBCT) in the diagnosis of VRF with chronic periapical inflammation
and different depth of periodontal exploration. Methods 40 teeth with chronic periapical inflammation suspected of VRF in 39 patients were
examined by X-ray apical film, CBCT and periodontal examination respectively. Diagnosis and statistical analysis were performed for each
affected tooth by two specialists, and subgroup analysis was performed according to the influence of the depth of the peridental pocket on the
diagnosis results of CBCT. Results The sensitivity, missed diagnosis rate and consistency rate of CBCT in the diagnosis of VRF were 78.8%,
21.2% and 82.5%, respectively, which were significantly different from that of X-ray root tip film (54.8%, 45.2% and 60.0%) (
Influence Of Wang Ji’s Theory Of “No Fixed Points For Treatment” On The Clinical Practice Of Acupuncture And Moxibustion
Get PDFWang Ji opposed the mechanical use of “a certain point for a certain disease” and proposed the theory of “no fixed point for the treatment of disease” in his “Acupuncture and Moxibustion”, believing that the diagnosis and treatment should be investigated into the cause of the disease, the transmission of the disease and the meridians and channels, and the division of qi and blood, in order to obtain the rationale of random adaptation. Wang Ji advocated that the method of acupuncture should be decided according to the specific situation of the patient, and this academic thought is consistent with the main theme of Chinese medicine’s diagnosis and treatment, and the theoretical ideas corresponding to various fields have been developed around the theory of “no fixed point for treating disease”, which has had a crucial impact on the clinical treatment of acupuncture
Mechanism of osteogenic differentiation of umbilical cord mesenchymal stem cells
Get PDFMesenchymal stem cells (MSCS) exist in a variety of tissues and have multi-lineage differentiation potential. Mesenchymal stem cells have great application prospects in the treatment of bone injury diseases. The rapid initiation and efficient induction of osteogenic signaling pathways are the key to mesenchymal stem cell-based bone tissue engineering technology. Multiple signaling pathways have been confirmed to play a regulatory role in the process of osteogenic differentiation of mesenchymal stem cells. This article reviews the research progress of the mechanism of osteogenic differentiation of mesenchymal stem cells
The Impact of Energy Level Zoning Nursing Mode on the Emergency Response Effect of Critically Ill Patients
Get PDFObjective: To improve the emergency response effect of critically ill patients, and to implement a level zoning nursing model in
clinical practice to clarify its impact on critically ill patients. Methods: A total of 95 critically ill patients who received diagnosis and treatment in the hospital during the period of January 2023 to December 2023 were analyzed. They were divided into a control group (49 cases)
and an observation group (46 cases) in order of diagnosis and treatment. Two groups of nursing interventions were implemented using conventional methods and level based nursing models, and the intervention situation was analyzed. In terms of the incidence of complications,
the observation group had a lower total value (
Research Progress on the effect of High altitude and hypoxia on Mitochondrial function in Obesity
Get PDFObesity is one of the diseases that threaten human health at present, and it can lead to the increasing prevalence of related complications, such as Insulin resistance, Non-alcoholic fatty liver diseases NAFLD and Type 2 diabetes mellitus and so on. In the whole world,
the prevalence rate of obesity is on the rise. Insulin resistance is one of the most common complications of obesity. More and more studies
have shown that there is a close relationship between mitochondrial dysfunction and insulin resistance. Skeletal muscle is an important target
organ of insulin. Skeletal muscle mitochondrial dysfunction can lead to abnormal glucose and lipid metabolism and further affect the signal
pathway of energy metabolism. The new epidemiological survey shows that the prevalence of obesity in high altitude areas is significantly
lower than that in plain areas, and the prevalence of overweight and obesity is negatively correlated with altitude. This paper discusses the
relationship between high altitude hypoxia and mitochondrial metabolism
Application of novel oral anticoagulants for the antithrombotic effect of cardiovascular system diseases
Get PDFLong-term oral anticoagulant is one of the methods for the treatment of cardiovascular system diseases, and the most widely used
anticoagulant drug is warfarin, but its clinical application has been greatly limited due to its slow onset, easy to affect by various factors, and
difficult dose control. In recent years, with the continuous in-depth research on cardiovascular system diseases, the emergence of new oral
anticoagulants (NOAC) has greatly impacted the status of traditional anticoagulant warfarin because of its safety, stability and convenience
of consumption. The purpose of this article is to review the classification and application of novel oral anticoagulants
Latest Advances In Geriatric Care: Enhancing Quality Of Life For Older Adults
Get PDFLatest advancements in elderly care aim to improve quality of life for older adults. Interactive technology and remote medical care
enhance socialization and entertainment, and facilitate remote diagnosis and monitoring. Professional training and nursing talent cultivation
equip caregivers with advanced skills and improve communication and collaboration. Policy intensification and societal support improve liv_x0002_ing conditions and resources for healthy aging. Evaluating implementation effectiveness and future research directions will optimize caregiving, further enhancing older adults’ quality of life. These advancements provide comprehensive, compassionate care, fostering continuous
development and innovation in elderly care
Prevention and Early Diagnosis of Gastric Cancer
Get PDFGastric cancer is one of the most common malignant tumors, posing a serious threat to people’s life and health. Therefore, prevention and early diagnosis are crucial for managing gastric cancer. This article provides an overview of the research progress in gastric cancer prevention, as well as related serological examinations, tumor markers, and endoscopic techniques.Serological tests and tumor markers are convenient, rapid, and easily accessible screening tools for gastric cancer. However, their sensitivity and specificity are not yet satisfactory and require further improvement. Endoscopic technology offers the advantage of directly observing lesion sites with a high detection rate. When combined with pathologic tissue biopsy, endoscopy serves as a means to confirm the diagnosis of gastric cancer. Nevertheless, it is important to note that endoscopy can be a cumbersome procedure with its detection rate depending on the level of experience of the examiner. Despite these advantages, due to its invasiveness to patients’ digestive tracts and potential discomfort during examination procedures leading to patient intolerance towards pain; endoscopy has not been widely adopted as a screening tool for early gastric cancer
Correlation Study between Genetic Polymorphisms and Blood Concentrations of Sodium Valproate in Pediatric Epilepsy Patients
Get PDFObjective: To explore the correlation between genetic polymorphisms and blood concentrations of sodium valproate in pediatric
epilepsy patients, providing evidence for individualized treatment of epilepsy patients. Methods: Pediatric epilepsy patients diagnosed with
epilepsy and treated with sodium valproate monotherapy in the outpatient and inpatient departments of a tertiary hospital from January 2020
to December 2023 were selected. The steady-state blood concentrations of sodium valproate were monitored, and polymerase chain reaction
(PCR) was used to genotype ABCB1G2677T/A and UGT1A6T19G genes. Data were analyzed using SPSS 17.0 statistical software. Results:
The UGT1A6T19G gene polymorphism significantly affected the blood concentrations of sodium valproate in epilepsy patients. Carriers of
the G allele had significantly lower blood concentrations of sodium valproate than wild-type homozygotes (TT) patients, and the decrease in
blood concentrations of sodium valproate was particularly significant in homozygous mutant GG genotype patients. The ABCB1G2677T/
A gene polymorphism had no statistically significant effect on the blood concentrations of sodium valproate in pediatric epilepsy patients.
Conclusion: Through the study of the correlation between genetic polymorphisms and blood concentrations of sodium valproate, factors in_x0002_fluencing the steady-state trough concentrations of valproate can be revealed from a genetic perspective, providing theoretical evidence for
the precise use of sodium valproate in pediatric epilepsy patients